| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Dai, Steven Gran. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 16. issue 2. 2010-04-12. PMID:20068082. |
the dna damage response (ddr) represents a complex network of multiple signaling pathways involving cell cycle checkpoints, dna repair, transcriptional programs, and apoptosis, through which cells maintain genomic integrity following various endogenous (metabolic) or environmental stresses. |
2010-04-12 |
2023-08-12 |
Not clear |
| Jay P Reddy, Sirisha Peddibhotla, Wen Bu, Jing Zhao, Svasti Haricharan, Yi-Chieh Nancy Du, Katrina Podsypanina, Jeffrey M Rosen, Larry A Donehower, Yi L. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 8. 2010-04-05. PMID:20133707. |
furthermore, in this somatic erbb2 tumor model, atm, and thus ddr, is required for p53 stabilization, apoptosis, and senescence. |
2010-04-05 |
2023-08-12 |
mouse |
| Jay P Reddy, Sirisha Peddibhotla, Wen Bu, Jing Zhao, Svasti Haricharan, Yi-Chieh Nancy Du, Katrina Podsypanina, Jeffrey M Rosen, Larry A Donehower, Yi L. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 8. 2010-04-05. PMID:20133707. |
thus, this murine model fully recapitulates early ddr signaling; the eventual suppression of its endpoints in tumorigenesis provides compelling evidence that erbb2-induced aberrant mammary cell proliferation leads to an atm-mediated ddr that activates apoptosis and senescence, and at least the former must be overcome to progress to malignancy. |
2010-04-05 |
2023-08-12 |
mouse |
| Courtney A Lovejoy, Xin Xu, Carol E Bansbach, Gloria G Glick, Runxiang Zhao, Fei Ye, Bianca M Sirbu, Laura C Titus, Yu Shyr, David Corte. Functional genomic screens identify CINP as a genome maintenance protein. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 46. 2009-12-15. PMID:19889979. |
the dna damage response (ddr) has a critical role in maintaining genome integrity and serves as a barrier to tumorigenesis by promoting cell-cycle arrest, dna repair, and apoptosis. |
2009-12-15 |
2023-08-12 |
human |
| Penny A Jegg. Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us. Health physics. vol 97. issue 5. 2009-12-01. PMID:19820451. |
ddr processes encompass repair pathways and signal transduction mechanisms that activate cell cycle checkpoint arrest and apoptosis. |
2009-12-01 |
2023-08-12 |
Not clear |
| Hong Zhao, Frank Traganos, Jurek Dobrucki, Donald Wlodkowic, Zbigniew Darzynkiewic. Induction of DNA damage response by the supravital probes of nucleic acids. Cytometry. Part A : the journal of the International Society for Analytical Cytology. vol 75. issue 6. 2009-08-20. PMID:19373929. |
the data indicate that supravital use of ho 42, draq5, and dcv induces various degrees of ddr, including activation of atm, chk2 and p53, which may have significant consequences on regulatory cell cycle pathways and apoptosis. |
2009-08-20 |
2023-08-12 |
Not clear |
| Stéphanie Solier, Yves Pommie. The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases. Cell cycle (Georgetown, Tex.). vol 8. issue 12. 2009-08-14. PMID:19448405. |
we recently showed that histone h2ax phosphorylated on serine 139 (gamma-h2ax), a hallmark of dna damage response (ddr), also forms early during apoptosis induced by death receptor activation. |
2009-08-14 |
2023-08-12 |
Not clear |
| Jamie L Wood, Junjie Che. DNA-damage checkpoints: location, location, location. Trends in cell biology. vol 18. issue 10. 2009-05-26. PMID:18760607. |
the dna-damage response (ddr) is an evolutionarily conserved signaling cascade crucial for sensing dna damage and activating cellular responses such as cell-cycle arrest, dna repair, senescence and apoptosis. |
2009-05-26 |
2023-08-12 |
Not clear |
