| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew S Gillespie, Kelly Chiang, Gemma L Regan-Mochrie, Soo-Youn Choi, Ciara M Ward, Debashish Sahay, Paloma Garcia, Roland Arnold, Clare C Davie. PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells. Oncogene. 2024-12-18. PMID:39695328. |
mechanistically, we identify prmt5 as a major regulator of dna damage response (ddr) gene splicing in bcscs, particularly those integral to the fanconi anaemia and homologous recombination pathways, with prmt5 inhibition synergising with chemotherapy to promote bcsc apoptosis. |
2024-12-18 |
2024-12-21 |
Not clear |
| Jessica Bigge, Laura L Koebbe, Ann-Sophie Giel, Dorothea Bornholdt, Benedikt Buerfent, Pouria Dasmeh, Alexander M Zink, Carlo Maj, Johannes Schumache. Expression quantitative trait loci influence DNA damage-induced apoptosis in cancer. BMC genomics. vol 25. issue 1. 2024-12-03. PMID:39623312. |
genomic instability and evading apoptosis are two fundamental hallmarks of cancer and closely linked to dna damage response (ddr). |
2024-12-03 |
2024-12-06 |
Not clear |
| Łukasz Biegała, Małgorzata Statkiewicz, Arkadiusz Gajek, Izabela Szymczak-Pajor, Natalia Rusetska, Agnieszka Śliwińska, Agnieszka Marczak, Michał Mikula, Aneta Rogalsk. Molecular mechanisms restoring olaparib efficacy through ATR/CHK1 pathway inhibition in olaparib-resistant BRCA1/2 Biochimica et biophysica acta. Molecular basis of disease. 2024-11-18. PMID:39557132. |
proliferation, apoptosis, atr/chk1 activity, parp signaling, dna damage response (ddr), epithelial-to-mesenchymal transition (emt), and mdr1 expression, were examined via rt-qpcr, western blot, and immunohistochemistry. |
2024-11-18 |
2024-11-22 |
Not clear |
| Jerry Tyler DeWitt, Megha Raghunathan, Svasti Harichara. Nonrepair functions of DNA mismatch repair proteins: new avenues for precision oncology. Trends in cancer. 2024-11-03. PMID:39490324. |
here, we explore the clinical implications of nonrepair roles for ddr proteins, using the growing evidence supporting roles for dna mmr proteins in cell cycle and apoptosis regulation, metabolic function, the cellular secretome, and immunomodulation. |
2024-11-03 |
2024-11-06 |
Not clear |
| Jiayi Li, Ziqi Jia, Lin Dong, Heng Cao, Yansong Huang, Hengyi Xu, Zhixuan Xie, Yiwen Jiang, Xiang Wang, Jiaqi Li. DNA damage response in breast cancer and its significant role in guiding novel precise therapies. Biomarker research. vol 12. issue 1. 2024-09-28. PMID:39334297. |
on the one hand, ddr coordinates cell cycle and signal transduction, whose dysfunction may lead to cell apoptosis, genomic instability, and tumor development. |
2024-09-28 |
2024-10-01 |
Not clear |
| Pavol Zelina, Anna Aster de Ruiter, Christy Kolsteeg, Ilona van Ginneken, Harmjan R Vos, Laura F Supiot, Boudewijn M T Burgering, Frank J Meye, Jan H Veldink, Leonard H van den Berg, R Jeroen Pasterkam. ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons. Acta neuropathologica communications. vol 12. issue 1. 2024-09-04. PMID:39227882. |
in addition, c21orf2-v58l induced post-transcriptional downregulation of nek1, an als-associated protein implicated in apoptosis and ddr. |
2024-09-04 |
2024-09-06 |
mouse |
| Hongjuan You, Chunfu Zhen. A Guideline Strategy for Identifying a Viral Gene/Protein Evading Antiviral Innate Immunity. Methods in molecular biology (Clifton, N.J.). vol 2854. 2024-08-27. PMID:39192113. |
the interferon (ifn) signaling pathway, the dna damage response (ddr), apoptosis, endoplasmic reticulum (er) stress, and autophagy are involved in antiviral innate immunity. |
2024-08-27 |
2024-08-30 |
Not clear |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
consistently, inhibition of set8 with either unc0379 or sirna mitigated apoptosis and ddr, and restored autophagy, along with pten preservation in cultured renal proximal tubular epithelial cell (tkpts) exposed to cisplatin. |
2024-08-26 |
2024-08-28 |
Not clear |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
further studies showed that inhibition of pten with bpv or sirna potentiated cisplatin-induced apoptosis, ddr, and hindered autophagy, and conversely, alleviated by overexpression of pten in tkpts. |
2024-08-26 |
2024-08-28 |
Not clear |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
taken together, these results suggest that set8 inhibition protects against cisplatin-induced aki and renal cell apoptosis through a mechanism associated with the preservation of pten, which in turn inhibits ddr and restores autophagy. |
2024-08-26 |
2024-08-28 |
Not clear |
| Shantanu Gupta, Daner A Silveira, Pedro R Lorenzoni, Jose Carlos M Mombach, Ronaldo F Hashimot. LncRNA PTENP1/miR-21/PTEN Axis Modulates EMT and Drug Resistance in Cancer: Dynamic Boolean Modeling for Cell Fates in DNA Damage Response. International journal of molecular sciences. vol 25. issue 15. 2024-08-10. PMID:39125832. |
