| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya-Ruo Lei, Xian-Lu He, Jun Li, Chun-Fen M. Drug Resistance in Hepatocellular Carcinoma: Theoretical Basis and Therapeutic Aspects. Frontiers in bioscience (Landmark edition). vol 29. issue 2. 2024-02-29. PMID:38420802. |
drug resistance exhibits multiple and complex molecular mechanisms to antagonize therapy under pharmacological pressure, including overexpression of drug efflux transporters, downstream adaptive response (such as apoptosis, autophagy, and endoplasmic reticulum stress), dysfunction of dna damage repair (ddr), epigenetic modification, tumor microenvironment (tme) as well as extracellular matrix (ecm). |
2024-02-29 |
2024-03-02 |
Not clear |
| Ragini Singh, Aishwarya Jaiswal, Rana P Sing. Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells. Biochimica et biophysica acta. Molecular cell research. 2024-01-25. PMID:38272357. |
taken together, our study revealed that microgravity is a strong stressor to trigger dna damage and apoptosis through activation of erk1/2 and akt, and impairment of dna repair capacity, albeit with a cell-type difference in ddr and nhej regulation, in microglial and glioblastoma cells. |
2024-01-25 |
2024-01-28 |
Not clear |
| Shohei Miyata, Takashi Ishii, Susumu Kitanak. Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia. Anticancer research. vol 44. issue 1. 2024-01-02. PMID:38159998. |
under severe hypoxia, cellular apoptosis is induced through hypoxia-inducible factor 1, alpha subunit (hif-1α)-dependent p53 accumulation and p53 phosphorylation via ataxia telangiectasia mutated and ataxia telangiectasia and rad3-related (atr) activation via replication stress-induced dna damage response (ddr) activation. |
2024-01-02 |
2024-01-05 |
Not clear |
| Evangelos Manousakis, Clàudia Martinez Miralles, Maria Guimerà Esquerda, Roni H G Wrigh. CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution? International journal of molecular sciences. vol 24. issue 24. 2023-12-23. PMID:38139316. |
over the years, extensive research has shed light on various additional mechanisms involving cdkn1a/p21, implicating it in processes such as apoptosis, dna damage response (ddr), and the regulation of stem cell fate. |
2023-12-23 |
2023-12-25 |
Not clear |
| Dimitrios Nasioudis, Erin M George, Haineng Xu, Hyoung Kim, Fiona Simpkin. Combination DNA Damage Response (DDR) Inhibitors to Overcome Drug Resistance in Ovarian Cancer. Cancer treatment and research. vol 186. 2023-11-17. PMID:37978137. |
ddr inhibitors such as parp inhibitors lead to the accumulation of dna damage in tumor cells and ultimately apoptosis. |
2023-11-17 |
2023-11-20 |
Not clear |
| Fabienne Becker, Meryem Ouzin, Stefanie Liedtke, Katharina Raba, Gesine Kogle. DNA damage response after treatment of cycling and quiescent cord blood hematopoietic stem cells with distinct genotoxic noxae. Stem cells (Dayton, Ohio). 2023-11-14. PMID:37962865. |
cycling cells employ both ddr and apoptosis mechanisms to prevent damage accumulation. |
2023-11-14 |
2023-11-20 |
Not clear |
| Xin Miao, Gilbert Koch, Shichen Shen, Xue Wang, Jun Li, Xiaomeng Shen, Jun Qu, Robert M Straubinger, William J Jusk. Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways. Journal of pharmaceutical sciences. 2023-11-02. PMID:37918792. |
here we describe drug effects on pathways associated with cell cycle, dna damage response (ddr), and apoptosis, and provide insights into underlying mechanisms. |
2023-11-02 |
2023-11-08 |
Not clear |
| Christina Pfeiffer, Alexander M Grandits, Hélène Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis. |
2023-10-29 |
2023-11-08 |
Not clear |
| H Libalova, T Zavodna, H Margaryan, F Elzeinova, A Milcova, K Vrbova, H Barosova, T Cervena, J Topinka, P Rössne. Differential DNA damage response and cell fate in human lung cells after exposure to genotoxic compounds. Toxicology in vitro : an international journal published in association with BIBRA. 2023-10-14. PMID:37838151. |
dox triggered the most robust p53 signaling indicating activation of ddr, followed by cell cycle arrest in the g2/m phase, induction of apoptosis and senescence, possibly due to the severe and irreparable dna lesions. |
2023-10-14 |
2023-11-08 |
human |
| Diana Ainembabazi, Youwei Zhang, John J Turch. The mechanistic role of cardiac glycosides in DNA damage response and repair signaling. Cellular and molecular life sciences : CMLS. vol 80. issue 9. 2023-08-16. PMID:37584722. |
ddr serves to coordinate numerous cellular pathways to initiate cell cycle arrest, promote dna repair, regulate replication fork firing and protection, or induce apoptosis to avoid the survival of cells with dna damage or cells carrying mutations. |
