| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chay Teng Yeo, Erin M Kropp, Polly A Hansen, Michael Pereckas, Bryndon J Oleson, Aaron Naatz, Jennifer S Stancill, Kyle A Ross, Rebekah L Gundry, John A Corbet. β-cell selective inhibition of DNA damage response signaling by nitric oxide is associated with an attenuation in glucose uptake. The Journal of biological chemistry. 2023-02-11. PMID:36773802. |
as a genotoxic agent, nitric oxide activates two types of ddr signaling; however, when produced at micromolar levels by the inducible isoform of nitric oxide synthase (inos), nitric oxide inhibits ddr signaling and ddr-induced apoptosis in a β-cell-selective manner. |
2023-02-11 |
2023-08-14 |
Not clear |
| Megan E Honeywell, Marie Sophie Lykke Isidor, Nicholas W Harper, Rachel E Fontana, Peter Cruz-Gordillo, Sydney A Porto, Jessica B Spinelli, David A Guertin, Michael J Le. p53 controls choice between apoptotic and non-apoptotic death following DNA damage. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36712034. |
the canonical response to dna damage involves p53-dependent activation of cell intrinsic apoptosis, downstream of dna damage response (ddr) activation. |
2023-01-30 |
2023-08-14 |
Not clear |
| Prokopios P Argyris, Flávia Saavedra, Chris Malz, Ian A Stone, Yuping Wei, William S Boyle, Karen F Johnstone, Ali Khammanivong, Mark C Herzber. Intracellular calprotectin (S100A8/A9) facilitates DNA damage responses and promotes apoptosis in head and neck squamous cell carcinoma. Oral oncology. vol 137. 2023-01-06. PMID:36608459. |
we investigated whether s100a8/a9 regulates dna damage responses (ddr) and apoptosis in hnscc after chemoradiation. |
2023-01-06 |
2023-08-14 |
Not clear |
| Kavya Pandya, Neeru Sing. In silico study reveals unconventional interactions between MDC1 of DDR and Beclin-1 of autophagy. Molecular diversity. 2022-12-09. PMID:36482226. |
mdc1 is an adaptor or scaffold protein known to regulate ddr, apoptosis, and cell cycle progression. |
2022-12-09 |
2023-08-14 |
Not clear |
| Amanda J Stock, Ross A McDevitt, Chandrakala Puligilla, Yajun Wang, Yongqing Zhang, Kun Wang, Chongkui Sun, Kevin G Becker, Elin Lehrmann, William H Wood, Yi Gong, Mohammad Aqdas, Myong-Hee Sung, Victoria Hoffmann, Chengyu Liu, Myriam Gorospe, Lea Harrington, Luigi Ferrucci, Yie Li. Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes. PLoS genetics. vol 18. issue 11. 2022-11-28. PMID:36441670. |
short telomeres induce a dna damage response (ddr) that evokes apoptosis and senescence in human cells. |
2022-11-28 |
2023-08-14 |
mouse |
| Fanwei Meng, Junfeng Ke, Jinze Li, Changhui Zhao, Jiaqing Yan, Liping Wan. A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo. Experimental cell research. 2022-11-28. PMID:36442518. |
dhhp-3 could reduce ros, down-regulate apoptotic proteins, suppress p53 phosphorylation, attenuate the dna damage response (ddr), and inhibit apoptosis in sh-sy5y cells subjected to oxygen-glucose deprivation/re-oxygenation (ogd/r) and in the brain of sprague dawley rats subjected to transient middle cerebral artery occlusion. |
2022-11-28 |
2023-08-14 |
human |
| Ken-Ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu, Akira Saka. ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response : ΔNp63α may cause genomic instability in epithelial stem cells. Radiation oncology (London, England). vol 17. issue 1. 2022-11-15. PMID:36380314. |
the dna damage response (ddr) is a mechanism that protects cells against radiation-induced oxidative dna damage by causing cell cycle arrest and apoptosis. |
2022-11-15 |
2023-08-14 |
Not clear |
| Jared R Erickson, Robert F Kalejta, Paul D Friese. Ataxia Telangiectasia-Mutated Is Activated but Not Required for Productive Autographa californica Multiple Nucleopolyhedrovirus Infection. Journal of virology. 2022-10-31. PMID:36314821. |
like other pikks, atm phosphorylates an array of host ddr proteins at serine/threonine glutamine (s/tq) motifs, the result of which leads to cell cycle arrest, dna repair, or apoptosis. |
2022-10-31 |
2023-08-14 |
Not clear |
| Sayanthooran Saravanabavan, Gopala K Ranga. Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293397. |
we hypothesized that inhibiting ataxia telangiectasia mutated (atm; a proximal ddr kinase) together with low-dose cisplatin overwhelms the ddr response and leads to selective apoptosis of cyst-lining epithelial cells (cecs). |
2022-10-27 |
2023-08-14 |
Not clear |
| Liam Widjaja, Rudolf A Werner, Elke Krischke, Hans Christiansen, Frank M Bengel, Natalia Bogdanova, Thorsten Derli. Individual radiosensitivity reflected by γ-H2AX and 53BP1 foci predicts outcome in PSMA-targeted radioligand therapy. European journal of nuclear medicine and molecular imaging. 2022-09-22. PMID:36136101. |
