| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aydanur Karg, Zekiye Aydoğdu Dinç, Oktay Başok, Ahmet Uçve. MUC4 expression and its relation to ErbB2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (NSCLC). Pathology, research and practice. vol 202. issue 8. 2006-09-21. PMID:16814944. |
muc4 expression and its relation to erbb2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (nsclc). |
2006-09-21 |
2023-08-12 |
human |
| Aydanur Karg, Zekiye Aydoğdu Dinç, Oktay Başok, Ahmet Uçve. MUC4 expression and its relation to ErbB2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (NSCLC). Pathology, research and practice. vol 202. issue 8. 2006-09-21. PMID:16814944. |
muc4 and erbb2 mediate intracellular signaling pathways that are linked to repression of apoptosis and either to proliferation or to differentiation of tumor cells. |
2006-09-21 |
2023-08-12 |
human |
| Aydanur Karg, Zekiye Aydoğdu Dinç, Oktay Başok, Ahmet Uçve. MUC4 expression and its relation to ErbB2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (NSCLC). Pathology, research and practice. vol 202. issue 8. 2006-09-21. PMID:16814944. |
this study investigates the expression of human muc4 in neoplastic and corresponding non-neoplastic tissues, and the relation of muc4 expression in neoplastic tissues to erbb2 expression, apoptosis, proliferation, differentiation, and tumor stage in a series of 100 non-small cell lung carcinomas (nsclcs). |
2006-09-21 |
2023-08-12 |
human |
| Jessica Kao, Jonathan R Pollac. RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes. Genes, chromosomes & cancer. vol 45. issue 8. 2006-09-15. PMID:16708353. |
in these cell lines (but not in control mcf7 breast cancer cells lacking 17q12 amplification), targeted knockdown of erbb2 expression using rna interference (rnai) methods results in decreased cell proliferation, decreased cell-cycle progression, and increased apoptosis. |
2006-09-15 |
2023-08-12 |
Not clear |
| Mariana Lopes dos Santos, Carolina Gonçalves Palanch, Sibeli Salaorni, Wilson Araujo Da Silva, Maria Aparecida Naga. Transcriptome characterization of human mammary cell lines expressing different levels of ERBB2 by serial analysis of gene expression. International journal of oncology. vol 28. issue 6. 2006-08-16. PMID:16685446. |
the c5.2 cell line, which over-express erbb2, showed in comparison to hb4a cells a higher percentage of genes involved in transport, rna processing, apoptosis and protein folding. |
2006-08-16 |
2023-08-12 |
human |
| Barbara Zsebik, Ami Citri, Jorma Isola, Yosef Yarden, János Szöllosi, György Vere. Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1. Immunology letters. vol 104. issue 1-2. 2006-05-25. PMID:16384610. |
baseline and stimulus-evoked dimerization and activation levels of erbb2, and the effects of trastuzumab and 17-aag alone and in combination on cell proliferation and apoptosis, as well as on erbb2 expression and phosphorylation have been measured. |
2006-05-25 |
2023-08-12 |
Not clear |
| Barbara Zsebik, Ami Citri, Jorma Isola, Yosef Yarden, János Szöllosi, György Vere. Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1. Immunology letters. vol 104. issue 1-2. 2006-05-25. PMID:16384610. |
the antiproliferative effect of 17-aag was positively correlated with phosphorylation and downregulation of erbb2 and was dominated by apoptosis, although, especially at higher doses, necrosis was also present. |
2006-05-25 |
2023-08-12 |
Not clear |
| Wenle Xia, John Bisi, Jay Strum, Leihua Liu, Kevin Carrick, Katherine M Graham, Amanda L Treece, Mary Ann Hardwicke, Michael Dush, Qiaoyin Liao, Ron E Westlund, Sumin Zhao, Sarah Bacus, Neil L Specto. Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers. Cancer research. vol 66. issue 3. 2006-03-21. PMID:16452223. |
in breast cancer, overexpression of erbb2 or aberrant regulation of survivin, a member of the inhibitor of apoptosis family, is associated with resistance to chemo/hormone therapy and predicts for a poor clinical outcome. |
2006-03-21 |
2023-08-12 |
Not clear |
| Wenle Xia, John Bisi, Jay Strum, Leihua Liu, Kevin Carrick, Katherine M Graham, Amanda L Treece, Mary Ann Hardwicke, Michael Dush, Qiaoyin Liao, Ron E Westlund, Sumin Zhao, Sarah Bacus, Neil L Specto. Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers. Cancer research. vol 66. issue 3. 2006-03-21. PMID:16452223. |
selective knockdown of erbb2 using small interfering rna markedly reduced survivin protein, resulting in apoptosis of erbb2-overexpressing breast cancer cell lines such as bt474. |
2006-03-21 |
2023-08-12 |
Not clear |
| Wenle Xia, John Bisi, Jay Strum, Leihua Liu, Kevin Carrick, Katherine M Graham, Amanda L Treece, Mary Ann Hardwicke, Michael Dush, Qiaoyin Liao, Ron E Westlund, Sumin Zhao, Sarah Bacus, Neil L Specto. Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers. Cancer research. vol 66. issue 3. 2006-03-21. PMID:16452223. |
