| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vidya C Sinha, Lan Qin, Yi L. A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis. Molecular cancer research : MCR. vol 13. issue 2. 2016-03-29. PMID:25253740. |
here, it is demonstrated that apoptosis unexpectedly remains robust in erbb2 (erbb2/her2)-initiated mammary early lesions arising in adult mice null for either p53 or arf. |
2016-03-29 |
2023-08-13 |
mouse |
| Vidya C Sinha, Lan Qin, Yi L. A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis. Molecular cancer research : MCR. vol 13. issue 2. 2016-03-29. PMID:25253740. |
thus, the arf-p53 pathway is dispensable for the apoptosis anticancer barrier in the initiation of erbb2 breast cancer, the apoptosis barrier alone cannot halt mammary tumorigenesis, and senescence is a key barrier against carcinogenesis. |
2016-03-29 |
2023-08-13 |
mouse |
| Qiu Zhang, Shumei Zhai, Liwen Li, Xiue Li, Cuijuan Jiang, Chengke Zhang, Bing Ya. P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model. Journal of pharmacological sciences. vol 126. issue 1. 2015-03-30. PMID:25185500. |
as a novel microtubule and heat shock protein 90 (hsp90) dual targeting inhibitor, cdbt causes the destabilization of microtubules and degradation of hsp90 client proteins craf-1 and erbb2, resulting in cell cycle arrest at the g2/m phase and apoptosis. |
2015-03-30 |
2023-08-13 |
mouse |
| Wei Li, Shi-Tao Zou, Ran Zhu, Jian-Mei Wan, Yan Xu, Hao-Rong W. B‑cell translocation 1 gene inhibits cellular metastasis‑associated behavior in breast cancer. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24714932. |
b-cell translocation gene 1 (btg1) is a member of the btg/transducer of erbb2 family, which regulates cell cycle progression in a variety of cell types and may have a role in inhibiting proliferation, promoting apoptosis and stimulating cellular differentiation in numerous cell types. |
2015-01-05 |
2023-08-13 |
mouse |
| Young-Soo Hong, Won-Jun Jang, Kyung-Soo Chun, Chul-Ho Jeon. Hsp90 inhibition by WK88-1 potently suppresses the growth of gefitinib-resistant H1975 cells harboring the T790M mutation in EGFR. Oncology reports. vol 31. issue 6. 2014-12-17. PMID:24789511. |
our data revealed that inhibition of hsp90 by wk88-1 induced overall degradation of multiple oncogenic signaling molecules including egfr, erbb2 and erbb3, leading to subsequent growth arrest and apoptosis in the gefitinib-resistant h1975 cell line. |
2014-12-17 |
2023-08-13 |
Not clear |
| Nuruliza Roslan, Ivan Bièche, Robert K Bright, Rosette Lidereau, Yuyan Chen, Jennifer A Byrn. TPD52 represents a survival factor in ERBB2-amplified breast cancer cells. Molecular carcinogenesis. vol 53. issue 10. 2014-11-03. PMID:23661506. |
transient tpd52 knock-down in the erbb2-amplified breast cancer cell lines sk-br-3 and bt-474 produced significant apoptosis, both singly and in combination with transient erbb2 knock-down. |
2014-11-03 |
2023-08-12 |
human |
| Wenle Xia, David Gooden, Leihua Liu, Sumin Zhao, Erik J Soderblom, Eric J Toone, Wayne F Beyer, Harold Walder, Neil L Specto. Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis. PloS one. vol 9. issue 2. 2014-10-21. PMID:24551203. |
photo-activated psoralen binds the erbb2 catalytic kinase domain, blocking erbb2 signaling and triggering tumor cell apoptosis. |
2014-10-21 |
2023-08-12 |
human |
