| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christina Brill, Till Scheuer, Christoph Bührer, Stefanie Endesfelder, Thomas Schmit. Oxygen impairs oligodendroglial development via oxidative stress and reduced expression of HIF-1α. Scientific reports. vol 7. 2018-10-30. PMID:28230075. |
maturation (a2b5, o4, o1, mbp, cnp, arborization), oxidative stress (nitrotyrosine western blot, nrf2 and sod2 expression), apoptosis (tunel), proliferation (ki67), and expression of transcription factors regulated by hypoxia-inducible-factor-1-alpha (hif-1α) expressed in opcs (olig1, olig2, sox9, sox10) were assessed in rat opcs and oln93 cells cultured at 5% o2 and 21% o2. |
2018-10-30 |
2023-08-13 |
rat |
| Zhangxiao Peng, Yan Wang, Jianhui Fan, Xuejing Lin, Chunying Liu, Yang Xu, Weidan Ji, Chao Yan, Changqing S. Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway. Scientific reports. vol 7. 2018-10-29. PMID:28117370. |
western blot coupled with cell cycle and apoptosis analysis validated the results of proteomics analysis. |
2018-10-29 |
2023-08-13 |
Not clear |
| Yifeng Yuan, Xue Li, Maoquan L. Overexpression of miR‑17‑5p protects against high glucose‑induced endothelial cell injury by targeting E2F1‑mediated suppression of autophagy and promotion of apoptosis. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29786752. |
the cell counting kit‑8 assay, flow cytometry, immunofluorescence, and reverse transcription‑quantitative polymerase chain reaction and western blot analyses were used to detect cell viability, apoptosis, autophagy, and relative mrna and protein expression, respectively. |
2018-10-29 |
2023-08-13 |
human |
| Jing Li, Zhongjun Ding, Yue Yang, Baohong Mao, Yanxia Wang, Xiaoying X. Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxide‑induced oxidative stress and apoptosis. Molecular medicine reports. vol 18. issue 3. 2018-10-26. PMID:30015960. |
reverse transcription‑quantitative polymerase chain reaction and western blot analysis were performed to detect the expression of apoptosis‑associated factors, including survivin, hypoxia inducible factor 1‑α (hif1‑α), bcl‑2 apoptosis regulator (bcl‑2), bcl‑2 associated x apoptosis regulator (bax). |
2018-10-26 |
2023-08-13 |
human |
| Hamid Ali Nagi Al-Jamal, Muhammad Farid Johan, Siti Asmaa Mat Jusoh, Imilia Ismail, Wan Rohani Wan Tai. Re-Expression of Bone Marrow Proteoglycan-2 by 5-Azacytidine is associated with STAT3 Inactivation and SensitivityResponse to Imatinib in Resistant CML Cells Asian Pacific journal of cancer prevention : APJCP. vol 19. issue 6. 2018-10-25. PMID:29936783. |
methods: cml cells resistant to imatinib weretreated with 5-aza and cytotoxicity of imatinib and apoptosis were determined by mts and annexin-v, respectively.gene expression analysis was detected by real time-pcr, stats activity examined using western blot and methylationstatus of prg2 was determined by pyrosequencing analysis. |
2018-10-25 |
2023-08-13 |
Not clear |
| Ganlu Deng, Shan Zeng, Junli Ma, Yan Zhang, Yanling Qu, Ying Han, Ling Yin, Changjing Cai, Cao Guo, Hong She. The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma. Scientific reports. vol 7. 2018-10-24. PMID:28134289. |
applying multiple assays of cell proliferation, flow cytometry, immunofluorescence staining, qrt-pcr, western blot, fluorescence molecular tomography imaging, the influences of neferine on emt-regulated viability, apoptosis, invasion, and oxaliplatin (oxa) sensitivity were assessed in hcc cells of hepg2 and bel-7402, as well as in xenograft animal models in vivo. |
2018-10-24 |
2023-08-13 |
Not clear |
