| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yake Liu, Xiaoyou Yang, Wei Wang, Xuefei Wu, Hai Zhu, Fan Li. Melatonin counteracts cobalt nanoparticle‑induced cytotoxicity and genotoxicity by deactivating reactive oxygen species‑dependent mechanisms in the NRK cell line. Molecular medicine reports. vol 16. issue 4. 2018-05-14. PMID:28849220. |
furthermore, western blot analysis demonstrated that conps led to an increase in the ratio of bcl‑2‑associated x/bcl‑2, and the expression of cleaved caspase‑3 was upregulated, which indicated increased apoptosis levels. |
2018-05-14 |
2023-08-13 |
rat |
| Shao-Ming Zhu, Ting Rao, Xiao Yang, Jin-Zhuo Ning, Wei-Ming Yu, Yuan Ruan, Run Yuan, Cheng-Long Li, Kun Jiang, Wei Hu, Hao-Yong Li, Fan Chen. Autophagy may play an important role in varicocele. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849201. |
furthermore, western blot analysis revealed that the protein expression of bcl‑2 decreased and apoptosis regulator bax increased. |
2018-05-11 |
2023-08-13 |
rat |
| Hong-Yan Lu, Xiao-Qing Chen, Wei Tang, Qiu-Xia Wang, Jie Zhan. GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway. Molecular medicine reports. vol 16. issue 2. 2018-05-10. PMID:28586043. |
sirna or pegfp‑n1 plasmid were used to knockdown or overexpress specific genes, reverse transcription-quantitative polymerase chain reaction and western blot analysis were used to detect rna and protein levels of gene expression, and flow cytometry was used to detect apoptosis. |
2018-05-10 |
2023-08-13 |
human |
| Dong Zhao, Jinhua Jia, Hong Sha. miR-30e targets GLIPR-2 to modulate diabetic nephropathy: Journal of molecular endocrinology. vol 59. issue 2. 2018-05-10. PMID:28733476. |
mtt and flow cytometry were utilized to measure the proliferation and apoptosis of rtecs, while qrt-pcr and western blot to detect the expression of glipr-2- and emt-related factors. |
2018-05-10 |
2023-08-13 |
mouse |
| Peiqing Gu, Lei Zhu, Yajun Liu, Lu Zhang, Junlou Liu, Hong She. Protective effects of paeoniflorin on TNBS-induced ulcerative colitis through inhibiting NF-kappaB pathway and apoptosis in mice. International immunopharmacology. vol 50. 2018-05-09. PMID:28666238. |
in addition, western blot demonstrated that paeoniflorin inhibited nf-kappab signaling pathway and apoptosis in tnbs-induced ulcerative colitis tissues. |
2018-05-09 |
2023-08-13 |
mouse |
| Vaikundamoorthy Ramalingam, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Rajendran Rajara. p53 mediated transcriptional regulation of long non-coding RNA by 1-hydroxy-1-norresistomycin triggers intrinsic apoptosis in adenocarcinoma lung cancer. Chemico-biological interactions. vol 287. 2018-05-09. PMID:29596799. |
further, hnm downregulates the numerous oncogenes which regulate cancer cell proliferation, metastasis and invasion and tumor suppressor genes which are involved in intrinsic apoptosis confirmed with adopting techniques such as rt-pcr and western blot analysis. |
2018-05-09 |
2023-08-13 |
Not clear |
| Ji-Sha Tian, Qi-Jin Zhai, Ying Zhao, Rui Chen, Lian-Dong Zha. 2-(2-benzofuranyl)-2-imidazoline (2-BFI) improved the impairments in AD rat models by inhibiting oxidative stress, inflammation and apoptosis. Journal of integrative neuroscience. vol 16. issue 4. 2018-05-07. PMID:28891528. |
additionally, the neuronal apoptosis was also attenuated, as shown by western blot results. |
2018-05-07 |
2023-08-13 |
rat |
| Shu Li, Binbin Cheng, Lixin Hou, Lanwei Huang, Yongkang Cui, Duo Xu, Xiaoping Shen, Shuang L. Dioscin inhibits colon cancer cells' growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways. Anti-cancer drugs. vol 29. issue 3. 2018-05-07. PMID:29389802. |
a western blot and an immunofluorescence staining were used to investigate how dioscin induces apoptosis in vitro. |
2018-05-07 |
2023-08-13 |
human |
| Shuang Chen, Qinggao Zhang, Duo Xu, Yiquan Li, Yuanyuan Fan, Wenjie Li, Xunzhe Yin, Yang Zhang, Jingwei Liu, Xiao Li, Lili Sun, Ningyi Ji. Antitumor effect of the Newcastle disease viral hemagglutinin-neuraminidase gene is expressed through an oncolytic adenovirus effect in osteosarcoma cells. Anti-cancer drugs. vol 29. issue 3. 2018-05-07. PMID:29438228. |
western blot analysis showed that cytochrome c increased significantly and apoptosis of the virus was confirmed in tumor cells. |
2018-05-07 |
2023-08-13 |
Not clear |
| Małgorzata Milczarek, Katarzyna Wiktorska, Lidia Mielczarek, Mirosława Koronkiewicz, Aleksandra Dąbrowska, Katarzyna Lubelska, Dariusz Matosiuk, Zdzisław Chilmonczy. Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 111. 2018-05-01. PMID:29104175. |
confocal microscopy, flow cytometry, western blot and spectrophotometry were used to examine apoptosis, autophagy and premature senescence. |
2018-05-01 |
2023-08-13 |
Not clear |
| Zhixuan Shang, Liwei Zhan. Digitoxin increases sensitivity of glioma stem cells to TRAIL-mediated apoptosis. Neuroscience letters. vol 653. 2018-04-30. PMID:28511914. |
