| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang-Yuan Xiong, Song-Tao Tang, Huan Su, Hai-Qin Tang, Pin Jiang, Qing Zhou, Yuan Wang, Hua-Qing Zh. Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115422. |
additionally, cellular apoptosis in rats with dm was increased, and the expression of bcl‑2 was downregulated, while levels of bcl‑2‑associated x and caspase‑3 were upregulated, and these observations were reversed by mlt, as determined by tunel and western blot analysis, respectively. |
2018-07-09 |
2023-08-13 |
rat |
| Hua Huang, Hong Zhang, Dan Li, Shigang Chen, Chanjuan Zhou, Qi Li, Peng He, Liang Fang, Yong Zhang, Xiaomei Li, Jingjing Zhou, Lin Sun, Siwen Liu, Yujie Guo, Ying Huang, Peng Xi. Different inhibitory effects on the proliferation and apoptosis of human and laboratory Borna disease virus‑infected human neuroblastoma SH‑SY5Y cells in vitro. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115502. |
western blot analysis confirmed the upregulation of apoptosis regulator bax protein and the downregulation of apoptosis regulator bcl‑2 protein caused by the two bdv strains. |
2018-07-09 |
2023-08-13 |
human |
| Jichan Shi, Hongye Ning, Guiqing He, Yitong Huang, Zhengxing Wu, Lingling Jin, Xiangao Jian. Rottlerin inhibits cell growth, induces apoptosis and cell cycle arrest, and inhibits cell invasion in human hepatocellular carcinoma. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115596. |
the present study investigated whether rottlerin has a tumor suppressive role via inhibiting the expression of taz, using cell viability assay, apoptosis and cell cycle analyses, western blot analysis and tanswell invasion assay. |
2018-07-09 |
2023-08-13 |
human |
| Yanyan Li, Feng Xu, Hanyan Xiao, Feng Ha. Long noncoding RNA BDNF-AS inversely regulated BDNF and modulated high-glucose induced apoptosis in human retinal pigment epithelial cells. Journal of cellular biochemistry. vol 119. issue 1. 2018-07-06. PMID:28657668. |
the effects of bdnf-as downregulation on dgi apoptosis and bdnf expression were assessed by tunel assay, qpcr, and western blot, respectively. |
2018-07-06 |
2023-08-13 |
human |
| Jingliang He, Xiaoxun Chen, Bowei Li, Wenjie Zhou, Jinfeng Xiao, Ke He, Jinqian Zhang, Guoan Xian. Chaetocin induces cell cycle arrest and apoptosis by regulating the ROS-mediated ASK-1/JNK signaling pathways. Oncology reports. vol 38. issue 4. 2018-07-05. PMID:28849240. |
as determined by western blot analysis, expression levels of the apoptosis signal-regulating kinase 1 (ask-1) signalosome and its downstream c-jun n-terminal kinase (jnk) signaling pathway were increased under oxidative stress stimulation. |
2018-07-05 |
2023-08-13 |
mouse |
| Xinfeng Wang, Lina Zhang, Fan Zhao, Ruirong Xu, Jie Jiang, Chenglu Zhang, Hong Liu, Hongming Huan. Long non-coding RNA taurine-upregulated gene 1 correlates with poor prognosis, induces cell proliferation, and represses cell apoptosis via targeting aurora kinase A in adult acute myeloid leukemia. Annals of hematology. vol 97. issue 8. 2018-07-03. PMID:29654398. |
cell proliferation, apoptosis, rna, and protein expressions were determined by ckk-8, annexin v-fitc-propidium iodide, quantitative polymerase chain reaction, and western blot assays. |
2018-07-03 |
2023-08-13 |
Not clear |
| Shuke Ge, Dan Wang, Qinglong Kong, Wei Gao, Jiayi Su. Function of miR-152 as a Tumor Suppressor in Human Breast Cancer by Targeting PIK3CA. Oncology research. vol 25. issue 8. 2018-07-02. PMID:28247844. |
the efficiency of mir-152-3p transfection was evaluated by quantitative real-time pcr, and the effects on cell viability and apoptosis as well as on the pi3k/akt signaling pathway were investigated by mtt assay, flow cytometry, and western blot analysis, respectively. |
2018-07-02 |
2023-08-13 |
human |
| Ji-Hong Pan, Hai-Bin Wang, Xiao-Fei Du, Jiang-Yue Liu, Dai-Juan Zhan. [Polydatin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 12. 2018-06-29. PMID:28822191. |
