| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Q Holmes-McNary, A S Baldwin, S H Zeise. Opposing regulation of choline deficiency-induced apoptosis by p53 and nuclear factor kappaB. The Journal of biological chemistry. vol 276. issue 44. 2001-12-07. PMID:11483591. |
transient transfection of a dominant negative p53 (p53dn) construct into pc12 cells, which inhibited endogenous p53 activation, significantly reduced the induction of apoptosis associated with cd. |
2001-12-07 |
2023-08-12 |
rat |
| M Q Holmes-McNary, A S Baldwin, S H Zeise. Opposing regulation of choline deficiency-induced apoptosis by p53 and nuclear factor kappaB. The Journal of biological chemistry. vol 276. issue 44. 2001-12-07. PMID:11483591. |
in summary, these results suggest that the effects of cd on apoptosis and subsequent cell survival are mediated through two different signaling pathways, p53 and nf-kappab, respectively. |
2001-12-07 |
2023-08-12 |
rat |
| X Shang, Y Shiono, Y Fujita, S Oka, Y Yamazak. Synergistic enhancement of apoptosis by DNA- and cytoskeleton-damaging agents: a basis for combination chemotherapy of cancer. Anticancer research. vol 21. issue 4A. 2001-12-07. PMID:11724325. |
actinomycin d (ad)-induced apoptosis in cmk-7 cells is greatly accelerated by cytoskeletal poisons such as colcemid (cl) and cytochalasin d (cd). |
2001-12-07 |
2023-08-12 |
human |
| J I Chao, J L Yan. Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest. Chemical research in toxicology. vol 14. issue 9. 2001-12-04. PMID:11559033. |
g(2)/m was the most sensitive cell cycle phase to cd for the induction of erk and p38 mapk activities, cytotoxicity, apoptosis, micronucleus, and intracellular peroxide; despite that similar cd accumulation was observed in g(1)-, s-, and g(2)/m-cells. |
2001-12-04 |
2023-08-12 |
human |
| J I Chao, J L Yan. Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest. Chemical research in toxicology. vol 14. issue 9. 2001-12-04. PMID:11559033. |
co-treatment early-g(2) cells with cd and sb202190, an inhibitor of p38 mapk, significantly decreased the induction of micronucleus, mitotic arrest, and apoptosis. |
2001-12-04 |
2023-08-12 |
human |
| S Masunaga, K Ono, Y Sakurai, M Takagaki, T Kobayashi, Y Kinashi, M Suzuk. Evaluation of apoptosis and micronucleation induced by reactor neutron beams with two different cadmium ratios in total and quiescent cell populations within solid tumors. International journal of radiation oncology, biology, physics. vol 51. issue 3. 2001-12-04. PMID:11697329. |
response of quiescent (q) and total tumor cells in solid tumors to reactor neutron beam irradiation with two different cadmium (cd) ratios was examined in terms of micronucleus (mn) frequency and apoptosis frequency, using four different tumor cell lines. |
2001-12-04 |
2023-08-12 |
Not clear |
| C D Albright, J Kuo, S Jeon. cAMP enhances Cx43 gap junction formation and function and reverses choline deficiency apoptosis. Experimental and molecular pathology. vol 71. issue 1. 2001-10-11. PMID:11502095. |
previously, it had been shown that acute choline deficiency (cd) induced apoptosis in cultured rat liver epithelial cells, whereas cells that are adapted to survive in low-choline-containing medium acquire resistance to cd apoptosis and undergo malignant transformation. |
2001-10-11 |
2023-08-12 |
rat |
| C D Albright, J Kuo, S Jeon. cAMP enhances Cx43 gap junction formation and function and reverses choline deficiency apoptosis. Experimental and molecular pathology. vol 71. issue 1. 2001-10-11. PMID:11502095. |
in nontumorigenic wb cells, cd apoptosis was associated with retention of cx43 in the golgi/er region of the cytoplasm and decreased gjic as measured using a preloading fluorescent dye transfer method (calcein am/diic(18)). |
2001-10-11 |
2023-08-12 |
rat |
| C D Albright, J Kuo, S Jeon. cAMP enhances Cx43 gap junction formation and function and reverses choline deficiency apoptosis. Experimental and molecular pathology. vol 71. issue 1. 2001-10-11. PMID:11502095. |
cells maintained in cd in the presence of 8-bromoadenosine 3':5'-cyclic monophosphate exhibited restoration of cx43 at the plasma membrane and increased gjic and inhibition of apoptosis. |
2001-10-11 |
2023-08-12 |
rat |
| C D Albright, J Kuo, S Jeon. cAMP enhances Cx43 gap junction formation and function and reverses choline deficiency apoptosis. Experimental and molecular pathology. vol 71. issue 1. 2001-10-11. PMID:11502095. |
these studies show that cd apoptosis in nontumorigenic liver epithelial cells is associated with alterations to cx43 and gjic and that an uncoupling of cx43 localization and gjic is related to resistance to cd apoptosis in transformed liver epithelial cells. |