| Yilin Che, Juan Li, Zongjuan Li, Jing Li, Shuai Wang, Ying Yan, Kun Zou, Lijuan Zo. Osthole enhances antitumor activity and irradiation sensitivity of cervical cancer cells by suppressing ATM/NF‑κB signaling. Oncology reports. vol 40. issue 2. 2018-10-24. PMID:29989651. |
hela, siha, c‑33a and caski cervical cancer cell lines were cultured and treated with osthole and/or irradiation and then subjected to 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑-diphenyl‑tetrazolium bromide cell viability, colony formation, apoptosis, acridine orange/ethidium bromide fluorescence staining, wound‑healing, transwell migration and invasion, immunofluorescence, comet and western blot assays. |
2018-10-24 |
2023-08-13 |
Not clear |
| Peng Wang, Na Shen, Danzheng Liu, Xianhui Ning, Daquan Wu, Xinsheng Huan. TRIM24 siRNA induced cell apoptosis and reduced cell viability in human nasopharyngeal carcinoma cells. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29749443. |
further, caspase kits and western blot analysis were used to detect the expression of apoptosis and angiogenesis‑associated proteins. |
2018-10-19 |
2023-08-13 |
human |
| Bingyi Shao, Xiaohui Fu, Yang Yu, Deqin Yan. Regulatory effects of miRNA‑181a on FasL expression in bone marrow mesenchymal stem cells and its effect on CD4+T lymphocyte apoptosis in estrogen deficiency‑induced osteoporosis. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845202. |
western blot analysis indicated that estrogen promoted the apoptosis of cd4+t lymphocytes through regulation of fasl expression in bmmscs in a concentration‑dependent manner. |
2018-10-19 |
2023-08-13 |
mouse |
| Wenxian Zheng, Shuyan Han, Shantong Jiang, Xiran He, Xiaohong Li, Huirong Ding, Minhua Cao, Pingping L. Antitumor effects of Xi Huang pills on MDA‑MB‑231 cells in vitro and in vivo. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29956784. |
in order to investigate the effects further, cell cycle distribution, apoptosis and mitochondrial membrane potential assays were performed, as well as western blot analyses. |
2018-10-19 |
2023-08-13 |
Not clear |
| Yan Yu, Wanting Li, Liqin Ren, Chunyan Yang, Dongze Li, Xin Han, Yeying Sun, Changjun Lv, Fang Ha. Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29956802. |
transmission electron microscope, ao‑pi staining, flow cytometry and western blot were used to examine the crosstalk between autophagy and apoptosis in hypoxic conditions. |
2018-10-19 |
2023-08-13 |
rat |
| Ya He, Ying Yang, Ruili Wang, Hui Wang, Qiaoya Ma, Songsheng Chen, Daiying Sh. Expression changes and roles of Sema3A and Nrp1 in cultured rat cortical neurons after oxygen glucose deprivation. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 9. 2018-10-19. PMID:30030955. |
western blot was performed to detect the expression of sema3a and nrp-1 protein and tunel was used to detect apoptosis. |
2018-10-19 |
2023-08-13 |
rat |
| Jian-Xia Shi, Qin Huan. Glucagon‑like peptide‑1 protects mouse podocytes against high glucose‑induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in vitro. Molecular medicine reports. vol 18. issue 2. 2018-10-18. PMID:29845208. |
notably, treatment with glp‑1 attenuated hg‑induced increases in ros production and podocyte apoptosis, which may occur via downregulation of the expression of caspase‑3 and caspase‑9, and increased expression of nephrin, podocin and sirt1, as determined by reverse transcription‑quantitative polymerase chain reaction and western blot analysis. |
2018-10-18 |
2023-08-13 |
mouse |
| Yuanxin Zhang, Yakun Ge, Xie Ping, Ming Yu, Dawei Lou, Wei Sh. Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines. Molecular medicine reports. vol 18. issue 2. 2018-10-18. PMID:29901126. |
