| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U Hoffmann, K Heilmann, C Hayford, A Stallmach, U Wahnschaffe, M Zeitz, U Günthert, B M Witti. CD44v7 ligation downregulates the inflammatory immune response in Crohn's disease patients by apoptosis induction in mononuclear cells from the lamina propria. Cell death and differentiation. vol 14. issue 8. 2007-12-20. PMID:17479111. |
furthermore, incubation with an anti-cd44v7 antibody induced apoptosis in lpmc isolated from inflamed mucosa of cd patients, but not from non-inflamed mucosa, from patients with ulcerative colitis (uc) or from normal controls. |
2007-12-20 |
2023-08-12 |
human |
| U Hoffmann, K Heilmann, C Hayford, A Stallmach, U Wahnschaffe, M Zeitz, U Günthert, B M Witti. CD44v7 ligation downregulates the inflammatory immune response in Crohn's disease patients by apoptosis induction in mononuclear cells from the lamina propria. Cell death and differentiation. vol 14. issue 8. 2007-12-20. PMID:17479111. |
these findings point to a novel mechanism of apoptosis induction in cd patients mediated by cd44v7 ligation. |
2007-12-20 |
2023-08-12 |
human |
| Behnam Sabayan, Farzaneh Foroughinia, Mohammad-Hadi Imanie. Can Campylobacter jejuni play a role in development of celiac disease? A hypothesis. World journal of gastroenterology. vol 13. issue 35. 2007-12-03. PMID:17729402. |
as presence of campylobacter jejuni in other diseases with antigangliosides antibody formation has been established, we propose the possible role of campylobacter jejuni in development of cd in association with other genetic and environmental factors by the mechanism that molecular mimicry of gangliosides-like epitopes common to both lipo-polysacharide coats of certain strains of campylobacter jejuni and gangliosides in cell structure of gastrointestinal mucosa may cause an autoimmune response and consequently lead to atrophy and degeneration of mucosa possibly by apoptosis. |
2007-12-03 |
2023-08-12 |
Not clear |
| Yoshiko Inoue, Taketoshi Asanuma, Nataliya Smith, Debra Saunders, Jenny Oblander, Yashige Kotake, Robert A Floyd, Rheal A Towne. Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats. Free radical research. vol 41. issue 9. 2007-11-27. PMID:17729114. |
this study focused on the detection of apoptosis related events in very early phases of choline-deficient (cd)-induced hepatocarcinogenesis (at 2-5 weeks). |
2007-11-27 |
2023-08-12 |
rat |
| Hiroyuki Mitomi, Yasuo Ohkura, Kaoru Yokoyama, Miwa Sada, Kiyonori Kobayashi, Satoshi Tanabe, Naoshi Fukui, Hideki Kanazawa, Ichiro Kishimoto, Katsunori Saigenj. Contribution of TIA-1+ and granzyme B+ cytotoxic T lymphocytes to cryptal apoptosis and ulceration in active inflammatory bowel disease. Pathology, research and practice. vol 203. issue 10. 2007-11-09. PMID:17869012. |
colonic mucosal biopsy specimens from patients with active cd (n=25) and uc (n=26) and normal controls (n=12) were immunohistochemically analyzed for the expression of cd3, cd4, cd8, and t cell-restricted intracellular antigen (tia)-1, which promotes apoptosis by alternative splicing of pre-messenger rna of the fas receptor, and granzyme b (grb), which leads to apoptosis through induction of perforin. |
2007-11-09 |
2023-08-12 |
Not clear |
| John J Shacka, Kevin A Rot. Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis. Autophagy. vol 3. issue 5. 2007-11-08. PMID:17495518. |
we have shown recently that the targeted deletion of the pro-apoptotic molecule bax prevents apoptotic markers but not neuron death and neurodegeneration induced by cd deficiency, which suggests that alterations in the macroautophagy-lysosomal degradation pathway can mediate neuron death in ncl/batten disease in the absence of apoptosis. |
2007-11-08 |
2023-08-12 |
Not clear |
| Wing-Kee Lee, Blazej Torchalski, Frank Théveno. Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells. American journal of physiology. Cell physiology. vol 293. issue 3. 2007-10-29. PMID:17596294. |
cd(2+)-induced apoptosis of pt cells is mediated by sequential activation of calpains at 3-6 h and caspases-9 and -3 after 24-h exposure. |
2007-10-29 |
2023-08-12 |
Not clear |
| Wing-Kee Lee, Blazej Torchalski, Frank Théveno. Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells. American journal of physiology. Cell physiology. vol 293. issue 3. 2007-10-29. PMID:17596294. |
calpains also partly contribute to caspase activation, which emphasizes the importance of calpains for pt apoptosis by cd(2+). |
2007-10-29 |
2023-08-12 |
Not clear |
| Wing-Kee Lee, Blazej Torchalski, Frank Théveno. Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells. American journal of physiology. Cell physiology. vol 293. issue 3. 2007-10-29. PMID:17596294. |
this indicates that cd(2+) enhances de novo ceramide synthesis and that calpains are a downstream target of ceramides in apoptosis execution. |
2007-10-29 |
2023-08-12 |
Not clear |
| Wing-Kee Lee, Blazej Torchalski, Frank Théveno. Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells. American journal of physiology. Cell physiology. vol 293. issue 3. 2007-10-29. PMID:17596294. |
we conclude that cd(2+)-induced apoptosis of pt cells entails endogenous ceramide elevation and subsequent ca(2+)-dependent calpain activation, which propagates kidney damage by cd(2+). |
