| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca Esposito, Raffaella Giuffrida, Gabriele Raciti, Caterina Puglisi, Stefano Fort. Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy. International journal of molecular sciences. vol 22. issue 19. 2021-11-01. PMID:34639030. |
toward this aim, cells have developed complex enzymatic machinery, the so-called dna damage response (ddr), which is able to repair dna, temporarily stopping the cell cycle to provide more time to repair, or if the damage is too severe, inducing apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Kerstin Felgentreff, Ulrich Baumann, Christian Klemann, Catharina Schuetz, Dorothee Viemann, Martin Wetzke, Ulrich Pannicke, Sandra von Hardenberg, Bernd Auber, Klaus-Michael Debatin, Eva-Maria Jacobsen, Manfred Hoenig, Ansgar Schulz, Klaus Schwar. Biomarkers of DNA Damage Response Enable Flow Cytometry-Based Diagnostic to Identify Inborn DNA Repair Defects in Primary Immunodeficiencies. Journal of clinical immunology. 2021-10-30. PMID:34716846. |
proteins of the dna damage response (ddr) network sense dna lesions and induce cell cycle arrest, dna repair, and apoptosis. |
2021-10-30 |
2023-08-13 |
Not clear |
| Gargi Ghosal, Junjie Che. DNA damage tolerance: a double-edged sword guarding the genome. Translational cancer research. vol 2. issue 3. 2021-10-21. PMID:24058901. |
ddr senses different types of dna damage and coordinates a response that includes activation of transcription, cell cycle control, dna repair pathways, apoptosis, senescence, and cell death. |
2021-10-21 |
2023-08-12 |
Not clear |
| Chao Wang, Mengfan Tang, Zhen Chen, Litong Nie, Siting Li, Yun Xiong, Klaudia Anna Szymonowicz, Jeong-Min Park, Huimin Zhang, Xu Feng, Min Huang, Dan Su, Traver Hart, Junjie Che. Genetic vulnerabilities upon inhibition of DNA damage response. Nucleic acids research. vol 49. issue 14. 2021-10-07. PMID:34320214. |
additionally, we compared the synergistic effects of combining different ddr inhibitors and found that an atm inhibitor plus a parp inhibitor induced dramatic levels of cell death, probably through promoting apoptosis. |
2021-10-07 |
2023-08-13 |
Not clear |
| Fares Hezam Al-Ostoot, Ankith Sherapura, Vikas H Malojirao, Prabhu Thirusangu, Tahani I Al-Muhimeed, Shaukath Ara Khanum, B T Prabhaka. Modulation of DNA damage response by targeting ATM kinase using newly synthesized di-phenoxy acetamide (DPA) analogs to induce anti-neoplasia. Pharmacological reports : PR. vol 73. issue 5. 2021-09-24. PMID:34109572. |
in response to dna damage, dna damage response (ddr) protein, ataxia telangiectasia mutated (atm), plays a pivotal role in the modulation of regulatory regions responsible for inhibition of apoptosis, thereby neoplastic progression. |
2021-09-24 |
2023-08-13 |
Not clear |
| Forough Alemi, Aydin Raei Sadigh, Faezeh Malakoti, Yusuf Elhaei, Seyed Hamed Ghaffari, Masomeh Maleki, Zatollah Asemi, Bahman Yousefi, Niloufar Targhazeh, Maryam Majidini. Molecular mechanisms involved in DNA repair in human cancers: An overview of PI3k/Akt signaling and PIKKs crosstalk. Journal of cellular physiology. 2021-09-17. PMID:34515349. |
if the dna damage is severe, such as when dna is the goal of chemo-radiotherapy, the ddr drives cells toward cell cycle arrest and apoptosis. |
2021-09-17 |
2023-08-13 |
human |
| Mohammad Shoeb, Helen C S Meier, James M Antonin. Telomeres in toxicology: Occupational health. Pharmacology & therapeutics. vol 220. 2021-08-16. PMID:33176178. |
