| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ronojoy Sen Gupta, Jisun Kim, Cynthia Gomes, Sungdug Oh, Juran Park, Wook-Bin Im, Jae Young Seong, Ryun Sup Ahn, Hyuk-Bang Kwon, Jaemog So. Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats. Molecular and cellular endocrinology. vol 221. issue 1-2. 2005-01-18. PMID:15223132. |
tunel assay showed that low doses of cd (0.13 and 0.15 mg/100g bw) exhibited typical characteristics of apoptosis while high doses of cd caused more necrosis than apoptosis. |
2005-01-18 |
2023-08-12 |
rat |
| Jaime García de Tena, Luis Manzano, Juan Carlos Leal, Esther San Antonio, Verónica Sualdea, Melchor Alvarez-Mo. Active Crohn's disease patients show a distinctive expansion of circulating memory CD4+CD45RO+CD28null T cells. Journal of clinical immunology. vol 24. issue 2. 2005-01-04. PMID:15024186. |
we analyzed in peripheral blood cd4(+)cd45ro(+) t cells from cd patients the expression of surface markers associated to immune activation, costimulation, and apoptosis. |
2005-01-04 |
2023-08-12 |
human |
| Jaime García de Tena, Luis Manzano, Juan Carlos Leal, Esther San Antonio, Verónica Sualdea, Melchor Alvarez-Mo. Active Crohn's disease patients show a distinctive expansion of circulating memory CD4+CD45RO+CD28null T cells. Journal of clinical immunology. vol 24. issue 2. 2005-01-04. PMID:15024186. |
significantly lower frequencies of memory cd4(+)cd45ro(+) t cells expressing cd95 apoptosis receptor were found in patients with active cd. |
2005-01-04 |
2023-08-12 |
human |
| Jaime García de Tena, Luis Manzano, Juan Carlos Leal, Esther San Antonio, Verónica Sualdea, Melchor Alvarez-Mo. Active Crohn's disease patients show a distinctive expansion of circulating memory CD4+CD45RO+CD28null T cells. Journal of clinical immunology. vol 24. issue 2. 2005-01-04. PMID:15024186. |
according to our data, circulating t lymphocytes from active cd patients show distinctive phenotypic and functional changes, characterized by an expansion of memory cd4(+)cd45ro(+)cd28(null) t cells expressing effector-associated cell surface molecules and displaying enhanced resistance to apoptosis. |
2005-01-04 |
2023-08-12 |
human |
| I M Sokolova, S Evans, F M Hughe. Cadmium-induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition. The Journal of experimental biology. vol 207. issue Pt 19. 2004-12-23. PMID:15326213. |
since cd(2+) is known to induce apoptosis in immune cells of vertebrates, we have investigated the effects of this metal on isolated oyster hemocytes, the main cellular immune defense in mollusks. |
2004-12-23 |
2023-08-12 |
Not clear |
| I M Sokolova, S Evans, F M Hughe. Cadmium-induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition. The Journal of experimental biology. vol 207. issue Pt 19. 2004-12-23. PMID:15326213. |
cd(2+) exposure induced apoptosis in oyster hemocytes in a dose-dependent manner in the range of 10-100 micromol l(-1), as indicated by the translocation of phosphatidylserine to the outer leaflet of the plasma membrane. |
2004-12-23 |
2023-08-12 |
Not clear |
| I M Sokolova, S Evans, F M Hughe. Cadmium-induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition. The Journal of experimental biology. vol 207. issue Pt 19. 2004-12-23. PMID:15326213. |
the results demonstrate that the important environmental pollutant cd(2+) induces apoptosis in oyster immune cells and does so through a mitochondria/caspase-independent pathway, suggesting that a novel, perhaps ancient, apoptotic pathway is active in these cells. |
2004-12-23 |
2023-08-12 |
