| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sajjad Vakili-Samiani, Omid Joodi Khanghah, Elham Gholipour, Fatemeh Najafi, Elham Zeinalzadeh, Parisa Samadi, Parisa Sarvarian, Shiva Pourvahdani, Shohre Karimi Kelaye, Michael R Hamblin, Abbas Ali Hosseinpour Feiz. Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy. Mutation research. vol 824. 2022-03-05. PMID:35247630. |
however, damaged cells can activate wee1 kinase (as a part of the ddr and rsr pathways), which prevents apoptosis and cell death by inducing cell cycle arrest at g2 phase. |
2022-03-05 |
2023-08-13 |
Not clear |
| Miriana Cardano, Giacomo Buscemi, Laura Zannin. Sex disparities in DNA damage response pathways: Novel determinants in cancer formation and therapy. iScience. vol 25. issue 3. 2022-03-04. PMID:35243237. |
one of the mechanisms that fuels carcinogenesis is the accumulation of defects in dna damage response (ddr) pathways, a complex signaling cascade that senses dna lesions and, depending on the severity, coordinates transient cell-cycle arrest, dna replication, repair, apoptosis, and senescence, preventing genomic instability and cancer. |
2022-03-04 |
2023-08-13 |
Not clear |
| Xin Ming, Zongyi Bo, Yurun Miao, Huan Chen, Chenyi Bao, Liumei Sun, Rui Xi, Qiuping Zhong, Pu Zhao, Yong-Sam Jung, Yingjuan Qia. Pseudorabies virus kinase UL13 phosphorylates H2AX to foster viral replication. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 3. 2022-02-24. PMID:35199383. |
pseudorabies virus (prv) infection was shown to induce apoptosis via stimulating ddr. |
2022-02-24 |
2023-08-13 |
Not clear |
| Richard Musson, Łukasz Gąsior, Simona Bisogno, Grażyna Ewa Pta. DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies. Human reproduction update. 2022-01-12. PMID:35021196. |
dna-damage repair (ddr) mechanisms are in place to repair damage and restore cellular function, as are other damage-induced processes such as apoptosis, autophagy and senescence. |
2022-01-12 |
2023-08-13 |
Not clear |
| Dan Liu, Ye Cheng, Junliang Chen, Xueying Mei, Zhipeng Tang, Xiangyu Cao, Jianli Li. Exploring the molecular mechanism of the inhibition of acrolein-induced BEAS-2B cytotoxicity by luteolin using network pharmacology and cell biology technology. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021-12-27. PMID:34958803. |
meanwhile, acrolein caused oxidative dna damage and double-strand breaks, induced dna damage response (ddr) and apoptosis. |
2021-12-27 |
2023-08-13 |
human |
| Dan Liu, Ye Cheng, Zhipeng Tang, Xueying Mei, Xiangyu Cao, Jianli Li. Toxicity mechanism of acrolein on DNA damage and apoptosis in BEAS-2B cells: Insights from cell biology and molecular docking analyses. Toxicology. 2021-12-27. PMID:34958888. |
all the results indicated that acrolein induced dna damage, activated ddr and mitochondrial apoptosis pathways, which might be the pivotal factors to mediate cytotoxicity in beas-2b cells. |
2021-12-27 |
2023-08-13 |
human |
| Dan Liu, Ye Cheng, Xueying Mei, Yanzhen Xie, Zhipeng Tang, Jianli Liu, Xiangyu Ca. Mechanisms of acrolein induces toxicity in human umbilical vein endothelial cells: Oxidative stress, DNA damage response, and apoptosis. Environmental toxicology. 2021-12-15. PMID:34908224. |
the molecular mechanism was studied based on oxidative stress, dna damage response (ddr), and mitochondrial apoptosis pathways. |
2021-12-15 |
2023-08-13 |
human |
