| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
further studies showed that inhibition of pten with bpv or sirna potentiated cisplatin-induced apoptosis, ddr, and hindered autophagy, and conversely, alleviated by overexpression of pten in tkpts. |
2024-08-26 |
2024-08-28 |
Not clear |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
taken together, these results suggest that set8 inhibition protects against cisplatin-induced aki and renal cell apoptosis through a mechanism associated with the preservation of pten, which in turn inhibits ddr and restores autophagy. |
2024-08-26 |
2024-08-28 |
Not clear |
| Shantanu Gupta, Daner A Silveira, Pedro R Lorenzoni, Jose Carlos M Mombach, Ronaldo F Hashimot. LncRNA PTENP1/miR-21/PTEN Axis Modulates EMT and Drug Resistance in Cancer: Dynamic Boolean Modeling for Cell Fates in DNA Damage Response. International journal of molecular sciences. vol 25. issue 15. 2024-08-10. PMID:39125832. |
our model shows good agreement with the experimental findings from breast cancer, hepatocellular carcinoma (hcc), and oral squamous cell carcinoma (oscc), elucidating how ddr activation transitions from the intra-s phase to the g2 checkpoint, leading to a cascade of cellular responses such as cell cycle arrest, senescence, autophagy, apoptosis, drug resistance, and emt. |
2024-08-10 |
2024-08-13 |
Not clear |
| Ben Ewen-Campen, Norbert Perrimo. Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway. PLoS biology. vol 22. issue 7. 2024-07-24. PMID:39047051. |
despite the deep conservation of the dna damage response (ddr) pathway, cells in different contexts vary widely in their susceptibility to dna damage and their propensity to undergo apoptosis as a result of genomic lesions. |
2024-07-24 |
2024-07-28 |
human |
| Sahar Omidvar, Vahid Vahedian, Zahra Sourani, Davood Yari, Mehrdad Asadi, Negin Jafari, Lida Khodavirdilou, Molood Bagherieh, Moein Shirzad, Vahid Hossein. The molecular crosstalk between innate immunity and DNA damage repair/response: Interactions and effects in cancers. Pathology, research and practice. vol 260. 2024-07-09. PMID:38981346. |
therefore, dna damage repair/response (ddr) detects and then corrects these potentially tumorigenic problems by inducing processes such as dna repair, cell cycle arrest, apoptosis, etc. |
2024-07-09 |
2024-07-12 |
Not clear |
| Wei Li, Yongjian Ha. Polo-Like Kinase 1 and DNA Damage Response. DNA and cell biology. 2024-07-03. PMID:38959179. |
the dna damage response (ddr) includes activation of the dna checkpoint, dna damage recovery, dna repair, and apoptosis. |
2024-07-03 |
2024-07-10 |
Not clear |
| Niladri K Sinha, Connor McKenney, Zhong Y Yeow, Jeffrey J Li, Ki Hong Nam, Tomer M Yaron-Barir, Jared L Johnson, Emily M Huntsman, Lewis C Cantley, Alban Ordureau, Sergi Regot, Rachel Gree. The ribotoxic stress response drives UV-mediated cell death. Cell. 2024-06-06. PMID:38843833. |
we discover that uv-induced apoptosis is mediated by the rsr kinase zak and not through the ddr. |
2024-06-06 |
2024-06-10 |
Not clear |
| Anthi Bouchla, Christina D Sotiropoulou, Christopher Esteb, Theodoros Loupis, Sotirios G Papageorgiou, Georgia G Deliconstantinos, Maria Pagoni, Eleftheria Hatzimichael, Maria Dellatola, Smaragdi Kalomoiri, Elisavet Apostolidou, Christos K Kontos, Thomas P Thomopoulos, Theodoros Karantanos, Vasiliki Papp. Silencing of the DNA damage repair regulator PPP1R15A sensitizes acute myeloid leukemia cells to chemotherapy. Annals of hematology. 2024-06-06. PMID:38842564. |
the dna damage response mechanism (ddr) comprises numerous molecules and pathways intended to arrest the cell cycle until dna damage is repaired or else drive the cell to apoptosis. |
2024-06-06 |
2024-06-08 |
Not clear |
| Yu Bin Ng, Semih Can Akincila. Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer. Current opinion in pharmacology. vol 76. 2024-05-22. PMID:38776747. |
unprotected telomeres lead to persistent ddr causing cell cycle inhibition, growth arrest, and apoptosis. |
2024-05-22 |
2024-05-27 |
Not clear |
| Koji Fukuda, Shinji Takeuchi, Sachiko Arai, Shigeki Nanjo, Shigeki Sato, Hiroshi Kotani, Kenji Kita, Akihiro Nishiyama, Hiroyuki Sakaguchi, Koshiro Ohtsubo, Seiji Yan. Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations. Cell reports. Medicine. 2024-05-22. PMID:38776912. |
mechanistically, wee1 inhibition promotes g2/m transition and reduces checkpoint kinase 2 (chk2) and rad51 expression in the dna damage response (ddr) pathway, which is associated with apoptosis and the repair of dna double-strand breaks, leading to mitotic catastrophe. |
2024-05-22 |
2024-05-27 |
rat |
