| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Cai, Sammy Iskander, M George Cherian, Robert R Hammon. Zinc- or cadmium-pre-induced metallothionein protects human central nervous system cells and astrocytes from radiation-induced apoptosis. Toxicology letters. vol 146. issue 3. 2004-02-10. PMID:14687759. |
the present study is to further define the types of cell death induced by different dose levels of radiation and investigate the effect of mt induction (by zn or cd) on radiation-induced apoptosis in primary human cns and astrocyte cultures. |
2004-02-10 |
2023-08-12 |
human |
| Song-Ja Kim, Sang-Gu Hwang, Il-Chul Kim, Jang-Soo Chu. Actin cytoskeletal architecture regulates nitric oxide-induced apoptosis, dedifferentiation, and cyclooxygenase-2 expression in articular chondrocytes via mitogen-activated protein kinase and protein kinase C pathways. The Journal of biological chemistry. vol 278. issue 43. 2004-01-05. PMID:12907684. |
disruption of the actin cytoskeleton by cytochalasin d (cd) inhibited no-induced apoptosis, dedifferentiation, cox-2 expression, and prostaglandin e2 production in chondrocytes cultured on plastic or during cartilage explants culture. |
2004-01-05 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Sang-Gu Hwang, Il-Chul Kim, Jang-Soo Chu. Actin cytoskeletal architecture regulates nitric oxide-induced apoptosis, dedifferentiation, and cyclooxygenase-2 expression in articular chondrocytes via mitogen-activated protein kinase and protein kinase C pathways. The Journal of biological chemistry. vol 278. issue 43. 2004-01-05. PMID:12907684. |
cd treatment did not affect erk-1/-2 activation but blocked the signaling events necessary for no-induced dedifferentiation, apoptosis, and cox-2 expression such as activation of p38 kinase and inhibition of pkcalpha and -zeta. |
2004-01-05 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Sang-Gu Hwang, Il-Chul Kim, Jang-Soo Chu. Actin cytoskeletal architecture regulates nitric oxide-induced apoptosis, dedifferentiation, and cyclooxygenase-2 expression in articular chondrocytes via mitogen-activated protein kinase and protein kinase C pathways. The Journal of biological chemistry. vol 278. issue 43. 2004-01-05. PMID:12907684. |
cd also suppressed activation of downstream signaling of p38 kinase and pkc, such as nf-kappab activation, p53 accumulation, and caspase-3 activation, which are necessary for no-induced apoptosis. |
2004-01-05 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Sang-Gu Hwang, Il-Chul Kim, Jang-Soo Chu. Actin cytoskeletal architecture regulates nitric oxide-induced apoptosis, dedifferentiation, and cyclooxygenase-2 expression in articular chondrocytes via mitogen-activated protein kinase and protein kinase C pathways. The Journal of biological chemistry. vol 278. issue 43. 2004-01-05. PMID:12907684. |
the down-regulation of pi 3-kinase and akt was blocked by cd treatment, and the cd effects on apoptosis, p38 kinase, and pkcalpha and -zeta were abolished by the inhibition of pi 3-kinase with ly294002. |
2004-01-05 |
2023-08-12 |
Not clear |
| R Graber, J C Farine, G A Los. Calcium Dobesilate protects human peripheral blood mononuclear cells from oxidation and apoptosis. Apoptosis : an international journal on programmed cell death. vol 3. issue 1. 2003-12-23. PMID:14646517. |
the antioxidant effects of calcium dobesilate (cd, doxium) were investigated in relation to the oxidative status, apoptosis and in vitro proliferation of human peripheral blood mononuclear cells (pbmc) isolated from healthy donors. |
2003-12-23 |
2023-08-12 |
human |
| T Hamada, A Tanimoto, Y Sasagur. Apoptosis induced by cadmium. Apoptosis : an international journal on programmed cell death. vol 2. issue 4. 2003-12-23. PMID:14646532. |
cell death resulting from cadmium (cd) intoxication has been confirmed to occur through apoptosis by morphological and biochemical studies. |
2003-12-23 |
2023-08-12 |
Not clear |
| T Hamada, A Tanimoto, Y Sasagur. Apoptosis induced by cadmium. Apoptosis : an international journal on programmed cell death. vol 2. issue 4. 2003-12-23. PMID:14646532. |
however it is still not clear whether cd itself or metallothionein (mt) induced by cd is the major factor responsible for the apoptosis. |
2003-12-23 |
2023-08-12 |
Not clear |
| T Hamada, A Tanimoto, Y Sasagur. Apoptosis induced by cadmium. Apoptosis : an international journal on programmed cell death. vol 2. issue 4. 2003-12-23. PMID:14646532. |
however, cd itself can be associated with apoptosis through indirect oxidative stress by inhibition of antioxidant enzymes and possible interaction with zinc finger protein. |
2003-12-23 |
2023-08-12 |
Not clear |
| T Hamada, A Tanimoto, Y Sasagur. Apoptosis induced by cadmium. Apoptosis : an international journal on programmed cell death. vol 2. issue 4. 2003-12-23. PMID:14646532. |
in addition to the direct effect of cd, mt appears to play dual roles in apoptosis induction: one as a cd carrier by which cd accumulates in the nucleus, and the other as an inhibitor of zinc finger proteins, which include transcriptional factors related to apoptosis such as the product of the apoptosis resistance gene a20. |
2003-12-23 |
2023-08-12 |
Not clear |
