| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Wang, Shunchang Wang, Xun Luo, Yanan Yang, Fenglei Jian, Xuemin Wang, Lucheng Xi. The roles of DNA damage-dependent signals and MAPK cascades in tributyltin-induced germline apoptosis in Caenorhabditis elegans. Chemosphere. vol 108. 2014-10-22. PMID:24534158. |
the present study indicated that tbt-induced apoptosis required the core apoptotic machinery, and that ddr genes and mapk pathways played essential roles in signaling the processes. |
2014-10-22 |
2023-08-12 |
caenorhabditis_elegans |
| Huijuan Liu, Dandan Bao, Xuechun Xia, Jenny Fung Ling Chau, Baojie L. An unconventional role of BMP-Smad1 signaling in DNA damage response: a mechanism for tumor suppression. Journal of cellular biochemistry. vol 115. issue 3. 2014-10-20. PMID:24142423. |
cells have evolved a dna damage response (ddr) system to sense dna damage, to halt cell cycle progression and repair the lesions, or to induce apoptosis if encountering irreparable damage. |
2014-10-20 |
2023-08-12 |
mouse |
| Mirella Tanori, Emanuela Pasquali, Simona Leonardi, Arianna Casciati, Paola Giardullo, Ilaria De Stefano, Mariateresa Mancuso, Anna Saran, Simonetta Pazzagli. Developmental and oncogenic radiation effects on neural stem cells and their differentiating progeny in mouse cerebellum. Stem cells (Dayton, Ohio). vol 31. issue 11. 2014-09-17. PMID:23897709. |
we found crucial differences in ddr and apoptosis between nscs and fate-restricted pcs, including lack of p21 expression in nscs. |
2014-09-17 |
2023-08-12 |
mouse |
| Maria Ermolaeva, Björn Schumache. The innate immune system as mediator of systemic DNA damage responses. Communicative & integrative biology. vol 6. issue 6. 2014-09-11. PMID:25210580. |
(1) cellular dna damage responses (ddr) mediate cell cycle arrest to allow time for dna repair, or induce cellular senescence and apoptosis to eliminate damaged cells. |
2014-09-11 |
2023-08-13 |
caenorhabditis_elegans |
| Pavel A Nikitin, Alexander M Price, Karyn McFadden, Christopher M Yan, Micah A Lufti. Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. PloS one. vol 9. issue 1. 2014-09-08. PMID:24498068. |
these two mitogens, but not ebv, modestly induced intrinsic apoptosis that was independent from the ddr. |
2014-09-08 |
2023-08-12 |
human |
| Kyle P Glover, Lauren K Markell, E Maria Donner, Xing Ha. Protein kinase C-activating tumor promoters modulate the DNA damage response in UVC-irradiated TK6 cells. Toxicology letters. vol 229. issue 1. 2014-09-08. PMID:24960060. |
nh32 (p53-null, isogenic to tk6) cells were resistant to the synergistic effects on apoptosis implicating p53 as a central mediator of the ddr modulating effects. |
2014-09-08 |
2023-08-13 |
human |
| Zhengwei Ma, Qingqing Wei, Guie Dong, Yuqing Huo, Zheng Don. DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells. Biochimica et biophysica acta. vol 1842. issue 7. 2014-07-24. PMID:24726884. |
the ddr is partially induced by apoptosis and oxidative stress-related dna damage. |
2014-07-24 |
2023-08-13 |
mouse |
| Larisa Pereboeva, Erik Westin, Toral Patel, Ian Flaniken, Lawrence Lamb, Aloysius Klingelhutz, Frederick Goldma. DNA damage responses and oxidative stress in dyskeratosis congenita. PloS one. vol 8. issue 10. 2014-05-22. PMID:24124565. |
apoptosis and reactive oxygen species (ros) were assessed by flow cytometry, and western blotting was used to measure expression of dna damage response (ddr) proteins, including total p53, p53s15, and p21(waf). |
2014-05-22 |
2023-08-12 |
human |
| Chang-Fu Yang, Li-Xia Peng, Tie-Jun Huang, Guang-Da Yang, Qiao-Qiao Chu, Ying-Ying Liang, Xue Cao, Ping Xie, Li-Sheng Zheng, Hong-Bing Huang, Mao-De Cai, Jia-Ling Huang, Ran-Yi Liu, Zhen-Yu Zhu, Chao-Nan Qian, Bi-Jun Huan. Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway. Cancer letters. vol 344. issue 2. 2014-03-24. PMID:24262659. |
our results also demonstrated that phosphorylation of the dna damage response (ddr) proteins, atm, chk1, chk2 and p53, was inactivated in the lmp1-induced cd44(+/high) cells in response to dna damage, and this was accompanied by a downregulation of the p53-targeted proapoptotic genes, which suggested that the inactivation of the p53-mediated apoptosis pathway was responsible for the radioresistance in the cd44(+/high) cells. |
2014-03-24 |
2023-08-12 |
Not clear |
| Anne Margriet Heijink, Małgorzata Krajewska, Marcel A T M van Vug. The DNA damage response during mitosis. Mutation research. vol 750. issue 1-2. 2014-01-22. PMID:23880065. |
alternatively, the ddr can mediate clearance of affected cells that are beyond repair through apoptosis or senescence. |
2014-01-22 |
2023-08-12 |
Not clear |
| Zbigniew Korwek, Anna Bielak-Zmijewska, Grazyna Mosieniak, Olga Alster, Maria Moreno-Villanueva, Alexander Burkle, Ewa Sikor. DNA damage-independent apoptosis induced by curcumin in normal resting human T cells and leukaemic Jurkat cells. Mutagenesis. vol 28. issue 4. 2014-01-16. PMID:23486648. |
