| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Christian Reinhardt, Björn Schumache. The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends in genetics : TIG. vol 28. issue 3. 2012-04-13. PMID:22265392. |
dna damage response (ddr) pathways that are mediated through the tumor suppressor p53 play an important role in the cell-intrinsic responses to genome instability, including a transient cell cycle arrest, senescence and apoptosis. |
2012-04-13 |
2023-08-12 |
Not clear |
| Maikel D Wouters, Dik C van Gent, Jan H J Hoeijmakers, Joris Potho. MicroRNAs, the DNA damage response and cancer. Mutation research. vol 717. issue 1-2. 2012-01-31. PMID:21477600. |
to deal with these potentially detrimental effects of dna damage, cells induce a complex dna damage response (ddr) that includes dna repair, cell cycle checkpoints, damage tolerance systems and apoptosis. |
2012-01-31 |
2023-08-12 |
human |
| Ho Jun Seol, Hae Yong Yoo, Juyoun Jin, Kyeung Min Joo, Doo-Sik Kong, Su Jin Yoon, Heekyoung Yang, Wonyoung Kang, Do-Hoon Lim, Kwan Park, Jong Hyun Kim, Jung-Ii Lee, Do-Hyun Na. Prognostic implications of the DNA damage response pathway in glioblastoma. Oncology reports. vol 26. issue 2. 2011-11-03. PMID:21617879. |
since atm induces cell cycle arrest or apoptosis through cell cycle regulators in response to genotoxic insults, these results indicate that aberrant ddr signaling through atm in gbm may be associated with resistance to genotoxic anti-tumor therapeutics. |
2011-11-03 |
2023-08-12 |
Not clear |
| Irina Neganova, Felipe Vilella, Stuart P Atkinson, Maria Lloret, João F Passos, Thomas von Zglinicki, José-Enrique O'Connor, Deborah Burks, Richard Jones, Lyle Armstrong, Majlinda Lak. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Stem cells (Dayton, Ohio). vol 29. issue 4. 2011-10-13. PMID:21319273. |
cdk2 downregulation causes high apoptosis at the early time points; however, this is gradually decreased overtime as the ddr is initiated. |
2011-10-13 |
2023-08-12 |
human |
| Renfeng Li, S Diane Haywar. The Ying-Yang of the virus-host interaction: control of the DNA damage response. Future microbiology. vol 6. issue 4. 2011-10-04. PMID:21526939. |
viruses have evolved elegant strategies to manipulate the host while the host counters with defense systems including the interferon response, apoptosis and the dna damage response (ddr). |
2011-10-04 |
2023-08-12 |
human |
| G S Herter-Sprie, S Chen, K Höpker, H C Reinhard. [Synthetic lethality as a new concept for the treatment of cancer]. Deutsche medizinische Wochenschrift (1946). vol 136. issue 30. 2011-09-30. PMID:21789751. |
following dna damage, cells activate a complex dna-damage-response (ddr) signaling network to arrest the cell cycle, repair dna and, if the extend of damage is beyond repair capacity, induce apoptosis. |
2011-09-30 |
2023-08-12 |
human |
| Hailiang Hu, Richard A Gatt. MicroRNAs: new players in the DNA damage response. Journal of molecular cell biology. vol 3. issue 3. 2011-09-28. PMID:21183529. |
the dna damage response (ddr) is a signal transduction pathway that decides the cell's fate either to repair dna damage or to undergo apoptosis if there is too much damage. |
2011-09-28 |
2023-08-12 |
Not clear |
| Mara H Sherman, Craig H Bassing, Michael A Teitel. Regulation of cell differentiation by the DNA damage response. Trends in cell biology. vol 21. issue 5. 2011-08-22. PMID:21354798. |
three established outcomes of the ddr include transient cell cycle arrest coupled with dna repair, apoptosis, or senescence. |
2011-08-22 |
2023-08-12 |
Not clear |
| Navjotsingh Pabla, Zhengwei Ma, Michael A McIlhatton, Richard Fishel, Zheng Don. hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. The Journal of biological chemistry. vol 286. issue 12. 2011-06-09. PMID:21285353. |
cisplatin, a major chemotherapy drug that cross-links dna, induces atr-dependent ddr, resulting in apoptosis. |
2011-06-09 |
2023-08-12 |
Not clear |
| S Nilsson, J Huelsenbeck, G Frit. Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells. Cancer letters. vol 304. issue 1. 2011-05-12. PMID:21356574. |
we comparatively analyzed the effect of equitoxic doses of lov, bp and met on cell viability, cell cycle progression, apoptosis and dna damage response (ddr) of human osteo- and fibrosarcoma cells exposed to doxorubicin or cisplatin. |
2011-05-12 |
2023-08-12 |
human |
| Raffaella Di Micco, Gabriele Sulli, Miryana Dobreva, Michalis Liontos, Oronza A Botrugno, Gaetano Gargiulo, Roberto dal Zuffo, Valentina Matti, Giovanni d'Ario, Erica Montani, Ciro Mercurio, William C Hahn, Vassilis Gorgoulis, Saverio Minucci, Fabrizio d'Adda di Fagagn. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nature cell biology. vol 13. issue 3. 2011-04-27. PMID:21336312. |
