| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanping Feng, Fang Liu, Zhixiang Du, Dongjie Zhao, Jianxin Cheng, Wei Gu. Wip1 regulates SKOV3 cell apoptosis through the p38 MAPK signaling pathway. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28440479. |
western blot analysis was performed to determine expression of tumor protein 53 (p53), cleaved caspase‑3, caspase‑3, bcl2 associated x (bax), bcl2 apoptosis regulator (bcl‑2), p38 mitogen‑activated protein kinase (p38 mapk) and phosphorylated (p)‑p38 mapk. |
2018-03-05 |
2023-08-13 |
human |
| Yun Ge, Wen Lei, Yingyu Ma, Yigang Wang, Buyun Wei, Xiaoyi Chen, Guoqing Ru, Xianglei He, Xiaozhou Mou, Shibing Wan. Synergistic antitumor effects of CDK inhibitor SNS‑032 and an oncolytic adenovirus co‑expressing TRAIL and Smac in pancreatic cancer. Molecular medicine reports. vol 15. issue 6. 2018-03-05. PMID:28440486. |
western blot assays suggested that the sns‑032 intensified zd55‑trail‑ietd‑smac‑induced apoptosis of pancreatic cancer cells by affecting anti‑apoptotic signaling elements, including cdk‑2, cdk‑9, mcl‑1 and xiap. |
2018-03-05 |
2023-08-13 |
human |
| Ping Chen, Jing-Yang Zhang, Bei-Bei Sha, Yan-Er Ma, Tao Hu, Yang-Cheng Ma, Hao Sun, Jian-Xiang Shi, Zi-Ming Dong, Pei L. Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450. Oncotarget. vol 8. issue 16. 2018-03-05. PMID:28460467. |
western blot results showed the expression of cell cycle regulatory protein p21 and p53 increased and three apoptosis related proteins that participate in mitochondrial apoptotic pathway, namely, bim, cyt-c and cparp, also increased in luteolin treated cells compared with control groups. |
2018-03-05 |
2023-08-13 |
mouse |
| Nan Wang, Fan Zhao, Pengfei Lin, Guangle Zhang, Keqiong Tang, Aihua Wang, Yaping Ji. Knockdown of XBP1 by RNAi in Mouse Granulosa Cells Promotes Apoptosis, Inhibits Cell Cycle, and Decreases Estradiol Synthesis. International journal of molecular sciences. vol 18. issue 6. 2018-03-05. PMID:28555054. |
in this study, rna interference, flow cytometry, western blot, real-time pcr, cell counting kit (cck8), and elisa were used to investigate the effect of xbp1 on steroidogenesis, apoptosis, cell cycle, and proliferation of mouse granulosa cells. |
2018-03-05 |
2023-08-13 |
mouse |
| Peng-Hui Li, Hong Jiang, Wen-Jin Zhang, Yong-Lian Li, Min-Cong Zhao, Wei Zhou, Lan-Yue Zhang, Ya-Dong Tang, Chang-Zhi Dong, Zhi-Shu Huang, Hui-Xiong Chen, Zhi-Yun D. Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers. European journal of medicinal chemistry. vol 145. 2018-03-02. PMID:29335211. |
western blot analysis revealed that compound 3h induces apoptosis likely through the activation of caspase proteins. |
2018-03-02 |
2023-08-13 |
human |
| Shuyi Li, Jianling Chen, Xiaoling Fang, Xiaomeng Xi. Sphingosine-1-phosphate activates the AKT pathway to inhibit chemotherapy induced human granulosa cell apoptosis. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 33. issue 6. 2018-03-01. PMID:28277139. |
western blot analysis was used to analyze the signaling pathway of proteins and cell apoptosis. |
2018-03-01 |
2023-08-13 |
human |
| Sheau-Yun Yuan, Ming-Yuh Shiau, Yen-Chuan Ou, Yu-Chia Huang, Cheng-Che Chen, Chen-Li Cheng, Kun-Yuan Chiu, Shian-Shiang Wang, Kan-Jen Tsa. Miconazole induces apoptosis via the death receptor 5-dependent and mitochondrial-mediated pathways in human bladder cancer cells. Oncology reports. vol 37. issue 6. 2018-03-01. PMID:28498480. |
dna fragmentation, mitochondrial membrane potential and western blot analyses showed that mic inhibited the growth of these cells by both mitochondrial‑mediated and death receptor (dr5)‑mediated apoptosis pathways. |
2018-03-01 |
2023-08-13 |
human |
