| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catalina Pereira, Marcus B Smolka, Robert S Weiss, Miguel A Brieño-Enríque. ATR signaling in mammalian meiosis: From upstream scaffolds to downstream signaling. Environmental and molecular mutagenesis. vol 61. issue 7. 2020-12-14. PMID:32725817. |
ddr signaling coordinates an extensive network of ddr effectors to induce cell cycle arrest and dna repair, or trigger apoptosis if the damage is extensive. |
2020-12-14 |
2023-08-13 |
Not clear |
| François Lallemand, Sophie Vacher, Leanne de Koning, Ambre Petitalot, Adrien Briaux, Keltouma Driouch, Céline Callens, Anne Schnitzler, Caroline Lecerf, Floriane Oulie-Bard, Aurélie Barbet, Anne Vincent, Sophie Zinn-Justin, Bernard S Lopez, Rosette Lidereau, Ivan Bieche, Sandrine M Caput. The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:32332845. |
foxo3 protein, but not foxo1 protein, appears to be a tumor suppressor that inhibits breast cancer by altering dna damage response (ddr), thereby inducing p53-dependent apoptosis. |
2020-11-30 |
2023-08-13 |
human |
| Vanessa S Y Tay, Surabhi Devaraj, Tracy Koh, Guo Ke, Karen C Crasta, Yusuf Al. Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31852915. |
we postulate that p21 plays a key role in ddr by preventing apoptosis, associated through its overexpression triggered by dna stand breaks (dsbs). |
2020-11-09 |
2023-08-13 |
mouse |
| Shohei Miyata, Tomonori Nakamura, Susumu Kitanak. 3EZ, 20Ac-ingenol-induced Apoptosis in Chemoresistant Cancers With Cyclin D1 Accumulation. Anticancer research. vol 40. issue 11. 2020-11-04. PMID:33109561. |
the topoisomerase 1 catalytic inhibitor 3ez, 20ac-ingenol specifically induces apoptosis through the activation of atr and the up-regulation of pten by enhancing the dna damage response (ddr) in human b lymphoma (ball-1) cells. |
2020-11-04 |
2023-08-13 |
human |
| Eduardo A Sagredo, Alfredo I Sagredo, Alejandro Blanco, Pamela Rojas De Santiago, Solange Rivas, Rodrigo Assar, Paola Pérez, Katherine Marcelain, Ricardo Armisé. ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response. Biochimica et biophysica acta. Molecular cell research. vol 1867. issue 8. 2020-10-26. PMID:32275931. |
breast cancer cells with reduced levels of adar show a decreased viability and an increase in apoptosis, displaying a significant decrease of their ddr activation, compared to control cells. |
2020-10-26 |
2023-08-13 |
Not clear |
| Guohong Liu, Francois X Claret, Fuling Zhou, Yunbao Pa. Jab1/COPS5 as a Novel Biomarker for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Human Cancer. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535627. |
c-jun activation domain-binding protein-1 (jab1) involves in controlling cellular proliferation, cell cycle, apoptosis, affecting a series of pathways, as well as regulating genomic instability and dna damage response (ddr). |
2020-10-01 |
2023-08-13 |
human |
| Yiping Dong, Dan Zhang, Mengjiao Cai, Zhenzhen Luo, Yue Zhu, Liuyun Gong, Yutiantian Lei, Xinyue Tan, Qing Zhu, Suxia Ha. SPOP regulates the DNA damage response and lung adenocarcinoma cell response to radiation. American journal of cancer research. vol 9. issue 7. 2020-10-01. PMID:31392082. |
spop knockdown affects ddr repair kinetics, apoptosis and cell cycle checkpoints that are induced by ir (ionizing radiation). |
2020-10-01 |
2023-08-13 |
Not clear |
| Liguang Wang, Kai Wang, Wei Dong, Hongchang Shen, Jiajun D. Regulation of response to radiotherapy by β-arrestin1 in Non-small cell lung cancer. Journal of Cancer. vol 10. issue 17. 2020-09-30. PMID:31417653. |
western blotting was applied to detect protein expression in apoptosis, ddr, erk and nf-kb pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Liguang Wang, Kai Wang, Wei Dong, Hongchang Shen, Jiajun D. Regulation of response to radiotherapy by β-arrestin1 in Non-small cell lung cancer. Journal of Cancer. vol 10. issue 17. 2020-09-30. PMID:31417653. |
overexpression of β-arrestin1 enhances ddr pathway activation induced by radiation, as well as downstream apoptosis, and depletion of β-arrestin1 inhibits ddr pathway. |
2020-09-30 |
2023-08-13 |
Not clear |
| Augusto Nogueira, Mara Fernandes, Raquel Catarino, Rui Medeiro. Cancers. vol 11. issue 11. 2020-09-28. PMID:31652722. |
these signaling pathways include the activation of cell cycle checkpoints, dna repair mechanisms, and apoptosis induction, also known as dna damage response (ddr)-mechanisms. |
