| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Herbette, M G Mercier, F Michal, D Cluet, C Burny, G Yvert, V J Robert, F Palladin. The C. elegans SET-2/SET1 histone H3 Lys4 (H3K4) methyltransferase preserves genome stability in the germline. DNA repair. vol 57. 2017-12-26. PMID:28779964. |
these defects are not due to a failure to activate the dna damage response (ddr) that allows detection, signaling and repair of dna lesions, because cell cycle arrest and apoptosis, key components of this pathway, are efficiently induced in set-2 mutant animal. |
2017-12-26 |
2023-08-13 |
caenorhabditis_elegans |
| Lin Yang, Yinan Yuan, Chengyu Fu, Xuefen Xu, Jieying Zhou, Shuhao Wang, Lingyi Kong, Zhiyu Li, Qinglong Guo, Libin We. LZ-106, a novel analog of enoxacin, inducing apoptosis via activation of ROS-dependent DNA damage response in NSCLCs. Free radical biology & medicine. vol 95. 2017-12-19. PMID:27012423. |
interestingly, additional evidence in our findings revealed that ddr and apoptosis could be alleviated in the presence of ros scavenger n-acetyl-cysteine (nac), indicating ros-dependent ddr involvement in lz-106-induced apoptosis. |
2017-12-19 |
2023-08-13 |
mouse |
| Vinay Jain, Birajalaxmi Da. Global transcriptome profile reveals abundance of DNA damage response and repair genes in individuals from high level natural radiation areas of Kerala coast. PloS one. vol 12. issue 11. 2017-12-06. PMID:29161272. |
gene ontology analysis revealed majority of these differentially expressed genes are involved in dna damage response (ddr) signaling, dna repair, cell cycle arrest, apoptosis, histone/chromatin modification and immune response. |
2017-12-06 |
2023-08-13 |
human |
| Qi-Nian Wu, Yi-Fu Liao, Yun-Xin Lu, Yun Wang, Jia-Huan Lu, Zhao-Lei Zeng, Qi-Tao Huang, Hui Sheng, Jing-Ping Yun, Dan Xie, Huai-Qiang Ju, Rui-Hua X. Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance. Cancer letters. vol 412. 2017-12-05. PMID:29050982. |
in summary, our findings indicated that disruption of dusp6 by bci enhanced cddp-induced cell death and apoptosis in gc may partly through erk and ddr pathways. |
2017-12-05 |
2023-08-13 |
Not clear |
| Jessica S Brown, Brent O'Carrigan, Stephen P Jackson, Timothy A Ya. Targeting DNA Repair in Cancer: Beyond PARP Inhibitors. Cancer discovery. vol 7. issue 1. 2017-11-02. PMID:28003236. |
herein, we detail how cellular ddr processes engage various proteins that sense dna damage, initiate signaling pathways to promote cell-cycle checkpoint activation, trigger apoptosis, and coordinate dna repair. |
2017-11-02 |
2023-08-13 |
Not clear |
| Andrea Celeghin, Silvia Giunco, Riccardo Freguja, Manuela Zangrossi, Silvia Nalio, Riccardo Dolcetti, Anita De Ross. Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells. Cell death & disease. vol 7. issue 12. 2017-10-09. PMID:28032863. |
the cell cycle arrest and apoptosis, consequent upon short-term tert inhibition, were associated with and likely dependent on the activation of the dna damage response (ddr), highlighted by the increased levels of γh2ax and activation of atm and atr pathways. |
2017-10-09 |
2023-08-13 |
Not clear |
| Ryan R White, Jan Vij. Do DNA Double-Strand Breaks Drive Aging? Molecular cell. vol 63. issue 5. 2017-09-06. PMID:27588601. |
dsbs trigger the dna damage response (ddr) that directs a cell to repair the break, undergo apoptosis, or become senescent. |
2017-09-06 |
2023-08-13 |
mouse |
| Angelo Agathanggelou, Edward Smith, Nicholas J Davies, Marwan Kwok, Anastasia Zlatanou, Ceri E Oldreive, Jingwen Mao, David Da Costa, Sina Yadollahi, Tracey Perry, Pamela Kearns, Anna Skowronska, Elliot Yates, Helen Parry, Peter Hillmen, Celine Reverdy, Remi Delansorne, Shankara Paneesha, Guy Pratt, Paul Moss, A Malcolm R Taylor, Grant S Stewart, Tatjana Stankovi. USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status. Blood. vol 130. issue 2. 2017-08-15. PMID:28495793. |
together, these results identify usp7 as a promising therapeutic target for the treatment of hematological malignancies with ddr defects, where atm/p53-dependent apoptosis is compromised. |
2017-08-15 |
2023-08-13 |
Not clear |
| Vanessa Enriquez-Rios, Lavinia C Dumitrache, Susanna M Downing, Yang Li, Eric J Brown, Helen R Russell, Peter J McKinno. DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 4. 2017-08-01. PMID:28123024. |
the dna damage response (ddr) orchestrates a network of cellular processes that integrates cell-cycle control and dna repair or apoptosis, which serves to maintain genome stability. |
2017-08-01 |
2023-08-13 |
mouse |
| Vanessa Enriquez-Rios, Lavinia C Dumitrache, Susanna M Downing, Yang Li, Eric J Brown, Helen R Russell, Peter J McKinno. DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 4. 2017-08-01. PMID:28123024. |
