| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu Yang, Yingjie Guan, George Bayliss, Ting C Zhao, Shougang Zhuan. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Cell death & disease. vol 16. issue 1. 2025-03-31. PMID:40164578. |
consistently, inhibition of set8 with either unc0379 or sirna mitigated apoptosis and ddr and restored autophagy, along with pten preservation in cultured renal proximal tubular epithelial cells (tkpts) exposed to cisplatin. |
2025-03-31 |
2025-04-03 |
Not clear |
| Xu Yang, Yingjie Guan, George Bayliss, Ting C Zhao, Shougang Zhuan. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Cell death & disease. vol 16. issue 1. 2025-03-31. PMID:40164578. |
further studies showed that inhibition of pten with bpv or sirna potentiated cisplatin-induced apoptosis and ddr, hindered autophagy, and conversely, alleviated by overexpression of pten in tkpts. |
2025-03-31 |
2025-04-03 |
Not clear |
| Xu Yang, Yingjie Guan, George Bayliss, Ting C Zhao, Shougang Zhuan. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Cell death & disease. vol 16. issue 1. 2025-03-31. PMID:40164578. |
taken together, these results suggest that set8 inhibition protects against cisplatin-induced aki and renal cell apoptosis through a mechanism associated with the preservation of pten, which in turn inhibits ddr and restores autophagy. |
2025-03-31 |
2025-04-03 |
Not clear |
| Niknam Riyahi, Rada Malko, Harlan E Shannon, Kyle W Jackson, Ryli E Justice, Keiko Kreklau, M Reza Saadatzadeh, Karen E Pollok, Pankita H Pandy. Therapeutic Targeting of BET proteins in Sarcoma. Molecular cancer therapeutics. 2025-03-26. PMID:40138251. |
preclinical studies demonstrate efficacy of beti in inducing apoptosis, disrupting ddr, and reducing tumor growth, either as monotherapy or in combination with chemotherapy or other targeted agents, such as pi3k, hdac, and chk1 inhibitors. |
2025-03-26 |
2025-03-30 |
Not clear |
| Preethi Murali, B Kavitha, Malathi Narasimha. Deubiquitinases and Cancer. Journal of pharmacy & bioallied sciences. vol 16. issue Suppl 5. 2025-03-10. PMID:40061651. |
dubs are related to different aspects of human cancer, including proliferation, cell cycle control, apoptosis, dna damage response (ddr), tumor suppression, oncogenesis, and metastasis. |
2025-03-10 |
2025-03-12 |
human |
| Meng Wu, Xiaofang Chen, Haoran Wang, Chang Li, Wenjin Liu, Xiao Zheng, Jingxin Yang, Xin Ye, Yali Weng, Tianyun Fan, Huimin Ho. Discovery of the Clinical Candidate Journal of medicinal chemistry. 2025-03-03. PMID:40029060. |
atr inhibition induces dna damage accumulation and apoptosis in ddr kinase mutation or deficiency cancer cells through synthetic lethality, making it a promising target for treatment of cancers with ddr defects. |
2025-03-03 |
2025-03-06 |
Not clear |
| Zixuan Xiong, Yichun Huang, Shulong Cao, Xuqun Huang, Haiyuan Zhan. A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment. Frontiers in immunology. vol 16. 2025-02-27. PMID:40013141. |
in the non-immune tme, mechanisms such as apoptosis inhibition, dna damage response (ddr), and epithelial-mesenchymal transition (emt) can promote tumor growth, metastasis, and drug resistance. |
2025-02-27 |
2025-03-01 |
Not clear |
| Shantanu Gupta, Daner A Silveira, José Carlos M Mombach, Ronaldo F Hashimot. DNA Damage-Induced Ferroptosis: A Boolean Model Regulating p53 and Non-Coding RNAs in Drug Resistance. Proteomes. vol 13. issue 1. 2025-01-23. PMID:39846637. |
the tumor suppressor p53, in its wild-type form, plays a central role in cellular homeostasis by regulating senescence, apoptosis, and autophagy within the dna damage response (ddr). |
2025-01-23 |
2025-01-25 |
Not clear |
| Shantanu Gupta, Daner A Silveira, José Carlos M Mombach, Ronaldo F Hashimot. DNA Damage-Induced Ferroptosis: A Boolean Model Regulating p53 and Non-Coding RNAs in Drug Resistance. Proteomes. vol 13. issue 1. 2025-01-23. PMID:39846637. |
to address this, we introduce the first dynamic boolean model that delineates the influence of these ncrnas and p53 on ferroptosis, apoptosis, and senescence within the ddr context. |
2025-01-23 |
2025-01-25 |
Not clear |
| Zhaoming Guo, Yi Zhang, Yuwei Gong, Guqing Li, Jiawei Pan, Danni Dou, Kun Ma, Changhao Cui, Yubo Liu, Xudong Zh. Antibody functionalized curcuma-derived extracellular vesicles loaded with doxorubicin overcome therapy-induced senescence and enhance chemotherapy. Journal of controlled release : official journal of the Controlled Release Society. vol 379. 2025-01-16. PMID:39814319. |
conventional cancer treatments often induce a sustained dna damage response (ddr) in tumor cells, leading to therapy-induced senescence (tis), characterized by permanent cell cycle arrest and resistance to apoptosis. |
2025-01-16 |
2025-01-19 |
Not clear |