2020-09-28 |
2023-08-13 |
Not clear |
| Janani Panneerselvam, Akhil Srivastava, Meghna Mehta, Allshine Chen, Yan D Zhao, Anupama Munshi, Rajagopal Rames. IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage. Cancers. vol 11. issue 12. 2020-09-28. PMID:31783569. |
furthermore, attenuation of gli1-associated ddr by il-24 increased caspase-3 and parp activity, resulting in cancer cell apoptosis. |
2020-09-28 |
2023-08-13 |
human |
| Rainer W J Kaiser, Johanna Erber, Katja Höpker, Francesca Fabretti, Roman-Ulrich Mülle. AATF/Che-1-An RNA Binding Protein at the Nexus of DNA Damage Response and Ribosome Biogenesis. Frontiers in oncology. vol 10. 2020-09-28. PMID:32587828. |
the apoptosis antagonizing transcription factor (aatf/che-1), an rna polymerase ii-interacting transcription factor and known downstream target of major ddr kinases, affects ddr signaling by inhibiting p53-mediated transcription of pro-apoptotic genes and promoting cell cycle arrest through various pathways instead. |
2020-09-28 |
2023-08-13 |
Not clear |
| Thom G A Reuvers, Roland Kanaar, Julie Nonneken. DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage. Cancers. vol 12. issue 8. 2020-09-28. PMID:32731592. |
of central importance in the cellular response to therapy-induced dna damage is the dna damage response (ddr), a protein network guiding both dna damage repair and the induction of cancer-eradicating mechanisms such as apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Charlie Gourley, Judith Balmaña, Jonathan A Ledermann, Violeta Serra, Rebecca Dent, Sibylle Loibl, Eric Pujade-Lauraine, Simon J Boulto. Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 37. issue 25. 2020-06-10. PMID:31050911. |
severe dna damage that cannot be repaired may trigger apoptosis; as such, the ddr pathway is of crucial importance as a cancer target. |
2020-06-10 |
2023-08-13 |
Not clear |
| Maryam Majidinia, Anupam Bishayee, Bahman Yousef. Polyphenols: Major regulators of key components of DNA damage response in cancer. DNA repair. vol 82. 2020-05-11. PMID:31450085. |
in this review, we aim to explain how polyphenolic compounds modulate ddr sensors, transducers and mediators, with discussion of how polyphenols modulate apoptosis in response to dna damage in various types of cancer. |
2020-05-11 |
2023-08-13 |
Not clear |
| Maria Rita Fabbrizi, Barbara Meyer, Sandeep Misri, Suyash Raj, Cheri L Zobel, Dennis E Hallahan, Girdhar G Sharm. Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy. Cell death & disease. vol 9. issue 5. 2020-03-30. PMID:29706648. |
and is believed to play dual role in regulating ddr and apoptosis. |
2020-03-30 |
2023-08-13 |
Not clear |
| Wei-Hsien Hou, Shih-Hsun Chen, Xiaochun Y. Poly-ADP ribosylation in DNA damage response and cancer therapy. Mutation research. Reviews in mutation research. vol 780. 2020-03-02. PMID:31395352. |
parylation regulates a number of biological processes including chromatin remodeling, the dna damage response (ddr), transcription, apoptosis, and mitosis. |
2020-03-02 |
2023-08-13 |
Not clear |
| Jaehong Park, Jihye Lee, Dong-Hyun Le. Identification of Protein Phosphatase 4 Inhibitory Protein That Plays an Indispensable Role in DNA Damage Response. Molecules and cells. vol 42. issue 7. 2019-12-27. PMID:31272138. |
protein phosphatase 4 (pp4) is a crucial protein complex that plays an important role in dna damage response (ddr), including dna repair, cell cycle arrest and apoptosis. |
2019-12-27 |
2023-08-13 |
Not clear |
| Ah-Rong Nam, Mei Hua Jin, Ji Eun Park, Ju-Hee Bang, Do-Youn Oh, Yung-Jue Ban. Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer. Cancer research and treatment. vol 51. issue 3. 2019-12-17. PMID:30514066. |
the dna damage response (ddr) is a multi-complex network of signaling pathways involved in dna damage repair, cell cycle checkpoints, and apoptosis. |
2019-12-17 |
2023-08-13 |
Not clear |
| Fan Xuan, Mengying Huang, Erhu Zhao, Hongjuan Cu. MINA53 deficiency leads to glioblastoma cell apoptosis via inducing DNA replication stress and diminishing DNA damage response. Cell death & disease. vol 9. issue 11. 2019-12-10. PMID:30333481. |
furthermore, mina53 knockdown diminished dna damage response (ddr) by reducing the atm/atr-h2ax pathway activity and finally led glioblastoma cells to apoptosis and death. |
2019-12-10 |
2023-08-13 |
Not clear |