| Craig D Albright, Rudolf I Salganik, Corneliu N Craciunescu, Mei-Heng Mar, Steven H Zeise. Mitochondrial and microsomal derived reactive oxygen species mediate apoptosis induced by transforming growth factor-beta1 in immortalized rat hepatocytes. Journal of cellular biochemistry. vol 89. issue 2. 2003-11-12. PMID:12704789. |
sv40-transformed cwsv-1 rat hepatocytes that are p53-defective undergo apoptosis in response to choline deficiency (cd) or tgfbeta1, which mediates cd-apoptosis. |
2003-11-12 |
2023-08-12 |
rat |
| J N Agrewala, S Suvas, V Singh, H Vohr. Delivery of antigen in allogeneic cells preferentially generates CD(4+) Th1 cells. Clinical and experimental immunology. vol 134. issue 1. 2003-10-28. PMID:12974749. |
because it is already known that mitomycin c-treated cells undergo apoptosis and dendritic cells engulf apoptotic cells, we therefore propose that generation of t cell response using antigen-pulsed allogeneic cells may be due to the engulfment of these cells by dendritic cells, which may then process and present antigen entrapped in allogeneic cells to activate naive cd(4+) t cells and differentiate them to th1 cells. |
2003-10-28 |
2023-08-12 |
mouse |
| Laurens Kruidenier, Ineke Kuiper, Cornelis B H W Lamers, Hein W Verspage. Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants. The Journal of pathology. vol 201. issue 1. 2003-10-24. PMID:12950014. |
in crohn's disease (cd), epithelial apoptosis levels were strongly associated with the expression of xo, implying a role for this enzyme in the regulation of epithelial cell homeostasis, although its levels were unaffected by intestinal inflammation and were comparable to those in normal control mucosa. |
2003-10-24 |
2023-08-12 |
Not clear |
| Sang Chan Kim, Min Kyung Cho, Sang Geon Ki. Cadmium-induced non-apoptotic cell death mediated by oxidative stress under the condition of sulfhydryl deficiency. Toxicology letters. vol 144. issue 3. 2003-10-21. PMID:12927350. |
cadmium (cd), which accumulates primarily in the liver and the kidney, induces apoptosis and also causes necrotic cell death in certain pathophysiologic situations. |
2003-10-21 |
2023-08-12 |
Not clear |
| Sang Chan Kim, Min Kyung Cho, Sang Geon Ki. Cadmium-induced non-apoptotic cell death mediated by oxidative stress under the condition of sulfhydryl deficiency. Toxicology letters. vol 144. issue 3. 2003-10-21. PMID:12927350. |
these results provide evidence that cd at the physiologically obtainable concentration causes non-apoptotic cell death under the condition of sufhydryl deficiency, whereas cd at the micromolar level induces apoptosis. |
2003-10-21 |
2023-08-12 |
Not clear |
| Marco Marini, Giorgos Bamias, Jesús Rivera-Nieves, Christopher A Moskaluk, Sharon B Hoang, William G Ross, Theresa T Pizarro, Fabio Cominell. TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 14. 2003-09-04. PMID:12832622. |
in this report, we tested the novel hypothesis that the beneficial effects of anti-tnf-alpha therapy in cd are mediated by a mechanism that involves down-regulation of intestinal epithelial cell (iec) apoptosis. |
2003-09-04 |
2023-08-12 |
mouse |
| Marco Marini, Giorgos Bamias, Jesús Rivera-Nieves, Christopher A Moskaluk, Sharon B Hoang, William G Ross, Theresa T Pizarro, Fabio Cominell. TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 14. 2003-09-04. PMID:12832622. |
these data demonstrate a novel mechanism of action of anti-tnf-alpha therapy that involves homeostatic regulation of mucosal cell apoptosis, which results in the net decrease of chronic inflammation typically found in cd. |
2003-09-04 |
2023-08-12 |
mouse |
| Ariel H B Poliandri, Jimena P Cabilla, Miguel O Velardez, Cristian C A Bodo, Beatriz H Duvilansk. Cadmium induces apoptosis in anterior pituitary cells that can be reversed by treatment with antioxidants. Toxicology and applied pharmacology. vol 190. issue 1. 2003-07-24. PMID:12831779. |
morphological studies as well as dna ladder fragmentation and caspase activation showed that cd(2+)-treated cells undergo apoptosis. |
2003-07-24 |
2023-08-12 |
Not clear |
| Ariel H B Poliandri, Jimena P Cabilla, Miguel O Velardez, Cristian C A Bodo, Beatriz H Duvilansk. Cadmium induces apoptosis in anterior pituitary cells that can be reversed by treatment with antioxidants. Toxicology and applied pharmacology. vol 190. issue 1. 2003-07-24. PMID:12831779. |
in summary, the present work demonstrates that cd(2+) is cytotoxic for anterior pituitary cells, that this effect is due to an induction of apoptosis, and that it can be reversed by antioxidants. |
2003-07-24 |
2023-08-12 |
Not clear |
| Jirí Ehrmann, Antonín Kolek, Rostislav Kod'ousek, Jana Zapletalová, Sona Lísová, Paul Gerard Murray, Jirí Drábek, Zdenek Kolá. Immunohistochemical study of the apoptotic mechanisms in the intestinal mucosa during children's coeliac disease. Virchows Archiv : an international journal of pathology. vol 442. issue 5. 2003-07-17. PMID:12698366. |
mechanisms leading to morphological changes of the small intestine during coeliac disease (cd) are not yet completely recognized; however, two main processes have been suggested recently: remodeling of mucosa by matrix metalloproteinases, and mucosal atrophy by apoptosis. |
2003-07-17 |
2023-08-12 |
Not clear |