| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuting Lu, Ruili Zhang, Zhenying Wang, Shuhua Zhou, Yali Song, Lamei Chen, Nan Chen, Wenmin Liu, Canan Ji, Wangli Wu, Li Zhan. Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 9. 2018-09-06. PMID:30043857. |
western blot analyses were performed to analyze the relevant clinical indicators of hidrotic ectodermal dysplasia and markers of apoptosis in transfected hacat cells. |
2018-09-06 |
2023-08-13 |
human |
| Shixiu Feng, Zhenzhen Wang, Min Zhang, Xiaohui Zhu, Zhanjun Re. HG30, a tetrahydroanthraquinone compound isolated from the roots of Prismatomeris connate, induces apoptosis in human non-small cell lung cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 100. 2018-09-03. PMID:29427923. |
western blot analysis further demonstrated that induction of apoptosis by hg30 in a549 and h1299 cells involves both caspase-dependent apoptosis pathways, including mitochondria- and death receptor-mediated pathways, and an apoptosis-inducing factor (aif) -associated caspase-independent apoptosis pathway. |
2018-09-03 |
2023-08-13 |
human |
| Jiajia Chen, Hui Yu, Jiahong Zhong, Hongfang Feng, Haitao Wang, Yufang Cheng, Zhengqiang Zou, Chang Huang, Zhongzhen Zhou, Wenhua Zheng, Jiangping X. The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion. Brain research bulletin. vol 137. 2018-08-31. PMID:29155261. |
tunel staining and western blot results showed that fcpr16 reduced apoptosis and regulated apoptotic-related proteins, with increased level of phosphorylated protein kinase b. |
2018-08-31 |
2023-08-13 |
rat |
| Sharada H Sharma, Jayasurya Suresh Kumar, David Raj Chellappan, Sangeetha Nagaraja. Molecular chemoprevention by morin - A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 100. 2018-08-31. PMID:29453046. |
the effect of morin on nf-κb signaling in dmh-induced carcinogenic events such as inflammation and apoptosis were analyzed by studying the histopathological analysis using hematoxylin and eosin staining (h &e), mrna expression using q-pcr, protein expression using immunohistochemistry (ihc) and western blot. |
2018-08-31 |
2023-08-13 |
rat |
| Lin Qiao, Jianhua Fu, Xindong Xue, Yongyan Shi, Li Yao, Wanjie Huang, Jun Li, Dan Zhang, Na Liu, Xin Tong, Yanna Du, Yuqing Pa. Neuronalinjury and roles of apoptosis and autophagy in a neonatal rat model of hypoxia-ischemia-induced periventricular leukomalacia. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29436652. |
cellular apoptosis was detected by terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) assay and the protein and mrna expression alterations of neuronal nuclei (neun), caspase‑3 and beclin 1 in the model group were detected by western blot analysis and reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) analyses. |
2018-08-30 |
2023-08-13 |
rat |
| Jing Chen, Guo Zheng, Hu Guo, Zhong-Nan Shi, Jiao Jiang, Xiao-Yu Wang, Xiao Yang, Xian-Yu Li. The effect of metformin treatment on endoplasmic reticulum (ER) stress induced by status epilepticus (SE) via the PERK-eIF2α-CHOP pathway. Bosnian journal of basic medical sciences. vol 18. issue 1. 2018-08-29. PMID:28686850. |
chop, eif2α, and perk expression was determined by western blot; apoptosis was analyzed by tunel assay. |
2018-08-29 |
2023-08-13 |
rat |
| Pan-Pan Kang, Shu-Tong Yao, Tian-Tian Guo, Zhi-Chao Wang, Hua Tian, Peng Jiao, Jian Zhou, Shu-Cun Qi. [Activating transcription factor 6-C/EBP homologous protein pathway mediates advanced glycated albumin-induced macrophage apoptosis]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 6. 2018-08-29. PMID:29270592. |
