| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria L Fell, Caroline Schild-Poulte. The Ku heterodimer: function in DNA repair and beyond. Mutation research. Reviews in mutation research. vol 763. 2015-05-28. PMID:25795113. |
there is also evidence that ku is involved in signaling to the dna damage response (ddr) machinery to modulate the activation of cell cycle checkpoints and the activation of apoptosis. |
2015-05-28 |
2023-08-13 |
mouse |
| A Dekanty, L Barrio, M Milá. Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells. Oncogene. vol 34. issue 8. 2015-04-28. PMID:24632609. |
when exposed to dna-damaging agents, components of the dna damage response (ddr) pathway trigger apoptosis, cell cycle arrest and dna repair. |
2015-04-28 |
2023-08-12 |
mouse |
| B C Nair, S R Krishnan, G R Sareddy, M Mann, B Xu, M Natarajan, P Hasty, D Brann, R R Tekmal, R K Vadlamud. Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response. Cell death and differentiation. vol 21. issue 9. 2015-04-22. PMID:24786831. |
p53 is an important transcription factor and tumor suppressor that has a critical role in dna damage response (ddr) including cell cycle arrest, repair or apoptosis. |
2015-04-22 |
2023-08-13 |
Not clear |
| Pranjal Sarma, M Janaki Ramaiah, Ahmed Kamal, Utpal Bhadra, Manika Pal Bhadr. A novel bisindole-PBD conjugate causes DNA damage induced apoptosis via inhibition of DNA repair pathway. Cancer biology & therapy. vol 15. issue 10. 2015-04-06. PMID:25010292. |
dna damage response (ddr) that includes cell cycle check points, dna repair, apoptosis, and senescence is intimately linked with cancer. |
2015-04-06 |
2023-08-13 |
Not clear |
| Nicolas Malaquin, Audrey Carrier-Leclerc, Mireille Dessureault, Francis Rodie. DDR-mediated crosstalk between DNA-damaged cells and their microenvironment. Frontiers in genetics. vol 6. 2015-03-27. PMID:25815006. |
in higher organisms, the ddr prevents neoplastic transformation by directly protecting the information contained in the genome and by regulating cell fate decisions, like apoptosis and senescence, to ensure the removal of severely damaged cells. |
2015-03-27 |
2023-08-13 |
Not clear |
| Kerstin Brinkmann, Michael Schell, Thorsten Hoppe, Hamid Kashka. Regulation of the DNA damage response by ubiquitin conjugation. Frontiers in genetics. vol 6. 2015-03-25. PMID:25806049. |
upon overwhelming damage the ddr provokes detrimental cellular actions by involving the apoptotic machinery and inducing a coordinated demise of the damaged cells (dna damage-induced apoptosis, ddia). |
2015-03-25 |
2023-08-13 |
human |
| Nicholas A Wallace, Denise A Gallowa. Manipulation of cellular DNA damage repair machinery facilitates propagation of human papillomaviruses. Seminars in cancer biology. vol 26. 2015-01-23. PMID:24412279. |
because the activation of the ddr response typically elicits a cell cycle arrest that would impeded the viral lifecycle, the second set of hpv proteins, hpv e6 and e7, prevents the ddr response from pausing cell cycle progression or inducing apoptosis. |
2015-01-23 |
2023-08-12 |
human |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Interplay between Mdm2 and HIPK2 in the DNA damage response. Journal of the Royal Society, Interface. vol 11. issue 96. 2014-12-28. PMID:24829283. |
the tumour suppressor p53 is activated to induce cell-cycle arrest or apoptosis in the dna damage response (ddr). |
2014-12-28 |
2023-08-13 |
Not clear |
| Shan Yan, Melanie Sorrell, Zachary Berma. Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress. Cellular and molecular life sciences : CMLS. vol 71. issue 20. 2014-11-17. PMID:24947324. |
dna damage response (ddr) pathways, including atm-chk2 and atr-chk1 checkpoints, are also activated in oxidative stress to coordinate dna repair, cell cycle progression, transcription, apoptosis, and senescence. |
2014-11-17 |
2023-08-13 |
human |
| Yun Wang, Shunchang Wang, Xun Luo, Yanan Yang, Fenglei Jian, Xuemin Wang, Lucheng Xi. The roles of DNA damage-dependent signals and MAPK cascades in tributyltin-induced germline apoptosis in Caenorhabditis elegans. Chemosphere. vol 108. 2014-10-22. PMID:24534158. |
in this study, using the nematode caenorhabditis elegans, we examined whether dna damage response (ddr) pathway and mitogen-activated protein kinase (mapk) signaling cascades are involved in tbt-induced germline apoptosis and cell cycle arrest. |
2014-10-22 |
2023-08-12 |
caenorhabditis_elegans |
