| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fanwei Meng, Junfeng Ke, Jinze Li, Changhui Zhao, Jiaqing Yan, Liping Wan. A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo. Experimental cell research. 2022-11-28. PMID:36442518. |
dhhp-3 could reduce ros, down-regulate apoptotic proteins, suppress p53 phosphorylation, attenuate the dna damage response (ddr), and inhibit apoptosis in sh-sy5y cells subjected to oxygen-glucose deprivation/re-oxygenation (ogd/r) and in the brain of sprague dawley rats subjected to transient middle cerebral artery occlusion. |
2022-11-28 |
2023-08-14 |
human |
| Ken-Ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu, Akira Saka. ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response : ΔNp63α may cause genomic instability in epithelial stem cells. Radiation oncology (London, England). vol 17. issue 1. 2022-11-15. PMID:36380314. |
the dna damage response (ddr) is a mechanism that protects cells against radiation-induced oxidative dna damage by causing cell cycle arrest and apoptosis. |
2022-11-15 |
2023-08-14 |
Not clear |
| Jared R Erickson, Robert F Kalejta, Paul D Friese. Ataxia Telangiectasia-Mutated Is Activated but Not Required for Productive Autographa californica Multiple Nucleopolyhedrovirus Infection. Journal of virology. 2022-10-31. PMID:36314821. |
like other pikks, atm phosphorylates an array of host ddr proteins at serine/threonine glutamine (s/tq) motifs, the result of which leads to cell cycle arrest, dna repair, or apoptosis. |
2022-10-31 |
2023-08-14 |
Not clear |
| Sayanthooran Saravanabavan, Gopala K Ranga. Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293397. |
we hypothesized that inhibiting ataxia telangiectasia mutated (atm; a proximal ddr kinase) together with low-dose cisplatin overwhelms the ddr response and leads to selective apoptosis of cyst-lining epithelial cells (cecs). |
2022-10-27 |
2023-08-14 |
Not clear |
| Liam Widjaja, Rudolf A Werner, Elke Krischke, Hans Christiansen, Frank M Bengel, Natalia Bogdanova, Thorsten Derli. Individual radiosensitivity reflected by γ-H2AX and 53BP1 foci predicts outcome in PSMA-targeted radioligand therapy. European journal of nuclear medicine and molecular imaging. 2022-09-22. PMID:36136101. |
γ-h2ax and 53bp1 are fundamental for cellular dna damage response (ddr) after radiation exposure and are linked to cell repair, arrest, or apoptosis. |
2022-09-22 |
2023-08-14 |
Not clear |
| Song Gao, Liping Shan, Mo Zhang, Yan Wang, Xi Zhan, Yalei Yin, Zhonghao Jiang, Xinyi Tao, Xinyu Li, Mingliang Ye, Yang Li. Inhibition of PP2A by LB100 sensitizes bladder cancer cells to chemotherapy by inducing p21 degradation. Cellular oncology (Dordrecht). 2022-09-22. PMID:36136269. |
protein phosphatase 2a (pp2a) is a serine/threonine phosphatase involved in a wide variety of regulatory cellular processes, including apoptosis and the dna-damage response (ddr). |
2022-09-22 |
2023-08-14 |
Not clear |
| Xinxin Lu, Haiqi Xu, Jiaqi Xu, Saien Lu, Shilong You, Xinyue Huang, Naijin Zhang, Lijun Zhan. The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response. Frontiers in physiology. vol 13. 2022-09-12. PMID:36091384. |
dna damage response (ddr) is induced in response to dna damage to maintain genome integrity and stability, and this process has crucial significance to a series of cell activities such as differentiation, apoptosis, cell cycle. |
2022-09-12 |
2023-08-14 |
Not clear |
| Tatsuya Shimada, Yohsuke Yabuki, Takuya Noguchi, Mei Tsuchida, Ryuto Komatsu, Shuhei Hamano, Mayuka Yamada, Yusuke Ezaki, Yusuke Hirata, Atsushi Matsuzaw. The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077459. |
in this study, we investigated the function of lkb1 in ddr induced by cisplatin, a representative dna-damaging agent, and found that lkb1 stabilizes and activates p53 through the c-jun n-terminal kinase (jnk) pathway, which promotes cisplatin-induced apoptosis in human fibrosarcoma cell line ht1080. |
2022-09-09 |
2023-08-14 |
human |
| Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuan. Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury. Cell death & disease. vol 13. issue 9. 2022-09-06. PMID:36068197. |
overall, we identify mll1 as a novel ddr regulator that drives cisplatin-induced rptc apoptosis and aki by modulating the mll1/wdr5-/atr/atm-chk-p53-e-cadherin axis. |
2022-09-06 |
2023-08-14 |
mouse |
| Karla E Lopez, Lisa Bouchier-Haye. Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response. Cells. vol 11. issue 12. 2022-06-24. PMID:35741016. |
however, emerging evidence of caspases positively or negatively impacting the accumulation of dna damage in the absence of cell death demonstrates that caspases play a role in the ddr that is independent of their role in apoptosis. |
2022-06-24 |
2023-08-14 |
Not clear |
