| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonio Di Sabatino, Sylvia L F Pender, Claire L Jackson, Joanna D Prothero, John N Gordon, Lucia Picariello, Laura Rovedatti, Guillermo Docena, Giovanni Monteleone, David S Rampton, Francesco Tonelli, Gino R Corazza, Thomas T MacDonal. Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies. Gastroenterology. vol 133. issue 1. 2007-08-16. PMID:17631138. |
we investigated the action of infliximab on apoptosis, the production of matrix metalloproteinases (mmps) and tissue inhibitor of metalloproteinases (timp)-1, and migration of crohn's disease (cd) myofibroblasts. |
2007-08-16 |
2023-08-12 |
Not clear |
| Walter Manucha, Liliana Carrizo, Celeste Ruete, Patricia G Vallé. Apoptosis induction is associated with decreased NHE1 expression in neonatal unilateral ureteric obstruction. BJU international. vol 100. issue 1. 2007-08-13. PMID:17552965. |
cellular apoptosis in proximal tubules (pt) and collecting ducts (cd) was assessed using a standard assay, and nhe1 expression in the renal cortex assessed using reverse transcription-polymerase chain reaction and western blots. |
2007-08-13 |
2023-08-12 |
rat |
| Andrea K Lawrance, Liyuan Deng, Lawrence C Brody, Richard H Finnell, Barry Shane, Rima Roze. Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice. The Journal of nutritional biochemistry. vol 18. issue 5. 2007-07-20. PMID:16963246. |
however, in both mtr groups of mice, dietary folate deficiency significantly increased adenoma number (from 32.3+/-3.8 on a cd to 48.1+/-4.2 on a folate-deficient diet), increased plasma homocysteine, decreased global dna methylation in preneoplastic intestines and increased apoptosis in tissues. |
2007-07-20 |
2023-08-12 |
mouse |
| Wei-Ping Mao, Ji-Lin Ye, Zheng-Bing Guan, Jie-Ming Zhao, Chao Zhang, Na-Na Zhang, Ping Jiang, Ting Tia. Cadmium induces apoptosis in human embryonic kidney (HEK) 293 cells by caspase-dependent and -independent pathways acting on mitochondria. Toxicology in vitro : an international journal published in association with BIBRA. vol 21. issue 3. 2007-06-07. PMID:17052885. |
therefore, we have studied the effects of cd on hek 293 cells and investigated the mechanisms of cd-induced apoptosis. |
2007-06-07 |
2023-08-12 |
human |
| Wei-Ping Mao, Ji-Lin Ye, Zheng-Bing Guan, Jie-Ming Zhao, Chao Zhang, Na-Na Zhang, Ping Jiang, Ting Tia. Cadmium induces apoptosis in human embryonic kidney (HEK) 293 cells by caspase-dependent and -independent pathways acting on mitochondria. Toxicology in vitro : an international journal published in association with BIBRA. vol 21. issue 3. 2007-06-07. PMID:17052885. |
studies of morphology and oligonucleosomal dna fragmentation demonstrated that 30-60 microm cd induced apoptosis as early as 6-9h with strong effects on mtt activity, whereas 120 microm cd revealed mainly necrosis, and the result of flow cytometry confirmed it. |
2007-06-07 |
2023-08-12 |
human |
| Ying Liu, Douglas M Templeto. Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells. FEBS letters. vol 581. issue 7. 2007-06-06. PMID:17367784. |
at 10-20 microm, cd(2+) initiates apoptosis in 25-55% of mesangial cells by 6h. |
2007-06-06 |
2023-08-12 |
Not clear |
| Ying Liu, Douglas M Templeto. Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells. FEBS letters. vol 581. issue 7. 2007-06-06. PMID:17367784. |
inhibition of camk-ii, but not of erk, suppresses cd(2+)-induced apoptosis. |
2007-06-06 |
2023-08-12 |
Not clear |
| Dominique Latinne, René Fiass. New insights into the cellular immunology of the intestine in relation to the pathophysiology of inflammatory bowel diseases. Acta gastro-enterologica Belgica. vol 69. issue 4. 2007-05-22. PMID:17343083. |
another defective mechanism in cd is t cell resistance to apoptosis, leading to inappropriate immune homeostasis and accumulation of t cells in the tissues. |
2007-05-22 |
2023-08-12 |
Not clear |
| Marleen I Verstege, Anje A te Velde, Daan W Homme. Apoptosis as a therapeutic paradigm in inflammatory bowel diseases. Acta gastro-enterologica Belgica. vol 69. issue 4. 2007-05-22. PMID:17343084. |
evidence is increasing that a defect in apoptosis is involved in the pathogenesis of inflammatory bowel diseases (ibd), including crohn's disease (cd) and ulcerative colitis (uc). |
2007-05-22 |
2023-08-12 |
Not clear |
| Pei-Ming Yang, Hung-Chi Chen, Jia-Shiuan Tsai, Lih-Yuan Li. Cadmium induces Ca2+-dependent necrotic cell death through calpain-triggered mitochondrial depolarization and reactive oxygen species-mediated inhibition of nuclear factor-kappaB activity. Chemical research in toxicology. vol 20. issue 3. 2007-05-21. PMID:17323976. |
cells exposed to 4 microm cd for 24 h did not show signs of apoptosis, such as dna fragmentation and caspase-3 activation. |
