| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Shimoda, T Nagamine, H Takagi, M Mori, M P Waalke. Induction of apoptosis in cells by cadmium: quantitative negative correlation between basal or induced metallothionein concentration and apoptotic rate. Toxicological sciences : an official journal of the Society of Toxicology. vol 64. issue 2. 2002-04-01. PMID:11719703. |
metallothionein (mt) often reduces the adverse effects of cadmium (cd), but how it may alter cd-induced apoptosis is unclear. |
2002-04-01 |
2023-08-12 |
human |
| R Shimoda, T Nagamine, H Takagi, M Mori, M P Waalke. Induction of apoptosis in cells by cadmium: quantitative negative correlation between basal or induced metallothionein concentration and apoptotic rate. Toxicological sciences : an official journal of the Society of Toxicology. vol 64. issue 2. 2002-04-01. PMID:11719703. |
the goal of this study was to define the role of mt in cd-induced apoptosis using cell lines with widely varying sensitivity to cd. |
2002-04-01 |
2023-08-12 |
human |
| R Shimoda, T Nagamine, H Takagi, M Mori, M P Waalke. Induction of apoptosis in cells by cadmium: quantitative negative correlation between basal or induced metallothionein concentration and apoptotic rate. Toxicological sciences : an official journal of the Society of Toxicology. vol 64. issue 2. 2002-04-01. PMID:11719703. |
when mt was measured, there was a highly significant negative linear correlation between the basal cellular mt concentration or cd-induced mt and the rate of apoptosis induced by cd in these cell lines. |
2002-04-01 |
2023-08-12 |
human |
| R Shimoda, T Nagamine, H Takagi, M Mori, M P Waalke. Induction of apoptosis in cells by cadmium: quantitative negative correlation between basal or induced metallothionein concentration and apoptotic rate. Toxicological sciences : an official journal of the Society of Toxicology. vol 64. issue 2. 2002-04-01. PMID:11719703. |
these findings revealed that basal or induced mt perturbs cd-induced apoptotic cell death in various cell lines, and a strong negative correlation exists between cellular mt content and the rate of apoptosis induced by cd. |
2002-04-01 |
2023-08-12 |
human |
| S Dong, H M Shen, C N On. Cadmium-induced apoptosis and phenotypic changes in mouse thymocytes. Molecular and cellular biochemistry. vol 222. issue 1-2. 2002-02-27. PMID:11678592. |
the results showed that cd was able to cause apoptosis in mouse thymocytes in a time- and dose-dependent manner. |
2002-02-27 |
2023-08-12 |
mouse |
| S M Chuang, J L Yan. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells. Molecular and cellular biochemistry. vol 222. issue 1-2. 2002-02-27. PMID:11678615. |
chromium(vi) [cr(vi)] and cadmium (cd) compounds are ubiquitous environmental carcinogens that have been associated with lung tumors and can induce apoptosis in various cell types. |
2002-02-27 |
2023-08-12 |
human |
| S M Chuang, J L Yan. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells. Molecular and cellular biochemistry. vol 222. issue 1-2. 2002-02-27. PMID:11678615. |
in this study we explore the abilities of cr(vi) and cd to activate jnk, p38 and erk, including their roles in metal-mediated growth inhibition and apoptosis in a human non-small-cell lung carcinoma cell line, cl3. |
2002-02-27 |
2023-08-12 |
human |
| S M Chuang, J L Yan. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells. Molecular and cellular biochemistry. vol 222. issue 1-2. 2002-02-27. PMID:11678615. |
pd98059, an inhibitor of the erk upstream activators mkk1/2, greatly enhanced the cytotoxicity and apoptosis of cells treated with low cd doses. |
2002-02-27 |
2023-08-12 |
human |
| S M Chuang, J L Yan. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells. Molecular and cellular biochemistry. vol 222. issue 1-2. 2002-02-27. PMID:11678615. |
sb202190, an inhibitor of p38, decreased the cytotoxicity and apoptosis induced by high cd doses. |
2002-02-27 |
2023-08-12 |
human |
| S M Chuang, J L Yan. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells. Molecular and cellular biochemistry. vol 222. issue 1-2. 2002-02-27. PMID:11678615. |
the results suggest that jnk and p38 signals cooperatively participate in apoptosis induced by cd and that the decreased erk signal by low cd doses contributes to growth inhibition or apoptosis. |
2002-02-27 |
2023-08-12 |
human |