2023-08-16 |
2023-09-07 |
Not clear |
| Gautam Chandra Sarkar, Umanshi Rautela, Anita Goyala, Sudeshna Datta, Nikhita Anand, Anupama Singh, Prachi Singh, Manish Chamoli, Arnab Mukhopadhya. DNA damage signals from somatic uterine tissue arrest oogenesis through activated FOXO/DAF-16. Development (Cambridge, England). 2023-08-14. PMID:37577954. |
organisms deploy the dna damage response (ddr) signaling to protect the germ line from genotoxic stress, facilitating the cell-cycle arrest of germ cells and dna repair or their apoptosis. |
2023-08-14 |
2023-08-16 |
caenorhabditis_elegans |
| Baochen Zhou, Ye Yang, Xuemeng Pang, Jingjing Shi, Ting Jiang, Xin Zhen. Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-06-30. PMID:37390710. |
however, whether quercetin regulates dna damage repair (ddr) and induces apoptosis through sirt5 in nsclc remains unknown. |
2023-06-30 |
2023-08-14 |
Not clear |
| Aamir Parvez, Ishrat Mahjabeen, Azhar Mehmood, Asad Ullah Khan, Asif Nisar, Mahmood Akhtar Kayan. Expression variations of DNA damage response genes ATM and ATR in blood cancer patients. Molecular genetics and genomics : MGG. 2023-06-20. PMID:37338595. |
ddr network detects a variety of dna damage and triggers the activation of cell cycle control, dna repair, senescence, and apoptosis. |
2023-06-20 |
2023-08-14 |
Not clear |
| Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Christina Poulianiti, Maria Anna Polyzou Konsta, Vassilios Liakopoulos, Ioannis Stefanidi. Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298591. |
briefly, albumin overload causes cellular apoptosis, senescence, and emt in rptecs by triggering upr and ddr. |
2023-06-11 |
2023-08-14 |
Not clear |
| Chi-Ju Kim, Anna Lk Gonye, Kevin Truskowski, Cheng-Fan Lee, Yoon-Kyoung Cho, Robert H Austin, Kenneth J Pienta, Sarah R Amen. Nuclear morphology predicts cell survival to cisplatin chemotherapy. Neoplasia (New York, N.Y.). vol 42. 2023-05-12. PMID:37172462. |
these data support a paradigm where soon after therapy release, the treated population mostly contains cells with a high level of widespread and catastrophic dna damage that leads to apoptosis, while the minority of cells that have successful ddr are more likely to access a pro-survival state. |
2023-05-12 |
2023-08-14 |
Not clear |
| Mu Zhang, Jiawei Zhao, Peter M Glazer, Wenlong Bai, Gerold Bepler, Xiaohong Mary Zhan. Acetylation of MLH1 by CBP increases cellular DNA mismatch repair activity. Journal of biochemistry. 2023-04-24. PMID:37094360. |
additionally, they are involved in regulation of the dna damage response (ddr), including cell cycle checkpoints and apoptosis. |
2023-04-24 |
2023-08-14 |
Not clear |
| Rui Zhao, Ke Cai, Jing-Jing Yang, Qian Zhou, Wei Cao, Jie Xiang, Yi-Hui Shen, Lei-Lei Cheng, Wei-Dong Zang, Yan Lin, Yi-Yuan Yuan, Wei Xu, Hui Tao, Shi-Min Zhao, Jian-Yuan Zha. Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response. Cell reports. vol 42. issue 4. 2023-04-18. PMID:37071536. |
increased tyrosine inhibits the nuclear localization of yars, inhibits the atr-mediated ddr, accumulates dna damage, and elevates cardiomyocyte apoptosis. |
2023-04-18 |
2023-08-14 |
mouse |
| Khoa Nguyen, Julia Boehling, Minh N Tran, Thomas Cheng, Andrew Rivera, Bridgette M Collins-Burow, Sean B Lee, David H Drewry, Matthew E Buro. NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types. Cancers. vol 15. issue 7. 2023-04-13. PMID:37046733. |
the never in mitosis gene a (nima)-related kinases (neks) are a group of serine/threonine kinases that are involved in a wide array of cellular processes including cell cycle regulation, dna damage repair response (ddr), apoptosis, and microtubule organization. |
2023-04-13 |
2023-08-14 |
Not clear |
| Shantanu Gupta, Pritam Kumar Panda, Daner A Silveira, Rajeev Ahuja, Ronaldo F Hashimot. Quadra-Stable Dynamics of p53 and PTEN in the DNA Damage Response. Cells. vol 12. issue 7. 2023-04-13. PMID:37048159. |
our network's wild-type system shows that ddr activates the g2/m checkpoint, and this triggers a cascade of events, involving p53 and pten, that ultimately lead to the four potential phenotypes: cell cycle arrest, senescence, autophagy, and apoptosis (quadra-stable dynamics). |
2023-04-13 |
2023-08-14 |
Not clear |
| Divya A Shiroor, Kuang-Tse Wang, Bhargav D Sanketi, Justin K Tapper, Carolyn E Adle. Inhibition of ATM kinase rescues planarian regeneration after lethal radiation. EMBO reports. 2023-03-21. PMID:36943023. |
to mitigate potentially deleterious outcomes, cells activate the dna damage response (ddr) network, which governs several cellular outcomes following dna damage, including repairing dna or undergoing apoptosis. |
2023-03-21 |
2023-08-14 |
Not clear |