Not clear |
| J Doering, B Begue, M J Lentze, F Rieux-Laucat, O Goulet, J Schmitz, N Cerf-Bensussan, F M Ruemmel. Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn's disease. Gut. vol 53. issue 11. 2004-12-02. PMID:15479684. |
in the present work, we aimed to analyse the effects and underlying molecular mechanisms of 5-amino salicylic acid (5-asa) and derivatives on apoptosis of lpl and peripheral blood lymphocytes (pbl) in patients with cd compared with ulcerative colitis (uc) and in non-inflammatory controls. |
2004-12-02 |
2023-08-12 |
Not clear |
| Seon-Hee Oh, Byung-Hoon Lee, Sung-Chul Li. Cadmium induces apoptotic cell death in WI 38 cells via caspase-dependent Bid cleavage and calpain-mediated mitochondrial Bax cleavage by Bcl-2-independent pathway. Biochemical pharmacology. vol 68. issue 9. 2004-11-23. PMID:15450950. |
previous reports have demonstrated that cadmium (cd) may induce cell death via apoptosis, but the mechanism responsible for cellular death is not clear. |
2004-11-23 |
2023-08-12 |
Not clear |
| C Risso-de Faverney, N Orsini, G de Sousa, R Rahman. Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: involvement of oxidative stress. Aquatic toxicology (Amsterdam, Netherlands). vol 69. issue 3. 2004-10-20. PMID:15276330. |
cadmium (cd) induces oxidative stress and apoptosis in trout hepatocytes. |
2004-10-20 |
2023-08-12 |
Not clear |
| C Risso-de Faverney, N Orsini, G de Sousa, R Rahman. Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: involvement of oxidative stress. Aquatic toxicology (Amsterdam, Netherlands). vol 69. issue 3. 2004-10-20. PMID:15276330. |
we also found that the expression of anti-apoptotic protein bcl-xl, known to be regulated under mild oxidative stress to protect cells from apoptosis, did not change after 3 and 6 h exposure to cd, then increased after 24 and 48 h exposure to 10 microm cd. |
2004-10-20 |
2023-08-12 |
Not clear |
| C Risso-de Faverney, N Orsini, G de Sousa, R Rahman. Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: involvement of oxidative stress. Aquatic toxicology (Amsterdam, Netherlands). vol 69. issue 3. 2004-10-20. PMID:15276330. |
taken together, these data clearly evidenced the key role of mitochondria in the cascade of events leading to trout hepatocyte apoptosis in response to cd and the relationship that exists between oxidative stress and cell death. |
2004-10-20 |
2023-08-12 |
Not clear |
| Chwen-Ming Shih, Wun-Chang Ko, Jui-Sheng Wu, Yau-Huei Wei, Leng-Fang Wang, E-E Chang, Tsui-Yun Lo, Huey-Hwa Cheng, Chien-Tsu Che. Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts. Journal of cellular biochemistry. vol 91. issue 2. 2004-10-19. PMID:14743397. |
our previous report demonstrated that 100 microm cd induces mrc-5 cells, normal human lung fibroblasts, to undergo caspase-independent apoptosis mediated by mitochondrial membrane depolarization and translocation of apoptosis-inducing factor (aif) from mitochondria into the nucleus. |
2004-10-19 |
2023-08-12 |
human |
| Chwen-Ming Shih, Wun-Chang Ko, Jui-Sheng Wu, Yau-Huei Wei, Leng-Fang Wang, E-E Chang, Tsui-Yun Lo, Huey-Hwa Cheng, Chien-Tsu Che. Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts. Journal of cellular biochemistry. vol 91. issue 2. 2004-10-19. PMID:14743397. |
here, using benzyloxycarbonyl-val-ala-asp-(ome) fluoromethyl ketone (z-vad.fmk) as a tool, we further demonstrated that cd could induce caspase-independent apoptosis at concentrations varied from 25 to 150 microm, which was modulated by reactive oxygen species (ros) scavengers, such as n-acetylcysteine (nac), mannitol, and tiron, indicating that ros play a crucial role in the apoptogenic activity of cd. |
