| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pius Josep. Mechanisms of cadmium carcinogenesis. Toxicology and applied pharmacology. vol 238. issue 3. 2009-07-23. PMID:19371617. |
it has been demonstrated that cd induces cancer by multiple mechanisms and the most important among them are aberrant gene expression, inhibition of dna damage repair, induction of oxidative stress, and inhibition of apoptosis. |
2009-07-23 |
2023-08-12 |
human |
| Pius Josep. Mechanisms of cadmium carcinogenesis. Toxicology and applied pharmacology. vol 238. issue 3. 2009-07-23. PMID:19371617. |
the available evidence indicates that, perhaps, oxidative stress plays a central role in cd carcinogenesis because of its involvement in cd-induced aberrant gene expression, inhibition of dna damage repair, and apoptosis. |
2009-07-23 |
2023-08-12 |
human |
| Changfu Hao, Weidong Hao, Xuetao Wei, Lina Xing, Jianjun Jiang, Lanqin Shan. The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 4. 2009-07-15. PMID:19327394. |
some studies show that cd(2+) and hg(2+) may induce cell proliferation and apoptosis via biphasic dose-response relationship in human cells. |
2009-07-15 |
2023-08-12 |
human |
| Changfu Hao, Weidong Hao, Xuetao Wei, Lina Xing, Jianjun Jiang, Lanqin Shan. The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 4. 2009-07-15. PMID:19327394. |
in this study, we aim at detecting the biphasic effects of cd(2+) and hg(2+) on proliferation and apoptosis of human embryonic kidney 293 (hek293) cells, analyzing the change of the mitogen-activated protein kinase (mapk) pathways, and discussing the relationship between them. |
2009-07-15 |
2023-08-12 |
human |
| Changfu Hao, Weidong Hao, Xuetao Wei, Lina Xing, Jianjun Jiang, Lanqin Shan. The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 4. 2009-07-15. PMID:19327394. |
apoptosis increases at higher concentrations (50 and 500 microm) of cd(2+) and hg(2+). |
2009-07-15 |
2023-08-12 |
human |
| Hae-Ok Byun, Na-Kyung Han, Hae-June Lee, Ki-Bum Kim, Young-Gyu Ko, Gyesoon Yoon, Yun-Sil Lee, Seok-Il Hong, Jae-Seon Le. Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. Cancer research. vol 69. issue 11. 2009-07-15. PMID:19487283. |
up-regulation of cd and down-regulation of eef1 seemed to be specific to senescence, as they were observed during cellular senescence induced by hydrogen peroxide or anticancer drugs (camptothecin, etoposide, or 50 ng doxorubicin) but not during apoptosis induced by taxol or 10 microg doxorubicin or autophagy induced by tamoxifen. |
2009-07-15 |
2023-08-12 |
human |
| Jisun Kim, Jaemog So. Cadmium-induced apoptosis is mediated by the translocation of AIF to the nucleus in rat testes. Toxicology letters. vol 188. issue 1. 2009-07-09. PMID:19433269. |
cd generates reactive oxygen species (ros) that induce apoptosis. |
2009-07-09 |
2023-08-12 |
rat |
| Jisun Kim, Jaemog So. Cadmium-induced apoptosis is mediated by the translocation of AIF to the nucleus in rat testes. Toxicology letters. vol 188. issue 1. 2009-07-09. PMID:19433269. |
we previously demonstrated that cd induces apoptosis in testicular germ cells and that apoptosis was prevented by the administration of ascorbic acid (aa), an ros scavenger. |
2009-07-09 |
2023-08-12 |
rat |
| Ida Ferrandino, Rossana Favorito, Martina Annunziata, Maria Consiglio Grimald. Cadmium induces apoptosis in the pituitary gland of Podarcis sicula. Annals of the New York Academy of Sciences. vol 1163. 2009-06-10. PMID:19456367. |
cd appears particularly toxic for pituitary cells in the lizard p. sicula; a single high intraperitoneal dose of cdcl(2) induces apoptosis, in particular in the rpd, and this effect appears irreversible. |
2009-06-10 |
2023-08-12 |
Not clear |
| Marc-Antoine Sani, Erick J Dufourc, Gerhard Gröbne. How does the Bax-alpha1 targeting sequence interact with mitochondrial membranes? The role of cardiolipin. Biochimica et biophysica acta. vol 1788. issue 3. 2009-05-14. PMID:19161978. |
cd studies revealed, that the cardiolipin mediated electrostatic locking of bax-alpha1 at the cs membrane surface promotes conformational changes into an alpha-helical state; a process which seems to be necessary to induce further conformational transition events in activated bax which finally causes irreversible membrane permeabilization during the mitochondrial apoptosis. |
2009-05-14 |
2023-08-12 |
Not clear |
| P F Litvitskiĭ, V G Kukes, N E Surnakov. [Changes of human immunophenotype during adaptation to environmental factors, in different forms of pathology and their specific treatment]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 11. 2009-03-24. PMID:19143078. |
