| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wing-Kee Lee, Blazej Torchalski, Naschla Kohistani, Frank Théveno. ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport. Toxicological sciences : an official journal of the Society of Toxicology. vol 121. issue 2. 2011-09-19. PMID:21436125. |
whereas pharmacological block of sphingomyelin synthase (0.1mm d609) or sphingosine kinase (1μm dimethylsphingosine), which increase the levels of ceramide and its metabolites, augmented cd(2+)-induced apoptosis, cd(2+) apoptosis was significantly decreased not only by prevention of de novo ceramide synthesis (0.1μm fumonisin b(1)) but also by inhibition of glucosylceramide synthase (2μm c(9)dgj). |
2011-09-19 |
2023-08-12 |
rat |
| Wing-Kee Lee, Blazej Torchalski, Naschla Kohistani, Frank Théveno. ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport. Toxicological sciences : an official journal of the Society of Toxicology. vol 121. issue 2. 2011-09-19. PMID:21436125. |
we therefore conclude that cd(2+) efflux is not the mechanism behind abcb1-mediated protection from cd(2+) apoptosis. |
2011-09-19 |
2023-08-12 |
rat |
| Nuray Yazihan, Mehtap Kacar Kocak, Ethem Akcil, Onur Erdem, Ahmet Saya. Role of midkine in cadmium-induced liver, heart and kidney damage. Human & experimental toxicology. vol 30. issue 5. 2011-08-29. PMID:20498035. |
cd, which can induce a broad spectrum of biological effects, is a toxic substance and is associated with inflammation and apoptosis. |
2011-08-29 |
2023-08-12 |
rat |
| Nuray Yazihan, Mehtap Kacar Kocak, Ethem Akcil, Onur Erdem, Ahmet Saya. Role of midkine in cadmium-induced liver, heart and kidney damage. Human & experimental toxicology. vol 30. issue 5. 2011-08-29. PMID:20498035. |
the aim of this study was to determine the possibility of relationship between tissue mk expression levels, tumor necrosis factor α(tnf-α) levels and apoptosis in a chronic cd toxicity model in rats. |
2011-08-29 |
2023-08-12 |
rat |
| Nuray Yazihan, Mehtap Kacar Kocak, Ethem Akcil, Onur Erdem, Ahmet Saya. Role of midkine in cadmium-induced liver, heart and kidney damage. Human & experimental toxicology. vol 30. issue 5. 2011-08-29. PMID:20498035. |
our results showed that chronic cd administration induces inflammation and apoptosis in rat liver, kidney and heart. |
2011-08-29 |
2023-08-12 |
rat |
| Baoshan Xu, Sujuan Chen, Yan Luo, Zi Chen, Lei Liu, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Long Chen, Shile Huan. Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PloS one. vol 6. issue 4. 2011-08-25. PMID:21544200. |
recently we have demonstrated that cd induces neuronal apoptosis in part by activation of the mitogen-activated protein kineses (mapk) and mammalian target of rapamycin (mtor) pathways. |
2011-08-25 |
2023-08-12 |
Not clear |
| Baoshan Xu, Sujuan Chen, Yan Luo, Zi Chen, Lei Liu, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Long Chen, Shile Huan. Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PloS one. vol 6. issue 4. 2011-08-25. PMID:21544200. |
our findings indicate that cd elevates [ca²+](i), which induces ros and activates mapk and mtor pathways, leading to neuronal apoptosis. |
2011-08-25 |
2023-08-12 |
Not clear |
| Abderrahman Chargui, Sami Zekri, Gregory Jacquillet, Isabelle Rubera, Marius Ilie, Amine Belaid, Christophe Duranton, Michel Tauc, Paul Hofman, Philippe Poujeol, Michèle V El May, Baharia Mograb. Cadmium-induced autophagy in rat kidney: an early biomarker of subtoxic exposure. Toxicological sciences : an official journal of the Society of Toxicology. vol 121. issue 1. 2011-08-16. PMID:21325019. |
we show that cd at such subtoxic doses does not affect the tubular functions nor does it induce apoptosis. |
2011-08-16 |
2023-08-12 |
human |
| S Thellung, A Corsaro, V Villa, A Simi, S Vella, A Pagano, T Flori. Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction. Cell death & disease. vol 2. 2011-08-05. PMID:21451573. |
remarkably, the inhibition of cd activity significantly reduced hprp-90-231-dependent apoptosis. |
2011-08-05 |
2023-08-12 |
human |
| Maki Tokumoto, Yasuyuki Fujiwara, Akinori Shimada, Tatsuya Hasegawa, Yoshiyuki Seko, Hisamitsu Nagase, Masahiko Sato. Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo. The Journal of toxicological sciences. vol 36. issue 2. 2011-07-19. PMID:21467746. |
in addition, cd induced phosphorylation of p53 and caused apoptosis in the nrk-52e cells. |
2011-07-19 |
2023-08-12 |
mouse |
| Maki Tokumoto, Yasuyuki Fujiwara, Akinori Shimada, Tatsuya Hasegawa, Yoshiyuki Seko, Hisamitsu Nagase, Masahiko Sato. Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo. The Journal of toxicological sciences. vol 36. issue 2. 2011-07-19. PMID:21467746. |
