| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vibha Singh, Praveen Kumar Jaiswal, Ishita Ghosh, Hari K Koul, Xiuping Yu, Arrigo De Benedett. Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors. International journal of cancer. vol 145. issue 4. 2019-12-03. PMID:30737777. |
following dna damage, addition of the tlk specific inhibitor, thioridazine (thd), impairs atr and chk1 activation, establishing the existence of a adt > tlk1 > nek1 > atr > chk1, ddr pathway, while its abrogation leads to apoptosis. |
2019-12-03 |
2023-08-13 |
Not clear |
| Yuki Kuwano, Kensei Nishida, Yoko Akaike, Ken Kurokawa, Tatsuya Nishikawa, Kiyoshi Masuda, Kazuhito Rokuta. Homeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the Epigenome. International journal of molecular sciences. vol 17. issue 10. 2019-11-20. PMID:27689990. |
the ddr regulates dna repair, cell cycle checkpoint activation, and apoptosis to restore genome integrity and cellular homeostasis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Cristina Fernández-Díez, Silvia González-Rojo, Marta Lombó, M Paz Herráe. Tolerance to paternal genotoxic damage promotes survival during embryo development in zebrafish ( Biology open. vol 7. issue 5. 2019-11-20. PMID:29712649. |
mammals have strong sperm selection mechanisms and activate a zygotic dna damage response (ddr) (including cell cycle arrest, dna repair and alternative apoptosis) in order to guarantee the genomic conformity of the reduced progeny. |
2019-11-20 |
2023-08-13 |
zebrafish |
| Riccardo Mezzadra, Marjolein de Bruijn, Lucas T Jae, Raquel Gomez-Eerland, Anja Duursma, Ferenc A Scheeren, Thijn R Brummelkamp, Ton N Schumache. SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing. PloS one. vol 14. issue 2. 2019-11-07. PMID:30753225. |
collectively, our data indicate that slfn11 can couple ifn-γ exposure of tumor cells to ddr and cellular apoptosis. |
2019-11-07 |
2023-08-13 |
human |
| Mohamed Sham Shihabudeen Haider Ali, Xiao Cheng, Matthew Moran, Stefan Haemmig, Michael J Naldrett, Sophie Alvarez, Mark W Feinberg, Xinghui Su. LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Nucleic acids research. vol 47. issue 3. 2019-08-20. PMID:30476192. |
in this study, we demonstrate that lncrna maternally expressed gene 3 (meg3) interacts with the rna binding protein polypyrimidine tract binding protein 3 (ptbp3) to regulate gene expression and endothelial function through p53 signaling ─ a major coordinator of apoptosis and cell proliferation triggered by the ddr. |
2019-08-20 |
2023-08-13 |
Not clear |
| Li Xu, Hailong Tang, Kai Wang, Yanhua Zheng, Juan Feng, Hongjuan Dong, Yulong Jin, Chun Cao, Xiequn Chen, Guangxun Ga. Pharmacological inhibition of EZH2 combined with DNA‑damaging agents interferes with the DNA damage response in MM cells. Molecular medicine reports. vol 19. issue 5. 2019-08-01. PMID:30942459. |
mechanistically, targeting ezh2 with minimal toxic concentrations of a pharmacological inhibitor (gsk126) markedly weakened the accompanying increase in the histone trimethylation h3k27me3 and aggravated dna damage response (ddr)‑associated apoptosis in vitro. |
2019-08-01 |
2023-08-13 |
Not clear |
| John Le, Eric Perez, Leah Nemzow, Feng Gon. Role of deubiquitinases in DNA damage response. DNA repair. vol 76. 2019-07-16. PMID:30831436. |
dna damage response (ddr) serves as an integrated cellular network to detect cellular stress and react by activating pathways responsible for halting cell cycle progression, stimulating dna damage repair, and initiating apoptosis. |
2019-07-16 |
2023-08-13 |
Not clear |
| Ana Laura Reyes-Ábalos, Pablo Liddle, Gustavo A Folle, María Vittoria Di Tomas. γH2AX prefers late replicating metaphase chromosome regions. Mutation research. Genetic toxicology and environmental mutagenesis. vol 836. issue Pt B. 2019-06-10. PMID:30442336. |
ddr engages the recruitment of signaling, transducer, effector, chromatin modifiers and remodeling proteins, allowing cell cycle delay, dna repair or induction of senescence or apoptosis. |
2019-06-10 |
2023-08-13 |
Not clear |
| Sahika Cingir Koker, Ermira Jahja, Huma Shehwana, Ayse Gokce Keskus, Ozlen Kon. Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in breast cancer. PloS one. vol 13. issue 12. 2019-05-10. PMID:30543688. |
our study suggests chrna5 rnai is associated with cell cycle inhibition, apoptosis as well as reduced ddr and increased drug sensitivity in breast cancer yet future studies are warranted since dose- and cell line-specific differences exist in response to chrna5 depletion. |
2019-05-10 |
2023-08-13 |
Not clear |
| Hailong Tang, Mimi Shu, Bo Dai, Li Xu, Baoxia Dong, Guangxun Gao, Xiequn Che. DNA damage response-initiated cytokine secretion in bone marrow stromal cells promotes chemoresistance of myeloma cells. Leukemia & lymphoma. vol 59. issue 9. 2019-03-18. PMID:29249192. |