| Adalberto Merighi, Nadia Gionchiglia, Alberto Granato, Laura Loss. The Phosphorylated Form of the Histone H2AX (γH2AX) in the Brain from Embryonic Life to Old Age. Molecules (Basel, Switzerland). vol 26. issue 23. 2021-12-10. PMID:34885784. |
in the first part of this review, we will briefly describe the intervention of h2ax in the dna damage response (ddr) and its role in some pivotal cellular events, such as regulation of cell cycle checkpoints, genomic instability, cell growth, mitosis, embryogenesis, and apoptosis. |
2021-12-10 |
2023-08-13 |
Not clear |
| Francesca Esposito, Raffaella Giuffrida, Gabriele Raciti, Caterina Puglisi, Stefano Fort. Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy. International journal of molecular sciences. vol 22. issue 19. 2021-11-01. PMID:34639030. |
toward this aim, cells have developed complex enzymatic machinery, the so-called dna damage response (ddr), which is able to repair dna, temporarily stopping the cell cycle to provide more time to repair, or if the damage is too severe, inducing apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Kerstin Felgentreff, Ulrich Baumann, Christian Klemann, Catharina Schuetz, Dorothee Viemann, Martin Wetzke, Ulrich Pannicke, Sandra von Hardenberg, Bernd Auber, Klaus-Michael Debatin, Eva-Maria Jacobsen, Manfred Hoenig, Ansgar Schulz, Klaus Schwar. Biomarkers of DNA Damage Response Enable Flow Cytometry-Based Diagnostic to Identify Inborn DNA Repair Defects in Primary Immunodeficiencies. Journal of clinical immunology. 2021-10-30. PMID:34716846. |
proteins of the dna damage response (ddr) network sense dna lesions and induce cell cycle arrest, dna repair, and apoptosis. |
2021-10-30 |
2023-08-13 |
Not clear |
| Gargi Ghosal, Junjie Che. DNA damage tolerance: a double-edged sword guarding the genome. Translational cancer research. vol 2. issue 3. 2021-10-21. PMID:24058901. |
ddr senses different types of dna damage and coordinates a response that includes activation of transcription, cell cycle control, dna repair pathways, apoptosis, senescence, and cell death. |
2021-10-21 |
2023-08-12 |
Not clear |
| Chao Wang, Mengfan Tang, Zhen Chen, Litong Nie, Siting Li, Yun Xiong, Klaudia Anna Szymonowicz, Jeong-Min Park, Huimin Zhang, Xu Feng, Min Huang, Dan Su, Traver Hart, Junjie Che. Genetic vulnerabilities upon inhibition of DNA damage response. Nucleic acids research. vol 49. issue 14. 2021-10-07. PMID:34320214. |
additionally, we compared the synergistic effects of combining different ddr inhibitors and found that an atm inhibitor plus a parp inhibitor induced dramatic levels of cell death, probably through promoting apoptosis. |
2021-10-07 |
2023-08-13 |
Not clear |
| Fares Hezam Al-Ostoot, Ankith Sherapura, Vikas H Malojirao, Prabhu Thirusangu, Tahani I Al-Muhimeed, Shaukath Ara Khanum, B T Prabhaka. Modulation of DNA damage response by targeting ATM kinase using newly synthesized di-phenoxy acetamide (DPA) analogs to induce anti-neoplasia. Pharmacological reports : PR. vol 73. issue 5. 2021-09-24. PMID:34109572. |
in response to dna damage, dna damage response (ddr) protein, ataxia telangiectasia mutated (atm), plays a pivotal role in the modulation of regulatory regions responsible for inhibition of apoptosis, thereby neoplastic progression. |
2021-09-24 |
2023-08-13 |
Not clear |
| Forough Alemi, Aydin Raei Sadigh, Faezeh Malakoti, Yusuf Elhaei, Seyed Hamed Ghaffari, Masomeh Maleki, Zatollah Asemi, Bahman Yousefi, Niloufar Targhazeh, Maryam Majidini. Molecular mechanisms involved in DNA repair in human cancers: An overview of PI3k/Akt signaling and PIKKs crosstalk. Journal of cellular physiology. 2021-09-17. PMID:34515349. |
