| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Tomashevski, D R Webster, P Grammas, M Gorospe, I I Kruma. Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons. Cell death and differentiation. vol 17. issue 7. 2010-09-27. PMID:20111042. |
these findings reveal the importance of cell-cycle activation for controlling both dna repair and apoptosis in postmitotic neurons, and underline the particular role of g(1) --> s progression in apoptotic signaling, providing new insights into the mechanisms of dna damage response (ddr) in postmitotic neurons. |
2010-09-27 |
2023-08-12 |
Not clear |
| Lise Mattera, Céline Courilleau, Gaëlle Legube, Takeshi Ueda, Rikiro Fukunaga, Martine Chevillard-Briet, Yvan Canitrot, Fabrice Escaffit, Didier Trouch. The E1A-associated p400 protein modulates cell fate decisions by the regulation of ROS homeostasis. PLoS genetics. vol 6. issue 6. 2010-09-27. PMID:20548951. |
suppression of the dna damage response using a sirna against atm inhibits the effects of p400 on cell cycle progression, apoptosis, or senescence, demonstrating the importance of atm-dependent ddr pathways in cell fates control by p400. |
2010-09-27 |
2023-08-12 |
Not clear |
| Shiaw-Yih Lin, Yulong Liang, Kaiyi L. Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression. Yonsei medical journal. vol 51. issue 3. 2010-07-15. PMID:20376879. |
two central kinases for the ddr pathway are atm and atr, which can phosphorylate and activate many downstream proteins for cell cycle arrest, dna repair, or apoptosis if the damages are irreparable. |
2010-07-15 |
2023-08-12 |
mouse |
| J-L Perfettini, R Nardacci, C Séror, S Q Raza, S Sepe, H Saïdi, F Brottes, A Amendola, F Subra, F Del Nonno, L Chessa, A D'Incecco, M-L Gougeon, M Piacentini, G Kroeme. 53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope. Cell death and differentiation. vol 17. issue 5. 2010-06-28. PMID:19876065. |
it colocalizes partially with the promyelomonocytic leukemia protein (pml), and the ataxia telangiectasia mutated kinase (atm), the two components of the ddr that mediate apoptosis induced by the hiv-1 envelope. |
2010-06-28 |
2023-08-12 |
human |
| Kazuhito Oka, Toshiki Tanaka, Tadahiko Enoki, Koichi Yoshimura, Mako Ohshima, Masayuki Kubo, Tomoyuki Murakami, Toshikazu Gondou, Yoshihide Minami, Yoshihiro Takemoto, Eijirou Harada, Takaaki Tsushimi, Tao-Sheng Li, Frank Traganos, Zbigniew Darzynkiewicz, Kimikazu Haman. DNA damage signaling is activated during cancer progression in human colorectal carcinoma. Cancer biology & therapy. vol 9. issue 3. 2010-06-17. PMID:20023412. |
recent studies have shown that the dna damage response (ddr) is activated in precancerous lesions, suggesting that neoplastic cells may avoid apoptosis by impairing the ddr which acts as a barrier against tumor progression. |
2010-06-17 |
2023-08-12 |
human |
| Yun Dai, Steven Gran. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 16. issue 2. 2010-04-12. PMID:20068082. |
the dna damage response (ddr) represents a complex network of multiple signaling pathways involving cell cycle checkpoints, dna repair, transcriptional programs, and apoptosis, through which cells maintain genomic integrity following various endogenous (metabolic) or environmental stresses. |
2010-04-12 |
2023-08-12 |
Not clear |
| Jay P Reddy, Sirisha Peddibhotla, Wen Bu, Jing Zhao, Svasti Haricharan, Yi-Chieh Nancy Du, Katrina Podsypanina, Jeffrey M Rosen, Larry A Donehower, Yi L. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 8. 2010-04-05. PMID:20133707. |
furthermore, in this somatic erbb2 tumor model, atm, and thus ddr, is required for p53 stabilization, apoptosis, and senescence. |
2010-04-05 |
2023-08-12 |
mouse |
| Jay P Reddy, Sirisha Peddibhotla, Wen Bu, Jing Zhao, Svasti Haricharan, Yi-Chieh Nancy Du, Katrina Podsypanina, Jeffrey M Rosen, Larry A Donehower, Yi L. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 8. 2010-04-05. PMID:20133707. |
thus, this murine model fully recapitulates early ddr signaling; the eventual suppression of its endpoints in tumorigenesis provides compelling evidence that erbb2-induced aberrant mammary cell proliferation leads to an atm-mediated ddr that activates apoptosis and senescence, and at least the former must be overcome to progress to malignancy. |
2010-04-05 |
2023-08-12 |
mouse |
| Courtney A Lovejoy, Xin Xu, Carol E Bansbach, Gloria G Glick, Runxiang Zhao, Fei Ye, Bianca M Sirbu, Laura C Titus, Yu Shyr, David Corte. Functional genomic screens identify CINP as a genome maintenance protein. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 46. 2009-12-15. PMID:19889979. |
the dna damage response (ddr) has a critical role in maintaining genome integrity and serves as a barrier to tumorigenesis by promoting cell-cycle arrest, dna repair, and apoptosis. |
2009-12-15 |
2023-08-12 |
human |
| Penny A Jegg. Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us. Health physics. vol 97. issue 5. 2009-12-01. PMID:19820451. |
ddr processes encompass repair pathways and signal transduction mechanisms that activate cell cycle checkpoint arrest and apoptosis. |
2009-12-01 |
2023-08-12 |
Not clear |
