| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tatsuya Shimada, Yohsuke Yabuki, Takuya Noguchi, Mei Tsuchida, Ryuto Komatsu, Shuhei Hamano, Mayuka Yamada, Yusuke Ezaki, Yusuke Hirata, Atsushi Matsuzaw. The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077459. |
in this study, we investigated the function of lkb1 in ddr induced by cisplatin, a representative dna-damaging agent, and found that lkb1 stabilizes and activates p53 through the c-jun n-terminal kinase (jnk) pathway, which promotes cisplatin-induced apoptosis in human fibrosarcoma cell line ht1080. |
2022-09-09 |
2023-08-14 |
human |
| Chunyun Zhang, Yingjie Guan, Jianan Zou, Xu Yang, Georgia Bayliss, Shougang Zhuan. Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury. Cell death & disease. vol 13. issue 9. 2022-09-06. PMID:36068197. |
overall, we identify mll1 as a novel ddr regulator that drives cisplatin-induced rptc apoptosis and aki by modulating the mll1/wdr5-/atr/atm-chk-p53-e-cadherin axis. |
2022-09-06 |
2023-08-14 |
mouse |
| Karla E Lopez, Lisa Bouchier-Haye. Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response. Cells. vol 11. issue 12. 2022-06-24. PMID:35741016. |
however, emerging evidence of caspases positively or negatively impacting the accumulation of dna damage in the absence of cell death demonstrates that caspases play a role in the ddr that is independent of their role in apoptosis. |
2022-06-24 |
2023-08-14 |
Not clear |
| Faezeh Malakoti, Maryam Majidinia, Yasin Ahmadi, Bahman Yousefi, Darioush Shaneband. Quercetin Augments Cisplatin-Induced Apoptosis, DNA Damage Response, and MiR-22 Expression While It Prevents DNA Repair in Osteosarcoma Cells. Drug research. 2022-06-20. PMID:35724673. |
herein, we aimed to evaluate the effects of cis plus quercetin on dna damage response (ddr), dna repair, and apoptosis in saos-2 cells. |
2022-06-20 |
2023-08-14 |
Not clear |
| Lin Wu, James R Sowers, Yingmei Zhang, Jun Re. Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications. Cardiovascular research. 2022-05-16. PMID:35576480. |
dna damage triggers a series of cellular responses termed dna damage response (ddr) including detection of dna lesions, cell cycle arrest, dna repair, cellular senescence and apoptosis, in all organ systems including hearts and vasculature. |
2022-05-16 |
2023-08-13 |
Not clear |
| Yuyang Gao, Xiaoyan Feng, Wenting Song, Hongwen Li, Cunzhen Shi, Mengyuan Jin, Zhaoming Li, Lei Zhang, Mingzhi Zhan. The Potential Efficacy and Mechanism of Bendamustine in Entra-nodal NK/T Cell Lymphoma. Hematological oncology. 2022-04-19. PMID:35439335. |
furthermore, we confirmed that bendamustine activated dna damage response (ddr) directly or through atm/chk2 and atr/chk1 pathway and increased the intracellular reactive oxygen species (ros) level in nktcl cells, which caused g2/m phase arrest and apoptosis. |
2022-04-19 |
2023-08-13 |
mouse |
| Shantanu Gupta, Pritam Kumar Panda, Ronaldo F Hashimoto, Shailesh Kumar Samal, Suman Mishra, Suresh Kr Verma, Yogendra Kumar Mishra, Rajeev Ahuj. Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells. Scientific reports. vol 12. issue 1. 2022-03-23. PMID:35318393. |
dynamical modeling of mir-34a, mir-449a, and mir-16 reveals numerous ddr signaling pathways regulating senescence, autophagy, and apoptosis in hela cells. |
2022-03-23 |
2023-08-13 |
Not clear |
| Yuan Le, Xilin Li, Si Chen, Kylie G Ning, Xiaoqing Guo, Charles G Wu, Mugimane G Manjanatha, Nan Me. Actein contributes to black cohosh extract-induced genotoxicity in human TK6 cells. Journal of applied toxicology : JAT. 2022-03-09. PMID:35261072. |
in addition, actein activated dna damage response (ddr) pathway through induction of p-atm, p-chk1, and p-chk2, which subsequently induced cell cycle changes and apoptosis. |
2022-03-09 |
2023-08-13 |
human |
| Sajjad Vakili-Samiani, Omid Joodi Khanghah, Elham Gholipour, Fatemeh Najafi, Elham Zeinalzadeh, Parisa Samadi, Parisa Sarvarian, Shiva Pourvahdani, Shohre Karimi Kelaye, Michael R Hamblin, Abbas Ali Hosseinpour Feiz. Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy. Mutation research. vol 824. 2022-03-05. PMID:35247630. |
however, damaged cells can activate wee1 kinase (as a part of the ddr and rsr pathways), which prevents apoptosis and cell death by inducing cell cycle arrest at g2 phase. |
2022-03-05 |
2023-08-13 |
Not clear |
| Miriana Cardano, Giacomo Buscemi, Laura Zannin. Sex disparities in DNA damage response pathways: Novel determinants in cancer formation and therapy. iScience. vol 25. issue 3. 2022-03-04. PMID:35243237. |
one of the mechanisms that fuels carcinogenesis is the accumulation of defects in dna damage response (ddr) pathways, a complex signaling cascade that senses dna lesions and, depending on the severity, coordinates transient cell-cycle arrest, dna replication, repair, apoptosis, and senescence, preventing genomic instability and cancer. |
2022-03-04 |
2023-08-13 |