we were interested in whether curcumin induces dna damage and the dna damage response (ddr) signalling pathway leading to apoptosis in normal resting human t cells. |
2014-01-16 |
2023-08-12 |
human |
| Yang Wang, Norman Sharpless, Sandy Chan. p16(INK4a) protects against dysfunctional telomere-induced ATR-dependent DNA damage responses. The Journal of clinical investigation. vol 123. issue 10. 2013-11-26. PMID:24091330. |
p16(ink4a) deletion enhanced the activation of the atr-dependent ddr in pot1bΔ/Δ hematopoietic cells, leading to p53 stabilization, increased p21-dependent cell cycle arrest, and elevated p53-dependent apoptosis. |
2013-11-26 |
2023-08-12 |
mouse |
| Dong Chen, Ayesha Siddiq, Luni Emdad, Devaraja Rajasekaran, Rachel Gredler, Xue-Ning Shen, Prasanna K Santhekadur, Jyoti Srivastava, Chadia L Robertson, Igor Dmitriev, Elena A Kashentseva, David T Curiel, Paul B Fisher, Devanand Sarka. Insulin-like growth factor-binding protein-7 (IGFBP7): a promising gene therapeutic for hepatocellular carcinoma (HCC). Molecular therapy : the journal of the American Society of Gene Therapy. vol 21. issue 4. 2013-11-01. PMID:23319057. |
ad.igfbp7 profoundly inhibited viability and induced apoptosis in multiple human hcc cell lines by inducing reactive oxygen species (ros) and activating a dna damage response (ddr) and p38 mapk. |
2013-11-01 |
2023-08-12 |
mouse |
| An Ning Cheng, Shih Sheng Jiang, Chi-Chen Fan, Yu-Kang Lo, Chan-Yen Kuo, Chung-Hsing Chen, Ying-Lan Liu, Chun-Chung Lee, Wei-Shone Chen, Tze-Sing Huang, Tao-Yeuan Wang, Alan Yueh-Luen Le. Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents. Cancer letters. vol 337. issue 2. 2013-09-27. PMID:23684929. |
cdc7 inhibits genotoxin-induced apoptosis and increases survival in cancer cells upon ddr, suggesting that high expression of cdc7 enhances the resistance to chemotherapy. |
2013-09-27 |
2023-08-12 |
Not clear |
| Giedre Krenciute, Shangfeng Liu, Nur Yucer, Yi Shi, Priscilla Ortiz, Qiongming Liu, Beom-Jun Kim, Abiola Ore Odejimi, Mei Leng, Jun Qin, Yi Wan. Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death. The Journal of biological chemistry. vol 288. issue 28. 2013-09-27. PMID:23723067. |
bcl2-associated athanogene 6 (bag6) is a member of the bag protein family, which is implicated in diverse cellular processes including apoptosis, co-chaperone, and dna damage response (ddr). |
2013-09-27 |
2023-08-12 |
Not clear |
| Shilpy Sharma, Corey M Helchowski, Christine E Canma. The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability. Mutation research. vol 743-744. 2013-09-19. PMID:23195997. |
the ddr is complex and includes activation of cell cycle checkpoints, dna repair, gene transcription, and induction of apoptosis. |
2013-09-19 |
2023-08-12 |
Not clear |
| David R Raleigh, Daphne A Haas-Koga. Molecular targets and mechanisms of radiosensitization using DNA damage response pathways. Future oncology (London, England). vol 9. issue 2. 2013-08-01. PMID:23414472. |
activated by a variety of dna lesions, the ddr orchestrates cell cycle arrest and dna repair, and initiates apoptosis in instances where damage cannot be repaired. |
2013-08-01 |
2023-08-12 |
Not clear |
| Jordi Carreras Puigvert, Louise von Stechow, Ramakrishnaiah Siddappa, Alex Pines, Mahnoush Bahjat, Lizette C J M Haazen, Jesper V Olsen, Harry Vrieling, John H N Meerman, Leon H F Mullenders, Bob van de Water, Erik H J Dane. Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells. Science signaling. vol 6. issue 259. 2013-07-04. PMID:23354688. |
together, our findings reveal a balance between p53-mediated elimination of stem cells (through loss of pluripotency and apoptosis) and wnt signaling that attenuates this response to tune the outcome of the ddr. |
2013-07-04 |
2023-08-12 |
mouse |
| T Shimura, N Noma, T Oikawa, Y Ochiai, S Kakuda, Y Kuwahara, Y Takai, A Takahashi, M Fukumot. Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells. Oncogenesis. vol 1. 2013-04-04. PMID:23552696. |
radioresistance, which is a major cause of failure of radiotherapy (rt), is proposed as one of the intrinsic characteristics of cancer stem cells (cscs) whose unique dna damage response (ddr), efficient dna repair and resistance to apoptosis are thought to confer the phenotype. |
2013-04-04 |
2023-08-12 |
mouse |
| Z Korwek, T Sewastianik, A Bielak-Zmijewska, G Mosieniak, O Alster, M Moreno-Villanueva, M Moreno-Villaneuva, A Burkle, E Sikor. Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells. DNA repair. vol 11. issue 11. 2013-03-27. PMID:23058634. |
lymphoblastoid leukemic jurkat cells, as cycling cells, were more sensitive to etoposide considering the level of dna damage, ddr and apoptosis. |
2013-03-27 |
2023-08-12 |
human |