specifically, expression of cd 95 (fas/apo-1) molecules triggering apoptosis increased in all patients with postmenopausal osteoporosis, pneumonia, and bronchial asthma but decreased in patients with rheumatic fever, erosive and ulcerative lesions in the digestive tract. |
2009-03-24 |
2023-08-12 |
human |
| David Garcia-Crespo, Erin Knock, Nada Jabado, Rima Roze. Intestinal neoplasia induced by low dietary folate is associated with altered tumor expression profiles and decreased apoptosis in mouse normal intestine. The Journal of nutrition. vol 139. issue 3. 2009-03-24. PMID:19176749. |
because apoptosis resistance is a hallmark of neoplasia, we assessed apoptosis in normal intestine of mice fed control (cd) and low-folate diets (fd); apoptosis was reduced in fd normal intestine compared with cd intestine by active caspase-3 expression (p = 0.027) and caspase-3/7 activities (p = 0.059). |
2009-03-24 |
2023-08-12 |
mouse |
| A V Stazi, B Trint. [Selenium deficiency in celiac disease: risk of autoimmune thyroid diseases]. Minerva medica. vol 99. issue 6. 2009-03-03. PMID:19034261. |
in active cd, overexpression of interleukin-15 (il-15) may increase activation of effector mechanisms of epithelial damage by stimulating t helper 1 cytokine proliferation and production and intraepithelial lymphocytes cytotoxicity by protecting these lymphocytes from apoptosis. |
2009-03-03 |
2023-08-12 |
human |
| F Caprioli, C Stolfi, R Caruso, D Fina, G Sica, L Biancone, F Pallone, G Monteleon. Transcriptional and post-translational regulation of Flip, an inhibitor of Fas-mediated apoptosis, in human gut inflammation. Gut. vol 57. issue 12. 2009-02-05. PMID:18625693. |
defects in fas-mediated apoptosis are supposed to contribute to the accumulation of t lymphocytes in the gut of patients with crohn's disease (cd). |
2009-02-05 |
2023-08-12 |
human |
| S H Wang, Y L Shih, W C Ko, Y H Wei, C M Shi. Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway. Cellular and molecular life sciences : CMLS. vol 65. issue 22. 2009-01-21. PMID:18850067. |
the cytotoxicity of cadmium (cd) induced autophagy and apoptosis in mes-13 cells was determined by flow cytometry. |
2009-01-21 |
2023-08-12 |
Not clear |
| S H Wang, Y L Shih, W C Ko, Y H Wei, C M Shi. Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway. Cellular and molecular life sciences : CMLS. vol 65. issue 22. 2009-01-21. PMID:18850067. |
these findings demonstrated that cd induces both autophagy and apoptosis through elevation of [ca(2+)](i), followed by ca(2+)-erk and ca(2+)-mitochondria-caspase signaling pathways. |
2009-01-21 |
2023-08-12 |
Not clear |
| R Castino, C Thepparit, N Bellio, D Murphy, C Isidor. Akt induces apoptosis in neuroblastoma cells expressing a C98X vasopressin mutant following autophagy suppression. Journal of neuroendocrinology. vol 20. issue 10. 2008-12-11. PMID:18673414. |
impairing autophagy-lysosomal sequestration or cathepsin d (cd)-mediated proteolysis triggered the activation of the intrinsic death pathway of apoptosis in c98x-expressing cells, but not in the wild-type -avp-expressing cells. |
2008-12-11 |
2023-08-12 |
Not clear |
| Petr Benes, Vaclav Vetvicka, Martin Fuse. Cathepsin D--many functions of one aspartic protease. Critical reviews in oncology/hematology. vol 68. issue 1. 2008-11-13. PMID:18396408. |
in the last decade, however, an increasing number of studies demonstrated that enzymatic function of cd is not restricted solely to acidic milieu of lysosomes with important consequences in regulation of apoptosis. |
2008-11-13 |
2023-08-12 |
mouse |
| Petr Benes, Vaclav Vetvicka, Martin Fuse. Cathepsin D--many functions of one aspartic protease. Critical reviews in oncology/hematology. vol 68. issue 1. 2008-11-13. PMID:18396408. |
in addition to cd enzymatic activity, it has been shown that apoptosis is also regulated by catalytically inactive mutants of cd which suggests that cd interacts with other important molecules and influences cell signaling. |
2008-11-13 |
2023-08-12 |
mouse |
| Tim Bourne, Gianluca Fossati, Andrew Nesbit. A PEGylated Fab' fragment against tumor necrosis factor for the treatment of Crohn disease: exploring a new mechanism of action. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 22. issue 5. 2008-11-13. PMID:18778114. |
this indicated that an additional mode of action is also involved in the efficacy of the anti-tnfalpha agents adalimumab, certolizumab pegol, and infliximab in cd; one suggestion was apoptosis. |
2008-11-13 |
2023-08-12 |
Not clear |