| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuliana Cavalloni, Ivana Sarotto, Ymera Pignochino, Loretta Gammaitoni, Giorgia Migliardi, Luca Sgro, Wanda Piacibello, Mauro Risio, Massimo Aglietta, Francesco Leon. Granulocyte-colony stimulating factor upregulates ErbB2 expression on breast cancer cell lines and converts primary resistance to trastuzumab. Anti-cancer drugs. vol 19. issue 7. 2008-09-08. PMID:18594210. |
g-csf treatment increases erbb2 expression in vitro and in vivo enhancing the activity of trastuzumab on bc cell lines inducing apoptosis of bc cells with low or no erbb2 genomic amplification. |
2008-09-08 |
2023-08-12 |
Not clear |
| Ali Naderi, Luke Hughes-Davie. A functionally significant cross-talk between androgen receptor and ErbB2 pathways in estrogen receptor negative breast cancer. Neoplasia (New York, N.Y.). vol 10. issue 6. 2008-09-02. PMID:18516291. |
importantly, there is a synergy with the combined use of flutamide and ag825 on cell proliferation and apoptosis, which indicates a therapeutic advantage in the combined blockage of ar and erbb2 pathways. |
2008-09-02 |
2023-08-12 |
Not clear |
| Katherine M Aird, Xiuyun Ding, Aris Baras, Junping Wei, Michael A Morse, Timothy Clay, Herbert K Lyerly, Gayathri R Dev. Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression. Molecular cancer therapeutics. vol 7. issue 1. 2008-04-03. PMID:18202008. |
a distinct mechanism involving increased expression of x-linked inhibitor of apoptosis protein (xiap) and survivin, key members of the inhibitor of apoptosis protein (iap) family, was observed post-trastuzumab (an erbb2 monoclonal antibody) treatment in an erbb2-overexpressing, estrogen receptor negative, ibc cellular model, sum190pt, isolated from a primary ibc tumor. |
2008-04-03 |
2023-08-12 |
Not clear |
| Eleftherios Vairaktaris, Sofia Spyridonidou, Lambros Goutzanis, Antonis Vylliotis, Andreas Lazaris, Ismini Donta, Despina Perrea, Christos Yapijakis, Efstratios Patsouri. Diabetes and oral oncogenesis. Anticancer research. vol 27. issue 6B. 2008-02-12. PMID:18225590. |
the expression of egfr, erbb2, erbb3, fgfr-2, fgfr-3, c-myc, n-ras, ets-1, h-ras, c-fos and c-jun, the tumor suppressor genes p53 and p16, apoptosis markers bax and bcl-2, and the cell proliferation marker ki-67 in the sequential stages of rat oral oncogenesis was investigated. |
2008-02-12 |
2023-08-12 |
rat |
| Eleftherios Vairaktaris, Sofia Spyridonidou, Lambros Goutzanis, Antonis Vylliotis, Andreas Lazaris, Ismini Donta, Despina Perrea, Christos Yapijakis, Efstratios Patsouri. Diabetes and oral oncogenesis. Anticancer research. vol 27. issue 6B. 2008-02-12. PMID:18225590. |
diabetes seems to promote the activation of the ras/raf/mapk signal transduction pathway mainly by induction of erbb2 and erbb3 receptors, leading to increased cell proliferation, while there was no difference in apoptosis levels during oncogenesis. |
2008-02-12 |
2023-08-12 |
rat |
| Linlin Wang, Thomas C Schulz, Eric S Sherrer, Derek S Dauphin, Soojung Shin, Angelique M Nelson, Carol B Ware, Mei Zhan, Chao-Zhong Song, Xiaoji Chen, Sandii N Brimble, Amanda McLean, Maria J Galeano, Elizabeth W Uhl, Kevin A D'Amour, Jonathan D Chesnut, Mahendra S Rao, C Anthony Blau, Allan J Robin. Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Blood. vol 110. issue 12. 2007-12-26. PMID:17761519. |
inhibition of igf1r using a blocking antibody or lentivirus-delivered shrna reduced hesc self-renewal and promoted differentiation, while disruption of erbb2 signaling with the selective inhibitor ag825 severely inhibited hesc proliferation and promoted apoptosis. |
2007-12-26 |
2023-08-12 |
mouse |