in addition, flow cytometry was employed to analyze apoptosis and cell cycle distribution； rt-pcr and western blot assay were used to detect pi3k, akt, mtor, and p70s6k mrna and protein expression levels. |
2018-06-29 |
2023-08-13 |
human |
| Qi Qi, Pei Zhang, Qi-Xiang Li, Qiong Pan, Hai-Lun Zheng, Su-Rong Zha. [Effect of oridonin on apoptosis and intracellular reactive oxygen species level in triple-negative breast cancer MDA-MB-231 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 42. issue 12. 2018-06-29. PMID:28822194. |
the inhibitory effect of oridonin on proliferation of mda-mb-231 cells was measured by mtt assay; apoptosis was analyzed by flow cytometry with pi staining and annexin v-fitc/pi staining; intracellular reactive oxygen species (ros) level was determined by ros detection kit, and expressions of parp, bcl-2, caspase-3 were analyzed by western blot. |
2018-06-29 |
2023-08-13 |
Not clear |
| Zhonghua Yang, Yuanyuan Geng, Zhiya Yao, Huimin Jia, Yuzuo Bai, Weilin Wan. Spatiotemporal Expression of Bcl-2/Bax and Neural Cell Apoptosis in the Developing Lumbosacral Spinal Cord of Rat Fetuses with Anorectal Malformations. Neurochemical research. vol 42. issue 11. 2018-06-26. PMID:28712050. |
tunel staining was performed to identify apoptosis, and the expression of bcl-2/bax was confirmed with immunohistochemical staining, rt-qpcr and western blot analysis on e16, e17, e19 and e21. |
2018-06-26 |
2023-08-13 |
rat |
| Maojun Liu, Shengquan Liu, Wenting Tan, Fen Tang, Junrong Long, Zining Li, Biao Liang, Chun Chu, Jun Yan. Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28990064. |
western blot analysis was performed to detect the expression of proteins associated with apoptosis, ers and the hippo‑mst signalling pathway. |
2018-06-26 |
2023-08-13 |
rat |
| Dohyun Kim, Mi Hee Lee, Min-Ah Koo, Byeong-Ju Kwon, Min Sung Kim, Gyeung Mi Seon, Seung Hee Hong, Jong-Chul Par. Suppression of T24 human bladder cancer cells by ROS from locally delivered hematoporphyrin-containing polyurethane films. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. vol 17. issue 6. 2018-06-22. PMID:29717739. |
after irradiating with led and incubating for 24 hours, cell viability analysis, cell cycle analysis, apoptosis assay, intracellular and extracellular ros generation study and western blot were performed. |
2018-06-22 |
2023-08-13 |
human |
| Kejin Huang, Jiashi Geng, Jing Wan. Long non-coding RNA RP11-552M11.4 promotes cells proliferation, migration and invasion by targeting BRCA2 in ovarian cancer. Cancer science. vol 109. issue 5. 2018-06-19. PMID:29478268. |
qpcr, western blot, ckk-8, annexin v/propidium iodide (av/pi), wound-healing and matrigel invasion assays were carried out to detect rna expression, protein expression, cell proliferation, apoptosis, migration, and invasion, respectively. |
2018-06-19 |
2023-08-13 |
Not clear |
| Elizabeth A McCart, Rajesh L Thangapazham, Eric D Lombardini, Steven R Mog, Ronald Allan M Panganiban, Kelley M Dickson, Rihab A Mansur, Vitaly Nagy, Sung-Yop Kim, Reed Selwyn, Michael R Landauer, Thomas N Darling, Regina M Da. Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury. Journal of radiation research. vol 58. issue 5. 2018-06-18. PMID:28340212. |
using western blot analysis of 17.9 gy-irradiated mice skin samples, we also detected a marker of accelerated senescence (p21/waf1) 7 days post-irradiation, and a marker of cellular apoptosis (activated caspase-3) at 30 days, both preceding histological evidence of inflammatory infiltrates. |
2018-06-18 |
2023-08-13 |
mouse |
| Shi Wanchao, Ma Chen, Su Zhiguo, Xie Futang, Shi Mengmen. Protective effect and mechanism of Lactobacillus on cerebral ischemia reperfusion injury in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 51. issue 7. 2018-06-15. PMID:29791585. |
cell apoptosis was assayed by tunnel and the toll-like receptor (tlr)-4, ikb, and a20 were assayed by western blot. |
2018-06-15 |
2023-08-13 |
rat |