Not clear |
| Xin Ming, Zongyi Bo, Yurun Miao, Huan Chen, Chenyi Bao, Liumei Sun, Rui Xi, Qiuping Zhong, Pu Zhao, Yong-Sam Jung, Yingjuan Qia. Pseudorabies virus kinase UL13 phosphorylates H2AX to foster viral replication. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 3. 2022-02-24. PMID:35199383. |
pseudorabies virus (prv) infection was shown to induce apoptosis via stimulating ddr. |
2022-02-24 |
2023-08-13 |
Not clear |
| Richard Musson, Łukasz Gąsior, Simona Bisogno, Grażyna Ewa Pta. DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies. Human reproduction update. 2022-01-12. PMID:35021196. |
dna-damage repair (ddr) mechanisms are in place to repair damage and restore cellular function, as are other damage-induced processes such as apoptosis, autophagy and senescence. |
2022-01-12 |
2023-08-13 |
Not clear |
| Dan Liu, Ye Cheng, Junliang Chen, Xueying Mei, Zhipeng Tang, Xiangyu Cao, Jianli Li. Exploring the molecular mechanism of the inhibition of acrolein-induced BEAS-2B cytotoxicity by luteolin using network pharmacology and cell biology technology. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021-12-27. PMID:34958803. |
meanwhile, acrolein caused oxidative dna damage and double-strand breaks, induced dna damage response (ddr) and apoptosis. |
2021-12-27 |
2023-08-13 |
human |
| Dan Liu, Ye Cheng, Zhipeng Tang, Xueying Mei, Xiangyu Cao, Jianli Li. Toxicity mechanism of acrolein on DNA damage and apoptosis in BEAS-2B cells: Insights from cell biology and molecular docking analyses. Toxicology. 2021-12-27. PMID:34958888. |
all the results indicated that acrolein induced dna damage, activated ddr and mitochondrial apoptosis pathways, which might be the pivotal factors to mediate cytotoxicity in beas-2b cells. |
2021-12-27 |
2023-08-13 |
human |
| Dan Liu, Ye Cheng, Xueying Mei, Yanzhen Xie, Zhipeng Tang, Jianli Liu, Xiangyu Ca. Mechanisms of acrolein induces toxicity in human umbilical vein endothelial cells: Oxidative stress, DNA damage response, and apoptosis. Environmental toxicology. 2021-12-15. PMID:34908224. |
the molecular mechanism was studied based on oxidative stress, dna damage response (ddr), and mitochondrial apoptosis pathways. |
2021-12-15 |
2023-08-13 |
human |
| Adalberto Merighi, Nadia Gionchiglia, Alberto Granato, Laura Loss. The Phosphorylated Form of the Histone H2AX (γH2AX) in the Brain from Embryonic Life to Old Age. Molecules (Basel, Switzerland). vol 26. issue 23. 2021-12-10. PMID:34885784. |
in the first part of this review, we will briefly describe the intervention of h2ax in the dna damage response (ddr) and its role in some pivotal cellular events, such as regulation of cell cycle checkpoints, genomic instability, cell growth, mitosis, embryogenesis, and apoptosis. |
2021-12-10 |
2023-08-13 |
Not clear |
| Francesca Esposito, Raffaella Giuffrida, Gabriele Raciti, Caterina Puglisi, Stefano Fort. Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy. International journal of molecular sciences. vol 22. issue 19. 2021-11-01. PMID:34639030. |
toward this aim, cells have developed complex enzymatic machinery, the so-called dna damage response (ddr), which is able to repair dna, temporarily stopping the cell cycle to provide more time to repair, or if the damage is too severe, inducing apoptosis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Kerstin Felgentreff, Ulrich Baumann, Christian Klemann, Catharina Schuetz, Dorothee Viemann, Martin Wetzke, Ulrich Pannicke, Sandra von Hardenberg, Bernd Auber, Klaus-Michael Debatin, Eva-Maria Jacobsen, Manfred Hoenig, Ansgar Schulz, Klaus Schwar. Biomarkers of DNA Damage Response Enable Flow Cytometry-Based Diagnostic to Identify Inborn DNA Repair Defects in Primary Immunodeficiencies. Journal of clinical immunology. 2021-10-30. PMID:34716846. |
proteins of the dna damage response (ddr) network sense dna lesions and induce cell cycle arrest, dna repair, and apoptosis. |
2021-10-30 |
2023-08-13 |
Not clear |
| Gargi Ghosal, Junjie Che. DNA damage tolerance: a double-edged sword guarding the genome. Translational cancer research. vol 2. issue 3. 2021-10-21. PMID:24058901. |
ddr senses different types of dna damage and coordinates a response that includes activation of transcription, cell cycle control, dna repair pathways, apoptosis, senescence, and cell death. |
2021-10-21 |
2023-08-12 |
Not clear |
| Chao Wang, Mengfan Tang, Zhen Chen, Litong Nie, Siting Li, Yun Xiong, Klaudia Anna Szymonowicz, Jeong-Min Park, Huimin Zhang, Xu Feng, Min Huang, Dan Su, Traver Hart, Junjie Che. Genetic vulnerabilities upon inhibition of DNA damage response. Nucleic acids research. vol 49. issue 14. 2021-10-07. PMID:34320214. |
additionally, we compared the synergistic effects of combining different ddr inhibitors and found that an atm inhibitor plus a parp inhibitor induced dramatic levels of cell death, probably through promoting apoptosis. |
2021-10-07 |
2023-08-13 |
Not clear |