| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guohong Liu, Francois X Claret, Fuling Zhou, Yunbao Pa. Jab1/COPS5 as a Novel Biomarker for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Human Cancer. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535627. |
c-jun activation domain-binding protein-1 (jab1) involves in controlling cellular proliferation, cell cycle, apoptosis, affecting a series of pathways, as well as regulating genomic instability and dna damage response (ddr). |
2020-10-01 |
2023-08-13 |
human |
| Yiping Dong, Dan Zhang, Mengjiao Cai, Zhenzhen Luo, Yue Zhu, Liuyun Gong, Yutiantian Lei, Xinyue Tan, Qing Zhu, Suxia Ha. SPOP regulates the DNA damage response and lung adenocarcinoma cell response to radiation. American journal of cancer research. vol 9. issue 7. 2020-10-01. PMID:31392082. |
spop knockdown affects ddr repair kinetics, apoptosis and cell cycle checkpoints that are induced by ir (ionizing radiation). |
2020-10-01 |
2023-08-13 |
Not clear |
| Liguang Wang, Kai Wang, Wei Dong, Hongchang Shen, Jiajun D. Regulation of response to radiotherapy by β-arrestin1 in Non-small cell lung cancer. Journal of Cancer. vol 10. issue 17. 2020-09-30. PMID:31417653. |
western blotting was applied to detect protein expression in apoptosis, ddr, erk and nf-kb pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Liguang Wang, Kai Wang, Wei Dong, Hongchang Shen, Jiajun D. Regulation of response to radiotherapy by β-arrestin1 in Non-small cell lung cancer. Journal of Cancer. vol 10. issue 17. 2020-09-30. PMID:31417653. |
overexpression of β-arrestin1 enhances ddr pathway activation induced by radiation, as well as downstream apoptosis, and depletion of β-arrestin1 inhibits ddr pathway. |
2020-09-30 |
2023-08-13 |
Not clear |
| Augusto Nogueira, Mara Fernandes, Raquel Catarino, Rui Medeiro. Cancers. vol 11. issue 11. 2020-09-28. PMID:31652722. |
these signaling pathways include the activation of cell cycle checkpoints, dna repair mechanisms, and apoptosis induction, also known as dna damage response (ddr)-mechanisms. |
2020-09-28 |
2023-08-13 |
Not clear |
| Janani Panneerselvam, Akhil Srivastava, Meghna Mehta, Allshine Chen, Yan D Zhao, Anupama Munshi, Rajagopal Rames. IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage. Cancers. vol 11. issue 12. 2020-09-28. PMID:31783569. |
furthermore, attenuation of gli1-associated ddr by il-24 increased caspase-3 and parp activity, resulting in cancer cell apoptosis. |
2020-09-28 |
2023-08-13 |
human |
| Rainer W J Kaiser, Johanna Erber, Katja Höpker, Francesca Fabretti, Roman-Ulrich Mülle. AATF/Che-1-An RNA Binding Protein at the Nexus of DNA Damage Response and Ribosome Biogenesis. Frontiers in oncology. vol 10. 2020-09-28. PMID:32587828. |
the apoptosis antagonizing transcription factor (aatf/che-1), an rna polymerase ii-interacting transcription factor and known downstream target of major ddr kinases, affects ddr signaling by inhibiting p53-mediated transcription of pro-apoptotic genes and promoting cell cycle arrest through various pathways instead. |
2020-09-28 |
2023-08-13 |
Not clear |
| Thom G A Reuvers, Roland Kanaar, Julie Nonneken. DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage. Cancers. vol 12. issue 8. 2020-09-28. PMID:32731592. |
of central importance in the cellular response to therapy-induced dna damage is the dna damage response (ddr), a protein network guiding both dna damage repair and the induction of cancer-eradicating mechanisms such as apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Charlie Gourley, Judith Balmaña, Jonathan A Ledermann, Violeta Serra, Rebecca Dent, Sibylle Loibl, Eric Pujade-Lauraine, Simon J Boulto. Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 37. issue 25. 2020-06-10. PMID:31050911. |
severe dna damage that cannot be repaired may trigger apoptosis; as such, the ddr pathway is of crucial importance as a cancer target. |
2020-06-10 |
2023-08-13 |
Not clear |
| Maryam Majidinia, Anupam Bishayee, Bahman Yousef. Polyphenols: Major regulators of key components of DNA damage response in cancer. DNA repair. vol 82. 2020-05-11. PMID:31450085. |
in this review, we aim to explain how polyphenolic compounds modulate ddr sensors, transducers and mediators, with discussion of how polyphenols modulate apoptosis in response to dna damage in various types of cancer. |
2020-05-11 |
2023-08-13 |
Not clear |