protein and mrna levels of c/ebp homologous protein (chop, a key-signaling component of ers-induced apoptosis) were detected by western blot and real-time fluorescence quantitative pcr, respectively. |
2018-08-29 |
2023-08-13 |
Not clear |
| Wei Shi, Xiaoling Wang, Lihong Ruan, Jiamei Fu, Fang Liu, Jinfeng Q. MiR-200a promotes epithelial-mesenchymal transition of endometrial cancer cells by negatively regulating FOXA2 expression. Die Pharmazie. vol 72. issue 11. 2018-08-29. PMID:29442045. |
mtt assay measured cell proliferation, apoptosis assay measured apoptosis, transwell invasion assay measured cell invasion, and western blot measured the protein expression of foxa2, e-cadherin, and vimentin. |
2018-08-29 |
2023-08-13 |
Not clear |
| Yan Feng, Li-Li Zu, Lei Zhan. MicroRNA-26b inhibits the tumor growth of human liver cancer through the PI3K/Akt and NF-κB/MMP-9/VEGF pathways. Oncology reports. vol 39. issue 5. 2018-08-29. PMID:29498407. |
forced upregulation of microrna-26b had anticancer effects, inhibited cell proliferation, induced apoptosis and promoted bax and caspase-3/-9 protein expression in a liver cancer cell line as determined by mtt assay, flow cytometry and western blot analysis. |
2018-08-29 |
2023-08-13 |
human |
| P Zhang, S-R Zhao, F Liu, X-J Sun, H Li. Oridonin Induces Apoptosis in Human Nasopharyngeal Carcinoma Cells Involving ROS Generation. Folia biologica. vol 63. issue 4. 2018-08-27. PMID:29256858. |
apoptosis, mitochondrial membrane potential (mmp), reactive oxygen species (ros), and expression of apoptosis-related proteins were analysed by flow cytometry with propidium iodide staining, jc-1 staining, dcfh-da staining, and western blot analysis, respectively. |
2018-08-27 |
2023-08-13 |
human |
| Fukun Chen, Shuting Yin, Jialun Zhu, Li Jia, Huaping Zhang, Chuanzhou Yang, Chao Liu, Zhiyong Den. Effects of nuclear factor‑κB on the uptake of 131iodine and apoptosis of thyroid carcinoma cells. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29393421. |
furthermore, western blot analysis revealed that the inhibition of nf‑κb expression downregulated the expression levels of xiap and ciap1 (p<0.05), while the expression levels of caspase‑3 were upregulated, indicating that the observed reduction in cell viability following nf‑κb inhibition may be due to an increased level of apoptosis. |
2018-08-27 |
2023-08-13 |
Not clear |
| Qipeng Zhao, Xiaobo Wang, Ailing Chen, Xiuli Cheng, Guoxin Zhang, Jianmin Sun, Yunsheng Zhao, Yu Huang, Yafei Zh. Rhein protects against cerebral ischemic‑/reperfusion‑induced oxidative stress and apoptosis in rats. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436613. |
levels of b‑cell lymphoma-2 (bcl‑2), apoptosis regulator bax (bax), caspase-9, caspase‑3 and cleaved caspase‑3 expression were analyzed using western blot analysis. |
2018-08-27 |
2023-08-13 |
rat |
| Seung Taek Lim, Ye Won Jeon, Hongki Gwak, Se Young Kim, Young Jin Su. Synergistic anticancer effects of ruxolitinib and calcitriol in estrogen receptor‑positive, human epidermal growth factor receptor 2‑positive breast cancer cells. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29436642. |
western blot analysis revealed that these synergistic effects of ruxolitinib and calcitriol were associated with reduced protein levels of jak2, phosphorylated jak2, c‑myc proto oncogene protein, cyclin‑d1, apoptosis regulator bcl‑2 and bcl‑2‑like protein 1, and with increased levels of caspase‑3 and bcl‑2‑associated agonist of cell death proteins. |