| Justin G Madson, Laura A Hanse. Multiple mechanisms of Erbb2 action after ultraviolet irradiation of the skin. Molecular carcinogenesis. vol 46. issue 8. 2007-09-18. PMID:17477367. |
erbb2 alters the expression of regulatory genes controlling inflammation, angiogenesis, cell division, apoptosis, cell adhesion, and migration following uv irradiation. |
2007-09-18 |
2023-08-12 |
human |
| Justin G Madson, Laura A Hanse. Multiple mechanisms of Erbb2 action after ultraviolet irradiation of the skin. Molecular carcinogenesis. vol 46. issue 8. 2007-09-18. PMID:17477367. |
in addition, erbb2 dampens uv-induced s-phase arrest, augments inflammation in response to uv irradiation, and suppresses uv-induced apoptosis. |
2007-09-18 |
2023-08-12 |
human |
| Corina Marx, Christina Yau, Surita Banwait, Yamei Zhou, Gary K Scott, Byron Hann, John W Park, Christopher C Ben. Proteasome-regulated ERBB2 and estrogen receptor pathways in breast cancer. Molecular pharmacology. vol 71. issue 6. 2007-07-18. PMID:17392524. |
reduction in 20s activity (> 60%) was associated with early (24 h) intracellular relocalization of er (nucleus to cytoplasm) and erbb2 (plasma membrane to perinuclear lysosomes), buildup of ubiquitinated and hsp70-associated receptor, degradation and loss of er and erbb2 function, and induction of cellular apoptosis. |
2007-07-18 |
2023-08-12 |
human |
| Laura Pentassuglia, Francesco Timolati, Franziska Seifriz, Kaisaier Abudukadier, Thomas M Suter, Christian Zuppinge. Inhibition of ErbB2/neuregulin signaling augments paclitaxel-induced cardiotoxicity in adult ventricular myocytes. Experimental cell research. vol 313. issue 8. 2007-06-11. PMID:17400210. |
treatment of arvm with paclitaxel or antibodies to erbb2 caused a significant increase in myofilament degradation, similarly as observed with an inhibitor of mapk-signaling, but not apoptosis, necrosis or changes in mitochondrial activity. |
2007-06-11 |
2023-08-12 |
rat |
| Xiu-Fang Wang, Marc Birringer, Lan-Feng Dong, Pavel Veprek, Pauline Low, Emma Swettenham, Marina Stantic, Lin-Hong Yuan, Renata Zobalova, Kun Wu, Miroslav Ledvina, Stephen J Ralph, Jiri Neuzi. A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Cancer research. vol 67. issue 7. 2007-05-09. PMID:17409443. |
overexpression of erbb2 is associated with resistance to apoptosis. |
2007-05-09 |
2023-08-12 |
mouse |
| Xiu-Fang Wang, Marc Birringer, Lan-Feng Dong, Pavel Veprek, Pauline Low, Emma Swettenham, Marina Stantic, Lin-Hong Yuan, Renata Zobalova, Kun Wu, Miroslav Ledvina, Stephen J Ralph, Jiri Neuzi. A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Cancer research. vol 67. issue 7. 2007-05-09. PMID:17409443. |
the extent of apoptosis induced in erbb2-high cells by alpha-tos-ltvspwy was suppressed by erbb2 rna interference as well as by inhibition of either endocytotic or lysosomal function. |
2007-05-09 |
2023-08-12 |
mouse |
| Bolin Liu, Dalia Ordonez-Ercan, Zeying Fan, Susan M Edgerton, Xiaohe Yang, Ann D Tho. Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells. International journal of cancer. vol 120. issue 9. 2007-04-17. PMID:17266042. |
specific erbb3 sirna sensitizes erbb2 transfected mcf-7 cells (mcf-7/erbb2) to tamoxifen-associated inhibition of both cell growth and colony formation and enhances tamoxifen-induced apoptosis, in contrast to control sirna transfected mcf-7/erbb2 cells which are tamoxifen-resistant. |
2007-04-17 |
2023-08-12 |
mouse |
| Stephen Strasser, Susanne Maier, Christina Leisser, Philipp Saiko, Sibylle Madlener, Yvonne Bader, Astrid Bernhaus, Marieta Gueorguieva, Susanne Richter, Robert M Mader, Jozefa Wesierska-Gadek, Herbert Schott, Thomas Szekeres, Monika Fritzer-Szekeres, Georg Krupitz. 5-FdUrd-araC heterodinucleoside re-establishes sensitivity in 5-FdUrd- and AraC-resistant MCF-7 breast cancer cells overexpressing ErbB2. Differentiation; research in biological diversity. vol 74. issue 9-10. 2007-02-27. PMID:17177846. |
