| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuanyuan Tang, Mao Xie, Neng Jiang, Feifei Huang, Xiao Zhang, Ruishan Li, Jingjing Lu, Shijie Liao, Yun Li. Icarisid II inhibits the proliferation of human osteosarcoma cells by inducing apoptosis and cell cycle arrest. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-06-22. PMID:28621234. |
quantitative real-time polymerase chain reaction and western blot assay were performed to measure the levels of genes and proteins related to cell cycle and apoptosis. |
2017-06-22 |
2023-08-13 |
human |
| Lin Zhuang, Ye Fan, Ling Lu, Wenbin Ding, Chuangye Ni, Xuehao Wang, Feng Zhang, Jianhua Ra. Ischemic Preconditioning protects hepatocytes from ischemia-reperfusion injury via TGR5-mediated anti-apoptosis. Biochemical and biophysical research communications. vol 473. issue 4. 2017-06-13. PMID:27045083. |
in addition, molecules related to apoptosis were detected by western blot, which showed that activation of tgr5 by ip increased expression of bcl-2, and inhibited expressions of irak4 and cleaved caspase-3, but tgr5 deficiency abolished ip-induced expressions of anti-apoptosis molecule. |
2017-06-13 |
2023-08-13 |
mouse |
| Jian-Fu Zhang, Xiang-Ming Yan, Bin Lan, Yin-Rui Lei, Xiao-Hu Li, Shuai Gao, Yi-Feng Guo, Fang Gu. Molecular mechanisms of synergistic induction of apoptosis by the combination therapy with hyperthermia and cisplatin in prostate cancer cells. Biochemical and biophysical research communications. vol 479. issue 2. 2017-06-13. PMID:27524236. |
to investigate whether the combination therapy would enhance apoptosis of pc-3 and du-145 cells, we used western blot analysis to detect expression level of proteins on apoptosis-regulated signaling pathway in pc-3 and du-145 cells. |
2017-06-13 |
2023-08-13 |
Not clear |
| Haibin Wang, Shengfa Zheng, Maodong Liu, Changxin Jia, Shilei Wang, Xue Wang, Sha Xue, Yunliang Gu. The Effect of Propofol on Mitochondrial Fission during Oxygen-Glucose Deprivation and Reperfusion Injury in Rat Hippocampal Neurons. PloS one. vol 11. issue 10. 2017-06-13. PMID:27788177. |
finally, the expression of drp1-ser 637 and fis1, apoptosis inducing factor (aif) and cytochrome c (cyt c) were detected by western blot. |
2017-06-13 |
2023-08-13 |
rat |
| Xiaowei Zheng, Changwei Wang, Yuanming Xing, Siying Chen, Ti Meng, Haisheng You, Iwao Ojima, Yalin Don. SB-T-121205, a next-generation taxane, enhances apoptosis and inhibits migration/invasion in MCF-7/PTX cells. International journal of oncology. vol 50. issue 3. 2017-06-13. PMID:28197640. |
flow cytometry and western blot methods revealed that sb-t-121205 induced cell cycle arrest at the g2/m phase and apoptosis in mcf-7/ptx cells through accelerating mitochondrial apoptotic pathway, resulting in reduction of bcl-2/bax ratio, as well as elevation of caspase-3, caspase-9, and poly(adp-ribose) polymerase (parp) levels. |
2017-06-13 |
2023-08-13 |
human |
| Xinchun Ye, Dandan Zuo, Lu Yu, Liang Zhang, Jiao Tang, Chengcheng Cui, Lei Bao, Kun Zan, Zuohui Zhang, Xinxin Yang, Hao Chen, Hai Tang, Jie Zu, Hongjuan Shi, Guiyun Cu. ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia. Biochemical and biophysical research communications. vol 485. issue 2. 2017-06-13. PMID:28202418. |
we used western blot to detect nlrp3 inflammasome activation and the expression of thioredoxin binding protein (txnip), dcfh-da to investigate intracellular reactive oxygen species (ros), flow cytometry to analyze apoptosis. |
2017-06-13 |
2023-08-13 |
human |
| Dan Sun, Fei Yan. Metformin improves cardiac function in mice with heart failure after myocardial infarction by regulating mitochondrial energy metabolism. Biochemical and biophysical research communications. vol 486. issue 2. 2017-06-13. PMID:28302481. |