this effect was also shown in the changes of expressions of cell apoptosis pathway related protein markers tested by western blot method. |
2018-04-30 |
2023-08-13 |
human |
| Nadiar Mussin, Seung Cheol Oh, Kwang Woong Lee, Min Young Park, Sooin Seo, Nam Joon Yi, Hyeyoung Kim, Kyung Chul Yoon, Sung Woo Ahn, Hyo Sin Kim, Suk Kyun Hong, Dong Kyu Oh, Kyung Suk Su. Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo. Journal of Korean medical science. vol 32. issue 9. 2018-04-30. PMID:28776332. |
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay was performed and western blot analyses were performed for mtor pathway proteins, apoptosis proteins, and epithelial-mesenchymal-transition (emt) proteins. |
2018-04-30 |
2023-08-13 |
mouse |
| Yuanle Deng, Yali Li, Fangfang Yang, Anqi Zeng, Shuping Yang, Yi Luo, Yiwen Zhang, Yongmei Xie, Tinghong Ye, Yong Xia, Wenya Yi. The extract from Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-25. PMID:28724216. |
western blot analysis showed that popx could increase the expression ratio of bax/bcl2 and activation of apoptosis executor caspase 3. |
2018-04-25 |
2023-08-13 |
Not clear |
| Xueqin Wang, Xuemei He, Xian Deng, Yanzheng He, Xiangyu Zho. Roles of miR‑4463 in H2O2‑induced oxidative stress in human umbilical vein endothelial cells. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28713907. |
flow cytometry was used to evaluate the percentage of apoptotic cells, and the protein expression levels of the apoptotic markers cleaved (c)‑caspase3, poly (adenosine diphosphate‑ribose) polymerase 1 (parp1), b cell lymphoma‑2 (bcl‑2), bcl‑2‑associated x protein (bax) and x‑linked inhibitor of apoptosis protein (xiap) were determined using western blot analysis. |
2018-04-24 |
2023-08-13 |
human |
| Lu Chen, Lei Liu, Zhi-Yang Xie, Feng Wang, Arjun Sinkemani, Cong Zhang, Xiao-Hu Wang, Kun Wang, Xin Hong, Xiao-Tao W. Endoplasmic Reticulum Stress Facilitates the Survival and Proliferation of Nucleus Pulposus Cells in TNF-α Stimulus by Activating Unfolded Protein Response. DNA and cell biology. vol 37. issue 4. 2018-04-24. PMID:29381432. |
apoptosis was detected by flow cytometry and western blot analyses. |
2018-04-24 |
2023-08-13 |
rat |
| Shi-Jie Zhang, Ting-Ting Xu, Lin Li, Yu-Min Xu, Zi-Ling Qu, Xin-Chen Wang, Shui-Qing Huang, Yi Luo, Na-Chuan Luo, Ping Lu, Ya-Fei Shi, Xin Yang, Qi Wan. Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28521305. |
in addition, western blot results (bcl-2, bax and caspase-3) and tunel staining show that bsyz prevents neuron from apoptosis, and elevates the expression of neurotrophic factors, including nerve growth factor (ngf), postsynapticdensity 95 (psd95) and synaptophysin (syn), in both hippocampus and cortex. |
2018-04-23 |
2023-08-13 |
mouse |
| Xiao-Qiang Wang, Hong-Min Bai, Shi-Ting Li, Hui Sun, Ling-Zhao Min, Bang-Bao Tao, Jun Zhong, Bin L. Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cells. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28624794. |
the expression of apoptosis and metastasis related molecules were detected by rt-pcr and western blot, respectively, in u251 and t98g cells with hdac1 knockdown. |
2018-04-23 |
2023-08-13 |
mouse |
| Wenlei Li, Guotao Jia, Yanwen Qu, Qian Du, Baoguo Liu, Bin Li. Long Non-Coding RNA (LncRNA) HOXA11-AS Promotes Breast Cancer Invasion and Metastasis by Regulating Epithelial-Mesenchymal Transition. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-04-23. PMID:28701685. |
material and methods in this study, fluorescent quantitative real-time pcr (qrt-pcr), mtt assay and clone formation assay, flow cytometry, transwell assay and wound healing assay, immunofluorescence, and western blot analysis were conducted to detect the expression of lncrna hoxa11-as, cell proliferation activity, cell apoptosis rate and cell cycle distribution, the changes of cell invasion and metastasis capacity, and the expressions of molecular markers of epithelial-mesenchymal transition (emt), respectively. |
2018-04-23 |
2023-08-13 |
mouse |
| Jing Wang, Lingqing Chen, Song Jin, Jun Lin, Hongmei Zheng, Hong Zhang, Hongtao Fan, Fang He, Sha Ma, Qin L. Altered expression of microRNA-98 in IL-1β-induced cartilage degradation and its role in chondrocyte apoptosis. Molecular medicine reports. vol 16. issue 3. 2018-04-23. PMID:28765925. |
the present study aimed to identify and characterize the expression profile of mir‑98 and apoptosis‑associated proteins in healthy and oa chondrocytes, and western blot analysis and tunel staining were used to evaluate the role of mir‑98 in the regulation of chondrocyte apoptosis. |
2018-04-23 |
2023-08-13 |
Not clear |
| Jin-Long Huang, Wei Liu, Li-Hong Tian, Ting-Ting Chai, Yang Liu, Feng Zhang, Hai-Ying Fu, Hua-Rong Zhou, Jian-Zhen She. Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia. Oncology reports. vol 38. issue 3. 2018-04-17. PMID:28713913. |
cell cycle progression and apoptosis were evaluated by flow cytometry and the expression of caspase-3, -8 and -9 was assessed by western blot analysis. |
2018-04-17 |
2023-08-13 |
Not clear |