alternatively, inhibition of erbb2 signaling using lapatinib (gw572016), a reversible small-molecule inhibitor of erbb1/erbb2 tyrosine kinases, at pharmacologically relevant concentrations, leads to marked inhibition of survivin protein with subsequent apoptosis. |
2006-03-21 |
2023-08-12 |
Not clear |
| Yunfei Zhou, Song Li, Yi P Hu, Jing Wang, Jennie Hauser, Alexis N Conway, Michelle A Vinci, Lisa Humphrey, Elizabeth Zborowska, James K V Willson, Michael G Brattai. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer research. vol 66. issue 1. 2006-02-23. PMID:16397255. |
blockade of egfr and erbb2 by the novel dual egfr and erbb2 tyrosine kinase inhibitor gw572016 sensitizes human colon carcinoma geo cells to apoptosis. |
2006-02-23 |
2023-08-12 |
human |
| Shannon Reagan-Shaw, Nihal Ahma. RNA interference-mediated depletion of phosphoinositide 3-kinase activates forkhead box class O transcription factors and induces cell cycle arrest and apoptosis in breast carcinoma cells. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16424042. |
transfection of pi3k sirna in breast cancer cells resulted in a significant decrease in cell viability and induction of apoptosis irrespective of their estrogen receptor alpha (eralpha) or erbb2 status. |
2006-02-14 |
2023-08-12 |
Not clear |
| Susanne Rohrbach, Bernd Niemann, Rolf-Edgar Silber, Juergen Holt. Neuregulin receptors erbB2 and erbB4 in failing human myocardium -- depressed expression and attenuated activation. Basic research in cardiology. vol 100. issue 3. 2005-12-30. PMID:15685397. |
in cultured cardiomyocytes, erbb2 and erbb4 receptors regulate apoptosis by controlling bcl-x splicing, and conditional elimination of erbb2 induces dilative cardiomyopathy in vivo. |
2005-12-30 |
2023-08-12 |
human |
| Wenle Xia, Catherine M Gerard, Leihua Liu, Nathalie M Baudson, Thierry L Ory, Neil L Specto. Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. vol 24. issue 41. 2005-11-21. PMID:16091755. |
combining lapatinib (gw572016), a small molecule inhibitor of erbb1 and erbb2 tyrosine kinases, with therapeutic anti-erbb2 antibodies enhances apoptosis of erbb2-overexpressing breast cancer cells. |
2005-11-21 |
2023-08-12 |
human |
| Wenle Xia, Catherine M Gerard, Leihua Liu, Nathalie M Baudson, Thierry L Ory, Neil L Specto. Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. vol 24. issue 41. 2005-11-21. PMID:16091755. |
here, apoptosis of erbb2-overexpressing breast cancer cells was enhanced by combining lapatinib, an inhibitor of erbb1 and erbb2 tyrosine kinases, with anti-erbb2 antibodies, including (i) trastuzumab, a humanized monoclonal antibody, and (ii) pab, rabbit polyclonal antisera generated by vaccination with a human erbb2 fusion protein. |
2005-11-21 |
2023-08-12 |
human |
| Wenle Xia, Catherine M Gerard, Leihua Liu, Nathalie M Baudson, Thierry L Ory, Neil L Specto. Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. vol 24. issue 41. 2005-11-21. PMID:16091755. |
exposure to pab alone reduced total erbb2 protein, disrupting erbb3 transactivation, leading to a marked inhibition of p-akt; however, survivin protein levels remained unchanged and apoptosis only increased slightly. |
2005-11-21 |
2023-08-12 |
human |
| Yunfei Zhou, Michael G Brattai. Synergy of epidermal growth factor receptor kinase inhibitor AG1478 and ErbB2 kinase inhibitor AG879 in human colon carcinoma cells is associated with induction of apoptosis. Cancer research. vol 65. issue 13. 2005-09-07. PMID:15994962. |
synergy of epidermal growth factor receptor kinase inhibitor ag1478 and erbb2 kinase inhibitor ag879 in human colon carcinoma cells is associated with induction of apoptosis. |
2005-09-07 |
2023-08-12 |
human |
| Yunfei Zhou, Michael G Brattai. Synergy of epidermal growth factor receptor kinase inhibitor AG1478 and ErbB2 kinase inhibitor AG879 in human colon carcinoma cells is associated with induction of apoptosis. Cancer research. vol 65. issue 13. 2005-09-07. PMID:15994962. |
similarly, ag879, a selective erbb2 tki, was incapable of inducing apoptosis in fet6alphas26x cells at concentrations sufficient to inhibit cell growth and erbb2 phosphorylation. |
2005-09-07 |
2023-08-12 |
human |
| Bo-Geon Yun, Robert L Matt. Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation. Experimental cell research. vol 307. issue 1. 2005-07-25. PMID:15922741. |
treatment of differentiating c2c12 myoblasts with geldanamycin blocked myogenin expression, inhibited myotubule formation, and led to the depletion of three hsp90-dependent protein kinases, erbb2, fyn, and akt, and induction of apoptosis. |
2005-07-25 |
2023-08-12 |
Not clear |
| Woo K Kim, Myung H Bang, Eul S Kim, Nam E Kang, Kyeong C Jung, Han J Cho, Jung H Y Par. Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. The Journal of nutritional biochemistry. vol 16. issue 3. 2005-06-24. PMID:15741050. |
in this study, we assessed quercetin regulation of ht-29 and sw480 cell apoptosis and the influence of quercetin on the protein expression of erbb2, erbb3, akt, bax and bcl-2. |
2005-06-24 |
2023-08-12 |
human |