| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alma Barajas-Espinosa, Ariel Basye, Erin Jesse, Haixu Yan, David Quan, Chun-An Che. Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²⁺-induced apoptosis. Free radical biology & medicine. vol 74. 2015-06-01. PMID:24973647. |
treatment with nac prevents dusp4 degradation and protects cells against cd(2+)-induced apoptosis. |
2015-06-01 |
2023-08-13 |
Not clear |
| Alma Barajas-Espinosa, Ariel Basye, Erin Jesse, Haixu Yan, David Quan, Chun-An Che. Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²⁺-induced apoptosis. Free radical biology & medicine. vol 74. 2015-06-01. PMID:24973647. |
depletion of intracellular gsh by buthionine sulfoximine makes cells more susceptible to cd(2+)-induced apoptosis. |
2015-06-01 |
2023-08-13 |
Not clear |
| Guiping Yuan, Shujun Dai, Zhongqiong Yin, Hongke Lu, Renyong Jia, Jiao Xu, Xu Song, Li Li, Yang Shu, Xinghong Zhao, Zhenzhen Chen, Qiaojia Fan, Xiaoxia Liang, Changliang He, Lizi Yin, Cheng Lv, Qiaobo Lei, Liang Wang, Yong Mi, Xiaolong Yu, Min Zhan. Sub-chronic lead and cadmium co-induce apoptosis protein expression in liver and kidney of rats. International journal of clinical and experimental pathology. vol 7. issue 6. 2015-05-26. PMID:25031709. |
these results suggested that low-dose exposure to pb and cd can cause significant hepatic and renal apoptosis and finally impair their function. |
2015-05-26 |
2023-08-13 |
rat |
| Dongmei Zhang, Liang Wang, Lijun Yan, Xianjing Miao, Chen Gong, Min Xiao, Runzhou Ni, Qiyun Tan. Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells via p38 MAPK in Crohn's disease. Experimental and molecular pathology. vol 98. issue 1. 2015-05-21. PMID:25533544. |
taken together, our findings suggested that vps4b may facilitate the iec apoptosis in cd via p38 mapk signaling pathway. |
2015-05-21 |
2023-08-13 |
mouse |
| Xiaobing Wang, Ting Wu, Feng Zhou, Shi Liu, Rui Zhou, Siying Zhu, Lu Song, Feng Zhu, Ge Wang, Bing Xi. IL12p40 regulates functional development of human CD4+ T cells: enlightenment by the elevated expressions of IL12p40 in patients with inflammatory bowel diseases. Medicine. vol 94. issue 10. 2015-05-06. PMID:25761185. |
we also found for the first time that neutralizing il12p40 secretion could inhibit proliferation, enhance apoptosis, induce a g0/g1 arrest, restrain t helper 1 type immune responses, and promote chemokine c-c motif ligand 20-mediated migration of human cd4⁺ t cells, which might be the mechanisms why anti-il12p40 treatment presented efficacy in cd. |
2015-05-06 |
2023-08-13 |
human |
| Gaspar Banfalv. Apoptotic agents inducing genotoxicity-specific chromatin changes. Apoptosis : an international journal on programmed cell death. vol 19. issue 9. 2015-03-30. PMID:25023960. |
genotoxic agents such as irradiation (alpha, gamma, uv-b) and heavy metals (cd, pb, ni, hg, ag) caused alterations in chromatin structures leading to apoptosis. |
2015-03-30 |
2023-08-13 |
human |
| Alessandra Zulian, Raffaella Cancello, Chiara Ruocco, Davide Gentilini, Anna Maria Di Blasio, Piergiorgio Danelli, Giancarlo Micheletto, Elisabetta Cesana, Cecilia Invitt. Differences in visceral fat and fat bacterial colonization between ulcerative colitis and Crohn's disease. An in vivo and in vitro study. PloS one. vol 8. issue 10. 2015-02-23. PMID:24205244. |
