| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Navjotsingh Pabla, Zhengwei Ma, Michael A McIlhatton, Richard Fishel, Zheng Don. hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. The Journal of biological chemistry. vol 286. issue 12. 2011-06-09. PMID:21285353. |
cisplatin, a major chemotherapy drug that cross-links dna, induces atr-dependent ddr, resulting in apoptosis. |
2011-06-09 |
2023-08-12 |
Not clear |
| S Nilsson, J Huelsenbeck, G Frit. Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. Cancer letters. vol 304. issue 1. 2011-05-12. PMID:21356574. |
we comparatively analyzed the effect of equitoxic doses of lov, bp and met on cell viability, cell cycle progression, apoptosis and dna damage response (ddr) of human osteo- and fibrosarcoma cells exposed to doxorubicin or cisplatin. |
2011-05-12 |
2023-08-12 |
human |
| Raffaella Di Micco, Gabriele Sulli, Miryana Dobreva, Michalis Liontos, Oronza A Botrugno, Gaetano Gargiulo, Roberto dal Zuffo, Valentina Matti, Giovanni d'Ario, Erica Montani, Ciro Mercurio, William C Hahn, Vassilis Gorgoulis, Saverio Minucci, Fabrizio d'Adda di Fagagn. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nature cell biology. vol 13. issue 3. 2011-04-27. PMID:21336312. |
pharmacological and genetic perturbation of heterochromatin in oncogene-expressing cells increase ddr signalling and lead to apoptosis. |
2011-04-27 |
2023-08-12 |
human |
| Raffaella Di Micco, Gabriele Sulli, Miryana Dobreva, Michalis Liontos, Oronza A Botrugno, Gaetano Gargiulo, Roberto dal Zuffo, Valentina Matti, Giovanni d'Ario, Erica Montani, Ciro Mercurio, William C Hahn, Vassilis Gorgoulis, Saverio Minucci, Fabrizio d'Adda di Fagagn. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nature cell biology. vol 13. issue 3. 2011-04-27. PMID:21336312. |
in vivo, a histone deacetylase inhibitor (hdaci) causes heterochromatin relaxation, increased ddr, apoptosis and tumour regression. |
2011-04-27 |
2023-08-12 |
human |
| Andrejs Ivanov, Peter D Adam. A damage limitation exercise. Nature cell biology. vol 13. issue 3. 2011-04-27. PMID:21364567. |
senescence-associated heterochromatin is now shown to limit ddr, thus reducing apoptosis and promoting survival of senescent cells. |
2011-04-27 |
2023-08-12 |
Not clear |
| Ranjana Pal, Niloo Srivastava, Rupali Chopra, Sailesh Gochhait, Pawan Gupta, Neeraj Prakash, Gaurav Agarwal, Rameshwar N K Bameza. Investigation of DNA damage response and apoptotic gene methylation pattern in sporadic breast tumors using high throughput quantitative DNA methylation analysis technology. Molecular cancer. vol 9. 2011-03-25. PMID:21092294. |
for the past decade our laboratory has identified genes involved in dna damage response (ddr), apoptosis and immunosurveillance pathways to influence sporadic breast cancer risk in north indian population. |
2011-03-25 |
2023-08-12 |
Not clear |
| Lijun Jia, Jeremy S Bickel, Jiaxue Wu, Meredith A Morgan, Hua Li, Jie Yang, Xiaochun Yu, Raymond C Chan, Yi Su. RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. The Journal of biological chemistry. vol 286. issue 5. 2011-03-21. PMID:21115485. |
our recent study showed that rbx1 silencing triggered a dna damage response (ddr) leading to g(2)-m arrest, senescence, and apoptosis, with the mechanism remaining elusive. |
2011-03-21 |
2023-08-12 |
human |
| Tali Eilon, Itamar Baras. Forced activation of Stat5 subjects mammary epithelial cells to DNA damage and preferential induction of the cellular response mechanism during proliferation. Journal of cellular physiology. vol 226. issue 3. 2011-01-27. PMID:20717961. |
however, the relative number of damaged cells was much lower than that in the reproduced in vitro stages and the insults were generally associated with apoptosis and ddr. |
2011-01-27 |
2023-08-12 |
mouse |
| A Tomashevski, D R Webster, P Grammas, M Gorospe, I I Kruma. Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons. Cell death and differentiation. vol 17. issue 7. 2010-09-27. PMID:20111042. |
these findings reveal the importance of cell-cycle activation for controlling both dna repair and apoptosis in postmitotic neurons, and underline the particular role of g(1) --> s progression in apoptotic signaling, providing new insights into the mechanisms of dna damage response (ddr) in postmitotic neurons. |
2010-09-27 |
2023-08-12 |
Not clear |
| Lise Mattera, Céline Courilleau, Gaëlle Legube, Takeshi Ueda, Rikiro Fukunaga, Martine Chevillard-Briet, Yvan Canitrot, Fabrice Escaffit, Didier Trouch. The E1A-associated p400 protein modulates cell fate decisions by the regulation of ROS homeostasis. PLoS genetics. vol 6. issue 6. 2010-09-27. PMID:20548951. |
suppression of the dna damage response using a sirna against atm inhibits the effects of p400 on cell cycle progression, apoptosis, or senescence, demonstrating the importance of atm-dependent ddr pathways in cell fates control by p400. |
2010-09-27 |
2023-08-12 |
Not clear |