hearts were taken from mice after 4 weeks, and cell apoptosis in myocardial tissue was detected using tunel method; fresh mitochondria were taken and changes in oxygen consumption rate (ocr) and respiratory control rate (rcr) of mitochondria in each group were detected using bio-energy metabolism tester, and change in mitochondrial membrane potential (mmp) of myocardial tissue was detected via jc-1 staining; the expressions and changes in bcl-2, bax, sirt3, pgc-1α and acetylated pgc-1α in myocardial tissue were detected by western blot. |
2017-06-13 |
2023-08-13 |
mouse |
| Yvonne de Jong, Annemiek M van Maldegem, Adrian Marino-Enriquez, Danielle de Jong, Johnny Suijker, Inge H Briaire-de Bruijn, Alwine B Kruisselbrink, Anne-Marie Cleton-Jansen, Karoly Szuhai, Hans Gelderblom, Jonathan A Fletcher, Judith V M G Bové. Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 10. 2017-06-12. PMID:27617402. |
apoptosis was determined using the caspase-glo 3/7 assay and western blot for parp cleavage. |
2017-06-12 |
2023-08-13 |
Not clear |
| Lei Shao, Di Meng, Fei Yang, Haibo Song, Dongqi Tan. Irisin-mediated protective effect on LPS-induced acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells. Biochemical and biophysical research communications. vol 487. issue 2. 2017-06-12. PMID:28396150. |
qrt-pcr assays demonstrated that irisin suppressed the production of il-1β, il-6, mcp-1 and tnf-α, and western blot assays demonstrated that irisin suppressed apoptosis of ali. |
2017-06-12 |
2023-08-13 |
mouse |
| Xuan Gao, Jun Zhang, Qiang Xu, Zun Huang, Yiyue Wang, Qi She. Hyaluronic acid-coated cationic nanostructured lipid carriers for oral vincristine sulfate delivery. Drug development and industrial pharmacy. vol 43. issue 4. 2017-06-08. PMID:28043185. |
the expressions of apoptosis related protein caspase-3, caspase-9, bax and bcl-2 were estimated by western blot assay in mcf-7 cells, and ha-nlcs exhibited the strongest effect in promoting cell apoptosis. |
2017-06-08 |
2023-08-13 |
rat |
| Zhiwei Ma, Yizhao Luo, Mingxing Qi. miR-143 Induces the Apoptosis of Prostate Cancer LNCap Cells by Suppressing Bcl-2 Expression. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-06-08. PMID:28109198. |
bcl-2 expression was detected by western blot, and cell apoptosis was measured by caspase-3 activity assay. |
2017-06-08 |
2023-08-13 |
Not clear |
| Ahmed Kamal, V Lakshma Nayak, Narayana Nagesh, M V P S Vishnuvardhan, N V Subba Redd. Benzo[b]furan derivatives induces apoptosis by targeting the PI3K/Akt/mTOR signaling pathway in human breast cancer cells. Bioorganic chemistry. vol 66. 2017-06-06. PMID:27149364. |
western blot analysis revealed that these compounds inhibit the pi3k/akt/mtor signaling pathway and induced mitochondrial mediated apoptosis in human breast cancer cells (mcf-7). |
2017-06-06 |
2023-08-13 |
human |
| X-G Li, W-G Sui, C-Q Gao, H-C Yan, Y-L Yin, H-C Li, X-Q Wan. L-Glutamate deficiency can trigger proliferation inhibition via down regulation of the mTOR/S6K1 pathway in pig intestinal epithelial cells. Journal of animal science. vol 94. issue 4. 2017-05-31. PMID:27136013. |
cell proliferation ( = 24), cell cycle distribution ( = 6), cell apoptosis ( = 6), and expression levels of proteins of interest ( = 4) were determined by mtt assay, flow cytometry, or western blot. |
2017-05-31 |
2023-08-13 |
Not clear |
| Liza J Burton, Mariela Rivera, Ohuod Hawsawi, Jin Zou, Tamaro Hudson, Guangdi Wang, Qiang Zhang, Luis Cubano, Nawal Boukli, Valerie Odero-Mara. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. PloS one. vol 11. issue 10. 2017-05-31. PMID:27755556. |
