| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Fujimaki, M Ishido, K Nohar. Induction of apoptosis in mouse thymocytes by cadmium. Toxicology letters. vol 115. issue 2. 2000-06-20. PMID:10802385. |
these results suggest that cd may modulate the function of the thymus by the induction of apoptosis through mechanisms that differ from those used by dex. |
2000-06-20 |
2023-08-12 |
mouse |
| S S Habeebu, J Liu, Y Liu, C D Klaasse. Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium. Toxicological sciences : an official journal of the Society of Toxicology. vol 55. issue 1. 2000-06-09. PMID:10788577. |
apoptosis and mitosis occurred concomitantly in liver following repeated cd exposure, whereas necrosis was mild. |
2000-06-09 |
2023-08-12 |
mouse |
| S S Habeebu, J Liu, Y Liu, C D Klaasse. Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium. Toxicological sciences : an official journal of the Society of Toxicology. vol 55. issue 1. 2000-06-09. PMID:10788577. |
in conclusion, these data indicate that (1) nonspecific chronic inflammation, granulomatous inflammation, apoptosis, liver cell regeneration, and presumably, preneoplastic proliferating nodules are major features of liver injury induced by repeated cd exposure, and (2) intracellular mt is an important protein protecting against this cd-induced liver injury. |
2000-06-09 |
2023-08-12 |
mouse |
| C Yuan, M Kadiiska, W E Achanzar, R P Mason, M P Waalke. Possible role of caspase-3 inhibition in cadmium-induced blockage of apoptosis. Toxicology and applied pharmacology. vol 164. issue 3. 2000-06-07. PMID:10799343. |
we previously found that cd blocks cr-induced apoptosis, which could allow a larger proportion of genetically damaged cells to escape and become transformed. |
2000-06-07 |
2023-08-12 |
human |
| C Yuan, M Kadiiska, W E Achanzar, R P Mason, M P Waalke. Possible role of caspase-3 inhibition in cadmium-induced blockage of apoptosis. Toxicology and applied pharmacology. vol 164. issue 3. 2000-06-07. PMID:10799343. |
chinese hamster ovary (cho k1-bh4) cells were treated with either cd (5-20 microm), cr(vi) (350 microm), or cd (5-20 microm) plus cr(vi) (350 microm) for 3 h and then cultured in metal-free media for an additional 48 h at which time dna was extracted or nuclei were examined to determine apoptosis. |
2000-06-07 |
2023-08-12 |
human |
| C Yuan, M Kadiiska, W E Achanzar, R P Mason, M P Waalke. Possible role of caspase-3 inhibition in cadmium-induced blockage of apoptosis. Toxicology and applied pharmacology. vol 164. issue 3. 2000-06-07. PMID:10799343. |
thus, cd suppression of cr-induced apoptosis is not based on altered cr toxicokinetics or metabolism. |
2000-06-07 |
2023-08-12 |
human |
| C Yuan, M Kadiiska, W E Achanzar, R P Mason, M P Waalke. Possible role of caspase-3 inhibition in cadmium-induced blockage of apoptosis. Toxicology and applied pharmacology. vol 164. issue 3. 2000-06-07. PMID:10799343. |
in addition to cr, cd also inhibited apoptosis induced by hygromycin b and actinomycin d. cd was a very effective inhibitor of caspase-3 activity, a central mediator of apoptosis, with nontoxic levels of cd resulting in up to approximately 60% inhibition. |
2000-06-07 |
2023-08-12 |
human |
| C Yuan, M Kadiiska, W E Achanzar, R P Mason, M P Waalke. Possible role of caspase-3 inhibition in cadmium-induced blockage of apoptosis. Toxicology and applied pharmacology. vol 164. issue 3. 2000-06-07. PMID:10799343. |
these results indicate that cd may have a generalized inhibitory effect on apoptosis, possibly by inhibiting caspase-3. |
2000-06-07 |
2023-08-12 |
human |
| C Yuan, M Kadiiska, W E Achanzar, R P Mason, M P Waalke. Possible role of caspase-3 inhibition in cadmium-induced blockage of apoptosis. Toxicology and applied pharmacology. vol 164. issue 3. 2000-06-07. PMID:10799343. |
inhibition of apoptosis by cd may allow a greater portion of genetically damaged cells to survive, or give selective growth advantages, and has implications as a potential nongenotoxic mechanism of cd carcinogenesis. |
2000-06-07 |
2023-08-12 |
human |
| b' A Szuster-Ciesielska, A Stachura, M S\\xc5\\x82otwi\\xc5\\x84ska, T Kami\\xc5\\x84ska, R Sniezko, R Paduch, D Abramczyk, J Filar, M Kandefer-Szersze\\xc5\\x8. The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology. vol 145. issue 2-3. 2000-06-02. PMID:10771141.' |
in this paper we have evaluated the effect of in vitro zncl(2) supplementation at a concentration corresponding to the physiological level (10 microm) and higher (50 microm), on apoptosis induced with different cd concentrations in two cell types: hela human tumor cell line and bovine aorta endothelial cells (baecs). |
2000-06-02 |
2023-08-12 |
human |
| b' A Szuster-Ciesielska, A Stachura, M S\\xc5\\x82otwi\\xc5\\x84ska, T Kami\\xc5\\x84ska, R Sniezko, R Paduch, D Abramczyk, J Filar, M Kandefer-Szersze\\xc5\\x8. The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology. vol 145. issue 2-3. 2000-06-02. PMID:10771141.' |
