| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Madison Schank, Juan Zhao, Ling Wang, Zhengke Li, Dechao Cao, Lam Nhat Nguyen, Xindi Dang, Sushant Khanal, Lam Ngoc Thao Nguyen, Bal Krishna Chand Thakuri, Stella C Ogbu, Zeyuan Lu, Jinyu Zhang, Xiao Y Wu, Zheng D Morrison, Mohamed El Gazzar, Shunbin Ning, Jonathan P Moorman, Zhi Q Ya. Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway. Cell death & disease. vol 11. issue 12. 2021-04-08. PMID:33268822. |
we have recently shown that disruption of telomere integrity by kml001, a telomere-targeting drug, induces t cell senescence and apoptosis via the telomeric dna damage response (ddr). |
2021-04-08 |
2023-08-13 |
human |
| Linxiao Sun, Xiandong Zhu, Jiao Luo, Cheng Wang, Bicheng Che. Role of DNA damage in the progress of chronic tubule‑interstitial injury. Molecular medicine reports. vol 22. issue 2. 2021-03-23. PMID:32626982. |
ataxia telangiectasia mutated (atm) is an important molecule of the ddr and the genetic knockdown of atm induced apoptosis, increased cell proliferation and promoted cell death. |
2021-03-23 |
2023-08-13 |
Not clear |
| Gabriela Betlej, Ewelina Bator, Antoni Pyrkosz, Aleksandra Kwiatkowsk. A Dual Face of APE1 in the Maintenance of Genetic Stability in Monocytes: An Overview of the Current Status and Future Perspectives. Genes. vol 11. issue 6. 2021-03-19. PMID:32545201. |
as they lack four key proteins responsible for dna damage response (ddr) pathways, they are especially prone to reactive oxygen species (ros) exposure leading to oxidative dna lesions and, consequently, ros-driven apoptosis. |
2021-03-19 |
2023-08-13 |
Not clear |
| Yuan Gao, Jiuli Zhou, Jin L. Discoidin domain receptors orchestrate cancer progression: A focus on cancer therapies. Cancer science. vol 112. issue 3. 2021-03-17. PMID:33377205. |
ddr are activated by binding to the triple-helical collagen and, in turn, ddr can activate signal transduction pathways that regulate cell-collagen interactions involved in multiple physiological and pathological processes such as cell proliferation, migration, apoptosis, and cytokine secretion. |
2021-03-17 |
2023-08-13 |
human |
| Yangping Ma, Yanfeng Song, Rong Shen, Panpan Li, Han Ding, Zhao Guo, Xiangwen Liu, Degui Wan. Loss of RAD6B induces degeneration of the cochlea in mice. Biochemical and biophysical research communications. vol 531. issue 3. 2021-03-10. PMID:32868078. |
in conclusion, our results suggest that the deletion of rad6b may lead to abnormalities in ddr, thereby accelerating the degeneration of various structures in the cochlea and senescence and apoptosis of cochlea cells. |
2021-03-10 |
2023-08-13 |
mouse |
| Thorsten Schaefer, Rebekah Steiner, Claudia Lengerk. SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer. International journal of molecular sciences. vol 21. issue 14. 2021-02-22. PMID:32664542. |
apoptosis, however, is a central element of dna damage response (ddr), where it provides a default mechanism for cell clearance when dna integrity cannot be maintained. |
2021-02-22 |
2023-08-13 |
Not clear |
| Jana van Stuijvenberg, Peter Proksch, Gerhard Frit. Targeting the DNA damage response (DDR) by natural compounds. Bioorganic & medicinal chemistry. vol 28. issue 4. 2021-02-05. PMID:31980363. |
since the ddr coordinates mechanisms of dna repair and apoptosis, hence regulating the balance between death and survival, it is an attractive target of novel anticancer strategies. |
2021-02-05 |
2023-08-13 |
cat |
| b' Venturina Stagni, Alessandra Ferri, Claudia Cirotti, Daniela Baril\\xc3\\xa. ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence? Frontiers in cell and developmental biology. vol 8. 2021-01-26. PMID:33490066.' |
recently, several papers have demonstrated a molecular connection between the dna damage response (ddr) and autophagy and have explored how this link influences cell fate and the choice between apoptosis and senescence in response to different stimuli. |
2021-01-26 |
2023-08-13 |
Not clear |
| b' Venturina Stagni, Alessandra Ferri, Claudia Cirotti, Daniela Baril\\xc3\\xa. ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence? Frontiers in cell and developmental biology. vol 8. 2021-01-26. PMID:33490066.' |
importantly, atm kinase plays a central role in the ddr, and it can finely tune the balance between senescence and apoptosis: activated atm promotes autophagy and in particular sustains the lysosomal-mitochondrial axis, which in turn promotes senescence and inhibits apoptosis. |
2021-01-26 |
2023-08-13 |
Not clear |
| Yingfeng Tu, Xiaoling Li, Xuefei Zhu, Xiaokang Liu, Caixia Guo, Da Jia, Tie-Shan Tan. Determining the Fate of Neurons in SCA3: ATX3, a Rising Decision Maker in Response to DNA Stresses and Beyond. Frontiers in cell and developmental biology. vol 8. 2021-01-12. PMID:33425926. |
dna damage response (ddr) and apoptosis are reported to be involved in the pathogenesis of many neurodegenerative diseases including polyglutamine (polyq) disorders, such as spinocerebellar ataxia type 3 (sca3) and huntington's disease (hd). |