the apoptosis assay and western blot analysis of poly‑adp‑ribose polymerase, pro‑caspase 3 and pro‑caspase 8 demonstrated that silibinin synergized with paclitaxel in promoting sgc‑7901 gc cell apoptosis. |
2018-10-18 |
2023-08-13 |
human |
| Hongliang Yu, Jian He, Qian Lu, Da Huo, Shanmei Yuan, Zhengyang Zhou, Peipei Xu, Yong H. Anti-Fas Antibody Conjugated Nanoparticles Enhancing the Antitumor Effect of Camptothecin by Activating the Fas-FasL Apoptotic Pathway. ACS applied materials & interfaces. vol 8. issue 44. 2018-10-16. PMID:27754664. |
results of western blot confirmed that these nps could mimic the function of activated cytotoxic lymphocyte (ctl) to activate the fas-fasl apoptosis pathway of tumor cells. |
2018-10-16 |
2023-08-13 |
Not clear |
| Yan Li, Yanjun Gu, Na Tang, Yanqing Liu, Zhankao Zha. miR-22-Notch Signaling Pathway Is Involved in the Regulation of the Apoptosis and Autophagy in Human Ovarian Cancer Cells. Biological & pharmaceutical bulletin. vol 41. issue 8. 2018-10-16. PMID:30068873. |
after over-expressing mir-22 in human ovarian cancer cell lines ovcar-3 and skov3, cell viability is determined by 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2h-tetrazolium-5-carboxanilide (xtt) method, cell apoptosis is observed by flow cytometry (fcm), mrna expression of mir-22 is measured by rna preparation and rt-pcr, protein expression of notch1, hes1, beclin1 and lc3b-ii is analyzed by western blot. |
2018-10-16 |
2023-08-13 |
human |
| Jie Yang, Lei Li, Yan Xi, Ruimei Sun, Hu Wang, Yanxin Ren, Liufang Zhao, Xiaoli Wang, Xiaojiang L. Combination of IFITM1 knockdown and radiotherapy inhibits the growth of oral cancer. Cancer science. vol 109. issue 10. 2018-10-12. PMID:29770536. |
after this, the survival rates, cell apoptosis, caspase-3 viability, expression and γ-h2ax were detected using colony formation, flow cytometry, western blot and immunofluorescence, respectively. |
2018-10-12 |
2023-08-13 |
mouse |
| Qingkai Meng, Yue Chen, Bo Lian, Yan Shang, Hongmei Yan. miR‑218 promotes apoptosis of SW1417 human colon cancer cells by targeting c‑FLIP. Oncology reports. vol 40. issue 2. 2018-10-12. PMID:29845219. |
following overexpression of mir‑218 in human colon cancer cells, cell viability was determined by ckk‑8 assay, cell apoptosis was observed using a tunel kit, the expression of caspase‑8, and its inhibitor cellular fas‑associated death domain‑like interleukin‑1β‑converting enzyme inhibitory protein (c‑flip) was assessed by rt‑pcr, western blot analysis and immunohistochemistry. |
2018-10-12 |
2023-08-13 |
human |
| Chuan Lin, Yu Qin, Hua Zhang, Ming-Yang Gao, Yan-Fu Wan. EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in non‑small cell lung cancer cells. Oncology reports. vol 40. issue 1. 2018-10-11. PMID:29749533. |
expression of rfpl3 and htert at the mrna and protein levels was determined by real‑time quantitative pcr (rt‑qpcr) and western blot analysis; cell viability was detected by mtt assay, and apoptosis was assayed via flow cytometry. |
2018-10-11 |
2023-08-13 |
human |
| Weilan Kong, Kai Kang, Yang Gao, Haitao Liu, Xianglin Meng, Yanhui Cao, Songliu Yang, Wen Liu, Jiannan Zhang, Kaijiang Yu, Mingyan Zha. GTS-21 Protected Against LPS-Induced Sepsis Myocardial Injury in Mice Through α7nAChR. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29680908. |
the pathological results of myocardial tissue were detected by the he method; the apoptosis rate was detected by the tunel method; the relative expressions of nf-κb p65, caspase-3, caspase-8, bcl-2, bax, p53, and a7nachr were detected by real-time quantitative pcr (rt-pcr); and the protein expressions of il-6, il-1 β, tnf-α, and pstat3 were detected by western blot. |
2018-10-10 |
2023-08-13 |
mouse |