| Xiaolong Gu, Dandan Han, Wei Chen, Limei Zhang, Qianyun Lin, Jian Gao, Séamus Fanning, Bo Ha. SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride. Oncotarget. vol 7. issue 40. 2018-02-23. PMID:27564107. |
via rt-pcr, western blot, flow cytometry assays, fluorescence and laser confocal microscopy, it was found that naf induced both cell apoptosis and autophagy. |
2018-02-23 |
2023-08-13 |
Not clear |
| Wenwen Qi, Mingjuan Sun, Xiangnan Kong, Yaming Li, Xiaolong Wang, Shangge Lv, Xia Ding, Sumei Gao, Jinjing Cun, Chang Cai, Xiaoting Wang, Junfei Chen, Aijun Yin, Qifeng Yan. Huaier extract synergizes with tamoxifen to induce autophagy and apoptosis in ER-positive breast cancer cells. Oncotarget. vol 7. issue 18. 2018-02-22. PMID:27027343. |
huaier extract enhanced tam-induced autophagy, apoptosis, and g0/g1 cell cycle arrest, as measured by acidic vesicular organelle (avo) staining, tunel, flow cytometry, and western blot. |
2018-02-22 |
2023-08-13 |
mouse |
| Taotao Ma, Cheng Huang, Xiaoming Meng, Xiaofeng Li, Yilong Zhang, Shuai Ji, Jun Li, Min Ye, Hong Lian. A potential adjuvant chemotherapeutics, 18β-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2. Scientific reports. vol 6. 2018-02-21. PMID:27145860. |
western blot and immunofluorescence results demonstrated that the expression of bmp-7 was clearly induced by 18βga in aki models while sirna bmp-7 could reduce the inhibitory effect of 18βga on apoptosis. |
2018-02-21 |
2023-08-13 |
mouse |
| Hong Zhao, Mei Xu, Guilan Ch. Association between myocardial cell apoptosis and calpain-1/caspase-3 expression in rats with hypoxic-ischemic brain damage. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447745. |
a terminal deoxynucleotidyl transferase dutp nick-end labeling assay was performed to detect myocardial apoptotic cells and calculate the apoptosis index (ai), reverse transcription-polymerase chain reaction was performed to detect myocardial calpain-1/caspase-3 mrna expression levels and a western blot analysis was conducted to detect calpain‑1 protein expression levels. |
2018-02-16 |
2023-08-13 |
rat |
| Yiyao Wang, Yu Li, Qunzhi Xing, Xuechan G Han, Xu Dong, Yiping Lu, Mintao Zho. Sevoflurane anesthesia in pregnant rats negatively affects nerve function in offspring potentially via inhibition of the Wnt/β-catenin pathway. Molecular medicine reports. vol 15. issue 5. 2018-02-16. PMID:28447764. |
western blot and reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) analyses were used to examine the expression of multiple critical factors associated with the proliferation and apoptosis of nerve cells, including ki67, nestin, b cell leukemia/lymphoma 2 (bcl-2), bcl2 associated x (bax) and caspase‑3. |
2018-02-16 |
2023-08-13 |
mouse |
| Roshini A, Srikanth Jagadeesan, Young-Jae Cho, Jong-Hwan Lim, Kyung Hyun Cho. Synthesis and evaluation of the cytotoxic and anti-proliferative properties of ZnO quantum dots against MCF-7 and MDA-MB-231 human breast cancer cells. Materials science & engineering. C, Materials for biological applications. vol 81. 2018-02-15. PMID:28888009. |
furthermore, our data suggested that zno qds regulated apoptosis via bax and bcl-2 proteins as validated by immunofluorescence and western blot. |
2018-02-15 |
2023-08-13 |
human |
| Hui-Fang Guo, Myeong-Hyeon Wan. Dichloromethane fraction of Asiasarum heterotropoides induces S phase arrest and apoptosis in KB oral epithelial carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-14. PMID:28254667. |
undergoing mechanism was detected by western blot, the upregulated expression of bax, cleaved caspase-3, and -9 meantime downregulation of bcl-2 explained it induced apoptosis by the intrinsic pathway. |
2018-02-14 |
2023-08-13 |
Not clear |