γ-h2ax and 53bp1 are fundamental for cellular dna damage response (ddr) after radiation exposure and are linked to cell repair, arrest, or apoptosis. |
2022-09-22 |
2023-08-14 |
Not clear |
| Song Gao, Liping Shan, Mo Zhang, Yan Wang, Xi Zhan, Yalei Yin, Zhonghao Jiang, Xinyi Tao, Xinyu Li, Mingliang Ye, Yang Li. Inhibition of PP2A by LB100 sensitizes bladder cancer cells to chemotherapy by inducing p21 degradation. Cellular oncology (Dordrecht). 2022-09-22. PMID:36136269. |
protein phosphatase 2a (pp2a) is a serine/threonine phosphatase involved in a wide variety of regulatory cellular processes, including apoptosis and the dna-damage response (ddr). |
2022-09-22 |
2023-08-14 |
Not clear |
| Xinxin Lu, Haiqi Xu, Jiaqi Xu, Saien Lu, Shilong You, Xinyue Huang, Naijin Zhang, Lijun Zhan. The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091384. |
dna damage response (ddr) is induced in response to dna damage to maintain genome integrity and stability, and this process has crucial significance to a series of cell activities such as differentiation, apoptosis, cell cycle. |
2022-09-12 |
2023-08-14 |
Not clear |
| Tatsuya Shimada, Yohsuke Yabuki, Takuya Noguchi, Mei Tsuchida, Ryuto Komatsu, Shuhei Hamano, Mayuka Yamada, Yusuke Ezaki, Yusuke Hirata, Atsushi Matsuzaw. The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077459. |
in this study, we investigated the function of lkb1 in ddr induced by cisplatin, a representative dna-damaging agent, and found that lkb1 stabilizes and activates p53 through the c-jun n-terminal kinase (jnk) pathway, which promotes cisplatin-induced apoptosis in human fibrosarcoma cell line ht1080. |
2022-09-09 |
2023-08-14 |
human |
| Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuan. Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury. Cell death & disease. vol 13. issue 9. 2022-09-06. PMID:36068197. |
overall, we identify mll1 as a novel ddr regulator that drives cisplatin-induced rptc apoptosis and aki by modulating the mll1/wdr5-/atr/atm-chk-p53-e-cadherin axis. |
2022-09-06 |
2023-08-14 |
mouse |
| Karla E Lopez, Lisa Bouchier-Haye. Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response. Cells. vol 11. issue 12. 2022-06-24. PMID:35741016. |
however, emerging evidence of caspases positively or negatively impacting the accumulation of dna damage in the absence of cell death demonstrates that caspases play a role in the ddr that is independent of their role in apoptosis. |
2022-06-24 |
2023-08-14 |
Not clear |
| Faezeh Malakoti, Maryam Majidinia, Yasin Ahmadi, Bahman Yousefi, Darioush Shaneband. Quercetin Augments Cisplatin-Induced Apoptosis, DNA Damage Response, and MiR-22 Expression While It Prevents DNA Repair in Osteosarcoma Cells. Drug research. 2022-06-20. PMID:35724673. |
herein, we aimed to evaluate the effects of cis plus quercetin on dna damage response (ddr), dna repair, and apoptosis in saos-2 cells. |
2022-06-20 |
2023-08-14 |
Not clear |
| Lin Wu, James R Sowers, Yingmei Zhang, Jun Re. Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications. Cardiovascular research. 2022-05-16. PMID:35576480. |
dna damage triggers a series of cellular responses termed dna damage response (ddr) including detection of dna lesions, cell cycle arrest, dna repair, cellular senescence and apoptosis, in all organ systems including hearts and vasculature. |
2022-05-16 |
2023-08-13 |
Not clear |
| Yuyang Gao, Xiaoyan Feng, Wenting Song, Hongwen Li, Cunzhen Shi, Mengyuan Jin, Zhaoming Li, Lei Zhang, Mingzhi Zhan. The Potential Efficacy and Mechanism of Bendamustine in Entra-nodal NK/T Cell Lymphoma. Hematological oncology. 2022-04-19. PMID:35439335. |
furthermore, we confirmed that bendamustine activated dna damage response (ddr) directly or through atm/chk2 and atr/chk1 pathway and increased the intracellular reactive oxygen species (ros) level in nktcl cells, which caused g2/m phase arrest and apoptosis. |
2022-04-19 |
2023-08-13 |
mouse |
| Shantanu Gupta, Pritam Kumar Panda, Ronaldo F Hashimoto, Shailesh Kumar Samal, Suman Mishra, Suresh Kr Verma, Yogendra Kumar Mishra, Rajeev Ahuj. Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells. Scientific reports. vol 12. issue 1. 2022-03-23. PMID:35318393. |
dynamical modeling of mir-34a, mir-449a, and mir-16 reveals numerous ddr signaling pathways regulating senescence, autophagy, and apoptosis in hela cells. |
2022-03-23 |
2023-08-13 |
Not clear |
| Yuan Le, Xilin Li, Si Chen, Kylie G Ning, Xiaoqing Guo, Charles G Wu, Mugimane G Manjanatha, Nan Me. Actein contributes to black cohosh extract-induced genotoxicity in human TK6 cells. Journal of applied toxicology : JAT. 2022-03-09. PMID:35261072. |
in addition, actein activated dna damage response (ddr) pathway through induction of p-atm, p-chk1, and p-chk2, which subsequently induced cell cycle changes and apoptosis. |
2022-03-09 |
2023-08-13 |
human |