| Masuo Kondoh, Saeko Araragi, Katsuya Sato, Minoru Higashimoto, Masufumi Takiguchi, Masao Sat. Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells. Toxicology. vol 170. issue 1-2. 2002-01-31. PMID:11750088. |
cadmium (cd), a potent immunotoxic metal, induces apoptosis both in vitro and in vivo. |
2002-01-31 |
2023-08-12 |
human |
| Masuo Kondoh, Saeko Araragi, Katsuya Sato, Minoru Higashimoto, Masufumi Takiguchi, Masao Sat. Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells. Toxicology. vol 170. issue 1-2. 2002-01-31. PMID:11750088. |
caspase-3 activation was subsequent to the cyt c release at 6 h. dna fragmentation, an index of induction of apoptosis, also appeared 6 h after cd treatment. |
2002-01-31 |
2023-08-12 |
human |
| A B Chukhlovi, S V Tokalov, A S Yagunov, J Westendorf, H Reincke, L Karb. In vitro suppression of thymocyte apoptosis by metal-rich complex environmental mixtures: potential role of zinc and cadmium excess. The Science of the total environment. vol 281. issue 1-3. 2002-01-23. PMID:11778948. |
by contrast, excess of zn and cd causes inhibition of apoptosis thus suggesting increased survival of genetically mutated cells and higher cancer risks in exposed populations. |
2002-01-23 |
2023-08-12 |
rat |
| A B Chukhlovi, S V Tokalov, A S Yagunov, J Westendorf, H Reincke, L Karb. In vitro suppression of thymocyte apoptosis by metal-rich complex environmental mixtures: potential role of zinc and cadmium excess. The Science of the total environment. vol 281. issue 1-3. 2002-01-23. PMID:11778948. |
apoptosis modulation was also tested with pure salts of mn(ii), zn(ii), cu(ii), cr(iii) and cd(ii), at the test concentrations of 1, 10 and 100 microm. |
2002-01-23 |
2023-08-12 |
rat |
| M F McAleer, R S Tua. Metallothionein overexpression in human trophoblastic cells protects against cadmium-induced apoptosis. In vitro & molecular toxicology. vol 14. issue 1. 2002-01-03. PMID:11689154. |
cellular responses to cd exposure include induction of the metal-binding protein, metallothionein (mt), and initiation of apoptosis. |
2002-01-03 |
2023-08-12 |
human |
| M F McAleer, R S Tua. Metallothionein overexpression in human trophoblastic cells protects against cadmium-induced apoptosis. In vitro & molecular toxicology. vol 14. issue 1. 2002-01-03. PMID:11689154. |
to analyze the functional relationship between cellular mt levels and apoptosis in trophoblasts, we have examined the effects of dna transfection-mediated alterations in mt levels on trophoblastic function and apoptosis, with and without cd exposure, using the trophoblast-like jeg-3 human choriocarcinoma cell line. |
2002-01-03 |
2023-08-12 |
human |
| M F McAleer, R S Tua. Metallothionein overexpression in human trophoblastic cells protects against cadmium-induced apoptosis. In vitro & molecular toxicology. vol 14. issue 1. 2002-01-03. PMID:11689154. |
these results suggest that while mt does not ameliorate heavy-metal induced perturbation of some trophoblastic functions, its expression is critical for protection of these cells from cd-induced apoptosis and could act to maintain placental integrity in cases of maternal cd exposure. |
2002-01-03 |
2023-08-12 |
human |
| M Q Holmes-McNary, A S Baldwin, S H Zeise. Opposing regulation of choline deficiency-induced apoptosis by p53 and nuclear factor kappaB. The Journal of biological chemistry. vol 276. issue 44. 2001-12-07. PMID:11483591. |
we have previously shown that fetal rat brain cells, preneuronal (pc12), and hepatocyte (cwsv-1) cells undergo apoptosis during choline deficiency (cd). |
2001-12-07 |
2023-08-12 |
rat |
| M Q Holmes-McNary, A S Baldwin, S H Zeise. Opposing regulation of choline deficiency-induced apoptosis by p53 and nuclear factor kappaB. The Journal of biological chemistry. vol 276. issue 44. 2001-12-07. PMID:11483591. |
the pc12 and epithelial cell culture models were used to determine the molecular mechanism by which cd induces apoptosis. |
2001-12-07 |
2023-08-12 |
rat |
| M Q Holmes-McNary, A S Baldwin, S H Zeise. Opposing regulation of choline deficiency-induced apoptosis by p53 and nuclear factor kappaB. The Journal of biological chemistry. vol 276. issue 44. 2001-12-07. PMID:11483591. |
our data indicate that cd leads to both growth arrest and apoptosis in a subpopulation of cells, which correlate with the up-regulation of the tumor suppressor protein p53 and concurrent up-regulation of the cyclin-dependent kinase-inhibitor p21(waf1/cip1). |
2001-12-07 |
2023-08-12 |
rat |