experiments with dimer 5-fdurd-arac in erbb2-overexpressing mcf-7(erbb2) cells, and also with nucleoside 5-fdurd in maternal mcf-7 cells, evidenced that the phenotypes of resistance to cell cycle inhibition and to apoptosis induction were differently affected. |
2007-02-27 |
2023-08-12 |
Not clear |
| Jie Zhang, Shailaja Kalyankrishna, Marie Wislez, Nishan Thilaganathan, Babita Saigal, Wei Wei, Long Ma, Ignacio I Wistuba, Faye M Johnson, Jonathan M Kuri. SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. The American journal of pathology. vol 170. issue 1. 2007-02-21. PMID:17200208. |
pp1 decreased phosphorylation of egfr, erbb2, and erbb3 and strikingly enhanced apoptosis by gefitinib, an egfr inhibitor. |
2007-02-21 |
2023-08-12 |
Not clear |
| Jie Zhang, Shailaja Kalyankrishna, Marie Wislez, Nishan Thilaganathan, Babita Saigal, Wei Wei, Long Ma, Ignacio I Wistuba, Faye M Johnson, Jonathan M Kuri. SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. The American journal of pathology. vol 170. issue 1. 2007-02-21. PMID:17200208. |
hcc827 cells transfected with c-src short hairpin rna exhibited diminished phosphorylation of egfr and erbb2 and decreased sensitivity to apoptosis by pp1 or gefitinib. |
2007-02-21 |
2023-08-12 |
Not clear |
| Ali Badache, Anthony Gonçalve. The ErbB2 signaling network as a target for breast cancer therapy. Journal of mammary gland biology and neoplasia. vol 11. issue 1. 2007-01-30. PMID:16947083. |
experimental studies have revealed that erbb2 shows many features of a therapeutic target: erbb2 is able to confer many of the characteristics of a cancerous cell, including uncontrolled proliferation, resistance to apoptosis and increased motility; erbb2 overexpression is specific to tumor cells; as a cell surface-associated protein, it is easily accessible to drugs and as a kinase it is amenable to targeted inhibition by small molecules. |
2007-01-30 |
2023-08-12 |
Not clear |
| Chuanwei Yang, Sally Trent, Viviana Ionescu-Tiba, Lan Lan, Toshi Shioda, Dennis Sgroi, Emmett V Schmid. Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression. Cancer research. vol 66. issue 24. 2007-01-25. PMID:17178859. |
these genes induced anchorage independence, increased cell proliferation, and protected against apoptosis, singly or in collaboration with erbb2. |
2007-01-25 |
2023-08-12 |
mouse |
| Victoria Aranda, Teresa Haire, Marissa E Nolan, Joseph P Calarco, Avi Z Rosenberg, James P Fawcett, Tony Pawson, Senthil K Muthuswam. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nature cell biology. vol 8. issue 11. 2006-12-12. PMID:17060907. |
inhibition of interaction between par6 and apkc blocked the ability of erbb2 to disrupt the acinar organization of breast epithelia and to protect cells from apoptosis but was not required for cell proliferation. |
2006-12-12 |
2023-08-12 |
Not clear |
| Demetrius M Kokkinakis, Anthony G Brickner, John M Kirkwood, Xiaoyan Liu, Jason E Goldwasser, Anastasiya Kastrama, Cindy Sander, Dora Bocangel, Sunil Chad. Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress. Molecular cancer research : MCR. vol 4. issue 8. 2006-10-12. PMID:16908595. |
although the genes controlling mitotic arrest and/or apoptosis in response to low extracellular methionine levels are unknown, it is likely that such control is exerted via the induction/up-regulation of tumor suppressors/growth inhibitor genes, such as tgfb, pten, gas1, egr3, btg3, mda7, and the proteoglycans (lum, bgn, and dcn), as well as the down-regulation/loss of function of prosurvival genes, such as nfkappab, myc, and erbb2. |
2006-10-12 |
2023-08-12 |
Not clear |