| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aamir Parvez, Ishrat Mahjabeen, Azhar Mehmood, Asad Ullah Khan, Asif Nisar, Mahmood Akhtar Kayan. Expression variations of DNA damage response genes ATM and ATR in blood cancer patients. Molecular genetics and genomics : MGG. 2023-06-20. PMID:37338595. |
ddr network detects a variety of dna damage and triggers the activation of cell cycle control, dna repair, senescence, and apoptosis. |
2023-06-20 |
2023-08-14 |
Not clear |
| Theodoros Eleftheriadis, Georgios Pissas, Spyridon Golfinopoulos, Maria Efthymiadi, Christina Poulianiti, Maria Anna Polyzou Konsta, Vassilios Liakopoulos, Ioannis Stefanidi. Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298591. |
briefly, albumin overload causes cellular apoptosis, senescence, and emt in rptecs by triggering upr and ddr. |
2023-06-11 |
2023-08-14 |
Not clear |
| Chi-Ju Kim, Anna Lk Gonye, Kevin Truskowski, Cheng-Fan Lee, Yoon-Kyoung Cho, Robert H Austin, Kenneth J Pienta, Sarah R Amen. Nuclear morphology predicts cell survival to cisplatin chemotherapy. Neoplasia (New York, N.Y.). vol 42. 2023-05-12. PMID:37172462. |
these data support a paradigm where soon after therapy release, the treated population mostly contains cells with a high level of widespread and catastrophic dna damage that leads to apoptosis, while the minority of cells that have successful ddr are more likely to access a pro-survival state. |
2023-05-12 |
2023-08-14 |
Not clear |
| Mu Zhang, Jiawei Zhao, Peter M Glazer, Wenlong Bai, Gerold Bepler, Xiaohong Mary Zhan. Acetylation of MLH1 by CBP increases cellular DNA mismatch repair activity. Journal of biochemistry. 2023-04-24. PMID:37094360. |
additionally, they are involved in regulation of the dna damage response (ddr), including cell cycle checkpoints and apoptosis. |
2023-04-24 |
2023-08-14 |
Not clear |
| Rui Zhao, Ke Cai, Jing-Jing Yang, Qian Zhou, Wei Cao, Jie Xiang, Yi-Hui Shen, Lei-Lei Cheng, Wei-Dong Zang, Yan Lin, Yi-Yuan Yuan, Wei Xu, Hui Tao, Shi-Min Zhao, Jian-Yuan Zha. Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response. Cell reports. vol 42. issue 4. 2023-04-18. PMID:37071536. |
increased tyrosine inhibits the nuclear localization of yars, inhibits the atr-mediated ddr, accumulates dna damage, and elevates cardiomyocyte apoptosis. |
2023-04-18 |
2023-08-14 |
mouse |
| Khoa Nguyen, Julia Boehling, Minh N Tran, Thomas Cheng, Andrew Rivera, Bridgette M Collins-Burow, Sean B Lee, David H Drewry, Matthew E Buro. NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types. Cancers. vol 15. issue 7. 2023-04-13. PMID:37046733. |
the never in mitosis gene a (nima)-related kinases (neks) are a group of serine/threonine kinases that are involved in a wide array of cellular processes including cell cycle regulation, dna damage repair response (ddr), apoptosis, and microtubule organization. |
2023-04-13 |
2023-08-14 |
Not clear |
| Shantanu Gupta, Pritam Kumar Panda, Daner A Silveira, Rajeev Ahuja, Ronaldo F Hashimot. Quadra-Stable Dynamics of p53 and PTEN in the DNA Damage Response. Cells. vol 12. issue 7. 2023-04-13. PMID:37048159. |
our network's wild-type system shows that ddr activates the g2/m checkpoint, and this triggers a cascade of events, involving p53 and pten, that ultimately lead to the four potential phenotypes: cell cycle arrest, senescence, autophagy, and apoptosis (quadra-stable dynamics). |
2023-04-13 |
2023-08-14 |
Not clear |
| Divya A Shiroor, Kuang-Tse Wang, Bhargav D Sanketi, Justin K Tapper, Carolyn E Adle. Inhibition of ATM kinase rescues planarian regeneration after lethal radiation. EMBO reports. 2023-03-21. PMID:36943023. |
to mitigate potentially deleterious outcomes, cells activate the dna damage response (ddr) network, which governs several cellular outcomes following dna damage, including repairing dna or undergoing apoptosis. |
2023-03-21 |
2023-08-14 |
Not clear |
| Chay Teng Yeo, Erin M Kropp, Polly A Hansen, Michael Pereckas, Bryndon J Oleson, Aaron Naatz, Jennifer S Stancill, Kyle A Ross, Rebekah L Gundry, John A Corbet. β-cell selective inhibition of DNA damage response signaling by nitric oxide is associated with an attenuation in glucose uptake. The Journal of biological chemistry. 2023-02-11. PMID:36773802. |
as a genotoxic agent, nitric oxide activates two types of ddr signaling; however, when produced at micromolar levels by the inducible isoform of nitric oxide synthase (inos), nitric oxide inhibits ddr signaling and ddr-induced apoptosis in a β-cell-selective manner. |
2023-02-11 |
2023-08-14 |
Not clear |
| Megan E Honeywell, Marie Sophie Lykke Isidor, Nicholas W Harper, Rachel E Fontana, Peter Cruz-Gordillo, Sydney A Porto, Jessica B Spinelli, David A Guertin, Michael J Le. p53 controls choice between apoptotic and non-apoptotic death following DNA damage. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36712034. |