2021-01-12 |
2023-08-13 |
Not clear |
| Yingfeng Tu, Xiaoling Li, Xuefei Zhu, Xiaokang Liu, Caixia Guo, Da Jia, Tie-Shan Tan. Determining the Fate of Neurons in SCA3: ATX3, a Rising Decision Maker in Response to DNA Stresses and Beyond. Frontiers in cell and developmental biology. vol 8. 2021-01-12. PMID:33425926. |
in this review, we provide a comprehensive overview of the current studies about the physiological roles of atx3 in ddr and related apoptosis, highlighting the crosslinks between these impaired pathways and the pathogenesis of sca3. |
2021-01-12 |
2023-08-13 |
Not clear |
| Yingfeng Tu, Xiaoling Li, Xuefei Zhu, Xiaokang Liu, Caixia Guo, Da Jia, Tie-Shan Tan. Determining the Fate of Neurons in SCA3: ATX3, a Rising Decision Maker in Response to DNA Stresses and Beyond. Frontiers in cell and developmental biology. vol 8. 2021-01-12. PMID:33425926. |
finally, the preclinical studies targeting ddr and related apoptosis for treatment of polyq disorders including sca3 and hd are also summarized and discussed. |
2021-01-12 |
2023-08-13 |
Not clear |
| Ling Wang, Mary E A Howell, Brooke McPeak, Katrina Riggs, Carissa Kohne, Jether Uel Yohanon, Daniel E Foxler, Tyson V Sharp, Jonathan P Moorman, Zhi Q Yao, Shunbin Nin. LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death. Oncotarget. vol 9. issue 5. 2021-01-09. PMID:29464072. |
our findings have identified limd1 as a novel player in ebv latency and oncogenesis, and open a novel research avenue, in which limd1 and p62 play crucial roles in linking dna damage response (ddr), apoptosis, and autophagy and their potential interplay during viral oncogenesis. |
2021-01-09 |
2023-08-13 |
Not clear |
| Brahim El Hasbaoui, Abdelhkim Elyajouri, Rachid Abilkassem, Aomar Agad. Nijmegen breakage syndrome: case report and review of literature. The Pan African medical journal. vol 35. 2020-12-24. PMID:32537088. |
ddr is a crucial signalling pathway in apoptosis and senescence. |
2020-12-24 |
2023-08-13 |
human |
| Y Garcia-Mayea, C Mir, F Masson, R Paciucci, M E LLeonar. Insights into new mechanisms and models of cancer stem cell multidrug resistance. Seminars in cancer biology. vol 60. 2020-12-17. PMID:31369817. |
many mechanisms have been proposed for csc resistance, such as drug efflux through abc transporters, overactivation of the dna damage response (ddr), apoptosis evasion, prosurvival pathways activation, cell cycle promotion and/or cell metabolic alterations. |
2020-12-17 |
2023-08-13 |
Not clear |
| Catalina Pereira, Marcus B Smolka, Robert S Weiss, Miguel A Brieño-Enríque. ATR signaling in mammalian meiosis: From upstream scaffolds to downstream signaling. Environmental and molecular mutagenesis. vol 61. issue 7. 2020-12-14. PMID:32725817. |
ddr signaling coordinates an extensive network of ddr effectors to induce cell cycle arrest and dna repair, or trigger apoptosis if the damage is extensive. |
2020-12-14 |
2023-08-13 |
Not clear |
| François Lallemand, Sophie Vacher, Leanne de Koning, Ambre Petitalot, Adrien Briaux, Keltouma Driouch, Céline Callens, Anne Schnitzler, Caroline Lecerf, Floriane Oulie-Bard, Aurélie Barbet, Anne Vincent, Sophie Zinn-Justin, Bernard S Lopez, Rosette Lidereau, Ivan Bieche, Sandrine M Caput. The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:32332845. |
foxo3 protein, but not foxo1 protein, appears to be a tumor suppressor that inhibits breast cancer by altering dna damage response (ddr), thereby inducing p53-dependent apoptosis. |
2020-11-30 |
2023-08-13 |
human |
| Vanessa S Y Tay, Surabhi Devaraj, Tracy Koh, Guo Ke, Karen C Crasta, Yusuf Al. Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31852915. |
we postulate that p21 plays a key role in ddr by preventing apoptosis, associated through its overexpression triggered by dna stand breaks (dsbs). |
2020-11-09 |
2023-08-13 |
mouse |
| Shohei Miyata, Tomonori Nakamura, Susumu Kitanak. 3EZ, 20Ac-ingenol-induced Apoptosis in Chemoresistant Cancers With Cyclin D1 Accumulation. Anticancer research. vol 40. issue 11. 2020-11-04. PMID:33109561. |
the topoisomerase 1 catalytic inhibitor 3ez, 20ac-ingenol specifically induces apoptosis through the activation of atr and the up-regulation of pten by enhancing the dna damage response (ddr) in human b lymphoma (ball-1) cells. |
2020-11-04 |
2023-08-13 |
human |
| Eduardo A Sagredo, Alfredo I Sagredo, Alejandro Blanco, Pamela Rojas De Santiago, Solange Rivas, Rodrigo Assar, Paola Pérez, Katherine Marcelain, Ricardo Armisé. ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response. Biochimica et biophysica acta. Molecular cell research. vol 1867. issue 8. 2020-10-26. PMID:32275931. |
breast cancer cells with reduced levels of adar show a decreased viability and an increase in apoptosis, displaying a significant decrease of their ddr activation, compared to control cells. |
2020-10-26 |
2023-08-13 |
Not clear |