er stress response, autophagy and apoptosis were analyzed by western blot, acridine orange and tunel/annexin v staining, respectively. |
2017-05-31 |
2023-08-13 |
Not clear |
| Liza J Burton, Mariela Rivera, Ohuod Hawsawi, Jin Zou, Tamaro Hudson, Guangdi Wang, Qiang Zhang, Luis Cubano, Nawal Boukli, Valerie Odero-Mara. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. PloS one. vol 11. issue 10. 2017-05-31. PMID:27755556. |
the up-regulation of pro-apoptotic markers parp, caspase-12, cleaved caspase-3, -7, bax and down-regulation of anti-apoptotic marker bcl2 was confirmed by western blot analysis and apoptosis was visualized by increased tunel/annexin v staining upon mske treatment. |
2017-05-31 |
2023-08-13 |
Not clear |
| D Bai, S Cong, L P Zh. Attenuation of Focal Adhesion Kinase Reduces Lipopolysaccharide-Induced Inflammation Injury through Inactivation of the Wnt and NF-κB Pathways in A549 Cells. Biochemistry. Biokhimiia. vol 82. issue 4. 2017-05-31. PMID:28371601. |
flow cytometry, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) assay, quantitative reverse transcription polymerase chain reaction, and western blot analysis were used to explore the correlation of fak expression with cell apoptosis, viability, and the inflammatory cytokine activity in a549 cells. |
2017-05-31 |
2023-08-13 |
Not clear |
| Fabiana Ourique, Maicon R Kviecinski, Guilherme Zirbel, Luiza S E P W Castro, Allisson Jhonatan Gomes Castro, Fátima Regina Mena Barreto Silva, Jaime A Valderrama, David Rios, Julio Benites, Pedro Buc Calderon, Rozangela Curi Pedros. In vivo inhibition of tumor progression by 5 hydroxy-1,4-naphthoquinone (juglone) and 2-(4-hydroxyanilino)-1,4-naphthoquinone (Q7) in combination with ascorbate. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-29. PMID:27346131. |
hypoxia inducible factor hif-1α, glut1, proteins driving cell cycle (p53, p16 and cyclin a) and apoptosis (poly-adp-polymerase parp, bax and bcl-xl) were assessed by western blot. |
2017-05-29 |
2023-08-13 |
mouse |
| Bing Pei, Miaomiao Yang, Xiaoyan Qi, Xin Shen, Xing Chen, Fayong Zhan. Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway. Biochemical and biophysical research communications. vol 478. issue 1. 2017-05-23. PMID:27450812. |
further, western blot analysis revealed that quercetin increased p-akt expression and decreased p-ask1, p-jnk3 and cleaved caspase-3 expression after cerebral i/r injury and led to inhibition of neuronal apoptosis. |
2017-05-23 |
2023-08-13 |
mouse |
| Zhong-Jun Du, Guan-Qun Cui, Juan Zhang, Xiao-Mei Liu, Zhi-Hu Zhang, Qiang Jia, Jack C Ng, Cheng Peng, Cun-Xiang Bo, Hua Sha. Inhibition of gap junction intercellular communication is involved in silica nanoparticles-induced H9c2 cardiomyocytes apoptosis via the mitochondrial pathway. International journal of nanomedicine. vol 12. 2017-05-22. PMID:28356735. |
the aim of the present study is to determine whether snps-decreased gjic promotes apoptosis in rat cardiomyocytes cell line (h9c2 cells) via the mitochondrial pathway using cck-8 kit, scrape-loading dye transfer technique, annexin v/pi double-staining assays, and western blot analysis. |
2017-05-22 |
2023-08-13 |
rat |
| Hua-Ying Zhou, Yu-Huang Zheng, Yan He, Zi Chen, Bo H. The role of autophagy in THP-1 macrophages resistance to HIV- vpr-induced apoptosis. Experimental cell research. vol 351. issue 1. 2017-05-18. PMID:28057470. |
we found that vpr is able to trigger autophagy in transfected thp-1 macrophages confirmed by electron microscopy (em) and western blot analysis, and inhibition of autophagy with 3ma increased vpr-induced apoptosis. |
2017-05-18 |
2023-08-13 |
Not clear |