| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chung-Hyun Park, Byung-Hoon Lee, Sang-Gun Ahn, Jung-Hoon Yoon, Seon-Hee O. Serine 9 and tyrosine 216 phosphorylation of GSK-3β differentially regulates autophagy in acquired cadmium resistance. Toxicological sciences : an official journal of the Society of Toxicology. vol 135. issue 2. 2014-06-17. PMID:23897984. |
taken together, this study shows that acquired cd resistance is regulated by gsk-3β phosphorylation state, but not activation state, and intracellular localization of p-ser gsk-3 regulates cd-induced autophagy and apoptosis. |
2014-06-17 |
2023-08-12 |
mouse |
| Rachele Ciccocioppo, Alessandro Vanoli, Catherine Klersy, Venerina Imbesi, Vincenzo Boccaccio, Rachele Manca, Elena Betti, Giuseppina Cristina Cangemi, Elena Strada, Roberta Besio, Antonio Rossi, Colomba Falcone, Sandro Ardizzone, Paolo Fociani, Piergiorgio Danelli, Gino Roberto Corazz. Role of the advanced glycation end products receptor in Crohn's disease inflammation. World journal of gastroenterology. vol 19. issue 45. 2014-06-12. PMID:24363518. |
to investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products (rage) in delayed apoptosis and tumor necrosis factor (tnf)-α production in crohn's disease (cd). |
2014-06-12 |
2023-08-12 |
Not clear |
| Shaozheng Weng, Wenxiang Wang, Yuchen Li, Hong Li, Xiaoli Lu, Shihua Xiao, Tingting Wu, Meimei Xie, Wenchang Zhan. Continuous cadmium exposure from weaning to maturity induces downregulation of ovarian follicle development-related SCF/c-kit gene expression and the corresponding changes of DNA methylation/microRNA pattern. Toxicology letters. vol 225. issue 3. 2014-05-21. PMID:24462979. |
transmission electron microscopy and tunel assay confirmed the increase of follicle apoptosis as cd concentration increased. |
2014-05-21 |
2023-08-12 |
rat |
| Grace Choong, Ying Liu, Douglas M Templeto. Interplay of calcium and cadmium in mediating cadmium toxicity. Chemico-biological interactions. vol 211. 2014-05-19. PMID:24463198. |
calmodulin is necessary for induction of apoptosis by several agents, yet induction of apoptosis by cd(2+) is prevented by camk-ii block, and ca(2+)-dependent phosphorylation of camk-ii has been linked to increased cd(2+)-dependent apoptosis. |
2014-05-19 |
2023-08-12 |
Not clear |
| Grace Choong, Ying Liu, Douglas M Templeto. Interplay of calcium and cadmium in mediating cadmium toxicity. Chemico-biological interactions. vol 211. 2014-05-19. PMID:24463198. |
a key question for future cadmium research is whether cytoskeletal disruption leads to apoptosis, or rather if apoptosis initiates cytoskeletal disruption in the context of cd(2+). |
2014-05-19 |
2023-08-12 |
Not clear |
| Roberto Chiarelli, Maria Carmela Roccher. Heavy metals and metalloids as autophagy inducing agents: focus on cadmium and arsenic. Cells. vol 1. issue 3. 2014-04-08. PMID:24710492. |
a more detailed discussion will concern the activation of autophagy in cd-exposed sea urchin embryo since it is a suitable model system that is very sensitive to environmental stress, and cd is one of the most studied heavy metal inductors of stress and modulator of different factors such as: protein kinase and phosphatase, caspases, mitochondria, heat shock proteins, metallothioneins, transcription factors, reactive oxygen species, apoptosis and autophagy. |
2014-04-08 |
2023-08-13 |
Not clear |