in contrast, atr coordinated the ddr during neurogenesis to direct apoptosis in cycling neural progenitors, whereas atm regulated apoptosis in both proliferative and noncycling cells. |
2017-08-01 |
2023-08-13 |
mouse |
| Wan Liu, Jun Li, Yu-Shu Song, Yue Li, Yu-Hong Jia, Hai-Dong Zha. Cdk5 links with DNA damage response and cancer. Molecular cancer. vol 16. issue 1. 2017-07-24. PMID:28288624. |
here we describe the regulatory mechanisms of cdk5, its controversial roles in apoptosis and focus on its links to ddr and cancer. |
2017-07-24 |
2023-08-13 |
Not clear |
| Benigno C Valdez, Jonathan E Brammer, Yang Li, David Murray, Esmeralda C Teo, Yan Liu, Chitra Hosing, Yago Nieto, Richard E Champlin, Borje S Andersso. Romidepsin enhances the cytotoxicity of fludarabine, clofarabine and busulfan combination in malignant T-cells. Leukemia research. vol 47. 2017-07-17. PMID:27294334. |
drug exposure resulted in histone modifications, dna-damage response (ddr), increased reactive oxygen species (ros), decreased glutathione (gsh) and mitochondrial membrane (mm) potential, and apoptosis. |
2017-07-17 |
2023-08-13 |
Not clear |
| Benigno C Valdez, Jonathan E Brammer, Yang Li, David Murray, Esmeralda C Teo, Yan Liu, Chitra Hosing, Yago Nieto, Richard E Champlin, Borje S Andersso. Romidepsin enhances the cytotoxicity of fludarabine, clofarabine and busulfan combination in malignant T-cells. Leukemia research. vol 47. 2017-07-17. PMID:27294334. |
similar activation of ddr and apoptosis was observed in patient samples. |
2017-07-17 |
2023-08-13 |
Not clear |
| Xuening Wang, Jonathan S Harrison, George P Studzinsk. Enhancement of arabinocytosine (AraC) toxicity to AML cells by a differentiation agent combination. The Journal of steroid biochemistry and molecular biology. vol 164. 2017-07-04. PMID:26319201. |
the enhancement of cell death occurred by both apoptosis and necrosis, was associated with increased dna damage and with higher levels of dna damage response (ddr) activated marker chk1, but the expression of p27, a cell cycle inhibitor protein, was not enhanced by 1-d2/ca. |
2017-07-04 |
2023-08-13 |
Not clear |
| Luciana E Giono, Nicolás Nieto Moreno, Adrián E Cambindo Botto, Gwendal Dujardin, Manuel J Muñoz, Alberto R Kornbliht. The RNA Response to DNA Damage. Journal of molecular biology. vol 428. issue 12. 2017-06-12. PMID:26979557. |
the dna damage response (ddr) is a complex network that senses, signals, and executes multiple programs including dna repair, cell cycle arrest, senescence, and apoptosis. |
2017-06-12 |
2023-08-13 |
Not clear |
| Mingjuan Yan, Chengyuan Tang, Zhengwei Ma, Shuang Huang, Zheng Don. DNA damage response in nephrotoxic and ischemic kidney injury. Toxicology and applied pharmacology. vol 313. 2017-05-24. PMID:27984128. |
in cisplatin-induced aki or nephrotoxicity, the ddr pathway of atr/chk2/p53 is activated and contributes to renal tubular cell apoptosis. |
2017-05-24 |
2023-08-13 |
Not clear |
| Huiting Wei, Xiaochun Y. Functions of PARylation in DNA Damage Repair Pathways. Genomics, proteomics & bioinformatics. vol 14. issue 3. 2017-05-23. PMID:27240471. |
this modification regulates a number of biological processes including chromatin reorganization, dna damage response (ddr), transcriptional regulation, apoptosis, and mitosis. |
2017-05-23 |
2023-08-13 |
Not clear |
| Ying Gao, Dan Xu, Lei Zhao, Yeqing Su. The DNA damage response of C. elegans affected by gravity sensing and radiosensitivity during the Shenzhou-8 spaceflight. Mutation research. vol 795. 2017-05-23. PMID:28088539. |
although the ddr profiles were significantly changed under both conditions, the ced-1 mutation favored dna repair under sf and apoptosis under sr. |
2017-05-23 |
2023-08-13 |
caenorhabditis_elegans |
| Bryndon J Oleson, Katarzyna A Broniowska, Aaron Naatz, Neil Hogg, Vera L Tarakanova, John A Corbet. Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response. Molecular and cellular biology. vol 36. issue 15. 2017-05-16. PMID:27185882. |
in this study, we identify a novel mechanism in which nitric oxide prevents β-cell apoptosis by attenuating the dna damage response (ddr). |
2017-05-16 |
2023-08-13 |
Not clear |
| Bryndon J Oleson, Katarzyna A Broniowska, Aaron Naatz, Neil Hogg, Vera L Tarakanova, John A Corbet. Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response. Molecular and cellular biology. vol 36. issue 15. 2017-05-16. PMID:27185882. |
while camptothecin and h2o2 both induce ddr activation, nitric oxide suppresses only camptothecin-induced apoptosis and not h2o2-induced necrosis. |
2017-05-16 |
2023-08-13 |
Not clear |