| Yun Wang, Shunchang Wang, Xun Luo, Yanan Yang, Fenglei Jian, Xuemin Wang, Lucheng Xi. The roles of DNA damage-dependent signals and MAPK cascades in tributyltin-induced germline apoptosis in Caenorhabditis elegans. Chemosphere. vol 108. 2014-10-22. PMID:24534158. |
the present study indicated that tbt-induced apoptosis required the core apoptotic machinery, and that ddr genes and mapk pathways played essential roles in signaling the processes. |
2014-10-22 |
2023-08-12 |
caenorhabditis_elegans |
| Huijuan Liu, Dandan Bao, Xuechun Xia, Jenny Fung Ling Chau, Baojie L. An unconventional role of BMP-Smad1 signaling in DNA damage response: a mechanism for tumor suppression. Journal of cellular biochemistry. vol 115. issue 3. 2014-10-20. PMID:24142423. |
cells have evolved a dna damage response (ddr) system to sense dna damage, to halt cell cycle progression and repair the lesions, or to induce apoptosis if encountering irreparable damage. |
2014-10-20 |
2023-08-12 |
mouse |
| Mirella Tanori, Emanuela Pasquali, Simona Leonardi, Arianna Casciati, Paola Giardullo, Ilaria De Stefano, Mariateresa Mancuso, Anna Saran, Simonetta Pazzagli. Developmental and oncogenic radiation effects on neural stem cells and their differentiating progeny in mouse cerebellum. Stem cells (Dayton, Ohio). vol 31. issue 11. 2014-09-17. PMID:23897709. |
we found crucial differences in ddr and apoptosis between nscs and fate-restricted pcs, including lack of p21 expression in nscs. |
2014-09-17 |
2023-08-12 |
mouse |
| Maria Ermolaeva, Björn Schumache. The innate immune system as mediator of systemic DNA damage responses. Communicative & integrative biology. vol 6. issue 6. 2014-09-11. PMID:25210580. |
(1) cellular dna damage responses (ddr) mediate cell cycle arrest to allow time for dna repair, or induce cellular senescence and apoptosis to eliminate damaged cells. |
2014-09-11 |
2023-08-13 |
caenorhabditis_elegans |
| Pavel A Nikitin, Alexander M Price, Karyn McFadden, Christopher M Yan, Micah A Lufti. Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. PloS one. vol 9. issue 1. 2014-09-08. PMID:24498068. |
these two mitogens, but not ebv, modestly induced intrinsic apoptosis that was independent from the ddr. |
2014-09-08 |
2023-08-12 |
human |
| Kyle P Glover, Lauren K Markell, E Maria Donner, Xing Ha. Protein kinase C-activating tumor promoters modulate the DNA damage response in UVC-irradiated TK6 cells. Toxicology letters. vol 229. issue 1. 2014-09-08. PMID:24960060. |
nh32 (p53-null, isogenic to tk6) cells were resistant to the synergistic effects on apoptosis implicating p53 as a central mediator of the ddr modulating effects. |
2014-09-08 |
2023-08-13 |
human |
| Zhengwei Ma, Qingqing Wei, Guie Dong, Yuqing Huo, Zheng Don. DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells. Biochimica et biophysica acta. vol 1842. issue 7. 2014-07-24. PMID:24726884. |
the ddr is partially induced by apoptosis and oxidative stress-related dna damage. |
2014-07-24 |
2023-08-13 |
mouse |
| Larisa Pereboeva, Erik Westin, Toral Patel, Ian Flaniken, Lawrence Lamb, Aloysius Klingelhutz, Frederick Goldma. DNA damage responses and oxidative stress in dyskeratosis congenita. PloS one. vol 8. issue 10. 2014-05-22. PMID:24124565. |
apoptosis and reactive oxygen species (ros) were assessed by flow cytometry, and western blotting was used to measure expression of dna damage response (ddr) proteins, including total p53, p53s15, and p21(waf). |
2014-05-22 |
2023-08-12 |
human |
| Chang-Fu Yang, Li-Xia Peng, Tie-Jun Huang, Guang-Da Yang, Qiao-Qiao Chu, Ying-Ying Liang, Xue Cao, Ping Xie, Li-Sheng Zheng, Hong-Bing Huang, Mao-De Cai, Jia-Ling Huang, Ran-Yi Liu, Zhen-Yu Zhu, Chao-Nan Qian, Bi-Jun Huan. Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway. Cancer letters. vol 344. issue 2. 2014-03-24. PMID:24262659. |
our results also demonstrated that phosphorylation of the dna damage response (ddr) proteins, atm, chk1, chk2 and p53, was inactivated in the lmp1-induced cd44(+/high) cells in response to dna damage, and this was accompanied by a downregulation of the p53-targeted proapoptotic genes, which suggested that the inactivation of the p53-mediated apoptosis pathway was responsible for the radioresistance in the cd44(+/high) cells. |
2014-03-24 |
2023-08-12 |
Not clear |
| Anne Margriet Heijink, Małgorzata Krajewska, Marcel A T M van Vug. The DNA damage response during mitosis. Mutation research. vol 750. issue 1-2. 2014-01-22. PMID:23880065. |
alternatively, the ddr can mediate clearance of affected cells that are beyond repair through apoptosis or senescence. |
2014-01-22 |
2023-08-12 |
Not clear |