| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G S Wu, P Saftig, C Peters, W S El-Deir. Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Oncogene. vol 16. issue 17. 1998-06-16. PMID:9619826. |
cathepsin d (cd), the major intracellular aspartyl protease, is a mediator of ifn-gamma and tnf-alpha induced apoptosis. |
1998-06-16 |
2023-08-12 |
human |
| G S Wu, P Saftig, C Peters, W S El-Deir. Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Oncogene. vol 16. issue 17. 1998-06-16. PMID:9619826. |
using subtractive hybridization screening we isolated cd as an upregulated transcript in pa1 human ovarian cancer cells undergoing adriamycin-induced apoptosis. |
1998-06-16 |
2023-08-12 |
human |
| G S Wu, P Saftig, C Peters, W S El-Deir. Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Oncogene. vol 16. issue 17. 1998-06-16. PMID:9619826. |
inhibition of cd protease with pepstatin a suppressed p53-dependent apoptosis in lymphoid cells, suggesting a possible role for cd in p53-dependent cell death. |
1998-06-16 |
2023-08-12 |
human |
| S S Habeebu, J Liu, C D Klaasse. Cadmium-induced apoptosis in mouse liver. Toxicology and applied pharmacology. vol 149. issue 2. 1998-05-21. PMID:9571989. |
although the acute hepatotoxic effects of cadmium (cd) are well described, little is known about the occurrence of apoptosis in cd toxicity. |
1998-05-21 |
2023-08-12 |
mouse |
| S S Habeebu, J Liu, C D Klaasse. Cadmium-induced apoptosis in mouse liver. Toxicology and applied pharmacology. vol 149. issue 2. 1998-05-21. PMID:9571989. |
these data demonstrate that apoptosis is a major mode of elimination of critically damaged cells in acute cd hepatotoxicity in the mouse, and it precedes necrosis. |
1998-05-21 |
2023-08-12 |
mouse |
| M V Dhodapkar, E Abe, A Theus, M Lacy, J K Langford, B Barlogie, R D Sanderso. Syndecan-1 is a multifunctional regulator of myeloma pathobiology: control of tumor cell survival, growth, and bone cell differentiation. Blood. vol 91. issue 8. 1998-05-12. PMID:9531576. |
we show that syndecan-1 (cd 138), a heparan sulfate proteoglycan, expressed on and actively shed from the surface of most myeloma cells, induces apoptosis and inhibits the growth of myeloma tumor cells and also mediates decreased osteoclast and increased osteoblast differentiation. |
1998-05-12 |
2023-08-12 |
mouse |
| M Weller, K Heimann, K U Bartz-Schmidt, A Fontana, P Esse. CD 95 expression in traumatic proliferative vitreoretinopathy: a target for the induction of apoptosis. German journal of ophthalmology. vol 5. issue 6. 1998-03-16. PMID:9479514. |
cd 95 expression in traumatic proliferative vitreoretinopathy: a target for the induction of apoptosis. |
1998-03-16 |
2023-08-12 |
human |
| M Weller, K Heimann, K U Bartz-Schmidt, A Fontana, P Esse. CD 95 expression in traumatic proliferative vitreoretinopathy: a target for the induction of apoptosis. German journal of ophthalmology. vol 5. issue 6. 1998-03-16. PMID:9479514. |
however, these cells are resistant to cd 95 antibody-induced apoptosis, presumably because they synthesize cytoprotective proteins, which interfere with the cd 95-dependent killing cascade. |
1998-03-16 |
2023-08-12 |
human |
| M Weller, K Heimann, K U Bartz-Schmidt, A Fontana, P Esse. CD 95 expression in traumatic proliferative vitreoretinopathy: a target for the induction of apoptosis. German journal of ophthalmology. vol 5. issue 6. 1998-03-16. PMID:9479514. |
coexposure to inhibitors of rna or protein synthesis sensitizes human rpe cells for cd 95-mediated apoptosis. |
1998-03-16 |
2023-08-12 |
human |
| M Weller, K Heimann, K U Bartz-Schmidt, A Fontana, P Esse. CD 95 expression in traumatic proliferative vitreoretinopathy: a target for the induction of apoptosis. German journal of ophthalmology. vol 5. issue 6. 1998-03-16. PMID:9479514. |
preexposure to cycloheximide does not abrogate cd 95-mediated apoptosis, suggesting that labile, short-lived proteins do not mediate the cytotoxic effects of cd 95 antibodies. |
1998-03-16 |
2023-08-12 |
human |
| C D Albright, S H Zeise. Choline deficiency causes increased localization of transforming growth factor-beta1 signaling proteins and apoptosis in the rat liver. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 65. issue 5. 1998-02-24. PMID:9459496. |
nuclear localization of p27kip1 protein, which may link tgf-beta1 expression to apoptosis, showed a 10-fold increase in cd hepatocytes (4.1 +/- 1.1 vs. 0.35 +/- 0.04% of cells) compared to controls. |
1998-02-24 |
2023-08-12 |
rat |
