| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Raffaele Pezzani, Beatrice Rubin, Loris Bertazza, Marco Redaelli, Susi Barollo, Halenya Monticelli, Enke Baldini, Caterina Mian, Carla Mucignat, Carla Scaroni, Franco Mantero, Salvatore Ulisse, Maurizio Iacobone, Marco Boscar. The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line. Investigational new drugs. vol 34. issue 5. 2017-12-14. PMID:27177645. |
biomolecular and cellular tests were performed (such as mtt, thymidine assay, wright's staining, cell cycle and apoptosis analysis, western blot, qrt-pcr, and mutation analysis). |
2017-12-14 |
2023-08-13 |
Not clear |
| Wei-Wei Dai, Li-Bo Wang, Guo-Qin Jin, Hong-Jin Wu, Jie Zhang, Cheng-Long Wang, Yuan-Ji Wei, Joon-Ho Lee, Yu-An Evan Lay, Wei Ya. Beta-Ecdysone Protects Mouse Osteoblasts from Glucocorticoid-Induced Apoptosis In Vitro. Planta medica. vol 83. issue 11. 2017-12-05. PMID:28388784. |
the expression levels of osteoblast growth and differentiation factors (runt-related transcription factor 2, osteogenic protein-1, and alkaline phosphatase), apoptosis-related genes (transformation-related protein 53, ataxia telangiectasia mutated protein, caspase-3, and caspase-8), and akt1 and phospho-akt (thr308) were then assessed via alkaline phosphatase staining, acridine orange-propidium iodide staining, annexin v/pi apoptosis assay, real-time rt-pcr, and western blot analyses. |
2017-12-05 |
2023-08-13 |
mouse |
| Guo-Dong Yao, Zhuo-Yang Cheng, Xin-Yue Shang, Pin-Yi Gao, Xiao-Xiao Huang, Shao-Jiang Son. Coumarins from the bark of Juglans mandshurica exhibited anti-hepatoma activities via inducing apoptosis. Journal of Asian natural products research. vol 19. issue 11. 2017-12-04. PMID:28276763. |
and further studies of antitumor mechanisms by the observation of morphological changes and western blot analyses exhibited that induction of apoptosis might be a possible way that inhibited cell growth. |
2017-12-04 |
2023-08-13 |
Not clear |
| Jiahong Xu, Yu Tang, Yihua Bei, Shengguang Ding, Lin Che, Jianhua Yao, Hongbao Wang, Dongchao Lv, Junjie Xia. miR-19b attenuates H2O2-induced apoptosis in rat H9C2 cardiomyocytes via targeting PTEN. Oncotarget. vol 7. issue 10. 2017-11-30. PMID:26918829. |
using flow cytometry and western blot analysis, we found that overexpression of mir-19b decreased h2o2-induced apoptosis and improved cell survival, while downregulation of that had inverse effects. |
2017-11-30 |
2023-08-13 |
rat |
| Zhi-Ying Zhao, Yang-Yang Gao, Li Gao, Ming Zhang, He Wang, Chun-Hong Zhan. Protective effects of bellidifolin in hypoxia-induced in pheochromocytoma cells (PC12) and underlying mechanisms. Journal of toxicology and environmental health. Part A. vol 80. issue 22. 2017-11-30. PMID:28895799. |
the results of western blot analysis showed that hypoxia induced the expression of the mapk signaling pathway downstream of the key apoptosis factor caspase-3. |
2017-11-30 |
2023-08-13 |
Not clear |
| Claire M Cannon, Janeen H Trembley, Betsy T Kren, Gretchen M Unger, M Gerard O'Sullivan, Ingrid Cornax, Jaime F Modiano, Khalil Ahme. Evaluation of protein kinase CK2 as a therapeutic target for squamous cell carcinoma of cats. American journal of veterinary research. vol 78. issue 8. 2017-11-29. PMID:28738012. |
the sccf1 cells were treated with sirna and assessed 72 hours later for ck2α and ck2α' expression and markers of apoptosis (via western blot analysis) and for viability (via 3-[4,5-dimethylthiazol-2-yl]-5-[3-carboxymethoxyphenyl]-2-[4-sulfophenyl]-2h-tetrazolium assays). |
2017-11-29 |
2023-08-13 |
Not clear |