genes linked to inflammation, bacterial response, chemotaxis and angiogenesis were down-regulated in adipocytes from uc compared to cd, whereas genes related to metallothioneins, apoptosis pathways and growth factor binding were up-regulated. |
2015-02-23 |
2023-08-12 |
Not clear |
| Chenyang Jiang, Yan Yuan, Feifei Hu, Qiwen Wang, Kangbao Zhang, Yi Wang, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Li. Cadmium induces PC12 cells apoptosis via an extracellular signal-regulated kinase and c-Jun N-terminal kinase-mediated mitochondrial apoptotic pathway. Biological trace element research. vol 158. issue 2. 2015-02-09. PMID:24577723. |
to investigate the role of mitogen-activated protein kinase (mapk) and downstream events in cadmium (cd)-induced neuronal apoptosis executed via the mitochondrial apoptotic pathway, this study used the pc-12 cell line as a neuronal model. |
2015-02-09 |
2023-08-12 |
Not clear |
| Mohamed S Othman, Ahmed Nada, Hassan S Zaki, Ahmed E Abdel Monei. Effect of Physalis peruviana L. on cadmium-induced testicular toxicity in rats. Biological trace element research. vol 159. issue 1-3. 2015-01-26. PMID:24728876. |
testicular histopathology showed that cd produced an extensive germ cell apoptosis, and the pretreatment of meph in cd-treated rats significantly reduced cd-induced testicular damage. |
2015-01-26 |
2023-08-13 |
rat |
| Seref Alpsoy, Mehmet Kanter, Cevat Aktas, Mustafa Erboga, Aydın Akyuz, Dursun Cayan Akkoyun, Mustafa Ora. Protective effects of onion extract on cadmium-induced oxidative stress, histological damage, and apoptosis in rat heart. Biological trace element research. vol 159. issue 1-3. 2015-01-26. PMID:24736979. |
furthermore, our data indicate a significant reduction of apoptosis in the cardiomyocytes of the cd group treated with ace therapy. |
2015-01-26 |
2023-08-13 |
rat |
| Helena Oliveira, Cristina Monteiro, Francisco Pinho, Sónia Pinho, José Miguel P Ferreira de Oliveira, Conceição Santo. Cadmium-induced genotoxicity in human osteoblast-like cells. Mutation research. Genetic toxicology and environmental mutagenesis. vol 775-776. 2015-01-21. PMID:25435354. |
also, the cytokinesis-block micronucleus (cbmn) assay parameters (mn, npbs and the percentage of cells under apoptosis or necrosis) together with the cell cycle appear as the most sensitive to cd cyto- and genotoxicity, being early affected even with the lowest cd dose. |
2015-01-21 |
2023-08-13 |
human |
| Cilene Bicca Dias, Marciane Milanski, Mariana Portovedo, Vivian Horita, Maria de Lourdes Setsuko Ayrizono, Núria Planell, Cláudio Saddy Rodrigues Coy, Lício Augusto Velloso, Luciana Rodrigues Meirelles, Raquel Franco Lea. Defective apoptosis in intestinal and mesenteric adipose tissue of Crohn's disease patients. PloS one. vol 9. issue 6. 2015-01-20. PMID:24887376. |
crohn's disease (cd) is associated with complex pathogenic pathways involving defects in apoptosis mechanisms. |
2015-01-20 |
2023-08-13 |
Not clear |
| Cilene Bicca Dias, Marciane Milanski, Mariana Portovedo, Vivian Horita, Maria de Lourdes Setsuko Ayrizono, Núria Planell, Cláudio Saddy Rodrigues Coy, Lício Augusto Velloso, Luciana Rodrigues Meirelles, Raquel Franco Lea. Defective apoptosis in intestinal and mesenteric adipose tissue of Crohn's disease patients. PloS one. vol 9. issue 6. 2015-01-20. PMID:24887376. |
