| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pei Min, Wenshuai Li, Deqing Zeng, Yanyun Ma, Diannan Xu, Wanwei Zheng, Feng Tang, Jian Chen, Jianping Shi, Heping Hu, Jiucun Wang, Dongqin Yang, Jie Liu, Jun Zhang, Mingqing Zhan. A single nucleotide variant in microRNA-1269a promotes the occurrence and process of hepatocellular carcinoma by targeting to oncogenes SPATS2L and LRP6. Bulletin du cancer. vol 104. issue 4. 2017-04-21. PMID:28081866. |
the effect of mir-1269a and the variant on the proliferation and apoptosis of hcc cells was examined by flow cytometry (fcm), cck8 assay and western blot. |
2017-04-21 |
2023-08-13 |
human |
| Ke Chen, Xiaohua Lv, Wei Li, Fei Yu, Jianjing Lin, Junxuan Ma, Deming Xia. Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc. Oxidative medicine and cellular longevity. vol 2017. 2017-04-20. PMID:28321270. |
herein, we found that oxidative stress could induce apoptosis and autophagy in endplate chondrocytes evidenced by western blot analysis, flow cytometry, immunofluorescence staining, gfp-lc3b transfection, and mdc staining. |
2017-04-20 |
2023-08-13 |
Not clear |
| Shi Zhong, You-Gui Li, Dong-Feng Ji, Tian-Bao Lin, Zhi-Qiang L. Protocatechualdehyde Induces S-Phase Arrest and Apoptosis by Stimulating the p27(KIP1)-Cyclin A/D1-CDK2 and Mitochondrial Apoptotic Pathways in HT-29 Cells. Molecules (Basel, Switzerland). vol 21. issue 7. 2017-04-18. PMID:27447597. |
we performed an in vitro study involving mtt, flow cytometry, rt-pcr, and western blot analyses to investigate the effects of pca treatment on cell proliferation, cell cycle distribution, apoptosis, and expression of several cell cycle-related genes in ht-29 cells. |
2017-04-18 |
2023-08-13 |
human |
| Jovana Francuz, Ivana Kovačević, Mirjana Popsavin, Goran Benedeković, Bojana Srećo Zelenović, Vesna Kojić, Dimitar Jakimov, Lidija Aleksić, Gordana Bogdanović, Tatjana Srdić-Rajić, Eva Lončar, Marko V Rodić, Vladimir Divjaković, Velimir Popsavi. Design, synthesis and in vitro antitumour activity of new goniofufurone and 7-epi-goniofufurone mimics with halogen or azido groups at the C-7 position. European journal of medicinal chemistry. vol 128. 2017-04-18. PMID:28135634. |
results of western blot analysis suggested that the most of synthesized compounds induce apoptosis in k562 cells in caspase-dependent way. |
2017-04-18 |
2023-08-13 |
human |
| Liang Zhu, Maohong Cao, Yaohui Ni, Lijian Han, Aihua Dai, Rongrong Chen, Xiaojin Ning, Xiaorong Liu, Kaifu K. Up-Regulation of TAB3 Is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage. Cellular and molecular neurobiology. vol 37. issue 4. 2017-04-17. PMID:27352012. |
our western blot result showed up-regulation of tab3 during neuronal apoptosis in the model of intracerebral hemorrhage (ich), which was also approved by immunofluorescence and immunohistochemistry result. |
2017-04-17 |
2023-08-13 |
human |
| Shouzhu Xu, Yanying Lv, Jing Zhao, Junping Wang, Xing Zhao, Siwang Wan. Inhibitory effects of Shenkang injection and its main component emodin on the proliferation of high glucose‑induced renal mesangial cells through cell cycle regulation and induction of apoptosis. Molecular medicine reports. vol 14. issue 4. 2017-04-17. PMID:27572472. |
transmission electron microscopy revealed morphological characteristics of apoptosis and western blot analysis demonstrated the upregulation of b‑cell lymphoma 2‑associated x protein (bax) and activation of caspases in rmcs following treatment with ski or em under high‑glucose conditions. |