cd did not induce severe kidney injury, but caused apoptosis in the renal tubules. |
2011-07-19 |
2023-08-12 |
mouse |
| Maki Tokumoto, Yasuyuki Fujiwara, Akinori Shimada, Tatsuya Hasegawa, Yoshiyuki Seko, Hisamitsu Nagase, Masahiko Sato. Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo. The Journal of toxicological sciences. vol 36. issue 2. 2011-07-19. PMID:21467746. |
these results suggest that the cd-induced accumulation of p53 may be due to inhibition of p53 degradation through the down-regulation of ube2d family genes, and that cd induces p53-dependent apoptosis in renal tubular cells. |
2011-07-19 |
2023-08-12 |
mouse |
| Xiaozhong Yu, Jaspreet S Sidhu, Sungwoo Hong, Joshua F Robinson, Rafael A Ponce, Elaine M Faustma. Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 120. issue 2. 2011-07-15. PMID:21252392. |
in the present study, we investigate the role of p53 to determine sensitivity to cadmium (cd) and whether induction of stress signaling responses and perturbation of the ups are involved in cd-induced cytotoxicity and apoptosis. |
2011-07-15 |
2023-08-12 |
mouse |
| Paul Bornstei. Thrombospondins function as regulators of angiogenesis. Journal of cell communication and signaling. vol 3. issue 3-4. 2011-07-14. PMID:19798599. |
a major pathway by which tsp1 or tsp2 inhibits angiogenesis involves an interaction with cd 36 on endothelial cells, which leads to apoptosis of both the liganded and adjacent cells. |
2011-07-14 |
2023-08-12 |
mouse |
| Vânia L Souza, Alex-Alan F de Almeida, Stella G C Lima, Júlio C de M Cascardo, Delmira da C Silva, Pedro A O Mangabeira, Fábio P Gome. Morphophysiological responses and programmed cell death induced by cadmium in Genipa americana L. (Rubiaceae). Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 24. issue 1. 2011-06-14. PMID:20838856. |
in tunel reaction, it was shown that cd caused morphological changes in the cell nucleus of root tip and leaf tissues, which are typical for apoptosis. |
2011-06-14 |
2023-08-12 |
human |
| Long Chen, Baoshan Xu, Lei Liu, Yan Luo, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Christopher D Kontos, Shile Huan. Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. Free radical biology & medicine. vol 50. issue 5. 2011-05-06. PMID:21195169. |
recently we have demonstrated that cd induces neuronal apoptosis in part through activation of the mammalian target of rapamycin (mtor) pathway. |
2011-05-06 |
2023-08-12 |
Not clear |
| Paula Ferreira, Marília Cravo, Catarina Sousa Guerreiro, Lourdes Tavares, Paula Moura Santos, Miguel Brit. Fat intake interacts with polymorphisms of Caspase9, FasLigand and PPARgamma apoptotic genes in modulating Crohn's disease activity. Clinical nutrition (Edinburgh, Scotland). vol 29. issue 6. 2011-03-24. PMID:20650551. |
crohn's disease (cd) is a multifactorial disease where resistance to apoptosis is one major defect. |
2011-03-24 |
2023-08-12 |
Not clear |
| Kalamegam Gauthaman, Chui-Yee Fong, Arjunan Subramanian, Arijit Biswas, Ariff Bongs. ROCK inhibitor Y-27632 increases thaw-survival rates and preserves stemness and differentiation potential of human Wharton's jelly stem cells after cryopreservation. Stem cell reviews and reports. vol 6. issue 4. 2011-01-20. PMID:20711690. |
cd marker stemness profiles, morphology and normal karyotypes were maintained in the treatment groups after thawing and there was no obvious evidence of apoptosis (annexin v-fitc and tunel assays). |
2011-01-20 |
2023-08-12 |
human |
| O Iu Rakhimova, Z K Paĭzullaeva, V B Aleksandro. [Neuroendocrine changes in patients with inflammatory diseases and colonic cancer]. Klinicheskaia meditsina. vol 88. issue 4. 2010-12-30. PMID:20919572. |
it was shown that uc and cd can be regarded as apudopathies based on reduced melatonin production associated with altered proliferative activity, apoptosis, and accumulation of free radicals. |
2010-12-30 |
2023-08-12 |
human |
| Jin-Long Li, Rui Gao, Shu Li, Jin-Tao Wang, Zhao-Xin Tang, Shi-Wen X. Testicular toxicity induced by dietary cadmium in cocks and ameliorative effect by selenium. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 23. issue 4. 2010-11-15. PMID:20372978. |
histological and ultrastructural changes in the testis, the concentrations of cd and se, amount of lipid peroxidation (lpo), the activities of the antioxidants superoxide dismutase (sod) and glutathione peroxidase (gpx), and apoptosis and serum testosterone levels were determined. |
2010-11-15 |
2023-08-12 |
Not clear |