2007-05-21 |
2023-08-12 |
Not clear |
| Sung Gu Han, Vince Castranova, Val Vallyatha. Comparative cytotoxicity of cadmium and mercury in a human bronchial epithelial cell line (BEAS-2B) and its role in oxidative stress and induction of heat shock protein 70. Journal of toxicology and environmental health. Part A. vol 70. issue 10. 2007-05-15. PMID:17454561. |
apoptosis was significantly increased in the cells exposed to 50 microm of cd (3.5-fold) and hg (3.6-fold). |
2007-05-15 |
2023-08-12 |
human |
| Sung Gu Han, Vince Castranova, Val Vallyatha. Comparative cytotoxicity of cadmium and mercury in a human bronchial epithelial cell line (BEAS-2B) and its role in oxidative stress and induction of heat shock protein 70. Journal of toxicology and environmental health. Part A. vol 70. issue 10. 2007-05-15. PMID:17454561. |
these results suggest that both cytotoxicity and apoptosis were significantly elevated with all metals tested; however, cd was relatively more toxic. |
2007-05-15 |
2023-08-12 |
human |
| Neelima Pathak, Shashi Khandelwa. Role of oxidative stress and apoptosis in cadmium induced thymic atrophy and splenomegaly in mice. Toxicology letters. vol 169. issue 2. 2007-05-03. PMID:17267144. |
a pronounced inhibition of cell proliferative response at 48 h and 72 h may also be linked to cd induced apoptosis. |
2007-05-03 |
2023-08-12 |
mouse |
| John J Shacka, Barbara J Klocke, Chainllie Young, Masahiro Shibata, John W Olney, Yasuo Uchiyama, Paul Saftig, Kevin A Rot. Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 8. 2007-03-22. PMID:17314303. |
the targeted deletion of cd in mice results in extensive neuropathology, including biochemical and morphological evidence of apoptosis and autophagic stress (aberrant autophagosome accumulation), effects that are similar to those observed in ncl. |
2007-03-22 |
2023-08-12 |
mouse |
| John J Shacka, Barbara J Klocke, Chainllie Young, Masahiro Shibata, John W Olney, Yasuo Uchiyama, Paul Saftig, Kevin A Rot. Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 8. 2007-03-22. PMID:17314303. |
together, these results suggest that cd deficiency-induced neuropathology does not require bax-dependent apoptosis and highlights the importance of caspase-independent neuron death and neurodegeneration resulting from the genetic disruption of lysosome function. |
2007-03-22 |
2023-08-12 |
mouse |
| Ponnusamy Murugavel, Leelavinothan Pari, Sandhya L Sitasawad, Sandeep Kumar, Santhosh Kuma. Cadmium induced mitochondrial injury and apoptosis in vero cells: protective effect of diallyl tetrasufide from garlic. The international journal of biochemistry & cell biology. vol 39. issue 1. 2007-02-02. PMID:16971165. |
the nuclei morphological analysis with 4',6-diamidino-2-phenylindole staining confirmed that diallyl tetrasulfide at 40 microg/ml prevented the cd (10 microm) induced apoptosis. |
2007-02-02 |
2023-08-12 |
Not clear |
| Elena A Belyaeva, Dorota Dymkowska, Mariusz R Wieckowski, Lech Wojtcza. Reactive oxygen species produced by the mitochondrial respiratory chain are involved in Cd2+-induced injury of rat ascites hepatoma AS-30D cells. Biochimica et biophysica acta. vol 1757. issue 12. 2007-01-29. PMID:17069748. |
it was found that cd(2+) induced both necrosis and apoptosis in a time- and dose-dependent way. |
2007-01-29 |
2023-08-12 |
rat |
| Elena A Belyaeva, Dorota Dymkowska, Mariusz R Wieckowski, Lech Wojtcza. Reactive oxygen species produced by the mitochondrial respiratory chain are involved in Cd2+-induced injury of rat ascites hepatoma AS-30D cells. Biochimica et biophysica acta. vol 1757. issue 12. 2007-01-29. PMID:17069748. |
it is concluded that cd(2+) toxicity in as-30d rat ascites hepatoma, manifested by cell necrosis and/or apoptosis, involves ros generation, most likely at the level of respiratory complex iii, and is related to opening of the mitochondrial permeability transition pore. |
2007-01-29 |
2023-08-12 |
rat |
| Xu-hong Zhang, Ai-jun Lin, Yu-hong Su, Yong-guan Zh. [DNA damages and apoptosis induced by cd in the leaves of horsebean Vicia faba]. Huan jing ke xue= Huanjing kexue. vol 27. issue 4. 2007-01-19. PMID:16768008. |
[dna damages and apoptosis induced by cd in the leaves of horsebean vicia faba]. |
2007-01-19 |
2023-08-12 |
Not clear |
| Xu-hong Zhang, Ai-jun Lin, Yu-hong Su, Yong-guan Zh. [DNA damages and apoptosis induced by cd in the leaves of horsebean Vicia faba]. Huan jing ke xue= Huanjing kexue. vol 27. issue 4. 2007-01-19. PMID:16768008. |
these results indicated that cd was an element with high genotoxicity and dna damage was one of the mechanisms of cell apoptosis induced by cd. |
2007-01-19 |
2023-08-12 |
Not clear |