| Ting-Ting Zhao, Tian-Lun Yang, Li Gong, Pei W. Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes. Gene. vol 666. 2018-06-13. PMID:29730426. |
apoptosis was evaluated by tunel staining, flow cytometry analysis and western blot assay for cleaved caspase-3. |
2018-06-13 |
2023-08-13 |
cat |
| Hae-Mi Kang, Bong-Soo Park, Hyun-Kyung Kang, Hae-Ryoun Park, Su-Bin Yu, In-Ryoung Ki. Delphinidin induces apoptosis and inhibits epithelial-to-mesenchymal transition via the ERK/p38 MAPK-signaling pathway in human osteosarcoma cell lines. Environmental toxicology. vol 33. issue 6. 2018-06-12. PMID:29451351. |
flow cytometry, confocal microscopy, and a western blot analysis also indicated evidence of apoptosis. |
2018-06-12 |
2023-08-13 |
human |
| Li Luo, Tinghe Yu, Dingqun Bai, Lina H. [Induction of Apoptosis of Human Cisplatin-resistance Lung Cancer Cells with MPPa-photodynamic Therapy]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 33. issue 4. 2018-06-12. PMID:29714913. |
lung cancer is the leading cause of cancer-related deaths worldwide.despite the development and use of several targeting drugs for lung cancer therapy,the five-year survival rate has remained as low as 15%for the past three decades.cisplatin-based chemotherapy is considered the first-line therapeutic strategy for lung cancer.however,developments of chemoresistance is a major obstacle for the successful treatment.therefore,the development of novel therapy against cisplatin-resistance lung cancer is imperative.photodynamic therapy(pdt),which is a non-invasive combinatorial therapeutic modality using light,photosensitizer(ps)and oxygen,may provide an unprecedented tool to develop more effective treatments.to provide experimental basis for its application in cisplatin-resistance lung cancer,we will discuss the biological effects of mppa-photodynamic therapy in human cisplatin-resistance lung cancer cells in this article.human cisplatin-resistance lung cancer cells a549/ddp were co-cultured with mppa(0,1,2,4,8,16μmol/l)and exposed to light(0,0.6,1.2,2.4,3.6,4.8j/cm2),and cell viability was determined with cck-8assay.flow cytometry was used to detect apoptosis,dcfh-da staining was employed to observe reactive oxygen species(ros),and western blot was used to detect the expressions of b-cell lymphoma-2(bcl-2)protein and bcl-2associated x protein(bax).the proliferation of a549/ddp cells was suppressed by pdt.the apoptotic rate in the pdt group was significantly higher than that in the control,mppa or light group(p<0.05).the level of ros was increased.the expression of bax was increased,and that of bcl-2was decreased.mppa-photodynamic therapy can significantly suppress cell viability,and induce apoptosis in human cisplatin-resistance lung cancer cells. |
2018-06-12 |
2023-08-13 |
human |
| Chong Huang, Xiong Guo, Huishou Zhao, Rui An, Kun Lian, Xiaomeng Zhang, Jinglong Zhang, Feng Yan, Huaning Xie, Shan Wang, Ling Ta. Nicotine induces H9C2 cell apoptosis via Akt protein degradation. Molecular medicine reports. vol 16. issue 5. 2018-06-08. PMID:28849146. |
cell counting kit‑8 and tunel assays were performed to assess cell viability and apoptosis, respectively, and reverse transcription‑quantitative polymerase chain reaction and western blot analysis were used to investigate the mrna and protein expression. |
2018-06-08 |
2023-08-13 |
Not clear |
| Raimundo F De Araújo, Jonas B Pessoa, Luis J Cruz, Alan B Chan, Emílio De Castro Miguel, Rômulo S Cavalcante, Gerly Anne C Brito, Heloiza Fernada O Silva, Luiz H S Gasparotto, Paulo M M Guedes, Aurigena A Araúj. Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins. International journal of oncology. vol 52. issue 1. 2018-06-08. PMID:29115423. |
apoptosis was analyzed by fitc/propidium iodide staining flow cytometry; caspase-3, caspase-8, bcl-2 and mapk/erk activity by immunofluorescence microscopy; gene expression of proteins related to cell death as akt, mtor, egfr, mdr1, survivin, fadd and apaf, by the real-time pcr; and western blot analysis for mapk/erk, akt and mtor. |
2018-06-08 |
2023-08-13 |
human |