telomeres and their interacting six shelterin complex proteins in coordination act as inhibitors of dna damage machinery by blocking ddr activation at chromosomes, thereby preventing the occurrence of genome instability, perturbed cell cycle, cellular senescence and apoptosis. |
2021-08-16 |
2023-08-13 |
Not clear |
| Parnia Rahnamay Farnood, Romina Danesh Pazhooh, Zatollah Asemi, Bahman Yousef. DNA damage response and repair in pancreatic cancer development and therapy. DNA repair. vol 103. 2021-08-16. PMID:33882393. |
according to the severity of the damage, ddr pathways respond appropriately to lesions through repairing damage, arresting the cell cycle, or apoptosis. |
2021-08-16 |
2023-08-13 |
Not clear |
| Nima Abbasia. Vascular Calcification Mechanisms: Updates and Renewed Insight into Signaling Pathways Involved in High Phosphate-Mediated Vascular Smooth Muscle Cell Calcification. Biomedicines. vol 9. issue 7. 2021-08-09. PMID:34356868. |
vc is a complex, active and cell-mediated process involving the transdifferentiation of vascular smcs to a bone-like phenotype, systemic inflammation, decreased anti-calcific events (loss of calcification inhibitors), loss in smc lineage markers and enhanced pro-calcific micrornas (mirs), an increased intracellular calcium level, apoptosis, aberrant dna damage response (ddr) and senescence of vascular smcs. |
2021-08-09 |
2023-08-13 |
Not clear |
| Jac A Nickoloff, Lynn Taylor, Neelam Sharma, Takamitsu A Kat. Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy. Cancer drug resistance (Alhambra, Calif.). vol 4. 2021-08-03. PMID:34337349. |
the ddr arrests the cell cycle, upregulates dna repair, and triggers apoptosis when damage is excessive. |
2021-08-03 |
2023-08-13 |
Not clear |
| Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Bal Krishna Chand Thakuri, Zeyuan Lu, Jinyu Zhang, Zhengke Li, Zheng D Morrison, Xiao Y Wu, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P Moorman, Zhi Q Ya. Long Non-coding RNA GAS5 Regulates T Cell Functions via miR21-Mediated Signaling in People Living With HIV. Frontiers in immunology. vol 12. 2021-06-23. PMID:33776993. |
here we show that an activation-induced decline of lncrna growth arrest-specific transcript 5 (gas5) activates dna damage response (ddr), and regulates cellular functions and apoptosis in cd4 t cells derived from people living with hiv (plhiv) via upregulation of mir-21. |
2021-06-23 |
2023-08-13 |
human |
| Feng Li, Edward M Bahnson, Jennifer Wilder, Robin Siletzky, John Hagaman, Volker Nickekeit, Sylvia Hiller, Azraa Ayesha, Lanfei Feng, Jerrold S Levine, Nobuyuki Takahashi, Nobuyo Maeda-Smithie. Oral high dose vitamin B12 decreases renal superoxide and post-ischemia/reperfusion injury in mice. Redox biology. vol 32. 2021-06-18. PMID:32182573. |
further, iri-induced changes in rna and protein markers of inflammation, fibrosis, apoptosis, and dna damage response (ddr) were significantly attenuated by at least 50% compared to those in untreated mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Eriko Ohsaki, Keiji Ued. Interplay Between KSHV and the Host DNA Damage Response. Frontiers in cellular and infection microbiology. vol 10. 2021-06-17. PMID:33425783. |
the dna damage response (ddr) orchestrates a molecular network of cellular mechanisms that integrates cell cycle regulation and dna repair or apoptosis. |
2021-06-17 |
2023-08-13 |
human |
