| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seon-Hee Oh, Sung-Chul Li. A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation. Toxicology and applied pharmacology. vol 212. issue 3. 2006-06-01. PMID:16169029. |
taken together, a rapid and transient ros generation by cd triggers apoptosis via caspase-dependent pathway and subsequent mitochondrial pathway. |
2006-06-01 |
2023-08-12 |
Not clear |
| C Geeth Gunawardana, Raul E Martinez, Weiqun Xiao, Douglas M Templeto. Cadmium inhibits both intrinsic and extrinsic apoptotic pathways in renal mesangial cells. American journal of physiology. Renal physiology. vol 290. issue 5. 2006-05-22. PMID:16263807. |
we investigated the effects of cd(2+) on rat mesangial cells induced to undergo apoptosis through either the extrinsic receptor-mediated pathway or the intrinsic mitochondrial-dependent pathway. |
2006-05-22 |
2023-08-12 |
rat |
| Daniel C Lee, Fran T Close, Carl B Goodman, Inneke M Jackson, Ceceile Wight-Mason, Lateesha M Wells, Tracy A Womble, Donald E Pal. Enhanced cystatin C and lysosomal protease expression following 6-hydroxydopamine exposure. Neurotoxicology. vol 27. issue 2. 2006-05-22. PMID:16414118. |
thus, these results suggest that apoptosis induced by 6-ohda exposure is mediated in part through caspase 3 activation and lysosomal protease cd. |
2006-05-22 |
2023-08-12 |
Not clear |
| Joanna Decker. Cadmium toxicity in plants: is there any analogy to its carcinogenic effect in mammalian cells? Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 18. issue 5. 2006-04-25. PMID:16333748. |
the following issues are discussed: cellular uptake of cd ions, their intracellular transport, the effects on cellular signaling, nucleic acids and proteins, modification of gene expression, cell cycle control and apoptosis. |
2006-04-25 |
2023-08-12 |
human |
| Joanna Decker. Cadmium toxicity in plants: is there any analogy to its carcinogenic effect in mammalian cells? Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 18. issue 5. 2006-04-25. PMID:16333748. |
reviewed data suggest that such features as: ability to remove the oxidized proteins, slightly different regulation of cell cycle genes, specific pattern of apoptosis, makes plants resistant to cd(2+)-induced uncontrolled cell proliferation. |
2006-04-25 |
2023-08-12 |
human |
| Ivan Monteleone, Giovanni Monteleone, Daniele Fina, Roberta Caruso, Carmelina Petruzziello, Emma Calabrese, Livia Biancone, Francesco Pallon. A functional role of flip in conferring resistance of Crohn's disease lamina propria lymphocytes to FAS-mediated apoptosis. Gastroenterology. vol 130. issue 2. 2006-04-13. PMID:16472594. |
there is evidence that, in crohn's disease (cd), lamina propria t lymphocytes (lpls) are resistant to fas-mediated apoptosis and that this defect contributes to the mucosal t-cell accumulation. |
2006-04-13 |
2023-08-12 |
Not clear |
| Ivan Monteleone, Giovanni Monteleone, Daniele Fina, Roberta Caruso, Carmelina Petruzziello, Emma Calabrese, Livia Biancone, Francesco Pallon. A functional role of flip in conferring resistance of Crohn's disease lamina propria lymphocytes to FAS-mediated apoptosis. Gastroenterology. vol 130. issue 2. 2006-04-13. PMID:16472594. |
in this study we examined the functional role of flip, a flice inhibitor protein, in the resistance of cd lpl to fas-mediated apoptosis. |
2006-04-13 |
2023-08-12 |
Not clear |
| Neelima Pathak, Shashi Khandelwa. Oxidative stress and apoptotic changes in murine splenocytes exposed to cadmium. Toxicology. vol 220. issue 1. 2006-03-16. PMID:16413650. |
hence, to delineate the action of cd, mouse splenic lymphocytes were exposed to cd (10, 25 and 50 microm) for 60 min, 1.5, 3, 6 and 18 h. at 6 h, apoptosis was reflected by dna fragmentation, increased sub-g1 population (apoptotic dna) and apoptotic cells (annexin v binding assay). |
2006-03-16 |
2023-08-12 |
mouse |
| Seon-Hee Oh, Jeong-Eun Choi, Sung-Chul Li. Protection of betulin against cadmium-induced apoptosis in hepatoma cells. Toxicology. vol 220. issue 1. 2006-03-16. PMID:16436312. |
taken together, it was found that cd can induce apoptosis via the fas-dependent and -independent apoptosis pathways. |
2006-03-16 |
2023-08-12 |
human |
| Kuo-Ching Yang, Chi-Chen Wu, Chih-Hsiung Wu, Jur-Hao Chen, Chien-Hwa Chu, Chien-Ho Chen, Yean-Hwei Chou, Ying-Jan Wang, Wen-Sen Lee, How Tseng, Shyr-Yi Lin, Chia-Hwa Lee, Yuan-Soon H. Involvement of proapoptotic Bcl-2 family members in terbinafine-induced mitochondrial dysfunction and apoptosis in HL60 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 44. issue 2. 2006-03-15. PMID:16125830. |
in addition, our results also revealed that tb-induced apoptosis was not through the cellular surface cd 95 receptor-mediated signaling pathway. |
2006-03-15 |
2023-08-12 |
human |