however, the potential role of altered apoptosis in mat of cd has not been addressed. |
2015-01-20 |
2023-08-13 |
Not clear |
| Zhen An, Yongmei Qi, Dejun Huang, Xueyan Gu, Yihong Tian, Ping Li, Hui Li, Yingmei Zhan. EGCG inhibits Cd(2+)-induced apoptosis through scavenging ROS rather than chelating Cd(2+) in HL-7702 cells. Toxicology mechanisms and methods. vol 24. issue 4. 2014-12-28. PMID:24392852. |
egcg inhibits cd(2+)-induced apoptosis through scavenging ros rather than chelating cd(2+) in hl-7702 cells. |
2014-12-28 |
2023-08-12 |
Not clear |
| Zhen An, Yongmei Qi, Dejun Huang, Xueyan Gu, Yihong Tian, Ping Li, Hui Li, Yingmei Zhan. EGCG inhibits Cd(2+)-induced apoptosis through scavenging ROS rather than chelating Cd(2+) in HL-7702 cells. Toxicology mechanisms and methods. vol 24. issue 4. 2014-12-28. PMID:24392852. |
apoptosis is one of the key events in cadmium (cd(2+))-induced cytotoxicity. |
2014-12-28 |
2023-08-12 |
Not clear |
| Zhen An, Yongmei Qi, Dejun Huang, Xueyan Gu, Yihong Tian, Ping Li, Hui Li, Yingmei Zhan. EGCG inhibits Cd(2+)-induced apoptosis through scavenging ROS rather than chelating Cd(2+) in HL-7702 cells. Toxicology mechanisms and methods. vol 24. issue 4. 2014-12-28. PMID:24392852. |
nevertheless, the study of egcg on cd(2+)-induced apoptosis is rarely reported. |
2014-12-28 |
2023-08-12 |
Not clear |
| Zhen An, Yongmei Qi, Dejun Huang, Xueyan Gu, Yihong Tian, Ping Li, Hui Li, Yingmei Zhan. EGCG inhibits Cd(2+)-induced apoptosis through scavenging ROS rather than chelating Cd(2+) in HL-7702 cells. Toxicology mechanisms and methods. vol 24. issue 4. 2014-12-28. PMID:24392852. |
the objective of this study was to clarify the effect and detailed mechanism of egcg on cd(2+)-induced apoptosis. |
2014-12-28 |
2023-08-12 |
Not clear |
| Basil Smith, Diandra Randle, Roman Mezencev, LeeShawn Thomas, Cimona Hinton, Valerie Odero-Mara. Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D. Molecules (Basel, Switzerland). vol 19. issue 4. 2014-11-25. PMID:24699144. |
lysosomes are vulnerable organelles to reactive oxygen species (ros)-induced injuries, with the potential to initiate and or facilitate apoptosis subsequent to release of proteases such as cathepsin d (cd) into the cytosol. |
2014-11-25 |
2023-08-13 |
Not clear |
| Basil Smith, Diandra Randle, Roman Mezencev, LeeShawn Thomas, Cimona Hinton, Valerie Odero-Mara. Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D. Molecules (Basel, Switzerland). vol 19. issue 4. 2014-11-25. PMID:24699144. |
immunocytochemical analysis revealed cd relocalization from the lysosome to the cytosol subsequent to camalexin treatments, which was associated with increased protein expression of mature cd; p53, a transcriptional activator of cd; bax, a downstream effector of cd, and cleaved parp, a hallmark for apoptosis. |
2014-11-25 |
2023-08-13 |
Not clear |
| Joe Luevano, Chendil Damodara. A review of molecular events of cadmium-induced carcinogenesis. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 33. issue 3. 2014-11-24. PMID:25272057. |
briefly, various in vitro studies demonstrate that cd can act as a mitogen, can stimulate cell proliferation and inhibit apoptosis and dna repair, and can induce carcinogenesis in several mammalian tissues and organs. |
2014-11-24 |
2023-08-13 |
human |