pharmacological and genetic perturbation of heterochromatin in oncogene-expressing cells increase ddr signalling and lead to apoptosis. |
2011-04-27 |
2023-08-12 |
human |
| Raffaella Di Micco, Gabriele Sulli, Miryana Dobreva, Michalis Liontos, Oronza A Botrugno, Gaetano Gargiulo, Roberto dal Zuffo, Valentina Matti, Giovanni d'Ario, Erica Montani, Ciro Mercurio, William C Hahn, Vassilis Gorgoulis, Saverio Minucci, Fabrizio d'Adda di Fagagn. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nature cell biology. vol 13. issue 3. 2011-04-27. PMID:21336312. |
in vivo, a histone deacetylase inhibitor (hdaci) causes heterochromatin relaxation, increased ddr, apoptosis and tumour regression. |
2011-04-27 |
2023-08-12 |
human |
| Andrejs Ivanov, Peter D Adam. A damage limitation exercise. Nature cell biology. vol 13. issue 3. 2011-04-27. PMID:21364567. |
senescence-associated heterochromatin is now shown to limit ddr, thus reducing apoptosis and promoting survival of senescent cells. |
2011-04-27 |
2023-08-12 |
Not clear |
| Ranjana Pal, Niloo Srivastava, Rupali Chopra, Sailesh Gochhait, Pawan Gupta, Neeraj Prakash, Gaurav Agarwal, Rameshwar N K Bameza. Investigation of DNA damage response and apoptotic gene methylation pattern in sporadic breast tumors using high throughput quantitative DNA methylation analysis technology. Molecular cancer. vol 9. 2011-03-25. PMID:21092294. |
for the past decade our laboratory has identified genes involved in dna damage response (ddr), apoptosis and immunosurveillance pathways to influence sporadic breast cancer risk in north indian population. |
2011-03-25 |
2023-08-12 |
Not clear |
| Lijun Jia, Jeremy S Bickel, Jiaxue Wu, Meredith A Morgan, Hua Li, Jie Yang, Xiaochun Yu, Raymond C Chan, Yi Su. RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. The Journal of biological chemistry. vol 286. issue 5. 2011-03-21. PMID:21115485. |
our recent study showed that rbx1 silencing triggered a dna damage response (ddr) leading to g(2)-m arrest, senescence, and apoptosis, with the mechanism remaining elusive. |
2011-03-21 |
2023-08-12 |
human |
| Tali Eilon, Itamar Baras. Forced activation of Stat5 subjects mammary epithelial cells to DNA damage and preferential induction of the cellular response mechanism during proliferation. Journal of cellular physiology. vol 226. issue 3. 2011-01-27. PMID:20717961. |
however, the relative number of damaged cells was much lower than that in the reproduced in vitro stages and the insults were generally associated with apoptosis and ddr. |
2011-01-27 |
2023-08-12 |
mouse |
| A Tomashevski, D R Webster, P Grammas, M Gorospe, I I Kruma. Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons. Cell death and differentiation. vol 17. issue 7. 2010-09-27. PMID:20111042. |
these findings reveal the importance of cell-cycle activation for controlling both dna repair and apoptosis in postmitotic neurons, and underline the particular role of g(1) --> s progression in apoptotic signaling, providing new insights into the mechanisms of dna damage response (ddr) in postmitotic neurons. |
2010-09-27 |
2023-08-12 |
Not clear |
| Lise Mattera, Céline Courilleau, Gaëlle Legube, Takeshi Ueda, Rikiro Fukunaga, Martine Chevillard-Briet, Yvan Canitrot, Fabrice Escaffit, Didier Trouch. The E1A-associated p400 protein modulates cell fate decisions by the regulation of ROS homeostasis. PLoS genetics. vol 6. issue 6. 2010-09-27. PMID:20548951. |
suppression of the dna damage response using a sirna against atm inhibits the effects of p400 on cell cycle progression, apoptosis, or senescence, demonstrating the importance of atm-dependent ddr pathways in cell fates control by p400. |
2010-09-27 |
2023-08-12 |
Not clear |
| Shiaw-Yih Lin, Yulong Liang, Kaiyi L. Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression. Yonsei medical journal. vol 51. issue 3. 2010-07-15. PMID:20376879. |
two central kinases for the ddr pathway are atm and atr, which can phosphorylate and activate many downstream proteins for cell cycle arrest, dna repair, or apoptosis if the damages are irreparable. |
2010-07-15 |
2023-08-12 |
mouse |
| J-L Perfettini, R Nardacci, C Séror, S Q Raza, S Sepe, H Saïdi, F Brottes, A Amendola, F Subra, F Del Nonno, L Chessa, A D'Incecco, M-L Gougeon, M Piacentini, G Kroeme. 53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope. Cell death and differentiation. vol 17. issue 5. 2010-06-28. PMID:19876065. |
it colocalizes partially with the promyelomonocytic leukemia protein (pml), and the ataxia telangiectasia mutated kinase (atm), the two components of the ddr that mediate apoptosis induced by the hiv-1 envelope. |
2010-06-28 |
2023-08-12 |
human |