| Shiaw-Yih Lin, Yulong Liang, Kaiyi L. Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression. Yonsei medical journal. vol 51. issue 3. 2010-07-15. PMID:20376879. |
two central kinases for the ddr pathway are atm and atr, which can phosphorylate and activate many downstream proteins for cell cycle arrest, dna repair, or apoptosis if the damages are irreparable. |
2010-07-15 |
2023-08-12 |
mouse |
| J-L Perfettini, R Nardacci, C Séror, S Q Raza, S Sepe, H Saïdi, F Brottes, A Amendola, F Subra, F Del Nonno, L Chessa, A D'Incecco, M-L Gougeon, M Piacentini, G Kroeme. 53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope. Cell death and differentiation. vol 17. issue 5. 2010-06-28. PMID:19876065. |
it colocalizes partially with the promyelomonocytic leukemia protein (pml), and the ataxia telangiectasia mutated kinase (atm), the two components of the ddr that mediate apoptosis induced by the hiv-1 envelope. |
2010-06-28 |
2023-08-12 |
human |
| Kazuhito Oka, Toshiki Tanaka, Tadahiko Enoki, Koichi Yoshimura, Mako Ohshima, Masayuki Kubo, Tomoyuki Murakami, Toshikazu Gondou, Yoshihide Minami, Yoshihiro Takemoto, Eijirou Harada, Takaaki Tsushimi, Tao-Sheng Li, Frank Traganos, Zbigniew Darzynkiewicz, Kimikazu Haman. DNA damage signaling is activated during cancer progression in human colorectal carcinoma. Cancer biology & therapy. vol 9. issue 3. 2010-06-17. PMID:20023412. |
recent studies have shown that the dna damage response (ddr) is activated in precancerous lesions, suggesting that neoplastic cells may avoid apoptosis by impairing the ddr which acts as a barrier against tumor progression. |
2010-06-17 |
2023-08-12 |
human |
| Yun Dai, Steven Gran. New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 16. issue 2. 2010-04-12. PMID:20068082. |
the dna damage response (ddr) represents a complex network of multiple signaling pathways involving cell cycle checkpoints, dna repair, transcriptional programs, and apoptosis, through which cells maintain genomic integrity following various endogenous (metabolic) or environmental stresses. |
2010-04-12 |
2023-08-12 |
Not clear |
| Jay P Reddy, Sirisha Peddibhotla, Wen Bu, Jing Zhao, Svasti Haricharan, Yi-Chieh Nancy Du, Katrina Podsypanina, Jeffrey M Rosen, Larry A Donehower, Yi L. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 8. 2010-04-05. PMID:20133707. |
furthermore, in this somatic erbb2 tumor model, atm, and thus ddr, is required for p53 stabilization, apoptosis, and senescence. |
2010-04-05 |
2023-08-12 |
mouse |
| Jay P Reddy, Sirisha Peddibhotla, Wen Bu, Jing Zhao, Svasti Haricharan, Yi-Chieh Nancy Du, Katrina Podsypanina, Jeffrey M Rosen, Larry A Donehower, Yi L. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 8. 2010-04-05. PMID:20133707. |
thus, this murine model fully recapitulates early ddr signaling; the eventual suppression of its endpoints in tumorigenesis provides compelling evidence that erbb2-induced aberrant mammary cell proliferation leads to an atm-mediated ddr that activates apoptosis and senescence, and at least the former must be overcome to progress to malignancy. |
2010-04-05 |
2023-08-12 |
mouse |
| Courtney A Lovejoy, Xin Xu, Carol E Bansbach, Gloria G Glick, Runxiang Zhao, Fei Ye, Bianca M Sirbu, Laura C Titus, Yu Shyr, David Corte. Functional genomic screens identify CINP as a genome maintenance protein. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 46. 2009-12-15. PMID:19889979. |
the dna damage response (ddr) has a critical role in maintaining genome integrity and serves as a barrier to tumorigenesis by promoting cell-cycle arrest, dna repair, and apoptosis. |
2009-12-15 |
2023-08-12 |
human |
| Penny A Jegg. Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us. Health physics. vol 97. issue 5. 2009-12-01. PMID:19820451. |
ddr processes encompass repair pathways and signal transduction mechanisms that activate cell cycle checkpoint arrest and apoptosis. |
2009-12-01 |
2023-08-12 |
Not clear |
| Hong Zhao, Frank Traganos, Jurek Dobrucki, Donald Wlodkowic, Zbigniew Darzynkiewic. Induction of DNA damage response by the supravital probes of nucleic acids. Cytometry. Part A : the journal of the International Society for Analytical Cytology. vol 75. issue 6. 2009-08-20. PMID:19373929. |
the data indicate that supravital use of ho 42, draq5, and dcv induces various degrees of ddr, including activation of atm, chk2 and p53, which may have significant consequences on regulatory cell cycle pathways and apoptosis. |
2009-08-20 |
2023-08-12 |
Not clear |
| Stéphanie Solier, Yves Pommie. The apoptotic ring: a novel entity with phosphorylated histones H2AX and H2B and activated DNA damage response kinases. Cell cycle (Georgetown, Tex.). vol 8. issue 12. 2009-08-14. PMID:19448405. |
we recently showed that histone h2ax phosphorylated on serine 139 (gamma-h2ax), a hallmark of dna damage response (ddr), also forms early during apoptosis induced by death receptor activation. |
2009-08-14 |
2023-08-12 |
Not clear |