| Linoy Mehazri, Sally Shpungin, Shai Bel, Uri Ni. Loss of Fer Jeopardizes Metabolic Plasticity and Mitochondrial Homeostasis in Lung and Breast Carcinoma Cells. International journal of molecular sciences. vol 22. issue 7. 2021-06-11. PMID:33806191. |
furthermore, glucose deficiency caused increased reactive oxygen species (ros) production and induction of a dna damage response (ddr), accompanied by the onset of apoptosis and attenuated cell-cycle progression. |
2021-06-11 |
2023-08-13 |
Not clear |
| Nipin Sp, Dong Young Kang, Jin-Moo Lee, Se Won Bae, Kyoung-Jin Jan. Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells. International journal of molecular sciences. vol 22. issue 9. 2021-05-24. PMID:33925065. |
increases in the level of reactive oxygen species (ros) can lead to dna damage and the induction of dna damage response (ddr) mechanism, leading to cell cycle arrest apoptosis and tumorsphere suppression. |
2021-05-24 |
2023-08-13 |
Not clear |
| Daniele Caracciolo, Francesca Scionti, Giada Juli, Emanuela Altomare, Gaetanina Golino, Katia Todoerti, Katia Grillone, Caterina Riillo, Mariamena Arbitrio, Michelangelo Iannone, Eugenio Morelli, Nicola Amodio, Maria Teresa Di Martino, Marco Rossi, Antonino Neri, Pierosandro Tagliaferri, Pierfrancesco Tasson. Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma. Haematologica. vol 106. issue 1. 2021-05-21. PMID:32079692. |
anti-proliferative effects induced by parp1-inhibition were correlated to increase of dna double-strand breaks, activation of dna damage response (ddr) and finally apoptosis. |
2021-05-21 |
2023-08-13 |
human |
| Hiroyuki Yamaguchi, Kohei Kitami, Xiao Wu, Li He, Jianbo Wang, Bin Wang, Yoshihiro Komats. Alteration of DNA Damage Response Causes Cleft Palate. Frontiers in physiology. vol 12. 2021-04-17. PMID:33854442. |
a compromised ddr caused by a poly (adp-ribose) polymerase (parp) enzyme inhibitor resulted in cleft palate in wild-type mouse embryos, with increased dna damage and apoptosis. |
2021-04-17 |
2023-08-13 |
mouse |
| Madison Schank, Juan Zhao, Ling Wang, Zhengke Li, Dechao Cao, Lam Nhat Nguyen, Xindi Dang, Sushant Khanal, Lam Ngoc Thao Nguyen, Bal Krishna Chand Thakuri, Stella C Ogbu, Zeyuan Lu, Jinyu Zhang, Xiao Y Wu, Zheng D Morrison, Mohamed El Gazzar, Shunbin Ning, Jonathan P Moorman, Zhi Q Ya. Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway. Cell death & disease. vol 11. issue 12. 2021-04-08. PMID:33268822. |
we have recently shown that disruption of telomere integrity by kml001, a telomere-targeting drug, induces t cell senescence and apoptosis via the telomeric dna damage response (ddr). |
2021-04-08 |
2023-08-13 |
human |
| Linxiao Sun, Xiandong Zhu, Jiao Luo, Cheng Wang, Bicheng Che. Role of DNA damage in the progress of chronic tubule‑interstitial injury. Molecular medicine reports. vol 22. issue 2. 2021-03-23. PMID:32626982. |
ataxia telangiectasia mutated (atm) is an important molecule of the ddr and the genetic knockdown of atm induced apoptosis, increased cell proliferation and promoted cell death. |
2021-03-23 |
2023-08-13 |
Not clear |
| Gabriela Betlej, Ewelina Bator, Antoni Pyrkosz, Aleksandra Kwiatkowsk. A Dual Face of APE1 in the Maintenance of Genetic Stability in Monocytes: An Overview of the Current Status and Future Perspectives. Genes. vol 11. issue 6. 2021-03-19. PMID:32545201. |
as they lack four key proteins responsible for dna damage response (ddr) pathways, they are especially prone to reactive oxygen species (ros) exposure leading to oxidative dna lesions and, consequently, ros-driven apoptosis. |
2021-03-19 |
2023-08-13 |
Not clear |