2004-10-19 |
2023-08-12 |
human |
| Chwen-Ming Shih, Wun-Chang Ko, Jui-Sheng Wu, Yau-Huei Wei, Leng-Fang Wang, E-E Chang, Tsui-Yun Lo, Huey-Hwa Cheng, Chien-Tsu Che. Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts. Journal of cellular biochemistry. vol 91. issue 2. 2004-10-19. PMID:14743397. |
in summary, this study demonstrated that, in mrc-5 fibroblasts, cd induced caspase-independent apoptosis through a mitochondria-ros pathway. |
2004-10-19 |
2023-08-12 |
human |
| Jie Bai, Zong-hong Shao, Hong Liu, Jun Shi, Guang-sheng He, Yan-ran Cao, Mei-feng Tu, Zhen-zhu Cui, Hai-rong Jia, Juan Sun, Lin-sheng Qian, Tian-ying Yang, Chong-li Yan. [Apoptosis and proliferation of CD34 positive bone marrow cells in patients with polycythemia vera]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. vol 25. issue 4. 2004-09-23. PMID:15182553. |
to study the apoptosis and proliferation of cd(34) positive (cd(34)(+)) bone marrow cells (bmc) in patients with polycythemia vera (pv). |
2004-09-23 |
2023-08-12 |
Not clear |
| Shiro Jimi, Masanobu Uchiyama, Aya Takaki, Jyunji Suzumiya, Syuji Har. Mechanisms of cell death induced by cadmium and arsenic. Annals of the New York Academy of Sciences. vol 1011. 2004-06-17. PMID:15126309. |
however, when buthionine sulfoximine (bso) was added to the metal-tolerant cultures, apoptosis was restored in both cd-t and as-t. our results indicate that (1) although gsh is increased in nrk52e by the addition of cd and as, mitochondria-mediated apoptosis can be still induced, (2) the protective property against metal-induced cytotoxicity is identical in cd-t and as-t cultures, and (3) although gsh was higher in the metal-tolerant cell lines, depression of gsh by bso induced apoptosis. |
2004-06-17 |
2023-08-12 |
rat |
| Momoko Yamada, Yoshiko Banno, Yoh Takuwa, Masahiro Koda, Akira Hara, Yoshinori Nozaw. Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells. The Biochemical journal. vol 378. issue Pt 2. 2004-05-19. PMID:14640974. |
treatment of s1p3-cho cells with actd (actinomycin d) induced apoptosis, as shown by the occurrence of nuclear fragmentation and the caspase-dependent proteolytic cleavage of parp [poly(adp-ribose) polymerase] and protein kinase cd. |
2004-05-19 |
2023-08-12 |
Not clear |
| Momoko Yamada, Yoshiko Banno, Yoh Takuwa, Masahiro Koda, Akira Hara, Yoshinori Nozaw. Overexpression of phospholipase D prevents actinomycin D-induced apoptosis through potentiation of phosphoinositide 3-kinase signalling pathways in Chinese-hamster ovary cells. The Biochemical journal. vol 378. issue Pt 2. 2004-05-19. PMID:14640974. |
overexpression of either pld1 or pld2 protected s1p3-cho cells from actd-induced apoptosis, as demonstrated by an increased number of viable cells and inhibition of parp and protein kinase cd cleavage. |
2004-05-19 |
2023-08-12 |
Not clear |
| P Maerten, C Shen, S Colpaert, Z Liu, D A M Bullens, G van Assche, F Penninckx, K Geboes, G Vanham, P Rutgeerts, J L Ceuppen. Involvement of interleukin 18 in Crohn's disease: evidence from in vitro analysis of human gut inflammatory cells and from experimental colitis models. Clinical and experimental immunology. vol 135. issue 2. 2004-03-10. PMID:14738461. |
we conclude that il-18 clearly has a modulatory role in the inflammatory cascade of cd and experimental colitis by affecting ifn-gamma and il-10 production, and apoptosis. |
2004-03-10 |
2023-08-12 |
mouse |