2017-04-17 |
2023-08-13 |
rat |
| Ai-Shun Guo, Yi-Qun Huang, Xu-Dong Ma, Rui-Sheng Li. Mechanism of G9a inhibitor BIX‑01294 acting on U251 glioma cells. Molecular medicine reports. vol 14. issue 5. 2017-04-17. PMID:27748874. |
in addition, the apoptosis percentage of u251 cells was analyzed by tunel assay and the expression levels of apoptosis‑associated proteins, including b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein (bax), caspase‑9 and caspase‑3, and the acetylation of histones, including h3k27me1, h3k27me2 and h3 in u251 were analyzed by western blot following bix‑01294 treatment. |
2017-04-17 |
2023-08-13 |
human |
| Qi Jiang, Qingwei Li, Jianmei Han, Meng Gou, Yuanyuan Zheng, Bowen Li, Rong Xiao, Jihong Wan. rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway. International journal of biological macromolecules. vol 96. 2017-04-17. PMID:28038913. |
according to the confocal microscope, flow cytometry and western blot analysis, rlj-rgd3 could trigger heya8 cells apoptosis by changing mitochondrial membrane potential, arrangement of f-actin, protein level of bcl2, bax, caspase 3, and cleaved caspase 3, concentration of cytoplasmic calcium, as well as phosphorylation level of erk/jnk/p38. |
2017-04-17 |
2023-08-13 |
human |
| Raj Kumar Thapa, Jae Hee Kim, Jee-Heon Jeong, Beom Soo Shin, Han-Gon Choi, Chul Soon Yong, Jong Oh Ki. Silver nanoparticle-embedded graphene oxide-methotrexate for targeted cancer treatment. Colloids and surfaces. B, Biointerfaces. vol 153. 2017-04-17. PMID:28231500. |
importantly, agnps enhanced the total ros production within the treated cells leading to improve cellular apoptosis, as evidenced by western blot. |
2017-04-17 |
2023-08-13 |
Not clear |
| Ke Xiao, Ying Zhou, Huai-Rui Yuan, Lu Cui, Zia Ur Rehman, Abdur Rahman Ansari, Zhi Yang, Ke-Mei Peng, Hui Son. The regulation mechanism of apoptosis by visfatin in the mesenteric lymph nodes of LPS-treated rats. Histology and histopathology. vol 31. issue 9. 2017-04-14. PMID:26857566. |
apoptosis was evaluated with tunel and flow cytometry, the mrna levels of the apoptosis-related genes were detected by qrt-pcr, and the protein levels of the apoptotic-related factors were detected by western blot. |
2017-04-14 |
2023-08-13 |
rat |
| Ziwei Miao, Fei Yu, Yahao Ren, Jun Yan. d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway. International journal of molecular sciences. vol 18. issue 1. 2017-04-13. PMID:28054986. |
cell viability assays, flow cytometry, immunofluorescence, and western blot results revealed that sfn could induced apoptosis of gbm cells in a dose- and time-dependent manner, via up-regulation of caspase-3 and bax, and down-regulation of bcl-2. |
2017-04-13 |
2023-08-13 |
human |
| T K Li, K Yin, Z Chen, Y Bao, S X Zhan. MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. Genetics and molecular research : GMR. vol 16. issue 1. 2017-04-12. PMID:28290615. |
caspase 3 activity, cell apoptosis, and total protein expression were measured by spectrophotometry, flow cytometry, and western blot, respectively. |
2017-04-12 |
2023-08-13 |
Not clear |
| Tao Wang, Si-Dong Yang, Sen Liu, Hui Wang, Huan Liu, Wen Yuan Din. 17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-11. PMID:27847386. |
furthermore, western blot and qrt-pcr showed that 17β-e2 protects tnf-α which can induced apoptosis by upregulating p-akt, whereas akt was essentially constant. |
2017-04-11 |
2023-08-13 |
human |