these results indicate that inhibition of cd-induced apoptosis in cells by zn might be due, not only by inhibition of cd accumulation in cells but, at least in part, to inhibition of cd-induced production of ros, which in turn are known as strong inducers of apoptosis. |
2000-06-02 |
2023-08-12 |
human |
| R Atreya, J Mudter, S Finotto, J Müllberg, T Jostock, S Wirtz, M Schütz, B Bartsch, M Holtmann, C Becker, D Strand, J Czaja, J F Schlaak, H A Lehr, F Autschbach, G Schürmann, N Nishimoto, K Yoshizaki, H Ito, T Kishimoto, P R Galle, S Rose-John, M F Neurat. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nature medicine. vol 6. issue 5. 2000-05-25. PMID:10802717. |
here, we have assessed the contribution of this system to the increased resistance of mucosal t cells against apoptosis in crohn disease (cd), a chronic inflammatory disease of the gastrointestinal tract. |
2000-05-25 |
2023-08-12 |
Not clear |
| R Atreya, J Mudter, S Finotto, J Müllberg, T Jostock, S Wirtz, M Schütz, B Bartsch, M Holtmann, C Becker, D Strand, J Czaja, J F Schlaak, H A Lehr, F Autschbach, G Schürmann, N Nishimoto, K Yoshizaki, H Ito, T Kishimoto, P R Galle, S Rose-John, M F Neurat. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nature medicine. vol 6. issue 5. 2000-05-25. PMID:10802717. |
a neutralizing antibody against il-6r suppressed established experimental colitis in various animal models of cd mediated by type 1 t-helper cells, by inducing apoptosis of lamina propria t cells. |
2000-05-25 |
2023-08-12 |
Not clear |
| R Atreya, J Mudter, S Finotto, J Müllberg, T Jostock, S Wirtz, M Schütz, B Bartsch, M Holtmann, C Becker, D Strand, J Czaja, J F Schlaak, H A Lehr, F Autschbach, G Schürmann, N Nishimoto, K Yoshizaki, H Ito, T Kishimoto, P R Galle, S Rose-John, M F Neurat. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nature medicine. vol 6. issue 5. 2000-05-25. PMID:10802717. |
blockade of il-6 trans signaling caused t-cell apoptosis, indicating that the il-6-sil-6r system mediates the resistance of t cells to apoptosis in cd. |
2000-05-25 |
2023-08-12 |
Not clear |
| D W Ju, Q Tao, D S Cheng, W Zhang, M Zhang, H Hamada, X Ca. Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma. Gene therapy. vol 7. issue 4. 2000-03-16. PMID:10694814. |
these findings suggested that increased immunogenicity and induction of apoptosis of the tumor cells, and efficient induction of local and systemic antitumor immunity of the host might contribute to the enhanced antitumor effects of the combined ltn and cd suicide therapy. |
2000-03-16 |
2023-08-12 |
mouse |
| H Raes, B P Braeckman, G R Criel, U Rzeznik, J R Vanfletere. Copper induces apoptosis in Aedes C6/36 cells. The Journal of experimental zoology. vol 286. issue 1. 2000-02-01. PMID:10607364. |
similar to cd(2+) and hg(2+), cu(2+) induces hyperpolymerization of the microtubules; moreover, with cu(2+) this is followed by cell aggregation and massive apoptosis. |
2000-02-01 |
2023-08-12 |
Not clear |
| D Bagchi, S S Joshi, M Bagchi, J Balmoori, E J Benner, C A Kuszynski, S J Stoh. Cadmium- and chromium-induced oxidative stress, DNA damage, and apoptotic cell death in cultured human chronic myelogenous leukemic K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripheral blood mononuclear cells. Journal of biochemical and molecular toxicology. vol 14. issue 1. 1999-11-23. PMID:10561080. |
cell cycle modulation and apoptosis of the k562 cells by cr(vi) and cd(ii) were determined by flow cytometry. |
1999-11-23 |
2023-08-12 |
human |
| D Bagchi, S S Joshi, M Bagchi, J Balmoori, E J Benner, C A Kuszynski, S J Stoh. Cadmium- and chromium-induced oxidative stress, DNA damage, and apoptotic cell death in cultured human chronic myelogenous leukemic K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripheral blood mononuclear cells. Journal of biochemical and molecular toxicology. vol 14. issue 1. 1999-11-23. PMID:10561080. |
at 12.5 microm, cr(vi) induced greater apoptosis in k562 cells as compared with cd(ii). |
1999-11-23 |
2023-08-12 |
human |
| F Thévenod, J M Friedman. Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K(+)-ATPase through proteasomal and endo-/lysosomal proteolytic pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 13. issue 13. 1999-11-02. PMID:10506578. |
cd also increased apoptosis (controls: 2.4+/-1.6%; cd: 8.1+/-1.9%), but not necrosis (controls: 0.5 +/- 0.3%; cd: 1.4+/- 2.5%). |
1999-11-02 |
2023-08-12 |
rat |
| C D Albright, C B Friedrich, E C Brown, M H Mar, S H Zeise. Maternal dietary choline availability alters mitosis, apoptosis and the localization of TOAD-64 protein in the developing fetal rat septum. Brain research. Developmental brain research. vol 115. issue 2. 1999-09-13. PMID:10407130. |
however, cd had no effect on apoptosis in the indusium griseum (ig), a region of cortex dorsal to the septum. |
1999-09-13 |
2023-08-12 |
rat |