| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tim Bourne, Gianluca Fossati, Andrew Nesbit. A PEGylated Fab' fragment against tumor necrosis factor for the treatment of Crohn disease: exploring a new mechanism of action. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 22. issue 5. 2008-11-13. PMID:18778114. |
furthermore, certolizumab pegol (which has demonstrated efficacy in cd) does not cause complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, apoptosis, or necrosis of neutrophils, all measured in vitro. |
2008-11-13 |
2023-08-12 |
Not clear |
| He Yuling, Xiao Ruijing, Ji Xiang, Jiang Yanping, Chen Lang, Li Li, Yang Dingping, Tan Xinti, Liu Jingyi, Tang Zhiqing, Bi Yongyi, Xia Bing, Wu Xinxing, Jin Youxin, David A Fox, Steven K Lundy, Ding Guohua, Tan Jinqua. CD19+CD5+ B cells in primary IgA nephropathy. Journal of the American Society of Nephrology : JASN. vol 19. issue 11. 2008-11-12. PMID:18650480. |
in this study, flow cytometry, quantitative pcr, and confocal microscopy were used to assess the frequency, distribution, ig production, cd phenotypes, cytokine production, and sensitivity to apoptosis of cd19(+)cd5(+) b cells in the peripheral blood, peritoneal fluid, and kidney biopsies of 36 patients with primary iga nephropathy. |
2008-11-12 |
2023-08-12 |
human |
| Long Chen, Lei Liu, Shile Huan. Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free radical biology & medicine. vol 45. issue 7. 2008-11-04. PMID:18703135. |
recently we have demonstrated that cd may induce neuronal apoptosis in part through activation of c-jun n-terminal kinase (jnk) and extracellular signal-regulated kinase 1/2 (erk1/2) pathways. |
2008-11-04 |
2023-08-12 |
Not clear |
| Long Chen, Lei Liu, Shile Huan. Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free radical biology & medicine. vol 45. issue 7. 2008-11-04. PMID:18703135. |
here we show that cd induced generation of reactive oxygen species (ros), leading to apoptosis of pc12 and sh-sy5y cells. |
2008-11-04 |
2023-08-12 |
Not clear |
| Long Chen, Lei Liu, Shile Huan. Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free radical biology & medicine. vol 45. issue 7. 2008-11-04. PMID:18703135. |
the results indicate that cd induction of ros inhibits pp2a and pp5, leading to activation of jnk and erk1/2 pathways, and consequently resulting in caspase-dependent and -independent apoptosis of neuronal cells. |
2008-11-04 |
2023-08-12 |
Not clear |
| Walter Fries, Carmelo Muja, Carmela Crisafulli, Giuseppe Costantino, Giuseppe Longo, Salvatore Cuzzocrea, Emanuela Mazzo. Infliximab and etanercept are equally effective in reducing enterocyte APOPTOSIS in experimental colitis. International journal of medical sciences. vol 5. issue 4. 2008-10-01. PMID:18645606. |
loss of epithelial barrier integrity is considered an early step in the pathogenesis of crohn's disease (cd), and the rate of enterocyte apoptosis is one of the determinants of the intestinal barrier function. |
2008-10-01 |
2023-08-12 |
mouse |
| Walter Fries, Carmelo Muja, Carmela Crisafulli, Giuseppe Costantino, Giuseppe Longo, Salvatore Cuzzocrea, Emanuela Mazzo. Infliximab and etanercept are equally effective in reducing enterocyte APOPTOSIS in experimental colitis. International journal of medical sciences. vol 5. issue 4. 2008-10-01. PMID:18645606. |
tumor necrosis factor-alpha (tnf-alpha), one of the major proinflammatory mediators in cd, is one of the extrinsic signals which initiate apoptosis of enterocytes. |
2008-10-01 |
2023-08-12 |
mouse |
| Daniel Bulut, Karin Maier, Nadine Bulut-Streich, Jan Börgel, Christoph Hanefeld, Andreas Mügg. Circulating endothelial microparticles correlate inversely with endothelial function in patients with ischemic left ventricular dysfunction. Journal of cardiac failure. vol 14. issue 4. 2008-09-22. PMID:18474347. |
bone-marrow derived endothelial progenitor cells (cd34+ and vegfr2+ kdr+ epc) and endothelial-derived microparticles (cd 31+annexin v+, emp; indicator for endothelial apoptosis) were examined in the peripheral blood of 35 male, clinically stable patients with 3-vessel coronary artery disease (cad). |
2008-09-22 |
2023-08-12 |
Not clear |
| Elena A Belyaeva, Dorota Dymkowska, Mariusz R Wieckowski, Lech Wojtcza. Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells. Toxicology and applied pharmacology. vol 231. issue 1. 2008-09-19. PMID:18501399. |
hg(2+) and cd(2+) produced a high percentage of cell death by both necrosis and apoptosis, whereas cu(2+) at concentrations up to 500 microm was weakly effective. |
2008-09-19 |
2023-08-12 |
rat |