these data indicate that dna-damaging drug triggers an atm-dependent ddr in bmscs, leading to increased cytokine secretion and resistance of myeloma cells to chemotherapy-induced apoptosis. |
2019-03-18 |
2023-08-13 |
Not clear |
| J Luis Espinoza, Mika Minam. Sensing Bacterial-Induced DNA Damaging Effects Frontiers in immunology. vol 9. 2019-02-28. PMID:29422899. |
in addition to well-defined outcomes, such as cell cycle arrest, apoptosis, and senescence, another consequence of ddr activation is the induction of natural killer group 2 member d ligands (nkg2d-ls) on the surface of stressed cells. |
2019-02-28 |
2023-08-13 |
human |
| Hui-Ling Ou, Björn Schumache. DNA damage responses and p53 in the aging process. Blood. vol 131. issue 5. 2019-02-01. PMID:29141944. |
conversely, radiation therapy and chemotherapy induce dna damage to drive cells into apoptosis or senescence as outcomes of the dna damage response (ddr). |
2019-02-01 |
2023-08-13 |
Not clear |
| Martina Magni, Giacomo Buscemi, Laura Zannin. Cell cycle and apoptosis regulator 2 at the interface between DNA damage response and cell physiology. Mutation research. Reviews in mutation research. vol 776. 2018-11-26. PMID:29807573. |
cell cycle and apoptosis regulator 2 (ccar2 or dbc1) is a human protein recently emerged as a novel and important player of the dna damage response (ddr). |
2018-11-26 |
2023-08-13 |
human |
| Shohei Miyata, Li-Yan Wang, Susumu Kitanak. 3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt. Leukemia research. vol 64. 2018-11-05. PMID:29179029. |
we have previously used western blot analysis to show that the catalytic topoisomerase (topo) inhibitor, 3ez, 20ac-ingenol, induced dna damage response (ddr), which activated atr, downregulated p-akt through upregulation of pten level, and led to cell cycle arrest or apoptosis. |
2018-11-05 |
2023-08-13 |
Not clear |
| Shohei Miyata, Li-Yan Wang, Susumu Kitanak. 3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt. Leukemia research. vol 64. 2018-11-05. PMID:29179029. |
in this study, we used atr or pten sirna and observed that the specific cell arrest and apoptosis of ball-1 cells in ddr caused by 3ez, 20ac-ingenol was dependant on activation of atr and downregulation of nuclear p-akt through upregulation of pten. |
2018-11-05 |
2023-08-13 |
Not clear |
| Li Wei, Shanshan Zhu, Jing Wang, Rong Quan, Xu Yan, Zixue Li, Lei Hou, Naidong Wang, Yi Yang, Haijun Jiang, Jue Li. Induction of a Cellular DNA Damage Response by Porcine Circovirus Type 2 Facilitates Viral Replication and Mediates Apoptotic Responses. Scientific reports. vol 6. 2018-06-19. PMID:27982097. |
cellular dna damage response (ddr) triggered by infection of dna viruses mediate cell cycle checkpoint activation, dna repair, or apoptosis induction. |
2018-06-19 |
2023-08-13 |
Not clear |
| Derek A Franklin, Yizhou He, Patrick L Leslie, Andrey P Tikunov, Nick Fenger, Jeffrey M Macdonald, Yanping Zhan. p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway. Scientific reports. vol 6. 2018-05-30. PMID:27901115. |
although previous studies have emphasized the importance of p53-dependent cell cycle arrest and apoptosis for tumor suppression, recent studies have suggested that other areas of p53 regulation, such as metabolism and dna damage repair (ddr), are also essential for p53-dependent tumor suppression. |
2018-05-30 |
2023-08-13 |
Not clear |
| Bryndon J Oleson, Aaron Naatz, Sarah C Proudfoot, Chay Teng Yeo, John A Corbet. Role of Protein Phosphatase 1 and Inhibitor of Protein Phosphatase 1 in Nitric Oxide-Dependent Inhibition of the DNA Damage Response in Pancreatic β-Cells. Diabetes. vol 67. issue 5. 2018-05-25. PMID:29444892. |
we have shown that nitric oxide, in a cell type-selective manner, inhibits the dna damage response (ddr) and, in doing so, protects β-cells from dna damage-induced apoptosis. |
2018-05-25 |
2023-08-13 |
Not clear |
| Bryndon J Oleson, Aaron Naatz, Sarah C Proudfoot, Chay Teng Yeo, John A Corbet. Role of Protein Phosphatase 1 and Inhibitor of Protein Phosphatase 1 in Nitric Oxide-Dependent Inhibition of the DNA Damage Response in Pancreatic β-Cells. Diabetes. vol 67. issue 5. 2018-05-25. PMID:29444892. |
these findings support a pp1-independent mechanism by which nitric oxide selectively impairs ddr signaling and protects β-cells from dna damage-induced apoptosis. |
2018-05-25 |
2023-08-13 |
Not clear |
| Dorota Piekna-Przybylska, Gaurav Sharma, Sanjay B Maggirwar, Robert A Bambar. Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1. Cell cycle (Georgetown, Tex.). vol 16. issue 10. 2018-03-09. PMID:28388353. |
cells with inefficient ddr are more vulnerable to therapeutic approaches that target ddr, thereby raising dna damage to a threshold that triggers apoptosis. |
2018-03-09 |
2023-08-13 |
Not clear |