| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jordi Carreras Puigvert, Louise von Stechow, Ramakrishnaiah Siddappa, Alex Pines, Mahnoush Bahjat, Lizette C J M Haazen, Jesper V Olsen, Harry Vrieling, John H N Meerman, Leon H F Mullenders, Bob van de Water, Erik H J Dane. Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells. Science signaling. vol 6. issue 259. 2013-07-04. PMID:23354688. |
together, our findings reveal a balance between p53-mediated elimination of stem cells (through loss of pluripotency and apoptosis) and wnt signaling that attenuates this response to tune the outcome of the ddr. |
2013-07-04 |
2023-08-12 |
mouse |
| T Shimura, N Noma, T Oikawa, Y Ochiai, S Kakuda, Y Kuwahara, Y Takai, A Takahashi, M Fukumot. Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells. Oncogenesis. vol 1. 2013-04-04. PMID:23552696. |
radioresistance, which is a major cause of failure of radiotherapy (rt), is proposed as one of the intrinsic characteristics of cancer stem cells (cscs) whose unique dna damage response (ddr), efficient dna repair and resistance to apoptosis are thought to confer the phenotype. |
2013-04-04 |
2023-08-12 |
mouse |
| Z Korwek, T Sewastianik, A Bielak-Zmijewska, G Mosieniak, O Alster, M Moreno-Villanueva, M Moreno-Villaneuva, A Burkle, E Sikor. Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells. DNA repair. vol 11. issue 11. 2013-03-27. PMID:23058634. |
lymphoblastoid leukemic jurkat cells, as cycling cells, were more sensitive to etoposide considering the level of dna damage, ddr and apoptosis. |
2013-03-27 |
2023-08-12 |
human |
| Z Korwek, T Sewastianik, A Bielak-Zmijewska, G Mosieniak, O Alster, M Moreno-Villanueva, M Moreno-Villaneuva, A Burkle, E Sikor. Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells. DNA repair. vol 11. issue 11. 2013-03-27. PMID:23058634. |
altogether our results show that ku 55933 blocks ddr and apoptosis induced by etoposide in normal resting t cells, but increased cytotoxic effect on proliferating leukemic jurkat cells. |
2013-03-27 |
2023-08-12 |
human |
| Joo-Shik Shin, Thein Ga Tut, Tao Yang, C Soon Le. Radiotherapy response in microsatellite instability related rectal cancer. Korean journal of pathology. vol 47. issue 1. 2013-03-14. PMID:23482947. |
at the cellular level, radiation injury initiates a complex molecular network of dna damage response (ddr) pathways that leads to cell cycle arrest, attempts at re-constituting the damaged dna and should this fail, then apoptosis. |
2013-03-14 |
2023-08-12 |
Not clear |
| Yulin Chen, Dan Li, Dapeng Wang, Xuefeng Liu, Ning Yin, Yongmei Song, Shih Hsin Lu, Zhenyu Ju, Qimin Zha. Quiescence and attenuated DNA damage response promote survival of esophageal cancer stem cells. Journal of cellular biochemistry. vol 113. issue 12. 2013-03-08. PMID:22711554. |
conclusively, we infer that the damage-resistance ability of ecscs is likely attributed to their slow-cycling status and avoidance of apoptosis or senescence triggered by an excessive ddr. |
2013-03-08 |
2023-08-12 |
Not clear |
| Rainer Poltz, Michael Nauman. Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention. BMC systems biology. vol 6. 2013-02-20. PMID:22979979. |
in addition, apoptosis could be counteracted by nuclear factor kappa b (nf-κb), the main anti-apoptotic transcription factor in the ddr. |
2013-02-20 |
2023-08-12 |
Not clear |
| Michelle Badura, Steve Braunstein, Jiri Zavadil, Robert J Schneide. DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 46. 2013-02-01. PMID:23112151. |
increased expression of eif4g1, common in breast cancers, was found to selectively increase translation of mrnas involved in cell survival and the ddr, preventing autophagy and apoptosis [survivin, hypoxia inducible factor 1α (hif1α), x-linked inhibitor of apoptosis (xiap)], promoting cell cycle arrest [growth arrest and dna damage protein 45a (gadd45a), protein 53 (p53), atr-interacting protein (atrip), check point kinase 1 (chk1)] and dna repair [p53 binding protein 1 (53bp1), breast cancer associated proteins 1, 2 (brca1/2), poly-adp ribose polymerase (parp), replication factor c2-5 (rfc2-5), ataxia telangiectasia mutated gene 1 (atm), meiotic recombination protein 11 (mre-11), and others]. |
2013-02-01 |
2023-08-12 |
Not clear |
| Jonathan K Mitchell, Paul D Friese. Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication. Journal of virology. vol 86. issue 24. 2013-01-28. PMID:23035220. |
to define the proapoptotic pathway and its role in antivirus defense, we investigated the link between the host's dna damage response (ddr) and apoptosis. |
2013-01-28 |
2023-08-12 |
drosophila_melanogaster |
| Jonathan K Mitchell, Paul D Friese. Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication. Journal of virology. vol 86. issue 24. 2013-01-28. PMID:23035220. |
the ddr kinase inhibitors caffeine and ku55933 also prevented virus-induced apoptosis in cells derived from the permissive acmnpv host, spodoptera frugiperda. |
2013-01-28 |
2023-08-12 |
drosophila_melanogaster |
| Fanny Caputo, Rolando Vegliante, Lina Ghibell. Redox modulation of the DNA damage response. Biochemical pharmacology. vol 84. issue 10. 2013-01-18. PMID:22846600. |