| Jun Yan, Anton M Jette. RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites. Cancer letters. vol 271. issue 2. 2008-10-28. PMID:18550271. |
the dna damage response (ddr) coordinates activation of cell cycle checkpoints, apoptosis, and dna repair networks, to ensure accurate repair and genomic integrity. |
2008-10-28 |
2023-08-12 |
Not clear |
| Bei Pei, Shunchang Wang, Xiaoyin Guo, Jun Wang, Gen Yang, Haiying Hang, Lijun W. Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans. Chemical research in toxicology. vol 21. issue 8. 2008-10-09. PMID:18597494. |
our results showed that the loss-of-function mutations of p53/ cep-1 and dna damage response (ddr) genes hus-1, clk-2, and egl-1 exhibited significant increase in germline apoptosis under arsenite exposure, whereas arsenite-induced germline apoptosis was blocked in loss-of-function alleles of extracellular signal-regulated kinase (erk) (lin-45 (ku51), mek-2 (n1989), and mpk-1 (ku1)), c-jun n-terminal kinase (jnk) (jkk-1 (km2), mek-1 (ks54), jnk-1 (gk7), mkk-4 (ju91)), and p38 ( nsy-1 (ag3), sek-1 (ag1), and pmk-1 (km25)) mapk cascades. |
2008-10-09 |
2023-08-12 |
caenorhabditis_elegans |
| Bei Pei, Shunchang Wang, Xiaoyin Guo, Jun Wang, Gen Yang, Haiying Hang, Lijun W. Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans. Chemical research in toxicology. vol 21. issue 8. 2008-10-09. PMID:18597494. |
these results suggest that arsenite-induced apoptosis occurs independently of p53/ cep-1 and the dna damage response (ddr) genes hus-1, clk-2, and egl-1 and that the c. elegans caspase gene ced-3, apaf-1 homologue ced-4, and the mapk signaling pathways are essential for germline apoptosis. |
2008-10-09 |
2023-08-12 |
caenorhabditis_elegans |
| Shunchang Wang, Minli Tang, Bei Pei, Xiang Xiao, Jun Wang, Haiying Hang, Lijun W. Cadmium-induced germline apoptosis in Caenorhabditis elegans: the roles of HUS1, p53, and MAPK signaling pathways. Toxicological sciences : an official journal of the Society of Toxicology. vol 102. issue 2. 2008-04-10. PMID:17728284. |
the loss-of-function mutations of dna damage response (ddr) genes hus1 and p53 exhibited significant increase in germline apoptosis under cd exposure, and the depletion of p53 antagonist abl1 significantly enhanced apoptosis. |
2008-04-10 |
2023-08-12 |
caenorhabditis_elegans |
| Shunchang Wang, Minli Tang, Bei Pei, Xiang Xiao, Jun Wang, Haiying Hang, Lijun W. Cadmium-induced germline apoptosis in Caenorhabditis elegans: the roles of HUS1, p53, and MAPK signaling pathways. Toxicological sciences : an official journal of the Society of Toxicology. vol 102. issue 2. 2008-04-10. PMID:17728284. |
together, the results of this study suggest the nonessential roles of the ddr genes hus1 and p53 in cd-induced germline apoptosis and that the apoptosis occurs through the ask1/2-mkk7-jnk and ask1/2-mkk3/6-p38 signaling pathways in a caspase-dependent manner. |
2008-04-10 |
2023-08-12 |
caenorhabditis_elegans |
| Maurice Reimann, Christoph Loddenkemper, Cornelia Rudolph, Ines Schildhauer, Bianca Teichmann, Harald Stein, Brigitte Schlegelberger, Bernd Dörken, Clemens A Schmit. The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo. Blood. vol 110. issue 8. 2007-11-28. PMID:17562874. |
in addition to the arf/p53 pathway, the dna damage response (ddr) has been recognized as another oncogene-provoked anticancer barrier in early human tumorigenesis leading to apoptosis or cellular senescence. |
2007-11-28 |
2023-08-12 |
mouse |
| Markus Löbrich, Penny A Jegg. The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nature reviews. Cancer. vol 7. issue 11. 2007-11-08. PMID:17943134. |
dna damage responses (ddr) encompass dna repair and signal transduction pathways that effect cell cycle checkpoint arrest and/or apoptosis. |
2007-11-08 |
2023-08-12 |
Not clear |