| Ying Liu, Douglas M Templeto. Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II. Journal of cellular physiology. vol 217. issue 2. 2008-09-12. PMID:18506790. |
here we demonstrate that cd(2+) increases jnk and p38 kinase phosphorylation, and inhibition of p38-but not of jnk-increases cell viability by suppressing apoptosis in preference to apoptosis-like death. |
2008-09-12 |
2023-08-12 |
mouse |
| Ying Liu, Douglas M Templeto. Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II. Journal of cellular physiology. vol 217. issue 2. 2008-09-12. PMID:18506790. |
inhibition of glutathione synthesis exacerbates a cd(2+)-dependent increase in cellular peroxides and favors apoptosis-like death over apoptosis. |
2008-09-12 |
2023-08-12 |
mouse |
| Ying Liu, Douglas M Templeto. Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II. Journal of cellular physiology. vol 217. issue 2. 2008-09-12. PMID:18506790. |
activation of p38 kinase and of camk-ii by cd(2+) are associated with caspase-independent apoptosis that is not dependent on mitochondrial destabilization. |
2008-09-12 |
2023-08-12 |
mouse |
| E A Drozdova, S N Teplov. [Role of impaired immune response regulatory processes in the pathogenesis of uveitis associated with rheumatic diseases]. Vestnik oftalmologii. vol 124. issue 3. 2008-09-11. PMID:18589650. |
the authors made cd typing of lymphocytes, by evaluating the processes of their activation and apoptosis, estimated the amount of the cytokines il-4, ifn-gamma, tnf-alpha, and soluble tnf-alpha receptor in the serum and tear. |
2008-09-11 |
2023-08-12 |
Not clear |
| Ling-Juan Pang, Jian-Yong Shao, Xiao-Man Liang, Yun-Fei Xia, Yi-Xin Zen. Mitochondrial DNA somatic mutations are frequent in nasopharyngeal carcinoma. Cancer biology & therapy. vol 7. issue 2. 2008-09-05. PMID:18376149. |
moreover, x-ray radiation could induce apoptosis and the cd mutation in a time- and dose-dependent manner, but did not induce mtdna point mutations. |
2008-09-05 |
2023-08-12 |
Not clear |
| Ling-Juan Pang, Jian-Yong Shao, Xiao-Man Liang, Yun-Fei Xia, Yi-Xin Zen. Mitochondrial DNA somatic mutations are frequent in nasopharyngeal carcinoma. Cancer biology & therapy. vol 7. issue 2. 2008-09-05. PMID:18376149. |
our results suggest that cd mutation induced by irradiation is one of the late events after apoptosis of the cancer cells, and the mtdna cd mutation may associated with the susceptibility of npc cells to ir-induced apoptosis. |
2008-09-05 |
2023-08-12 |
Not clear |
| Xiaozhong Yu, Sungwoo Hong, Elaine M Faustma. Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures. Toxicological sciences : an official journal of the Society of Toxicology. vol 104. issue 2. 2008-08-28. PMID:18463101. |
our results demonstrated that cd exposure lead to time- and dose-dependent morphological changes that are associated with the induction of apoptosis. |
2008-08-28 |
2023-08-12 |
rat |
| Jennifer Thompson, John Banniga. Cadmium: toxic effects on the reproductive system and the embryo. Reproductive toxicology (Elmsford, N.Y.). vol 25. issue 3. 2008-08-05. PMID:18367374. |
cd has been shown to accumulate in embryos from the four-cell stage onwards, and higher dosage exposure inhibits progression to the blastocyst stage, and can cause degeneration and decompaction in blastocysts following formation, with apoptosis and breakdown in cell adhesion. |
2008-08-05 |
2023-08-12 |
chicken |
| Lihua Li, Huanjie Yang, Di Chen, Cindy Cui, Q Ping Do. Disulfiram promotes the conversion of carcinogenic cadmium to a proteasome inhibitor with pro-apoptotic activity in human cancer cells. Toxicology and applied pharmacology. vol 229. issue 2. 2008-08-04. PMID:18304598. |
in the current study, we report, for the first time, that dsf is able to convert the carcinogen cd to a proteasome-inhibitor and cancer cell apoptosis inducer. |
2008-08-04 |
2023-08-12 |
human |
| Melanie Beaujouin, Emmanuelle Liaudet-Coopma. Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity. Advances in experimental medicine and biology. vol 617. 2008-07-10. PMID:18497069. |
during apoptosis, cd is translocated to the cytosol. |
2008-07-10 |
2023-08-12 |
Not clear |
| Melanie Beaujouin, Emmanuelle Liaudet-Coopma. Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity. Advances in experimental medicine and biology. vol 617. 2008-07-10. PMID:18497069. |
here, we have investigated the role of (wild-type) wt cd and its proteolytically inactive counterpart overexpressed by 3y1-ad12 cancer cells during chemotherapeutic-induced cytotoxicity and apoptosis, as well as the relevance of cd catalytic function. |
2008-07-10 |
2023-08-12 |
Not clear |