| Yolande Asara, Juan A Marchal, Esther Carrasco, Houria Boulaiz, Giuliana Solinas, Pasquale Bandiera, Maria A Garcia, Cristiano Farace, Andrea Montella, Roberto Madedd. Cadmium modifies the cell cycle and apoptotic profiles of human breast cancer cells treated with 5-fluorouracil. International journal of molecular sciences. vol 14. issue 8. 2014-04-07. PMID:23941782. |
the purpose of this work was to study the effects of cd on cell cycle, apoptosis, and gene and protein expression in mcf-7 breast cancer cells treated with 5-fu. |
2014-04-07 |
2023-08-12 |
human |
| Yolande Asara, Juan A Marchal, Esther Carrasco, Houria Boulaiz, Giuliana Solinas, Pasquale Bandiera, Maria A Garcia, Cristiano Farace, Andrea Montella, Roberto Madedd. Cadmium modifies the cell cycle and apoptotic profiles of human breast cancer cells treated with 5-fluorouracil. International journal of molecular sciences. vol 14. issue 8. 2014-04-07. PMID:23941782. |
cd significantly suppressed apoptosis of mcf-7 cells pre-treated with 5-fu. |
2014-04-07 |
2023-08-12 |
human |
| Dian Gao, Zhen'e Xu, Xiaoyan Zhang, Hongmei Wang, Yannan Wang, Weiping Mi. Molecular cloning, immunohistochemical localization, characterization and expression analysis of caspase-9 from the purse red common carp (Cyprinus carpio) exposed to cadmium. Aquatic toxicology (Amsterdam, Netherlands). vol 142-143. 2014-03-20. PMID:23958785. |
accordingly, the results signify that caspase-9 may play an essential role in cd induced apoptosis. |
2014-03-20 |
2023-08-12 |
human |
| John I Aneto. Rising environmental cadmium levels in developing countries: threat to genome stability and health. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 27. issue 2. 2014-03-06. PMID:23652223. |
although the rising level of cd in the environment is widely acknowledged, the occult threat it poses to genome stability largely through inhibition of normal dna damage repair, oxidative stress and apoptosis and health is poorly recognized. |
2014-03-06 |
2023-08-12 |
human |
| Frank Thévenod, Giuliano Ciarimboli, Marcus Leistner, Natascha A Wolff, Wing-Kee Lee, Irina Schatz, Thorsten Keller, Rouvier Al-Monajjed, Valentin Gorboulev, Hermann Koepsel. Substrate- and cell contact-dependent inhibitor affinity of human organic cation transporter 2: studies with two classical organic cation substrates and the novel substrate cd2+. Molecular pharmaceutics. vol 10. issue 8. 2014-03-05. PMID:23763587. |
incubation of hoct2 overexpressing human embryonic kidney 293 cells (hek-hoct2-c) or rat renal proximal tubule cells expressing roct2 (nrk-52e-c) with cd(2+) resulted in an increased level of apoptosis that was reduced by oct2 inhibitory ligand cimetidine(+). |
2014-03-05 |
2023-08-12 |
human |
| Dongmei Liu, Jian Yang, Yingjun Li, Meng Zhang, Lan Wan. Cd-induced apoptosis through the mitochondrial pathway in the hepatopancreas of the freshwater crab Sinopotamon henanense. PloS one. vol 8. issue 7. 2014-02-24. PMID:23894343. |
cd is one of the most common pollutants in the environment that also induces the apoptosis. |
2014-02-24 |
2023-08-12 |
Not clear |
| Dongmei Liu, Jian Yang, Yingjun Li, Meng Zhang, Lan Wan. Cd-induced apoptosis through the mitochondrial pathway in the hepatopancreas of the freshwater crab Sinopotamon henanense. PloS one. vol 8. issue 7. 2014-02-24. PMID:23894343. |