our model shows good agreement with the experimental findings from breast cancer, hepatocellular carcinoma (hcc), and oral squamous cell carcinoma (oscc), elucidating how ddr activation transitions from the intra-s phase to the g2 checkpoint, leading to a cascade of cellular responses such as cell cycle arrest, senescence, autophagy, apoptosis, drug resistance, and emt. |
2024-08-10 |
2024-08-13 |
Not clear |
| Ben Ewen-Campen, Norbert Perrimo. Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway. PLoS biology. vol 22. issue 7. 2024-07-24. PMID:39047051. |
despite the deep conservation of the dna damage response (ddr) pathway, cells in different contexts vary widely in their susceptibility to dna damage and their propensity to undergo apoptosis as a result of genomic lesions. |
2024-07-24 |
2024-07-28 |
human |
| Sahar Omidvar, Vahid Vahedian, Zahra Sourani, Davood Yari, Mehrdad Asadi, Negin Jafari, Lida Khodavirdilou, Molood Bagherieh, Moein Shirzad, Vahid Hossein. The molecular crosstalk between innate immunity and DNA damage repair/response: Interactions and effects in cancers. Pathology, research and practice. vol 260. 2024-07-09. PMID:38981346. |
therefore, dna damage repair/response (ddr) detects and then corrects these potentially tumorigenic problems by inducing processes such as dna repair, cell cycle arrest, apoptosis, etc. |
2024-07-09 |
2024-07-12 |
Not clear |
| Wei Li, Yongjian Ha. Polo-Like Kinase 1 and DNA Damage Response. DNA and cell biology. 2024-07-03. PMID:38959179. |
the dna damage response (ddr) includes activation of the dna checkpoint, dna damage recovery, dna repair, and apoptosis. |
2024-07-03 |
2024-07-10 |
Not clear |
| Niladri K Sinha, Connor McKenney, Zhong Y Yeow, Jeffrey J Li, Ki Hong Nam, Tomer M Yaron-Barir, Jared L Johnson, Emily M Huntsman, Lewis C Cantley, Alban Ordureau, Sergi Regot, Rachel Gree. The ribotoxic stress response drives UV-mediated cell death. Cell. 2024-06-06. PMID:38843833. |
we discover that uv-induced apoptosis is mediated by the rsr kinase zak and not through the ddr. |
2024-06-06 |
2024-06-10 |
Not clear |
| Anthi Bouchla, Christina D Sotiropoulou, Christopher Esteb, Theodoros Loupis, Sotirios G Papageorgiou, Georgia G Deliconstantinos, Maria Pagoni, Eleftheria Hatzimichael, Maria Dellatola, Smaragdi Kalomoiri, Elisavet Apostolidou, Christos K Kontos, Thomas P Thomopoulos, Theodoros Karantanos, Vasiliki Papp. Silencing of the DNA damage repair regulator PPP1R15A sensitizes acute myeloid leukemia cells to chemotherapy. Annals of hematology. 2024-06-06. PMID:38842564. |
the dna damage response mechanism (ddr) comprises numerous molecules and pathways intended to arrest the cell cycle until dna damage is repaired or else drive the cell to apoptosis. |
2024-06-06 |
2024-06-08 |
Not clear |
| Yu Bin Ng, Semih Can Akincila. Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer. Current opinion in pharmacology. vol 76. 2024-05-22. PMID:38776747. |
unprotected telomeres lead to persistent ddr causing cell cycle inhibition, growth arrest, and apoptosis. |
2024-05-22 |
2024-05-27 |
Not clear |
| Koji Fukuda, Shinji Takeuchi, Sachiko Arai, Shigeki Nanjo, Shigeki Sato, Hiroshi Kotani, Kenji Kita, Akihiro Nishiyama, Hiroyuki Sakaguchi, Koshiro Ohtsubo, Seiji Yan. Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations. Cell reports. Medicine. 2024-05-22. PMID:38776912. |
mechanistically, wee1 inhibition promotes g2/m transition and reduces checkpoint kinase 2 (chk2) and rad51 expression in the dna damage response (ddr) pathway, which is associated with apoptosis and the repair of dna double-strand breaks, leading to mitotic catastrophe. |
2024-05-22 |
2024-05-27 |
rat |
| Dimitra Mavroeidi, Anastasia Georganta, Emmanouil Panagiotou, Konstantinos Syrigos, Vassilis L Soulioti. Targeting ATR Pathway in Solid Tumors: Evidence of Improving Therapeutic Outcomes. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474014. |
the dna damage response (ddr) system is a complicated network of signaling pathways that detects and repairs dna damage or induces apoptosis. |
2024-03-13 |
2024-03-15 |
Not clear |
| Songbiao Chen, Feifei Liu, Aofei Yang, Ke Shan. For better or worse: crosstalk of parvovirus and host DNA damage response. Frontiers in immunology. vol 15. 2024-03-11. PMID:38464523. |
ns1 is the largest and most complex non-structural protein in the parvovirus genome, which is indispensable in the life cycle of parvovirus and is closely related to viral replication, induction of host cell apoptosis, cycle arrest, dna damage response (ddr), and other processes. |
2024-03-11 |
2024-03-14 |
Not clear |