2018-08-27 |
2023-08-13 |
human |
| Bo Yu, Wei Li, Fen Al, Zhen Che. MicroRNA-33a deficiency inhibits proliferation and fibrosis through inactivation of TGF-β/Smad pathway in human cardiac fibroblasts. Die Pharmazie. vol 72. issue 8. 2018-08-24. PMID:29441904. |
cell viability, apoptosis, and fibrosis which reflected by expressions of col-i, col-iii and α-smooth muscle actin (α-sma) were evaluated by cck-8 assay, flow cytometry, qrt-pcr and western blot analysis. |
2018-08-24 |
2023-08-13 |
human |
| Yefang Hu, Xi Li, Ling Lin, Siting Liang, Jian Ya. Puerarin inhibits non-small cell lung cancer cell growth via the induction of apoptosis. Oncology reports. vol 39. issue 4. 2018-08-23. PMID:29393465. |
this result was further confirmed by western blot analysis of expression levels of proteins involved in the mitochondrial-mediated apoptosis pathway. |
2018-08-23 |
2023-08-13 |
mouse |
| Donghui Zhou, Yong Zhou, Chao Li, Lina Yan. Silencing of B7-H4 suppresses the tumorigenicity of the MGC-803 human gastric cancer cell line and promotes cell apoptosis via the mitochondrial signaling pathway. International journal of oncology. vol 52. issue 4. 2018-08-23. PMID:29436630. |
furthermore, the results of western blot analysis indicated that the downregulation of b7-h4 induced the apoptosis of the mgc-803 cells via the mitochondrial signaling pathway through the activation of caspase‑3 and caspase‑9, and by altering the bax/bcl-2 ratio in a manner that favored apoptosis. |
2018-08-23 |
2023-08-13 |
human |
| D L Chang, W Wei, Z P Yu, C K Qi. miR-152-5p inhibits proliferation and induces apoptosis of liver cancer cells by up-regulating FOXO expression. Die Pharmazie. vol 72. issue 6. 2018-08-22. PMID:29442022. |
the protein expressions of fork head transcription factor o (foxo) and apoptosis related factors in mir-transfected cells were detected by western blot assay. |
2018-08-22 |
2023-08-13 |
Not clear |
| Xirui Yang, Qi Zhang, Zhaomeng Gao, Chunyan Yu, Lei Zhan. Baicalin alleviates IL-1β-induced inflammatory injury via down-regulating miR-126 in chondrocytes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 99. 2018-08-21. PMID:29331857. |
thereafter, cells were treated with baicalin, and cell viability, apoptosis, the expressions of apoptosis-related protein and pro-inflammatory factors were respectively detected using cck-8 assay, flow cytometry, qrt-pcr and western blot analysis. |
2018-08-21 |
2023-08-13 |
Not clear |
| Ilaria Passacantilli, Valentina Panzeri, Francesca Terracciano, Gianfranco Delle Fave, Claudio Sette, Gabriele Capurs. Co-treatment with gemcitabine and nab-paclitaxel exerts additive effects on pancreatic cancer cell death. Oncology reports. vol 39. issue 4. 2018-08-21. PMID:29393478. |
the combined treatment caused an increase in cell death by apoptosis and in cell cycle blockage in s phase, as assessed by flow cytometry and western blot analysis of the parp-1 cleavage. |
2018-08-21 |
2023-08-13 |
Not clear |
| Karolina Janyst, Michał Janyst, Marta Siernicka, Witold Lase. Synergistic antitumor effects of histone deacetylase inhibitor scriptaid and bortezomib against ovarian cancer cells. Oncology reports. vol 39. issue 4. 2018-08-21. PMID:29436692. |
as shown in the annexin v-fitc/pi assay and western blot analysis of caspase‑3/-9 and p21 protein expression, these synergistic antitumor effects were due to both induction of apoptosis and inhibition of proliferation. |
2018-08-21 |
2023-08-13 |
Not clear |