| C D Albright, S H Zeise. Choline deficiency causes increased localization of transforming growth factor-beta1 signaling proteins and apoptosis in the rat liver. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 65. issue 5. 1998-02-24. PMID:9459496. |
we conclude that feeding a cd diet for 6 weeks induces apoptosis in hepatocytes in the whole rat liver and that this form of cell death appears to be mediated, in part, by tgf-beta1 and related proteins. |
1998-02-24 |
2023-08-12 |
rat |
| C D Albright, R Liu, M H Mar, O H Shin, A S Vrablic, R I Salganik, S H Zeise. Diet, apoptosis, and carcinogenesis. Advances in experimental medicine and biology. vol 422. 1997-12-23. PMID:9361818. |
when grown in cd medium (5 microm or 0 microm choline) cwsv-1 rat hepatocytes immortalized with sv40 large t-antigen underwent p53-independent apoptosis (terminal dutp end-labeling of fragmented dna; laddering of dna in agarose gel). |
1997-12-23 |
2023-08-12 |
mouse |
| M Q Holmes-McNary, R Loy, M H Mar, C D Albright, S H Zeise. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain research. Developmental brain research. vol 101. issue 1-2. 1997-10-01. PMID:9263575. |
timed-bred sprague dawley rats were fed a choline-deficient (cd), choline-control, or choline-supplemented (cs) diet for 6 days and, on embryonic day 18, fetal brain slices were prepared and apoptosis was assessed using terminal dutp nucleotide end labeling (tunel) to detect dna strand breaks and by counting of apoptotic bodies. |
1997-10-01 |
2023-08-12 |
rat |
| S H Zeisel, C D Albright, O H Shin, M H Mar, R I Salganik, K A da Cost. Choline deficiency selects for resistance to p53-independent apoptosis and causes tumorigenic transformation of rat hepatocytes. Carcinogenesis. vol 18. issue 4. 1997-05-09. PMID:9111207. |
choline deficiency (cd)-induced apoptosis is probably mediated by tgfbeta1 and reactive oxygen species, since immunoneutralization of tgfbeta1 in the medium or treatment with n-acetylcysteine (an antioxidant) or addition of neocuproine (a transition metal chelator) prevented cd-induced apoptosis. |
1997-05-09 |
2023-08-12 |
mouse |
| S H Zeisel, C D Albright, O H Shin, M H Mar, R I Salganik, K A da Cost. Choline deficiency selects for resistance to p53-independent apoptosis and causes tumorigenic transformation of rat hepatocytes. Carcinogenesis. vol 18. issue 4. 1997-05-09. PMID:9111207. |
cell transformation was dependent on exposure to the selective pressure of cd apoptosis, as we observed that when cd apoptosis was inhibited with an antioxidant during adaptation, cells did not become anchorage independent. |
1997-05-09 |
2023-08-12 |
mouse |
| S H Zeisel, C D Albright, O H Shin, M H Mar, R I Salganik, K A da Cost. Choline deficiency selects for resistance to p53-independent apoptosis and causes tumorigenic transformation of rat hepatocytes. Carcinogenesis. vol 18. issue 4. 1997-05-09. PMID:9111207. |
acquisition by p53-deficient cells of resistance to p53-independent inducers of apoptosis (cd, tgfbeta1 and reactive oxygen species) may leave cells without another important apoptotic defensive barrier and may be responsible for the progression of initiated cells to frank carcinomas. |
1997-05-09 |
2023-08-12 |
mouse |
| H J Grön. [Systemic lupus erythematosus and antiphospholipid syndrome]. Verhandlungen der Deutschen Gesellschaft fur Pathologie. vol 80. 1997-03-17. PMID:9065004. |
the autoreactivity in sle has been elucidated in drug-induced sle: hypomethylation of dna leads to overexpression of integrin cd 11a/cd 18, increased binding of t-cells to macrophages and b-cells, a higher rate of apoptosis of macrophages and elevated b-cell activity with consecutive production of autoantibodies. |
1997-03-17 |
2023-08-12 |
Not clear |
| T Hamada, T Sasaguri, A Tanimoto, N Arima, S Shimajiri, T Abe, Y Sasagur. Apoptosis of human kidney 293 cells is promoted by polymerized cadmium-metallothionein. Biochemical and biophysical research communications. vol 219. issue 3. 1996-07-15. PMID:8645265. |
higher concentrations of cd were less effective in inducing apoptosis. |
1996-07-15 |
2023-08-12 |
human |
| T Hamada, T Sasaguri, A Tanimoto, N Arima, S Shimajiri, T Abe, Y Sasagur. Apoptosis of human kidney 293 cells is promoted by polymerized cadmium-metallothionein. Biochemical and biophysical research communications. vol 219. issue 3. 1996-07-15. PMID:8645265. |
the present findings suggest that apoptosis is induced not only by cd itself but also by polymerized metallothionein molecules (mt) released from cells into the medium. |
1996-07-15 |
2023-08-12 |
human |