2007-10-29 |
2023-08-12 |
Not clear |
| E Kovesdi, E Czeiter, A Tamas, D Reglodi, D Szellar, J Pal, P Bukovics, T Doczi, A Buk. Rescuing neurons and glia: is inhibition of apoptosis useful? Progress in brain research. vol 161. 2007-10-25. PMID:17618971. |
on noxious stimuli three major forms of cd, apoptosis, autophagia and necrosis may occur. |
2007-10-25 |
2023-08-12 |
Not clear |
| E Kovesdi, E Czeiter, A Tamas, D Reglodi, D Szellar, J Pal, P Bukovics, T Doczi, A Buk. Rescuing neurons and glia: is inhibition of apoptosis useful? Progress in brain research. vol 161. 2007-10-25. PMID:17618971. |
although, theoretically pan-caspase inhibition could be an efficient tool to limit apoptosis and thereby the extent of tbi, potential cross-talk between various avenues of cd suggests that more upstream events, particularly the preservation of the cellular energy homeostasis (cyclosporine-a, poly adp ribose polymerase (parp) inhibition, hypothermia treatment) may represent more efficient therapeutic targets hopefully also translated to the clinical care of the severely head injured. |
2007-10-25 |
2023-08-12 |
Not clear |
| F Mouchet, M Baudrimont, P Gonzalez, Y Cuenot, J P Bourdineaud, A Boudou, L Gauthie. Genotoxic and stress inductive potential of cadmium in Xenopus laevis larvae. Aquatic toxicology (Amsterdam, Netherlands). vol 78. issue 2. 2007-10-18. PMID:16616381. |
the results show: (i) micronucleus induction at environmental levels of cd contamination (2, 10, 30 microgl(-1)); (ii) an increased and concentration-dependent quantity of mt in the whole organism after contamination with 10 and 30 microgcdl(-1) (a three- and six-fold increase, respectively) although no significant difference was observed after contamination with 2 microgcdl(-1); (iii) cd uptake by the whole organism and by the liver as a response to cd exposure conditions; (4) up-regulation of the genes involved in detoxification processes and response to oxidative stress, while genes involved in dna repair and apoptosis were repressed. |
2007-10-18 |
2023-08-12 |
xenopus_laevis |
| André Amaral, Carolina Cabral, Cláudia Guedes, Armindo Rodrigue. Apoptosis, metallothionein, and bioavailable metals in domestic mice (Mus musculus L.) from a human-inhabited volcanic area. Ecotoxicology (London, England). vol 16. issue 6. 2007-10-09. PMID:17588205. |
in the excised organs, analysis of metals (al, cd, pb, zn), tunel assay for apoptosis, and immunohistochemistry for metallothionein were undertook. |
2007-10-09 |
2023-08-12 |
mouse |
| Tianying Jiang, Dianne Robert Soprano, Kenneth J Sopran. GADD45A is a mediator of CD437 induced apoptosis in ovarian carcinoma cells. Journal of cellular physiology. vol 212. issue 3. 2007-09-27. PMID:17474084. |
the synthetic retinoid cd 437 induces apoptosis in ovarian tumor cells by a mechanism that is not completely understood. |
2007-09-27 |
2023-08-12 |
Not clear |
| Zafer Gurel, Dervis Ozcelik, Sefik Dursu. Apoptotic rate and metallothionein levels in the tissues of cadmium- and copper-exposed rats. Biological trace element research. vol 116. issue 2. 2007-09-26. PMID:17646688. |
it is well known that cadmium (cd) has toxic and carcinogenic effects in rodents and humans, but the effects of cd on apoptosis are still not clear. |
2007-09-26 |
2023-08-12 |
rat |
| Zafer Gurel, Dervis Ozcelik, Sefik Dursu. Apoptotic rate and metallothionein levels in the tissues of cadmium- and copper-exposed rats. Biological trace element research. vol 116. issue 2. 2007-09-26. PMID:17646688. |
parameters such as sensitivity of the exposed organism or cells and the exposure conditions should be important in delineating the effect of cd on apoptosis. |
2007-09-26 |
2023-08-12 |
rat |
| Zafer Gurel, Dervis Ozcelik, Sefik Dursu. Apoptotic rate and metallothionein levels in the tissues of cadmium- and copper-exposed rats. Biological trace element research. vol 116. issue 2. 2007-09-26. PMID:17646688. |
these findings indicate that cd can suppress apoptosis in vivo. |
2007-09-26 |
2023-08-12 |
rat |
| Anja Wistop, Ulrike Keller, Carl N Sprung, Gerhard G Grabenbauer, Rolf Sauer, Luitpold V R Diste. Individual radiosensitivity does not correlate with radiation-induced apoptosis in lymphoblastoid cell lines or CD3+ lymphocytes. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. vol 181. issue 5. 2007-09-25. PMID:15900430. |
spontaneous and radiation-induced apoptosis of lymphoblastoid cell lines (lcls) derived from healthy donors, cancer patients and donors with radiosensitivity syndromes as well as cd(3+) lymphocytes from patients with > or = grade 3 late toxicity were investigated as a possible marker for the detection of individual radiosensitivity. |
2007-09-25 |
2023-08-12 |
Not clear |
| J Wei, J Wahl, H Knauss, S Zeller, G Jarmy, G Fitze, K-M Debatin, C Beltinge. Cytosine deaminase/5-fluorocytosine gene therapy and Apo2L/TRAIL cooperate to kill TRAIL-resistant tumor cells. Cancer gene therapy. vol 14. issue 7. 2007-09-12. PMID:17479107. |
transfection of human lan-5 neuroblastoma cells with cd rendered the cells (lan-5-cd) sensitive to 5-fc-induced, caspase-dependent apoptosis. |
2007-09-12 |
2023-08-12 |
mouse |