| Zhiqiang Li, Shaihong Zhu, Lihua Huang, Mingming Shang, Can Yu, Hongwei Zhu, Duo Han, Hui Huang, Xiao Yu, Xia L. Exendin-4 impairs the autophagic flux to induce apoptosis in pancreatic acinar AR42J cells by down-regulating LAMP-2. Biochemical and biophysical research communications. vol 496. issue 2. 2018-02-14. PMID:29317206. |
then the ar42j cells were treated by 10pm exendin-4 for 72 h, the cell death was analyzed by flow cytometry and caspase-3 level was examined by western blot with or without the pretreatment of z-vad-fmk to testify whether exendin-4 induces the cell apoptosis. |
2018-02-14 |
2023-08-13 |
rat |
| Sajita Shah, Chaemin Lee, Hyukjae Choi, Jaya Gautam, Hyeonjin Jang, Geum Jin Kim, Yu-Jeong Lee, Chhabi Lal Chaudhary, Sang Won Park, Tae-Gyu Nam, Jung-Ae Kim, Byeong-Seon Jeon. 5-Hydroxy-7-azaindolin-2-one, a novel hybrid of pyridinol and sunitinib: design, synthesis and cytotoxicity against cancer cells. Organic & biomolecular chemistry. vol 14. issue 21. 2018-02-12. PMID:27145715. |
signaling pathway-associated transcription factor reporter assay and western blot analyses revealed that apoptosis induction in mda-mb-231 human breast cancer cells by 6f is mainly mediated through the p53 increase and down-regulation of phospho-signal transducer and activator of transcription 3 (stat3) and its target gene products, cyclin d, bcl-2, and survivin. |
2018-02-12 |
2023-08-13 |
human |
| Jianlin Qiao, Yulu Wu, Yun Liu, Xiaoqian Li, Xiaoqing Wu, Na Liu, Feng Zhu, Kunming Qi, Hai Cheng, Depeng Li, Hongchun Li, Zhenyu Li, Lingyu Zeng, Ping Ma, Kailin X. Busulfan Triggers Intrinsic Mitochondrial-Dependent Platelet Apoptosis Independent of Platelet Activation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 22. issue 9. 2018-02-12. PMID:27292166. |
isolated human platelets were incubated with busulfan followed by analysis of platelet apoptosis by flow cytometry or western blot, including mitochondrial depolarization, expression of bcl-2, and bax and caspase 3 activation. |
2018-02-12 |
2023-08-13 |
mouse |
| Huidan Deng, Ping Kuang, Hengmin Cui, Lian Chen, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Ling Zha. Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice. Oncotarget. vol 7. issue 42. 2018-02-12. PMID:27655720. |
therefore, this study was conducted with objective of investigating apoptosis induced by sodium fluoride (naf) and the mechanism behind that in the cultured splenic lymphocytes by flow cytometry, western blot and hoechst 33258 staining. |
2018-02-12 |
2023-08-13 |
mouse |
| Ya-Ni Huang, Ling-Yu Yang, Jing-Ya Wang, Chien-Cheng Lai, Chien-Tsai Chiu, Jia-Yi Wan. L-Ascorbate Protects Against Methamphetamine-Induced Neurotoxicity of Cortical Cells via Inhibiting Oxidative Stress, Autophagy, and Apoptosis. Molecular neurobiology. vol 54. issue 1. 2018-02-09. PMID:26732595. |
we confirmed meth-induced apoptosis (by nuclear morphology revealed by hoechst 33258 staining and western blot showing the protein levels of pro-caspase 3 and cleaved caspase 3) and autophagy (by western blot showing the protein levels of belin-1 and conversion of microtubule-associated light chain (lc)3-i to lc3-ii and autophagosome staining by monodansylcadaverine). |
2018-02-09 |
2023-08-13 |
Not clear |
| Bing Li, Rui Chen, Ling Chen, Pingming Qiu, Xiuyun Ai, Enping Huang, Weiye Huang, Chuanxiang Chen, Chao Liu, Zhoumeng Lin, Wei-Bing Xie, Huijun Wan. Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26873849. |
flow cytometry and western blot were used to determine apoptosis and the expression of apoptotic markers (cleaved caspase-3 and cleaved parp) after blocking ddit4 expression in pc12 cells and sh-sy5y cells with synthetic sirna, as well as in the striatum of rats by injecting lv-shddit4 lentivirus using a stereotaxic positioning system. |
2018-02-07 |
2023-08-13 |
human |