| Maria Rita Fabbrizi, Barbara Meyer, Sandeep Misri, Suyash Raj, Cheri L Zobel, Dennis E Hallahan, Girdhar G Sharm. Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy. Cell death & disease. vol 9. issue 5. 2020-03-30. PMID:29706648. |
and is believed to play dual role in regulating ddr and apoptosis. |
2020-03-30 |
2023-08-13 |
Not clear |
| Wei-Hsien Hou, Shih-Hsun Chen, Xiaochun Y. Poly-ADP ribosylation in DNA damage response and cancer therapy. Mutation research. Reviews in mutation research. vol 780. 2020-03-02. PMID:31395352. |
parylation regulates a number of biological processes including chromatin remodeling, the dna damage response (ddr), transcription, apoptosis, and mitosis. |
2020-03-02 |
2023-08-13 |
Not clear |
| Jaehong Park, Jihye Lee, Dong-Hyun Le. Identification of Protein Phosphatase 4 Inhibitory Protein That Plays an Indispensable Role in DNA Damage Response. Molecules and cells. vol 42. issue 7. 2019-12-27. PMID:31272138. |
protein phosphatase 4 (pp4) is a crucial protein complex that plays an important role in dna damage response (ddr), including dna repair, cell cycle arrest and apoptosis. |
2019-12-27 |
2023-08-13 |
Not clear |
| Ah-Rong Nam, Mei Hua Jin, Ji Eun Park, Ju-Hee Bang, Do-Youn Oh, Yung-Jue Ban. Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer. Cancer research and treatment. vol 51. issue 3. 2019-12-17. PMID:30514066. |
the dna damage response (ddr) is a multi-complex network of signaling pathways involved in dna damage repair, cell cycle checkpoints, and apoptosis. |
2019-12-17 |
2023-08-13 |
Not clear |
| Fan Xuan, Mengying Huang, Erhu Zhao, Hongjuan Cu. MINA53 deficiency leads to glioblastoma cell apoptosis via inducing DNA replication stress and diminishing DNA damage response. Cell death & disease. vol 9. issue 11. 2019-12-10. PMID:30333481. |
furthermore, mina53 knockdown diminished dna damage response (ddr) by reducing the atm/atr-h2ax pathway activity and finally led glioblastoma cells to apoptosis and death. |
2019-12-10 |
2023-08-13 |
Not clear |
| Vibha Singh, Praveen Kumar Jaiswal, Ishita Ghosh, Hari K Koul, Xiuping Yu, Arrigo De Benedett. Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors. International journal of cancer. vol 145. issue 4. 2019-12-03. PMID:30737777. |
following dna damage, addition of the tlk specific inhibitor, thioridazine (thd), impairs atr and chk1 activation, establishing the existence of a adt > tlk1 > nek1 > atr > chk1, ddr pathway, while its abrogation leads to apoptosis. |
2019-12-03 |
2023-08-13 |
Not clear |
| Yuki Kuwano, Kensei Nishida, Yoko Akaike, Ken Kurokawa, Tatsuya Nishikawa, Kiyoshi Masuda, Kazuhito Rokuta. Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome. International journal of molecular sciences. vol 17. issue 10. 2019-11-20. PMID:27689990. |
the ddr regulates dna repair, cell cycle checkpoint activation, and apoptosis to restore genome integrity and cellular homeostasis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Cristina Fernández-Díez, Silvia González-Rojo, Marta Lombó, M Paz Herráe. Tolerance to paternal genotoxic damage promotes survival during embryo development in zebrafish ( Biology open. vol 7. issue 5. 2019-11-20. PMID:29712649. |
mammals have strong sperm selection mechanisms and activate a zygotic dna damage response (ddr) (including cell cycle arrest, dna repair and alternative apoptosis) in order to guarantee the genomic conformity of the reduced progeny. |
2019-11-20 |
2023-08-13 |
zebrafish |
| Riccardo Mezzadra, Marjolein de Bruijn, Lucas T Jae, Raquel Gomez-Eerland, Anja Duursma, Ferenc A Scheeren, Thijn R Brummelkamp, Ton N Schumache. SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing. PloS one. vol 14. issue 2. 2019-11-07. PMID:30753225. |
collectively, our data indicate that slfn11 can couple ifn-γ exposure of tumor cells to ddr and cellular apoptosis. |
2019-11-07 |
2023-08-13 |
human |
| Mohamed Sham Shihabudeen Haider Ali, Xiao Cheng, Matthew Moran, Stefan Haemmig, Michael J Naldrett, Sophie Alvarez, Mark W Feinberg, Xinghui Su. LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Nucleic acids research. vol 47. issue 3. 2019-08-20. PMID:30476192. |
in this study, we demonstrate that lncrna maternally expressed gene 3 (meg3) interacts with the rna binding protein polypyrimidine tract binding protein 3 (ptbp3) to regulate gene expression and endothelial function through p53 signaling ─ a major coordinator of apoptosis and cell proliferation triggered by the ddr. |
2019-08-20 |
2023-08-13 |
Not clear |