| Hong Zhao, Frank Traganos, Jurek Dobrucki, Donald Wlodkowic, Zbigniew Darzynkiewic. Induction of DNA damage response by the supravital probes of nucleic acids. Cytometry. Part A : the journal of the International Society for Analytical Cytology. vol 75. issue 6. 2009-08-20. PMID:19373929. |
the data indicate that supravital use of ho 42, draq5, and dcv induces various degrees of ddr, including activation of atm, chk2 and p53, which may have significant consequences on regulatory cell cycle pathways and apoptosis. |
2009-08-20 |
2023-08-12 |
Not clear |
| Stéphanie Solier, Yves Pommie. The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases. Cell cycle (Georgetown, Tex.). vol 8. issue 12. 2009-08-14. PMID:19448405. |
we recently showed that histone h2ax phosphorylated on serine 139 (gamma-h2ax), a hallmark of dna damage response (ddr), also forms early during apoptosis induced by death receptor activation. |
2009-08-14 |
2023-08-12 |
Not clear |
| Jamie L Wood, Junjie Che. DNA-damage checkpoints: location, location, location. Trends in cell biology. vol 18. issue 10. 2009-05-26. PMID:18760607. |
the dna-damage response (ddr) is an evolutionarily conserved signaling cascade crucial for sensing dna damage and activating cellular responses such as cell-cycle arrest, dna repair, senescence and apoptosis. |
2009-05-26 |
2023-08-12 |
Not clear |
| Jun Yan, Anton M Jette. RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites. Cancer letters. vol 271. issue 2. 2008-10-28. PMID:18550271. |
the dna damage response (ddr) coordinates activation of cell cycle checkpoints, apoptosis, and dna repair networks, to ensure accurate repair and genomic integrity. |
2008-10-28 |
2023-08-12 |
Not clear |
| Bei Pei, Shunchang Wang, Xiaoyin Guo, Jun Wang, Gen Yang, Haiying Hang, Lijun W. Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans. Chemical research in toxicology. vol 21. issue 8. 2008-10-09. PMID:18597494. |
our results showed that the loss-of-function mutations of p53/ cep-1 and dna damage response (ddr) genes hus-1, clk-2, and egl-1 exhibited significant increase in germline apoptosis under arsenite exposure, whereas arsenite-induced germline apoptosis was blocked in loss-of-function alleles of extracellular signal-regulated kinase (erk) (lin-45 (ku51), mek-2 (n1989), and mpk-1 (ku1)), c-jun n-terminal kinase (jnk) (jkk-1 (km2), mek-1 (ks54), jnk-1 (gk7), mkk-4 (ju91)), and p38 ( nsy-1 (ag3), sek-1 (ag1), and pmk-1 (km25)) mapk cascades. |
2008-10-09 |
2023-08-12 |
caenorhabditis_elegans |
| Bei Pei, Shunchang Wang, Xiaoyin Guo, Jun Wang, Gen Yang, Haiying Hang, Lijun W. Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans. Chemical research in toxicology. vol 21. issue 8. 2008-10-09. PMID:18597494. |
these results suggest that arsenite-induced apoptosis occurs independently of p53/ cep-1 and the dna damage response (ddr) genes hus-1, clk-2, and egl-1 and that the c. elegans caspase gene ced-3, apaf-1 homologue ced-4, and the mapk signaling pathways are essential for germline apoptosis. |
2008-10-09 |
2023-08-12 |
caenorhabditis_elegans |
| Shunchang Wang, Minli Tang, Bei Pei, Xiang Xiao, Jun Wang, Haiying Hang, Lijun W. Cadmium-induced germline apoptosis in Caenorhabditis elegans: the roles of HUS1, p53, and MAPK signaling pathways. Toxicological sciences : an official journal of the Society of Toxicology. vol 102. issue 2. 2008-04-10. PMID:17728284. |
the loss-of-function mutations of dna damage response (ddr) genes hus1 and p53 exhibited significant increase in germline apoptosis under cd exposure, and the depletion of p53 antagonist abl1 significantly enhanced apoptosis. |
2008-04-10 |
2023-08-12 |
caenorhabditis_elegans |
| Shunchang Wang, Minli Tang, Bei Pei, Xiang Xiao, Jun Wang, Haiying Hang, Lijun W. Cadmium-induced germline apoptosis in Caenorhabditis elegans: the roles of HUS1, p53, and MAPK signaling pathways. Toxicological sciences : an official journal of the Society of Toxicology. vol 102. issue 2. 2008-04-10. PMID:17728284. |
together, the results of this study suggest the nonessential roles of the ddr genes hus1 and p53 in cd-induced germline apoptosis and that the apoptosis occurs through the ask1/2-mkk7-jnk and ask1/2-mkk3/6-p38 signaling pathways in a caspase-dependent manner. |
2008-04-10 |
2023-08-12 |
caenorhabditis_elegans |
| Maurice Reimann, Christoph Loddenkemper, Cornelia Rudolph, Ines Schildhauer, Bianca Teichmann, Harald Stein, Brigitte Schlegelberger, Bernd Dörken, Clemens A Schmit. The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo. Blood. vol 110. issue 8. 2007-11-28. PMID:17562874. |
in addition to the arf/p53 pathway, the dna damage response (ddr) has been recognized as another oncogene-provoked anticancer barrier in early human tumorigenesis leading to apoptosis or cellular senescence. |
2007-11-28 |
2023-08-12 |
mouse |
| Markus Löbrich, Penny A Jegg. The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nature reviews. Cancer. vol 7. issue 11. 2007-11-08. PMID:17943134. |
dna damage responses (ddr) encompass dna repair and signal transduction pathways that effect cell cycle checkpoint arrest and/or apoptosis. |
2007-11-08 |
2023-08-12 |
Not clear |