| Wenle Xia, David Gooden, Leihua Liu, Sumin Zhao, Erik J Soderblom, Eric J Toone, Wayne F Beyer, Harold Walder, Neil L Specto. Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis. PloS one. vol 9. issue 2. 2014-10-21. PMID:24551203. |
here we show that puva reduced p85(erbb2) phosphorylation leading to tumor cell apoptosis. |
2014-10-21 |
2023-08-12 |
human |
| Maria Giovanna Scioli, Valerio Cervelli, Gaetano Arcuri, Pietro Gentile, Elena Doldo, Alessandra Bielli, Elena Bonanno, Augusto Orland. High insulin-induced down-regulation of Erk-1/IGF-1R/FGFR-1 signaling is required for oxidative stress-mediated apoptosis of adipose-derived stem cells. Journal of cellular physiology. vol 229. issue 12. 2014-10-20. PMID:24818995. |
specific inhibition of erk-1/2, igf-1r, and fgfr activity promoted asc apoptosis but did not increase insulin effects, whereas egfr and erbb2 inhibition potentiated insulin-induced apoptosis. |
2014-10-20 |
2023-08-13 |
human |
| Wen Bu, Xiang Zhang, Hua Dai, Shixia Huang, Yi L. Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesis. PloS one. vol 8. issue 11. 2014-09-03. PMID:24265712. |
therefore, we conclude that the wnt pathway-active cell subset in the normal mammary epithelium does not evolve into tumors following erbb2 activation-rather, they apparently die due to apoptosis, an anticancer "barrier" that we have reported to be erected in some mammary cells followed erbb2 activation. |
2014-09-03 |
2023-08-12 |
mouse |
| Qiu Zhang, Shumei Zhai, Liwen Li, Xiue Li, Hongyu Zhou, Aifeng Liu, Gaoxing Su, Qingxin Mu, Yuhong Du, Bing Ya. Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models. Biochemical pharmacology. vol 86. issue 3. 2013-09-24. PMID:23743233. |
cdbt blocks microtubule formation, decreases cancer-essential proteins craf-1, erbb2 and phosphorylated akt, and causes g2/m arrest and apoptosis. |
2013-09-24 |
2023-08-12 |
mouse |
| S Wang, J Huang, H Lyu, C-K Lee, J Tan, J Wang, B Li. Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells. Cell death & disease. vol 4. 2013-08-23. PMID:23519125. |
we reported that the class i hdac inhibitor entinostat induced apoptosis in erbb2-overexpressing breast cancer cells via downregulation of erbb2 and erbb3. |
2013-08-23 |
2023-08-12 |
Not clear |
| Hiromitsu Michikoshi, Takahiro Nakamura, Katsuya Sakai, Yoshinori Suzuki, Eri Adachi, Seiichi Matsugo, Kunio Matsumot. α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells. Cancer letters. vol 335. issue 2. 2013-07-30. PMID:23507559. |
a phospho-receptor tyrosine kinase array and cell cycle analysis indicated that α-la decreased tyrosine phosphorylation levels of egfr, erbb2, and met, and this was associated with an inhibition in the cell-cycle transition from the g1 phase to the s phase without inducing apoptosis. |
2013-07-30 |
2023-08-12 |
human |
| Elżbieta Płuciennik, Magdalena Nowakowska, Wioletta I Wujcicka, Anna Sitkiewicz, Bernarda Kazanowska, Elżbieta Zielińska, Andrzej K Bednare. Genetic alterations of WWOX in Wilms' tumor are involved in its carcinogenesis. Oncology reports. vol 28. issue 4. 2013-05-09. PMID:22842668. |
we evaluated the correlation between expression of wwox and genes involved in proliferation (ki67), apoptosis (bcl2, bax), signal transduction (erbb4, erbb2, egfr), cell cycle (ccne1, ccnd1), cell adhesion (cdh1) and transcription (tp73) using real-time rt-pcr in 23 tumor samples. |
2013-05-09 |
2023-08-12 |
Not clear |