lesions to dna trigger the dna-damage response (ddr), a complex, multi-branched cell-intrinsic process targeted to dna repair, or elimination of the damaged cells by apoptosis. |
2013-01-18 |
2023-08-12 |
Not clear |
| Alexandros Sfikas, Christina Batsi, Evangelia Tselikou, George Vartholomatos, Nikolaos Monokrousos, Periklis Pappas, Savvas Christoforidis, Theodoros Tzavaras, Panagiotis Kanavaros, Vassilis G Gorgoulis, Kenneth B Marcu, Evangelos Koletta. The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage. Cellular signalling. vol 24. issue 11. 2013-01-09. PMID:22750558. |
dna damage responses (ddr) invoke senescence or apoptosis depending on stimulus intensity and the degree of activation of the p53-p21(cip1/waf1) axis; but the functional impact of nf-κb signaling on these different outcomes in normal vs. human cancer cells remains poorly understood. |
2013-01-09 |
2023-08-12 |
human |
| Alexandros Sfikas, Christina Batsi, Evangelia Tselikou, George Vartholomatos, Nikolaos Monokrousos, Periklis Pappas, Savvas Christoforidis, Theodoros Tzavaras, Panagiotis Kanavaros, Vassilis G Gorgoulis, Kenneth B Marcu, Evangelos Koletta. The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage. Cellular signalling. vol 24. issue 11. 2013-01-09. PMID:22750558. |
however, ros-mediated ddr eventually culminated in different end points with hdfs undergoing premature senescence and a549 cancer cells succumbing to apoptosis. |
2013-01-09 |
2023-08-12 |
human |
| Jason M Beckta, Scott C Henderson, Kristoffer Valeri. Two- and three-dimensional live cell imaging of DNA damage response proteins. Journal of visualized experiments : JoVE. issue 67. 2012-12-27. PMID:23052275. |
when stimulated, the ddr works to preserve genomic integrity by triggering cell cycle arrest to allow for repair to take place or force the cell to undergo apoptosis. |
2012-12-27 |
2023-08-12 |
Not clear |
| Stefan Brunner, Dietmar Herndler-Brandstetter, Christoph R Arnold, Gerrit Jan Wiegers, Andreas Villunger, Matthias Hackl, Johannes Grillari, María Moreno-Villanueva, Alexander Bürkle, Beatrix Grubeck-Loebenstei. Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death. Aging cell. vol 11. issue 4. 2012-11-13. PMID:22435726. |
following treatment with the classic chemotherapeutic agent etoposide, a topoisomerase ii inhibitor, apoptosis was increased in cd8(+) cd28(-) when compared to cd8(+) cd28(+) t cells and correlated with an impaired ddr in this cell type. |
2012-11-13 |
2023-08-12 |
Not clear |
| Weibin Zhou, Edgar A Otto, Andrew Cluckey, Rannar Airik, Toby W Hurd, Moumita Chaki, Katrina Diaz, Francis P Lach, Geoffrey R Bennett, Heon Yung Gee, Amiya K Ghosh, Sivakumar Natarajan, Supawat Thongthip, Uma Veturi, Susan J Allen, Sabine Janssen, Gokul Ramaswami, Joanne Dixon, Felix Burkhalter, Martin Spoendlin, Holger Moch, Michael J Mihatsch, Jerome Verine, Richard Reade, Hany Soliman, Michel Godin, Denes Kiss, Guido Monga, Gianna Mazzucco, Kerstin Amann, Ferruh Artunc, Ronald C Newland, Thorsten Wiech, Stefan Zschiedrich, Tobias B Huber, Andreas Friedl, Gisela G Slaats, Jaap A Joles, Roel Goldschmeding, Joseph Washburn, Rachel H Giles, Shawn Levy, Agata Smogorzewska, Friedhelm Hildebrand. FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair. Nature genetics. vol 44. issue 8. 2012-10-09. PMID:22772369. |
depletion of fan1 in zebrafish caused increased ddr, apoptosis and kidney cysts. |
2012-10-09 |
2023-08-12 |
zebrafish |
| P T Ferrao, E P Bukczynska, R W Johnstone, G A McArthu. Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells. Oncogene. vol 31. issue 13. 2012-05-31. PMID:21841818. |
eμ-myc lymphoma cells showed a dramatic increase in the extent of dna damage and dna damage response (ddr) signalling within 1 h of treatment with chk1 inhibitors followed by caspase-dependent apoptosis and cell death. |
2012-05-31 |
2023-08-12 |
Not clear |
| Sung Hee Jang, Joo Weon Lim, Tomohiro Morio, Hyeyoung Ki. Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells. Free radical biology & medicine. vol 52. issue 3. 2012-05-17. PMID:22178412. |
the dna damage response (ddr) coordinates cell-cycle transitions, dna repair, and apoptosis through the activation of ataxia-telangiectasia-mutated (atm) and atm and rad3-related (atr) and their target proteins. |
2012-05-17 |
2023-08-12 |
Not clear |
| Sung Hee Jang, Joo Weon Lim, Tomohiro Morio, Hyeyoung Ki. Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells. Free radical biology & medicine. vol 52. issue 3. 2012-05-17. PMID:22178412. |
lycopene inhibited h. pylori-induced increases in ros, apoptosis, alterations in cell-cycle distribution, dsbs, and atm- and atr-mediated ddr in ags cells. |
2012-05-17 |
2023-08-12 |
Not clear |
| H Christian Reinhardt, Björn Schumache. The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends in genetics : TIG. vol 28. issue 3. 2012-04-13. PMID:22265392. |
dna damage response (ddr) pathways that are mediated through the tumor suppressor p53 play an important role in the cell-intrinsic responses to genome instability, including a transient cell cycle arrest, senescence and apoptosis. |
2012-04-13 |
2023-08-12 |
Not clear |