| Faezeh Malakoti, Maryam Majidinia, Yasin Ahmadi, Bahman Yousefi, Darioush Shaneband. Quercetin Augments Cisplatin-Induced Apoptosis, DNA Damage Response, and MiR-22 Expression While It Prevents DNA Repair in Osteosarcoma Cells. Drug research. 2022-06-20. PMID:35724673. |
herein, we aimed to evaluate the effects of cis plus quercetin on dna damage response (ddr), dna repair, and apoptosis in saos-2 cells. |
2022-06-20 |
2023-08-14 |
Not clear |
| Lin Wu, James R Sowers, Yingmei Zhang, Jun Re. Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications. Cardiovascular research. 2022-05-16. PMID:35576480. |
dna damage triggers a series of cellular responses termed dna damage response (ddr) including detection of dna lesions, cell cycle arrest, dna repair, cellular senescence and apoptosis, in all organ systems including hearts and vasculature. |
2022-05-16 |
2023-08-13 |
Not clear |
| Yuyang Gao, Xiaoyan Feng, Wenting Song, Hongwen Li, Cunzhen Shi, Mengyuan Jin, Zhaoming Li, Lei Zhang, Mingzhi Zhan. The Potential Efficacy and Mechanism of Bendamustine in Entra-nodal NK/T Cell Lymphoma. Hematological oncology. 2022-04-19. PMID:35439335. |
furthermore, we confirmed that bendamustine activated dna damage response (ddr) directly or through atm/chk2 and atr/chk1 pathway and increased the intracellular reactive oxygen species (ros) level in nktcl cells, which caused g2/m phase arrest and apoptosis. |
2022-04-19 |
2023-08-13 |
mouse |
| Shantanu Gupta, Pritam Kumar Panda, Ronaldo F Hashimoto, Shailesh Kumar Samal, Suman Mishra, Suresh Kr Verma, Yogendra Kumar Mishra, Rajeev Ahuj. Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells. Scientific reports. vol 12. issue 1. 2022-03-23. PMID:35318393. |
dynamical modeling of mir-34a, mir-449a, and mir-16 reveals numerous ddr signaling pathways regulating senescence, autophagy, and apoptosis in hela cells. |
2022-03-23 |
2023-08-13 |
Not clear |
| Yuan Le, Xilin Li, Si Chen, Kylie G Ning, Xiaoqing Guo, Charles G Wu, Mugimane G Manjanatha, Nan Me. Actein contributes to black cohosh extract-induced genotoxicity in human TK6 cells. Journal of applied toxicology : JAT. 2022-03-09. PMID:35261072. |
in addition, actein activated dna damage response (ddr) pathway through induction of p-atm, p-chk1, and p-chk2, which subsequently induced cell cycle changes and apoptosis. |
2022-03-09 |
2023-08-13 |
human |
| Sajjad Vakili-Samiani, Omid Joodi Khanghah, Elham Gholipour, Fatemeh Najafi, Elham Zeinalzadeh, Parisa Samadi, Parisa Sarvarian, Shiva Pourvahdani, Shohre Karimi Kelaye, Michael R Hamblin, Abbas Ali Hosseinpour Feiz. Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy. Mutation research. vol 824. 2022-03-05. PMID:35247630. |
however, damaged cells can activate wee1 kinase (as a part of the ddr and rsr pathways), which prevents apoptosis and cell death by inducing cell cycle arrest at g2 phase. |
2022-03-05 |
2023-08-13 |
Not clear |
| Miriana Cardano, Giacomo Buscemi, Laura Zannin. Sex disparities in DNA damage response pathways: Novel determinants in cancer formation and therapy. iScience. vol 25. issue 3. 2022-03-04. PMID:35243237. |
one of the mechanisms that fuels carcinogenesis is the accumulation of defects in dna damage response (ddr) pathways, a complex signaling cascade that senses dna lesions and, depending on the severity, coordinates transient cell-cycle arrest, dna replication, repair, apoptosis, and senescence, preventing genomic instability and cancer. |
2022-03-04 |
2023-08-13 |
Not clear |
| Xin Ming, Zongyi Bo, Yurun Miao, Huan Chen, Chenyi Bao, Liumei Sun, Rui Xi, Qiuping Zhong, Pu Zhao, Yong-Sam Jung, Yingjuan Qia. Pseudorabies virus kinase UL13 phosphorylates H2AX to foster viral replication. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 3. 2022-02-24. PMID:35199383. |
pseudorabies virus (prv) infection was shown to induce apoptosis via stimulating ddr. |
2022-02-24 |
2023-08-13 |
Not clear |
| Richard Musson, Łukasz Gąsior, Simona Bisogno, Grażyna Ewa Pta. DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies. Human reproduction update. 2022-01-12. PMID:35021196. |
dna-damage repair (ddr) mechanisms are in place to repair damage and restore cellular function, as are other damage-induced processes such as apoptosis, autophagy and senescence. |
2022-01-12 |
2023-08-13 |
Not clear |
| Dan Liu, Ye Cheng, Junliang Chen, Xueying Mei, Zhipeng Tang, Xiangyu Cao, Jianli Li. Exploring the molecular mechanism of the inhibition of acrolein-induced BEAS-2B cytotoxicity by luteolin using network pharmacology and cell biology technology. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021-12-27. PMID:34958803. |
meanwhile, acrolein caused oxidative dna damage and double-strand breaks, induced dna damage response (ddr) and apoptosis. |
2021-12-27 |
2023-08-13 |
human |