| Manuel Rieber, Mary Strasberg-Riebe. Hypoxia, Mn-SOD and H(2)O(2) regulate p53 reactivation and PRIMA-1 toxicity irrespective of p53 status in human breast cancer cells. Biochemical pharmacology. vol 84. issue 12. 2013-01-25. PMID:22982566. |
since it is important to suppress tumor adaptation to hypoxia, irrespective of p53 status, we compared the efficacy of nutlin-3 which prevents mdm2-wt p53 interactions and prima-1 which promotes mutant p53 reactivation and induction of massive apoptosis, under normoxia and hypoxia, against (a) skbr3 breast carcinoma harboring a mutant p53r175h and over-expressing erbb2; and (b) genetically matched breast cancer erα positive mcf-7 cells harboring either wt p53 or mutant p53 r175h. |
2013-01-25 |
2023-08-12 |
human |
| Jun Hong, Ahmed Katsha, Pengcheng Lu, Yu Shyr, Abbes Belkhiri, Wael El-Rifa. Regulation of ERBB2 receptor by t-DARPP mediates trastuzumab resistance in human esophageal adenocarcinoma. Cancer research. vol 72. issue 17. 2012-11-19. PMID:22745369. |
the annexin-v staining and western blot analysis indicated that t-darpp effectively abrogated trastuzumab-induced apoptosis, inhibited cleavage of caspase-3, and blocked trastuzumab-induced dephosphorylation of erbb2 and akt proteins. |
2012-11-19 |
2023-08-12 |
mouse |
| Xinyi Liu, Indira Jutooru, Ping Lei, KyoungHyun Kim, Syng-Ook Lee, Lisa K Brents, Paul L Prather, Stephen Saf. Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Molecular cancer therapeutics. vol 11. issue 7. 2012-10-31. PMID:22553354. |
treatment of erbb2-overexpressing bt474 and mda-mb-453 breast cancer cells with 1 to 10 μmol/l betulinic acid inhibited cell growth, induced apoptosis, downregulated specificity protein (sp) transcription factors sp1, sp3, and sp4, and decreased expression of erbb2. |
2012-10-31 |
2023-08-12 |
Not clear |
| Sarala Manandhar, Bo-hyun Choi, Kyeong-Ah Jung, In-Geun Ryoo, Mingu Song, Su Jin Kang, Han-Gon Choi, Jung-Ae Kim, Pil-Hoon Park, Mi-Kyoung Kwa. NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: implications for tumor growth retardation and docetaxel sensitivity. Free radical biology & medicine. vol 52. issue 9. 2012-09-28. PMID:22387177. |
furthermore, nrf2 inhibition-mediated erbb2 repression increases the sensitivity of these cells to docetaxel cytotoxicity and apoptosis. |
2012-09-28 |
2023-08-12 |
mouse |
| G Paroni, M Fratelli, G Gardini, C Bassano, M Flora, A Zanetti, V Guarnaccia, P Ubezio, F Centritto, M Terao, E Garattin. Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA. Oncogene. vol 31. issue 29. 2012-09-25. PMID:22056878. |
in estrogen-receptor-negative cellular models showing coamplification of erbb2 and rara, simultaneous targeting of the corresponding gene products with combinations of lapatinib and atra causes synergistic growth inhibition, cyto-differentiation and apoptosis. |
2012-09-25 |
2023-08-12 |
human |
| Soichiro Yoshida, Fumitaka Koga, Manabu Tatokoro, Satoru Kawakami, Yasuhisa Fujii, Jiro Kumagai, Len Neckers, Kazunori Kihar. Low-dose Hsp90 inhibitors tumor-selectively sensitize bladder cancer cells to chemoradiotherapy. Cell cycle (Georgetown, Tex.). vol 10. issue 24. 2012-08-29. PMID:22134243. |
hsp90 inhibitors at low concentrations, which did not exert cytocidal effects but inactivated key anti-apoptotic proteins including erbb2, akt, and nf-κb, efficiently sensitized bladder cancer cells (t24, 5637 and um-uc-3 cells) to in vitro crt by enhancing apoptosis. |
2012-08-29 |
2023-08-12 |
mouse |