| Chunyu Cao, Jingyun Li, Jun Li, Lan Liu, Xiaoyan Cheng, Ruizhe Ji. Long Non-Coding RNA Uc.187 Is Upregulated in Preeclampsia and Modulates Proliferation, Apoptosis, and Invasion of HTR-8/SVneo Trophoblast Cells. Journal of cellular biochemistry. vol 118. issue 6. 2017-11-28. PMID:27883216. |
the proteins related to proliferation (pcna, ki67), invasion (mmp-2/-9 and timp-1), and apoptosis (caspase-3, bcl-2) were evaluated with a western blot assay. |
2017-11-28 |
2023-08-13 |
Not clear |
| Zichen Xu, Weiwei Hu, Zhimei Wang, Shaohua Go. Platinum(IV) prodrugs multiply targeting genomic DNA, histone deacetylases and PARP-1. European journal of medicinal chemistry. vol 141. 2017-11-28. PMID:29031068. |
the mechanism of action of saa1 was preliminarily investigated, in which cellular uptake, cell apoptosis and cell cycle arrest as well as western blot analysis were made by treating saa1 with sgc7901/cddp cells. |
2017-11-28 |
2023-08-13 |
Not clear |
| F Guo, S C Lin, M S Zhao, B Yu, X Y Li, Q Gao, D J Li. microRNA-142-3p inhibits apoptosis and inflammation induced by bleomycin through down-regulation of Cox-2 in MLE-12 cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 7. 2017-11-24. PMID:28678919. |
thereafter, cell viability, apoptosis and the expression of pro-inflammatory cytokines were assessed using cck-8, flow cytometry, rt-pcr and western blot analyses. |
2017-11-24 |
2023-08-13 |
Not clear |
| Yan Zhong, Yi Xu, Ai-Xia Zhang, Xiao-Feng Li, Zhao-Ying Xu, Ping Li, Bin W. Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents. Bioorganic & medicinal chemistry letters. vol 26. issue 10. 2017-11-22. PMID:27038495. |
the results of western blot analysis demonstrated these compounds suppressed apoptosis of glutamate-induced pc12 cells via caspase-3 pathway. |
2017-11-22 |
2023-08-13 |
rat |
| Yu An, Dan-Di Zhang, Huan-Ling Yu, Wei-Wei Ma, Yan-Hui Lu, Quan-Ri Liu, Rong Xia. 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells. Neurotoxicology. vol 59. 2017-11-22. PMID:28167099. |
c6 cells were treated with 5, 10 and 20μm 27-ohc for 24h and the cell viability and apoptosis, the cholesterol levels and metabolism-related mediators, genes and proteins were subsequently assessed using cell-counting kit (cck)-8, amplex red, elisa, real-time pcr and western blot, respectively. |
2017-11-22 |
2023-08-13 |
Not clear |
| Kasthuri Natarajan, Premila Abraham, Rekha Kot. Activation of the mitochondrial apoptotic pathway contributes to methotrexate-induced small intestinal injury in rats. Cell biochemistry and function. vol 35. issue 7. 2017-11-22. PMID:28871597. |
mitochondrial pathway of apoptosis was activated in the small intestines of mtx-treated rats as evidenced by intense immunostaining for cyt c, caspases 9 and 3, and parp-1 and mitochondrial release of cyt c, activation of caspases, and parp-1 cleavage by western blot. |
2017-11-22 |
2023-08-13 |
rat |
| Fatima Abdelmutaal Ahmed Omer, Najihah Binti Mohd Hashim, Mohamed Yousif Ibrahim, Firouzeh Dehghan, Maizatulakmal Yahayu, Hamed Karimian, Landa Zeenelabdin Ali Salim, Syam Moha. Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 11. 2017-11-13. PMID:29110583. |
caspase-3 and caspase-9 activities; reactive oxygen species; real-time polymerase chain reaction for bcl-2, bax, caspase-3, and caspase-9 hsp70 genes; and western blot for p53, cytochrome c, and pro- and cleavage-caspase-3 and caspase-9 were assessed to examine the apoptosis mechanism. |
2017-11-13 |
2023-08-13 |
human |
| Dongyuan Wu, Zhirong Jiang, Bing Gong, Yue Dou, Mingxuan Song, Xiaoxia Song, Yu Tia. Vitamin E Reversed Apoptosis of Cardiomyocytes Induced by Exposure to High Dose Formaldehyde During Mice Pregnancy. International heart journal. vol 58. issue 5. 2017-11-02. PMID:28966308. |