2001-10-11 |
2023-08-12 |
rat |
| A Di Sabatino, S D'Alò, D Millimaggi, R Ciccocioppo, R Parroni, G Sciarra, M G Cifone, G R Corazz. Apoptosis and peripheral blood lymphocyte depletion in coeliac disease. Immunology. vol 103. issue 4. 2001-09-27. PMID:11529933. |
in the light of the recent findings about the fas-fas ligand (fasl) system in regulating lymphocyte homeostasis, the aim of the present study was to investigate peripheral lymphocyte fas-mediated apoptosis in cd to establish whether the homeostatic role of apoptosis in peripheral t-cell selection is maintained. |
2001-09-27 |
2023-08-12 |
Not clear |
| A Di Sabatino, S D'Alò, D Millimaggi, R Ciccocioppo, R Parroni, G Sciarra, M G Cifone, G R Corazz. Apoptosis and peripheral blood lymphocyte depletion in coeliac disease. Immunology. vol 103. issue 4. 2001-09-27. PMID:11529933. |
finally, we evaluated whether the increased prevalence of anticardiolipin antibodies, recently described in cd, could be related to pbl apoptosis in this condition. |
2001-09-27 |
2023-08-12 |
Not clear |
| A Di Sabatino, S D'Alò, D Millimaggi, R Ciccocioppo, R Parroni, G Sciarra, M G Cifone, G R Corazz. Apoptosis and peripheral blood lymphocyte depletion in coeliac disease. Immunology. vol 103. issue 4. 2001-09-27. PMID:11529933. |
in addition, low levels of soluble fas and a significant positive correlation between anticardiolipin antibodies and pbl apoptosis were found in untreated cd. |
2001-09-27 |
2023-08-12 |
Not clear |
| A Di Sabatino, S D'Alò, D Millimaggi, R Ciccocioppo, R Parroni, G Sciarra, M G Cifone, G R Corazz. Apoptosis and peripheral blood lymphocyte depletion in coeliac disease. Immunology. vol 103. issue 4. 2001-09-27. PMID:11529933. |
then, our results showed an increased susceptibility of pbl to undergo fas-mediated apoptosis in active cd. |
2001-09-27 |
2023-08-12 |
Not clear |
| A S Vrablic, C D Albright, C N Craciunescu, R I Salganik, S H Zeise. Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 15. issue 10. 2001-08-30. PMID:11481221. |
rotenone, an inhibitor of the mitochondrial electron transport chain, significantly reduced the intracellular level of ros and prevented mitochondrial membrane depolarization, correlating with a reduction of apoptosis in response to either et-18-och3 or cd. |
2001-08-30 |
2023-08-12 |
rat |
| J Itoh, C de La Motte, S A Strong, A D Levine, C Fiocch. Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease. Gut. vol 49. issue 1. 2001-08-02. PMID:11413108. |
on the other hand, in crohn's disease (cd) mucosal t cells are resistant to apoptosis, suggesting abnormal regulation of cell death mechanisms. |
2001-08-02 |
2023-08-12 |
Not clear |
| T Tsukuba, K Okamoto, Y Yasuda, W Morikawa, H Nakanishi, K Yamamot. New functional aspects of cathepsin D and cathepsin E. Molecules and cells. vol 10. issue 6. 2001-06-21. PMID:11211863. |
cd has also been shown to mediate apoptosis induced by various stimuli and p53-dependent tumor suppression. |
2001-06-21 |
2023-08-12 |
mouse |
| R Ciccocioppo, A Di Sabatino, R Parroni, P Muzi, S D'Alò, T Ventura, M A Pistoia, M G Cifone, G R Corazz. Increased enterocyte apoptosis and Fas-Fas ligand system in celiac disease. American journal of clinical pathology. vol 115. issue 4. 2001-04-26. PMID:11293896. |
our aim was to evaluate whether increased enterocyte apoptosis was responsible for mucosal flattening in celiac disease (cd), and, since the mechanisms responsible for tissue injury in this condition are unknown, we studied the possibility that the fas-fas ligand (fasl) system may be involved. |
2001-04-26 |
2023-08-12 |
human |
| R Ciccocioppo, A Di Sabatino, R Parroni, P Muzi, S D'Alò, T Ventura, M A Pistoia, M G Cifone, G R Corazz. Increased enterocyte apoptosis and Fas-Fas ligand system in celiac disease. American journal of clinical pathology. vol 115. issue 4. 2001-04-26. PMID:11293896. |
endoscopic duodenal biopsy specimens from 12 patients with untreated and 12 with treated cd and 12 control subjects were evaluated for enterocyte apoptosis by the terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine triphosphate nick-end labeling assay and for fas and fasl expression by immunohistochemistry. |
2001-04-26 |
2023-08-12 |
human |
| R Ciccocioppo, A Di Sabatino, R Parroni, P Muzi, S D'Alò, T Ventura, M A Pistoia, M G Cifone, G R Corazz. Increased enterocyte apoptosis and Fas-Fas ligand system in celiac disease. American journal of clinical pathology. vol 115. issue 4. 2001-04-26. PMID:11293896. |
these results directly demonstrate that fasl-mediated apoptosis is a major mechanism responsible for enterocyte death in cd. |
2001-04-26 |
2023-08-12 |
human |