to explore the mechanism of apoptosis in the hepatopancreas, freshwater crab s. henanense were treated with 0, 3.56, 7.12, 14.25, 28.49 and 56.98 mg/l cd for 72 h. apoptosis was noticeable in every treatment group and necrosis was observed clearly in the high concentration cd groups. |
2014-02-24 |
2023-08-12 |
Not clear |
| Dongmei Liu, Jian Yang, Yingjun Li, Meng Zhang, Lan Wan. Cd-induced apoptosis through the mitochondrial pathway in the hepatopancreas of the freshwater crab Sinopotamon henanense. PloS one. vol 8. issue 7. 2014-02-24. PMID:23894343. |
the apoptosis index increased following the elevation of cd concentration and got 32.9% in the highest cd group. |
2014-02-24 |
2023-08-12 |
Not clear |
| Dongmei Liu, Jian Yang, Yingjun Li, Meng Zhang, Lan Wan. Cd-induced apoptosis through the mitochondrial pathway in the hepatopancreas of the freshwater crab Sinopotamon henanense. PloS one. vol 8. issue 7. 2014-02-24. PMID:23894343. |
these results implied that apoptosis in the hepatopancreas induced by cd occurrs through the mitochondrial caspase-dependent pathway. |
2014-02-24 |
2023-08-12 |
Not clear |
| Yan Yuan, Chen-yang Jiang, Hui Xu, Ya Sun, Fei-fei Hu, Jian-chun Bian, Xue-zhong Liu, Jian-hong Gu, Zong-ping Li. Cadmium-induced apoptosis in primary rat cerebral cortical neurons culture is mediated by a calcium signaling pathway. PloS one. vol 8. issue 5. 2014-02-18. PMID:23741317. |
studies have shown that cd disrupts intracellular free calcium ([ca(2+)]i) homeostasis, leading to apoptosis in a variety of cells including primary murine neurons. |
2014-02-18 |
2023-08-12 |
rat |
| Yan Yuan, Chen-yang Jiang, Hui Xu, Ya Sun, Fei-fei Hu, Jian-chun Bian, Xue-zhong Liu, Jian-hong Gu, Zong-ping Li. Cadmium-induced apoptosis in primary rat cerebral cortical neurons culture is mediated by a calcium signaling pathway. PloS one. vol 8. issue 5. 2014-02-18. PMID:23741317. |
consistent with known toxic properties of cd, exposure of cerebral cortical neurons to cd caused morphological changes indicative of apoptosis and cell death. |
2014-02-18 |
2023-08-12 |
rat |
| Yan Yuan, Chen-yang Jiang, Hui Xu, Ya Sun, Fei-fei Hu, Jian-chun Bian, Xue-zhong Liu, Jian-hong Gu, Zong-ping Li. Cadmium-induced apoptosis in primary rat cerebral cortical neurons culture is mediated by a calcium signaling pathway. PloS one. vol 8. issue 5. 2014-02-18. PMID:23741317. |
interestingly, apoptosis, cell death and these cellular events induced by cd were blocked by bapta-am, a specific intracellular ca(2+) chelator. |
2014-02-18 |
2023-08-12 |
rat |
| Sabana Khatun, Shail K Chaube, Chandra N Bhattacharyy. Generation of hydrogen peroxide mediates hanging death-induced neuronal cell apoptosis in the dentate gyrus of the rat brain. Brain research bulletin. vol 95. 2014-02-10. PMID:23608114. |
the increased caspase-3 activity induced neuronal cell apoptosis during early period (0-9h) of hd as compare to cd group. |
2014-02-10 |
2023-08-12 |
rat |
| Sabana Khatun, Shail K Chaube, Chandra N Bhattacharyy. Generation of hydrogen peroxide mediates hanging death-induced neuronal cell apoptosis in the dentate gyrus of the rat brain. Brain research bulletin. vol 95. 2014-02-10. PMID:23608114. |
in conclusion, data of the present study suggest that the permanent global brain ischemia induces neuronal cell apoptosis during early period of hd through ros-mediated pathway, while cd induces neuronal cell necrosis and disruption of the histoarchitecture of the dg region. |
2014-02-10 |
2023-08-12 |
rat |