tunel staining was used to reveal the apoptosis in cardiomyocytes, and sod, mda, gsh, livin, and caspase-3 in cardiomyocytes were detected by elisa, rt-pcr, and western blot. |
2017-11-02 |
2023-08-13 |
mouse |
| Sung-Suk Suh, Se Kyung Oh, Sung Gu Lee, Il-Chan Kim, Sanghee Ki. Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells. Acta pharmaceutica (Zagreb, Croatia). vol 67. issue 2. 2017-10-30. PMID:28590914. |
herein, human hacat cells were used to determine the biological activities of porphyra- 334 by various in vitro assays, including proliferation, apoptosis and western blot assays. |
2017-10-30 |
2023-08-13 |
human |
| Sun Young Park, Seon Yeong Chae, Jin Oh Park, Kyu Jin Lee, Geuntae Par. Kalopanacis Cortex extract-capped gold nanoparticles activate NRF2 signaling and ameliorate damage in human neuronal SH-SY5Y cells exposed to oxygen-glucose deprivation and reoxygenation. International journal of nanomedicine. vol 12. 2017-10-30. PMID:28790819. |
western blot analysis indicated that the ogd/r-induced cellular apoptosis and simultaneous increases in the expression of cleaved caspase-3, p53, p21, and b-cell lymphoma 2-associated x protein were reversed by kc-gns. |
2017-10-30 |
2023-08-13 |
human |
| Ting-Hong Ye, Fang-Fang Yang, Yong-Xia Zhu, Ya-Li Li, Qian Lei, Xue-Jiao Song, Yong Xia, Ying Xiong, Li-Dan Zhang, Ning-Yu Wang, Li-Feng Zhao, Hong-Feng Gou, Yong-Mei Xie, Sheng-Yong Yang, Luo-Ting Yu, Li Yang, Yu-Quan We. Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis. Cell death & disease. vol 8. issue 1. 2017-10-26. PMID:28055016. |
moreover, western blot analysis demonstrated that the occurrence of its apoptosis was correlated with the activation of bax and cleaved caspase-3, and decreased the expression of bcl-2. |
2017-10-26 |
2023-08-13 |
Not clear |
| Xiao-Long Huang, Hao Zhang, Xiao-Yu Yang, Xiao-Yong Dong, Xiang-Yu Xie, Hu-Bin Yin, Xin Gou, Yong Lin, Wei-Yang H. Activation of a c-Jun N-terminal kinase-mediated autophagy pathway attenuates the anticancer activity of gemcitabine in human bladder cancer cells. Anti-cancer drugs. vol 28. issue 6. 2017-10-26. PMID:28430744. |
apoptosis was detected by annexin v assay and western blot. |
2017-10-26 |
2023-08-13 |
human |
| Maike Busch, Jan Große-Kreul, Janina Jasmin Wirtz, Manfred Beier, Harald Stephan, Brigitte Royer-Pokora, Klaus Metz, Nicole Dünke. Reduction of the tumorigenic potential of human retinoblastoma cell lines by TFF1 overexpression involves p53/caspase signaling and miR-18a regulation. International journal of cancer. vol 141. issue 3. 2017-10-13. PMID:28481041. |
results from pg13-luciferase reporter assays and western blot analyses indicate that tff1-induced apoptosis is mediated through transcriptional activity of p53 with concurrently downregulated mir-18a expression. |
2017-10-13 |
2023-08-13 |
human |
| Lifeng Wang, Yingjie Lu, Xian Liu, Xiaoyun Wan. Ghrelin protected neonatal rat cardiomyocyte against hypoxia/reoxygenation injury by inhibiting apoptosis through Akt-mTOR signal. Molecular biology reports. vol 44. issue 2. 2017-10-10. PMID:28281036. |
we isolated the nrcms, established myocardial h/r model, blocked growth hormone secretagogue receptor (ghsr) by sirna technique, examined cell activity by mtt and ldh assay, detected apoptosis by hoechst 33258 staining and flow cytometry and determined the expression levels of apoptosis related proteins and signaling pathway proteins by western blot. |
2017-10-10 |
2023-08-13 |
rat |