| Dimitra Mavroeidi, Anastasia Georganta, Emmanouil Panagiotou, Konstantinos Syrigos, Vassilis L Soulioti. Targeting ATR Pathway in Solid Tumors: Evidence of Improving Therapeutic Outcomes. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474014. |
the dna damage response (ddr) system is a complicated network of signaling pathways that detects and repairs dna damage or induces apoptosis. |
2024-03-13 |
2024-03-15 |
Not clear |
| Songbiao Chen, Feifei Liu, Aofei Yang, Ke Shan. For better or worse: crosstalk of parvovirus and host DNA damage response. Frontiers in immunology. vol 15. 2024-03-11. PMID:38464523. |
ns1 is the largest and most complex non-structural protein in the parvovirus genome, which is indispensable in the life cycle of parvovirus and is closely related to viral replication, induction of host cell apoptosis, cycle arrest, dna damage response (ddr), and other processes. |
2024-03-11 |
2024-03-14 |
Not clear |
| Ya-Ruo Lei, Xian-Lu He, Jun Li, Chun-Fen M. Drug Resistance in Hepatocellular Carcinoma: Theoretical Basis and Therapeutic Aspects. Frontiers in bioscience (Landmark edition). vol 29. issue 2. 2024-02-29. PMID:38420802. |
drug resistance exhibits multiple and complex molecular mechanisms to antagonize therapy under pharmacological pressure, including overexpression of drug efflux transporters, downstream adaptive response (such as apoptosis, autophagy, and endoplasmic reticulum stress), dysfunction of dna damage repair (ddr), epigenetic modification, tumor microenvironment (tme) as well as extracellular matrix (ecm). |
2024-02-29 |
2024-03-02 |
Not clear |
| Ragini Singh, Aishwarya Jaiswal, Rana P Sing. Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells. Biochimica et biophysica acta. Molecular cell research. 2024-01-25. PMID:38272357. |
taken together, our study revealed that microgravity is a strong stressor to trigger dna damage and apoptosis through activation of erk1/2 and akt, and impairment of dna repair capacity, albeit with a cell-type difference in ddr and nhej regulation, in microglial and glioblastoma cells. |
2024-01-25 |
2024-01-28 |
Not clear |
| Shohei Miyata, Takashi Ishii, Susumu Kitanak. Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia. Anticancer research. vol 44. issue 1. 2024-01-02. PMID:38159998. |
under severe hypoxia, cellular apoptosis is induced through hypoxia-inducible factor 1, alpha subunit (hif-1α)-dependent p53 accumulation and p53 phosphorylation via ataxia telangiectasia mutated and ataxia telangiectasia and rad3-related (atr) activation via replication stress-induced dna damage response (ddr) activation. |
2024-01-02 |
2024-01-05 |
Not clear |
| Evangelos Manousakis, Clàudia Martinez Miralles, Maria Guimerà Esquerda, Roni H G Wrigh. CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution? International journal of molecular sciences. vol 24. issue 24. 2023-12-23. PMID:38139316. |
over the years, extensive research has shed light on various additional mechanisms involving cdkn1a/p21, implicating it in processes such as apoptosis, dna damage response (ddr), and the regulation of stem cell fate. |
2023-12-23 |
2023-12-25 |
Not clear |
| Dimitrios Nasioudis, Erin M George, Haineng Xu, Hyoung Kim, Fiona Simpkin. Combination DNA Damage Response (DDR) Inhibitors to Overcome Drug Resistance in Ovarian Cancer. Cancer treatment and research. vol 186. 2023-11-17. PMID:37978137. |
ddr inhibitors such as parp inhibitors lead to the accumulation of dna damage in tumor cells and ultimately apoptosis. |
2023-11-17 |
2023-11-20 |
Not clear |
| Fabienne Becker, Meryem Ouzin, Stefanie Liedtke, Katharina Raba, Gesine Kogle. DNA damage response after treatment of cycling and quiescent cord blood hematopoietic stem cells with distinct genotoxic noxae. Stem cells (Dayton, Ohio). 2023-11-14. PMID:37962865. |
cycling cells employ both ddr and apoptosis mechanisms to prevent damage accumulation. |
2023-11-14 |
2023-11-20 |
Not clear |
| Xin Miao, Gilbert Koch, Shichen Shen, Xue Wang, Jun Li, Xiaomeng Shen, Jun Qu, Robert M Straubinger, William J Jusk. Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways. Journal of pharmaceutical sciences. 2023-11-02. PMID:37918792. |
here we describe drug effects on pathways associated with cell cycle, dna damage response (ddr), and apoptosis, and provide insights into underlying mechanisms. |
2023-11-02 |
2023-11-08 |
Not clear |
| Christina Pfeiffer, Alexander M Grandits, Hélène Asnagli, Anja Schneller, Julia Huber, Niklas Zojer, Martin Schreder, Andrew E Parker, Arnold Bolomsky, Philip A Beer, Heinz Ludwi. CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1. Leukemia. 2023-10-29. PMID:37898670. |
combination of stp-b with pharmacological inhibitors of key components of the ddr pathway (atr, chek1 or wee1) resulted in synergistic growth inhibition and early apoptosis. |
2023-10-29 |
2023-11-08 |
Not clear |