| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bryndon J Oleson, Katarzyna A Broniowska, Aaron Naatz, Neil Hogg, Vera L Tarakanova, John A Corbet. Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response. Molecular and cellular biology. vol 36. issue 15. 2017-05-16. PMID:27185882. |
while originally described as the damaging agent responsible for cytokine-induced β-cell death, these studies identify a novel role for nitric oxide as a protective molecule that promotes β-cell survival by suppressing ddr signaling and attenuating dna damage-induced apoptosis. |
2017-05-16 |
2023-08-13 |
Not clear |
| Hee-Jun Kim, Ahrum Min, Seock-Ah Im, Hyemin Jang, Kyung Hun Lee, Alan Lau, Miso Lee, Seongyeong Kim, Yaewon Yang, Jungeun Kim, Tae Yong Kim, Do-Youn Oh, Jeffrey Brown, Mark J O'Connor, Yung-Jue Ban. Anti-tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells. International journal of cancer. vol 140. issue 1. 2017-05-08. PMID:27501113. |
atr is a master regulator of dna damage repair (ddr), signaling to control dna replication, dna repair and apoptosis. |
2017-05-08 |
2023-08-13 |
human |
| Hong-Ru Chen, Hsien-Chia Juan, Yu-Hui Wong, Jin-Wu Tsai, Ming-Ji Fan. Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 3. 2017-04-28. PMID:27073218. |
we show that npcs of mutant mice accumulate at g2 and m phase, and have lower expression of ddr genes, more dna double-strand breaks and increased apoptosis. |
2017-04-28 |
2023-08-13 |
mouse |
| Shahar Biechonski, Muhammad Yassin, Michael Milyavsk. DNA-damage response in hematopoietic stem cells: an evolutionary trade-off between blood regeneration and leukemia suppression. Carcinogenesis. vol 38. issue 4. 2017-04-25. PMID:28334174. |
recent observations exposed remarkable differences in several dna-damage response (ddr) aspects between hscs and progenitors, especially in their dna-repair capacities and susceptibility to apoptosis. |
2017-04-25 |
2023-08-13 |
mouse |
| Felicia Carotenuto, Maria C Albertini, Dario Coletti, Alessandra Vilmercati, Luigi Campanella, Zbigniew Darzynkiewicz, Laura Teodor. How Diet Intervention via Modulation of DNA Damage Response through MicroRNAs May Have an Effect on Cancer Prevention and Aging, an in Silico Study. International journal of molecular sciences. vol 17. issue 5. 2017-03-02. PMID:27213347. |
the dna damage response (ddr) is a molecular mechanism that cells have evolved to sense dna damage (dd) to promote dna repair, or to lead to apoptosis, or cellular senescence if the damage is too extensive. |
2017-03-02 |
2023-08-13 |
Not clear |
| Keith M Jacobs, Sandeep Misri, Barbara Meyer, Suyash Raj, Cheri L Zobel, Barry P Sleckman, Dennis E Hallahan, Girdhar G Sharm. Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses. Molecular biology of the cell. vol 27. issue 8. 2017-01-16. PMID:26941327. |
we also observed persistent phosphorylation of h2ax-y142 along the dna breaks in stem cells, which promotes apoptosis while inhibiting ddr signaling. |
2017-01-16 |
2023-08-13 |
Not clear |
| Zhengqiang Bao, Juan Xiong, Wen Li, Zhihua Chen, Huahao Shen, Songmin Yin. Genomic instability in chronic airway inflammatory diseases. Biomedical journal. vol 38. issue 2. 2016-12-13. PMID:25355386. |
dna damage response (ddr), regarded as one of the many causes of apoptosis and cell senescence, as well as a factor involved in carcinogenesis, has recently begun to attract attention as a source of chronic inflammation. |
2016-12-13 |
2023-08-13 |
Not clear |
| Zi-Zhen Xu, Wan-Bin Fu, Zhen Jin, Pei Guo, Wen-Fang Wang, Jun-Min L. Reactive oxygen species mediate oridonin-induced apoptosis through DNA damage response and activation of JNK pathway in diffuse large B cell lymphoma. Leukemia & lymphoma. vol 57. issue 4. 2016-12-13. PMID:26415087. |
ori treatment caused reactive oxygen species (ros)-mediated oxidative dna damage response (ddr) and the c-jun n-terminal kinase (jnk) pathway activation, leading to an induction of intrinsic apoptosis. |
2016-12-13 |
2023-08-13 |
human |
| b' Sara Nicolai, Antonello Rossi, Nicola Di Daniele, Gerry Melino, Margherita Annicchiarico-Petruzzelli, Giuseppe Raschell\\xc3\\xa. DNA repair and aging: the impact of the p53 family. Aging. vol 7. issue 12. 2016-10-25. PMID:26668111.' |
the ddr orchestrates different cellular processes, such as dna repair, senescence and apoptosis. |
2016-10-25 |
2023-08-13 |
Not clear |
| Zhongdao Li, Alexander H Pearlman, Peggy Hsie. DNA mismatch repair and the DNA damage response. DNA repair. vol 38. 2016-10-24. PMID:26704428. |
this review discusses the role of dna mismatch repair (mmr) in the dna damage response (ddr) that triggers cell cycle arrest and, in some cases, apoptosis. |
2016-10-24 |
2023-08-13 |
Not clear |
| Xiangjing Gao, Guanglin Zhang, Shigang Shan, Yunlong Shang, Linfeng Chi, Hongjuan Li, Yifei Cao, Xinqiang Zhu, Meibian Zhang, Jun Yan. Depletion of Paraspeckle Protein 1 Enhances Methyl Methanesulfonate-Induced Apoptosis through Mitotic Catastrophe. PloS one. vol 11. issue 1. 2016-07-28. PMID:26785254. |