the canonical response to dna damage involves p53-dependent activation of cell intrinsic apoptosis, downstream of dna damage response (ddr) activation. |
2023-01-30 |
2023-08-14 |
Not clear |
| Prokopios P Argyris, Flávia Saavedra, Chris Malz, Ian A Stone, Yuping Wei, William S Boyle, Karen F Johnstone, Ali Khammanivong, Mark C Herzber. Intracellular calprotectin (S100A8/A9) facilitates DNA damage responses and promotes apoptosis in head and neck squamous cell carcinoma. Oral oncology. vol 137. 2023-01-06. PMID:36608459. |
we investigated whether s100a8/a9 regulates dna damage responses (ddr) and apoptosis in hnscc after chemoradiation. |
2023-01-06 |
2023-08-14 |
Not clear |
| Kavya Pandya, Neeru Sing. In silico study reveals unconventional interactions between MDC1 of DDR and Beclin-1 of autophagy. Molecular diversity. 2022-12-09. PMID:36482226. |
mdc1 is an adaptor or scaffold protein known to regulate ddr, apoptosis, and cell cycle progression. |
2022-12-09 |
2023-08-14 |
Not clear |
| Amanda J Stock, Ross A McDevitt, Chandrakala Puligilla, Yajun Wang, Yongqing Zhang, Kun Wang, Chongkui Sun, Kevin G Becker, Elin Lehrmann, William H Wood, Yi Gong, Mohammad Aqdas, Myong-Hee Sung, Victoria Hoffmann, Chengyu Liu, Myriam Gorospe, Lea Harrington, Luigi Ferrucci, Yie Li. Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes. PLoS genetics. vol 18. issue 11. 2022-11-28. PMID:36441670. |
short telomeres induce a dna damage response (ddr) that evokes apoptosis and senescence in human cells. |
2022-11-28 |
2023-08-14 |
mouse |
| Fanwei Meng, Junfeng Ke, Jinze Li, Changhui Zhao, Jiaqing Yan, Liping Wan. A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo. Experimental cell research. 2022-11-28. PMID:36442518. |
dhhp-3 could reduce ros, down-regulate apoptotic proteins, suppress p53 phosphorylation, attenuate the dna damage response (ddr), and inhibit apoptosis in sh-sy5y cells subjected to oxygen-glucose deprivation/re-oxygenation (ogd/r) and in the brain of sprague dawley rats subjected to transient middle cerebral artery occlusion. |
2022-11-28 |
2023-08-14 |
human |
| Ken-Ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu, Akira Saka. ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response : ΔNp63α may cause genomic instability in epithelial stem cells. Radiation oncology (London, England). vol 17. issue 1. 2022-11-15. PMID:36380314. |
the dna damage response (ddr) is a mechanism that protects cells against radiation-induced oxidative dna damage by causing cell cycle arrest and apoptosis. |
2022-11-15 |
2023-08-14 |
Not clear |
| Jared R Erickson, Robert F Kalejta, Paul D Friese. Ataxia Telangiectasia-Mutated Is Activated but Not Required for Productive Autographa californica Multiple Nucleopolyhedrovirus Infection. Journal of virology. 2022-10-31. PMID:36314821. |
like other pikks, atm phosphorylates an array of host ddr proteins at serine/threonine glutamine (s/tq) motifs, the result of which leads to cell cycle arrest, dna repair, or apoptosis. |
2022-10-31 |
2023-08-14 |
Not clear |
| Sayanthooran Saravanabavan, Gopala K Ranga. Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293397. |
we hypothesized that inhibiting ataxia telangiectasia mutated (atm; a proximal ddr kinase) together with low-dose cisplatin overwhelms the ddr response and leads to selective apoptosis of cyst-lining epithelial cells (cecs). |
2022-10-27 |
2023-08-14 |
Not clear |
| Liam Widjaja, Rudolf A Werner, Elke Krischke, Hans Christiansen, Frank M Bengel, Natalia Bogdanova, Thorsten Derli. Individual radiosensitivity reflected by γ-H2AX and 53BP1 foci predicts outcome in PSMA-targeted radioligand therapy. European journal of nuclear medicine and molecular imaging. 2022-09-22. PMID:36136101. |
γ-h2ax and 53bp1 are fundamental for cellular dna damage response (ddr) after radiation exposure and are linked to cell repair, arrest, or apoptosis. |
2022-09-22 |
2023-08-14 |
Not clear |
| Song Gao, Liping Shan, Mo Zhang, Yan Wang, Xi Zhan, Yalei Yin, Zhonghao Jiang, Xinyi Tao, Xinyu Li, Mingliang Ye, Yang Li. Inhibition of PP2A by LB100 sensitizes bladder cancer cells to chemotherapy by inducing p21 degradation. Cellular oncology (Dordrecht). 2022-09-22. PMID:36136269. |
protein phosphatase 2a (pp2a) is a serine/threonine phosphatase involved in a wide variety of regulatory cellular processes, including apoptosis and the dna-damage response (ddr). |
2022-09-22 |
2023-08-14 |
Not clear |
| Xinxin Lu, Haiqi Xu, Jiaqi Xu, Saien Lu, Shilong You, Xinyue Huang, Naijin Zhang, Lijun Zhan. The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091384. |
dna damage response (ddr) is induced in response to dna damage to maintain genome integrity and stability, and this process has crucial significance to a series of cell activities such as differentiation, apoptosis, cell cycle. |
2022-09-12 |
2023-08-14 |
Not clear |