| Lijing Qin, Geng Tang, Ruirui Gui, Yanming Yang, Li Wang, Weiqiang Xu, Hongyuan Tian, Lei Yu, Xiangshan Yang, Zhicheng Wan. ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cells. Scientific reports. vol 15. issue 1. 2025-01-05. PMID:39755758. |
to explore the potential mechanism, we focused on the impact of the ionizing radiation (ir)-induced dna damage response (ddr), apoptosis, and senescence and the activation of the daxx/mdm2/p53 pathway caused by atrx loss. |
2025-01-05 |
2025-01-08 |
Not clear |
| Yixiang Gu, Ruifeng Yang, Yang Zhang, Miaomiao Guo, Kyle Takehiro, Ming Zhan, Linhua Yang, Hui Wan. Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer. Molecular biomedicine. vol 6. issue 1. 2025-01-05. PMID:39757310. |
this review provides a comprehensive analysis of the key molecular mechanisms underlying chemotherapy resistance, including drug efflux, enhanced dna damage repair (ddr), apoptosis evasion, epigenetic modifications, altered intracellular drug metabolism, and the role of cancer stem cells (cscs). |
2025-01-05 |
2025-01-08 |
Not clear |
| Matthew S Gillespie, Kelly Chiang, Gemma L Regan-Mochrie, Soo-Youn Choi, Ciara M Ward, Debashish Sahay, Paloma Garcia, Roland Arnold, Clare C Davie. PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells. Oncogene. 2024-12-18. PMID:39695328. |
mechanistically, we identify prmt5 as a major regulator of dna damage response (ddr) gene splicing in bcscs, particularly those integral to the fanconi anaemia and homologous recombination pathways, with prmt5 inhibition synergising with chemotherapy to promote bcsc apoptosis. |
2024-12-18 |
2024-12-21 |
Not clear |
| Jessica Bigge, Laura L Koebbe, Ann-Sophie Giel, Dorothea Bornholdt, Benedikt Buerfent, Pouria Dasmeh, Alexander M Zink, Carlo Maj, Johannes Schumache. Expression quantitative trait loci influence DNA damage-induced apoptosis in cancer. BMC genomics. vol 25. issue 1. 2024-12-03. PMID:39623312. |
genomic instability and evading apoptosis are two fundamental hallmarks of cancer and closely linked to dna damage response (ddr). |
2024-12-03 |
2024-12-06 |
Not clear |
| Łukasz Biegała, Małgorzata Statkiewicz, Arkadiusz Gajek, Izabela Szymczak-Pajor, Natalia Rusetska, Agnieszka Śliwińska, Agnieszka Marczak, Michał Mikula, Aneta Rogalsk. Molecular mechanisms restoring olaparib efficacy through ATR/CHK1 pathway inhibition in olaparib-resistant BRCA1/2 Biochimica et biophysica acta. Molecular basis of disease. 2024-11-18. PMID:39557132. |
proliferation, apoptosis, atr/chk1 activity, parp signaling, dna damage response (ddr), epithelial-to-mesenchymal transition (emt), and mdr1 expression, were examined via rt-qpcr, western blot, and immunohistochemistry. |
2024-11-18 |
2024-11-22 |
Not clear |
| Jerry Tyler DeWitt, Megha Raghunathan, Svasti Harichara. Nonrepair functions of DNA mismatch repair proteins: new avenues for precision oncology. Trends in cancer. 2024-11-03. PMID:39490324. |
here, we explore the clinical implications of nonrepair roles for ddr proteins, using the growing evidence supporting roles for dna mmr proteins in cell cycle and apoptosis regulation, metabolic function, the cellular secretome, and immunomodulation. |
2024-11-03 |
2024-11-06 |
Not clear |
| Jiayi Li, Ziqi Jia, Lin Dong, Heng Cao, Yansong Huang, Hengyi Xu, Zhixuan Xie, Yiwen Jiang, Xiang Wang, Jiaqi Li. DNA damage response in breast cancer and its significant role in guiding novel precise therapies. Biomarker research. vol 12. issue 1. 2024-09-28. PMID:39334297. |
on the one hand, ddr coordinates cell cycle and signal transduction, whose dysfunction may lead to cell apoptosis, genomic instability, and tumor development. |
2024-09-28 |
2024-10-01 |
Not clear |
| Pavol Zelina, Anna Aster de Ruiter, Christy Kolsteeg, Ilona van Ginneken, Harmjan R Vos, Laura F Supiot, Boudewijn M T Burgering, Frank J Meye, Jan H Veldink, Leonard H van den Berg, R Jeroen Pasterkam. ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons. Acta neuropathologica communications. vol 12. issue 1. 2024-09-04. PMID:39227882. |
in addition, c21orf2-v58l induced post-transcriptional downregulation of nek1, an als-associated protein implicated in apoptosis and ddr. |
2024-09-04 |
2024-09-06 |
mouse |
| Hongjuan You, Chunfu Zhen. A Guideline Strategy for Identifying a Viral Gene/Protein Evading Antiviral Innate Immunity. Methods in molecular biology (Clifton, N.J.). vol 2854. 2024-08-27. PMID:39192113. |
the interferon (ifn) signaling pathway, the dna damage response (ddr), apoptosis, endoplasmic reticulum (er) stress, and autophagy are involved in antiviral innate immunity. |
2024-08-27 |
2024-08-30 |
Not clear |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
consistently, inhibition of set8 with either unc0379 or sirna mitigated apoptosis and ddr, and restored autophagy, along with pten preservation in cultured renal proximal tubular epithelial cell (tkpts) exposed to cisplatin. |
2024-08-26 |
2024-08-28 |
Not clear |