| Naoki Makino, Toyoki Maeda, Masahiro Sugano, Shinji Satoh, Reiko Watanabe, Nobuyuki Ab. High serum TNF-alpha level in Type 2 diabetic patients with microangiopathy is associated with eNOS down-regulation and apoptosis in endothelial cells. Journal of diabetes and its complications. vol 19. issue 6. 2006-02-03. PMID:16260352. |
enos down-regulation and apoptosis were seen in huvecs incubated with serum from cd for 24 h, but those observations were completely counteracted in the incubation by the addition of the antihuman tnf-alpha antibody. |
2006-02-03 |
2023-08-12 |
human |
| Hiroaki It. Novel therapy for Crohn's disease targeting IL-6 signalling. Expert opinion on therapeutic targets. vol 8. issue 4. 2006-01-16. PMID:15268624. |
to pursue the therapeutic potential of il-6 signalling blockade for cd, anti-il-6r monoclonal antibody (mab) was introduced to experimental colitis, and successfully prevented and treated intestinal inflammation by suppressing vascular adhesion molecules and by inducing lamina propria t cell apoptosis. |
2006-01-16 |
2023-08-12 |
Not clear |
| Christine L Powell, Oksana Kosyk, Blair U Bradford, Joel S Parker, Edward K Lobenhofer, Ayumi Denda, Fumiyuki Uematsu, Dai Nakae, Ivan Rusy. Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury. Hepatology (Baltimore, Md.). vol 42. issue 5. 2005-12-09. PMID:16250055. |
the choline-deficient (cd) model of rodent hcc involves the consecutive emergence of a fatty liver, apoptosis, compensatory proliferation, fibrosis, and cirrhosis that is markedly similar to the sequence of events typified by human hcc. |
2005-12-09 |
2023-08-12 |
human |
| Wei-Xing Guo, Quentin N Pye, Kelly S Williamson, Charles A Stewart, Kenneth L Hensley, Yashige Kotake, Robert A Floyd, Robert H Broyle. Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes. Free radical biology & medicine. vol 39. issue 5. 2005-11-23. PMID:16085182. |
our recent studies have demonstrated that generation of ros is associated with choline deficiency (cd)-induced apoptosis in cwsv-1 cells, an immortalized rat hepatocyte that becomes tumorigenic by stepwise culturing in decreasing levels of choline. |
2005-11-23 |
2023-08-12 |
rat |
| Wei-Xing Guo, Quentin N Pye, Kelly S Williamson, Charles A Stewart, Kenneth L Hensley, Yashige Kotake, Robert A Floyd, Robert H Broyle. Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes. Free radical biology & medicine. vol 39. issue 5. 2005-11-23. PMID:16085182. |
in order to investigate further the relationship among the cd-induced ros, mmp collapse, and apoptosis, we examined the effects of different inhibitors on ros production, mmp disruption, and apoptosis in cd or hc-cultured cwsv-1 cells. |
2005-11-23 |
2023-08-12 |
rat |
| Begoña Diosdado, Erica van Oort, Cisca Wijmeng. "Coelionomics": towards understanding the molecular pathology of coeliac disease. Clinical chemistry and laboratory medicine. vol 43. issue 7. 2005-11-22. PMID:16207126. |
four mechanisms, namely apoptosis, oxidative stress, matrix metalloproteinases and dysregulation of proliferation and differentiation, are thought to play a role in the pathophysiology of cd. |
2005-11-22 |
2023-08-12 |
Not clear |
| S Lísová, J Ehrmann, A Kolek, E Sedláková, Z Kolá. [Immunohistochemical study of the apoptotic and proliferative mechanisms in the intestinal mucosa during coeliac disease]. Ceskoslovenska patologie. vol 41. issue 3. 2005-11-08. PMID:16161453. |
the aim of this study was to analyze the expression of proteins regulating apoptosis and some markers of proliferation in the mucosa of the small intestine of children with active (acd) and latent form (lcd) of coeliac disease (cd). |
2005-11-08 |
2023-08-12 |
Not clear |
| S Lísová, J Ehrmann, A Kolek, E Sedláková, Z Kolá. [Immunohistochemical study of the apoptotic and proliferative mechanisms in the intestinal mucosa during coeliac disease]. Ceskoslovenska patologie. vol 41. issue 3. 2005-11-08. PMID:16161453. |
our findings showed that fas/fas-l, bcl-2, and cas 8 may be involved in modulation of apoptosis during cd. |
2005-11-08 |
2023-08-12 |
Not clear |
| S Lísová, J Ehrmann, A Kolek, E Sedláková, Z Kolá. [Immunohistochemical study of the apoptotic and proliferative mechanisms in the intestinal mucosa during coeliac disease]. Ceskoslovenska patologie. vol 41. issue 3. 2005-11-08. PMID:16161453. |
increased ttg expression may be an early sign of increased apoptosis or may be related to its role in cd pathogenesis. |
2005-11-08 |
2023-08-12 |
Not clear |
| Paola Gavazzo, Elisabetta Morelli, Carla Marchett. Susceptibility of insulinoma cells to cadmium and modulation by L-type calcium channels. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 18. issue 2. 2005-11-07. PMID:15954739. |
cadmium (cd), a toxic metal that induces apoptosis and necrosis in a variety of cells, accumulates in pancreas and may be a cause of diabetes in humans. |
2005-11-07 |
2023-08-12 |
Not clear |