if the dna damage is severe, such as when dna is the goal of chemo-radiotherapy, the ddr drives cells toward cell cycle arrest and apoptosis. |
2021-09-17 |
2023-08-13 |
human |
| Mohammad Shoeb, Helen C S Meier, James M Antonin. Telomeres in toxicology: Occupational health. Pharmacology & therapeutics. vol 220. 2021-08-16. PMID:33176178. |
telomeres and their interacting six shelterin complex proteins in coordination act as inhibitors of dna damage machinery by blocking ddr activation at chromosomes, thereby preventing the occurrence of genome instability, perturbed cell cycle, cellular senescence and apoptosis. |
2021-08-16 |
2023-08-13 |
Not clear |
| Parnia Rahnamay Farnood, Romina Danesh Pazhooh, Zatollah Asemi, Bahman Yousef. DNA damage response and repair in pancreatic cancer development and therapy. DNA repair. vol 103. 2021-08-16. PMID:33882393. |
according to the severity of the damage, ddr pathways respond appropriately to lesions through repairing damage, arresting the cell cycle, or apoptosis. |
2021-08-16 |
2023-08-13 |
Not clear |
| Nima Abbasia. Vascular Calcification Mechanisms: Updates and Renewed Insight into Signaling Pathways Involved in High Phosphate-Mediated Vascular Smooth Muscle Cell Calcification. Biomedicines. vol 9. issue 7. 2021-08-09. PMID:34356868. |
vc is a complex, active and cell-mediated process involving the transdifferentiation of vascular smcs to a bone-like phenotype, systemic inflammation, decreased anti-calcific events (loss of calcification inhibitors), loss in smc lineage markers and enhanced pro-calcific micrornas (mirs), an increased intracellular calcium level, apoptosis, aberrant dna damage response (ddr) and senescence of vascular smcs. |
2021-08-09 |
2023-08-13 |
Not clear |
| Jac A Nickoloff, Lynn Taylor, Neelam Sharma, Takamitsu A Kat. Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy. Cancer drug resistance (Alhambra, Calif.). vol 4. 2021-08-03. PMID:34337349. |
the ddr arrests the cell cycle, upregulates dna repair, and triggers apoptosis when damage is excessive. |
2021-08-03 |
2023-08-13 |
Not clear |
| Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Bal Krishna Chand Thakuri, Zeyuan Lu, Jinyu Zhang, Zhengke Li, Zheng D Morrison, Xiao Y Wu, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P Moorman, Zhi Q Ya. Long Non-coding RNA GAS5 Regulates T Cell Functions via miR21-Mediated Signaling in People Living With HIV. Frontiers in immunology. vol 12. 2021-06-23. PMID:33776993. |
here we show that an activation-induced decline of lncrna growth arrest-specific transcript 5 (gas5) activates dna damage response (ddr), and regulates cellular functions and apoptosis in cd4 t cells derived from people living with hiv (plhiv) via upregulation of mir-21. |
2021-06-23 |
2023-08-13 |
human |
| Feng Li, Edward M Bahnson, Jennifer Wilder, Robin Siletzky, John Hagaman, Volker Nickekeit, Sylvia Hiller, Azraa Ayesha, Lanfei Feng, Jerrold S Levine, Nobuyuki Takahashi, Nobuyo Maeda-Smithie. Oral high dose vitamin B12 decreases renal superoxide and post-ischemia/reperfusion injury in mice. Redox biology. vol 32. 2021-06-18. PMID:32182573. |
further, iri-induced changes in rna and protein markers of inflammation, fibrosis, apoptosis, and dna damage response (ddr) were significantly attenuated by at least 50% compared to those in untreated mice. |
2021-06-18 |
2023-08-13 |
mouse |