in the current study, we further examined the role of pspc1 in another dna-damaging agent, methyl methanesulfonate (mms)-induced ddr, in particular, focusing on mms-induced apoptosis in hela cells. |
2016-07-28 |
2023-08-13 |
Not clear |
| Xiangjing Gao, Guanglin Zhang, Shigang Shan, Yunlong Shang, Linfeng Chi, Hongjuan Li, Yifei Cao, Xinqiang Zhu, Meibian Zhang, Jun Yan. Depletion of Paraspeckle Protein 1 Enhances Methyl Methanesulfonate-Induced Apoptosis through Mitotic Catastrophe. PloS one. vol 11. issue 1. 2016-07-28. PMID:26785254. |
taken together, these observations suggest an important role for pspc1 in mms-induced ddr, and in particular, depletion of pspc1 can enhance mms-induced apoptosis through mitotic catastrophe. |
2016-07-28 |
2023-08-13 |
Not clear |
| Larissa Lezina, Vasilisa Aksenova, Olga Fedorova, Daria Malikova, Oleg Shuvalov, Alexey V Antonov, Dmitri Tentler, Alexander V Garabadgiu, Gerry Melino, Nikolai A Barle. KMT Set7/9 affects genotoxic stress response via the Mdm2 axis. Oncotarget. vol 6. issue 28. 2016-07-25. PMID:26317544. |
signal transduction pathways, besides ddr itself, also control expression of genes whose products cause cell cycle arrest and/or apoptosis thus ultimately affecting the sensitivity of cells to genotoxic stress. |
2016-07-25 |
2023-08-13 |
Not clear |
| Anna Brestovitsky, Keren Nebenzahl-Sharon, Peter Kechker, Rakefet Sharf, Tamar Kleinberge. The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response. PLoS pathogens. vol 12. issue 2. 2016-06-30. PMID:26867009. |
the dna damage response (ddr) is a conglomerate of pathways designed to detect dna damage and signal its presence to cell cycle checkpoints and to the repair machinery, allowing the cell to pause and mend the damage, or if the damage is too severe, to trigger apoptosis or senescence. |
2016-06-30 |
2023-08-13 |
Not clear |
| Hussein Basma, Sandra E Ghayad, Ghina Rammal, Angelo Mancinelli, Mohammad Harajly, Farah Ghamloush, Loai Dweik, Rabab El-Eit, Hassan Zalzali, Wissam Rabeh, Claudio Pisano, Nadine Darwiche, Raya Saa. The synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma. International journal of cancer. vol 138. issue 6. 2016-05-13. PMID:26453552. |
st1926 induced an early dna damage response (ddr), which led to increase in apoptosis, in addition to s-phase cell cycle arrest and a reduction in protein levels of the cell cycle kinase cdk1. |
2016-05-13 |
2023-08-13 |
mouse |
| Gautier Chene, Veronique Ouellet, Kurosh Rahimi, Veronique Barres, Katia Caceres, Liliane Meunier, Louis Cyr, Manon De Ladurantaye, Diane Provencher, Anne Marie Mes Masso. DNA damage signaling and apoptosis in preinvasive tubal lesions of ovarian carcinoma. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 25. issue 5. 2016-03-08. PMID:24987917. |
because dna damage response (ddr) has been described as 1 of the first phases in genomic instability, we investigated the level of ddr activation and the apoptosis pathway in serous tubal intraepithelial carcinoma (stic), the potential precursor of hgsc. |
2016-03-08 |
2023-08-13 |
human |
| Bo Zhao, Wei-Dao Zhang, Ying-Liang Duan, Yong-Qing Lu, Yi-Xian Cun, Chao-Hui Li, Kun Guo, Wen-Hui Nie, Lei Li, Rugang Zhang, Ping Zhen. Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability. Cell stem cell. vol 16. issue 6. 2016-03-01. PMID:25936915. |
filia promotes centrosome integrity and regulates the dna damage response (ddr) through multiple pathways, including ddr signaling, cell-cycle checkpoints and damage repair, esc differentiation, and apoptosis. |
2016-03-01 |
2023-08-13 |
mouse |
| Haiqing Hu, Xuanzhong Zhao, Zhao Jin, Mingxing Ho. Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. The Journal of toxicological sciences. vol 40. issue 3. 2016-02-29. PMID:25972194. |
further study confirmed hsa-let-7 g caused the apoptosis and loss of proliferation in gc cells exposed to h2o2 associated with repression of ddr system. |
2016-02-29 |
2023-08-13 |
Not clear |
| Alexandros G Georgakilas, Athanasia Pavlopoulou, Maria Louka, Zacharenia Nikitaki, Constantinos E Vorgias, Pantelis G Bagos, Ioannis Michalopoulo. Emerging molecular networks common in ionizing radiation, immune and inflammatory responses by employing bioinformatics approaches. Cancer letters. vol 368. issue 2. 2016-01-06. PMID:25841996. |
dna damage response (ddr), dna repair, apoptosis and, most importantly, systemic effects through the instigation of inflammatory 'danger' signals and innate immune response activation. |
2016-01-06 |
2023-08-13 |
Not clear |
| Christopher P Allen, Walter Tinganelli, Neelam Sharma, Jingyi Nie, Cory Sicard, Francesco Natale, Maurice King, Steven B Keysar, Antonio Jimeno, Yoshiya Furusawa, Ryuichi Okayasu, Akira Fujimori, Marco Durante, Jac A Nickolof. DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation. Frontiers in oncology. vol 5. 2015-12-23. PMID:26697402. |
if damage is severe enough, the dna damage response (ddr) triggers programed cell death by apoptosis or other pathways. |
2015-12-23 |
2023-08-13 |
Not clear |