| Chao Meng, Linlin Song, Juan Wang, Di Li, Yanhong Liu, Xiaoguang Cu. Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231. Oncology reports. vol 37. issue 2. 2017-04-11. PMID:28035403. |
cell apoptosis, caspase-3 activity, and western blot analysis for p53 and nrf2 protein were also assessed. |
2017-04-11 |
2023-08-13 |
human |
| Jinjiang Yang, Ying Lu, Ai Gu. Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis. Molecular medicine reports. vol 14. issue 5. 2017-04-10. PMID:27665780. |
cell viability was determined using the cell counting kit‑8 assay, cell apoptosis was evaluated by flow cytometry, and the expression of apoptosis‑, anabolism‑ and catabolism-associated genes were detected by quantitative polymerase chain reaction; protein expression was detected by western blot analysis. |
2017-04-10 |
2023-08-13 |
rat |
| Bo Liu, Fei Li, Jingshan Shi, Danli Yang, Yuanyuan Deng, Qihai Gon. Gastrodin ameliorates subacute phase cerebral ischemia‑reperfusion injury by inhibiting inflammation and apoptosis in rats. Molecular medicine reports. vol 14. issue 5. 2017-04-10. PMID:27748849. |
2,3,5‑triphenyltetrazolium chloride staining was using to measure the infarct volume; morphological alterations were observed by hematoxylin and eosin staining under an optical microscope; apoptosis in the hippocampus and cortex was observed by terminal deoxynucleotidyl transferase dutp nick end labeling staining; and the level of mrna and protein expression was tested by reverse transcription‑quantitative polymerase chain reation and western blot analysis, respectively. |
2017-04-10 |
2023-08-13 |
rat |
| In-Su Kim, Palanivel Ganesan, Dong-Kug Cho. Cx43 Mediates Resistance against MPP⁺-Induced Apoptosis in SH-SY5Y Neuroblastoma Cells via Modulating the Mitochondrial Apoptosis Pathway. International journal of molecular sciences. vol 17. issue 11. 2017-04-10. PMID:27809287. |
in another experiment, we demonstrated that over-expression of cx43 in the sh-sy5y cell system decreased mpp⁺-induced apoptosis based on the mtt assay and reduced the bax/bcl-2 ratio and the release of cytochrome c based on western blot analysis. |
2017-04-10 |
2023-08-13 |
human |
| Rui An, Lei Zhao, Jian Xu, Cong Xi, Haixun Li, Guohong Shen, Wei Zhang, Shumiao Zhang, Lijun Su. Resveratrol alleviates sepsis‑induced myocardial injury in rats by suppressing neutrophil accumulation, the induction of TNF‑α and myocardial apoptosis via activation of Sirt1. Molecular medicine reports. vol 14. issue 6. 2017-04-07. PMID:27779675. |
the protein expression levels of sirt1, acetylated (ac)‑forkhead box o1 (foxo1), b cell lymphoma 2 apoptosis regulator (bcl‑2) and bcl‑2 associated protein x apoptosis regulator (bax) were detected by western blot analysis. |
2017-04-07 |
2023-08-13 |
rat |
| Youguang Gao, Ting Chen, Xianghui Lei, Yunfeng Li, Xingui Dai, Yuanyuan Cao, Qionglei Ding, Xiabao Lei, Tao Li, Xianzhong Li. Neuroprotective effects of polydatin against mitochondrial-dependent apoptosis in the rat cerebral cortex following ischemia/reperfusion injury. Molecular medicine reports. vol 14. issue 6. 2017-04-07. PMID:27840959. |
western blot analysis revealed an increase in b‑cell lymphoma 2 apoptosis regulator (bcl-2) expression, and a decrease in bcl‑2‑associated protein x apoptosis regulator expression in the pd group in comparison with the vehicle treated group. |
2017-04-07 |
2023-08-13 |
rat |
| Jiaying Zhao, You Lv, Yuankun Cai, Wangui Wei, Chenqing Yin, Xin Wang, Zong Hao, Chenxia Shen, Huipeng Wan. Hyperthermic carbon dioxide pneumoperitoneum reinforces the inhibition of 5-FU on the proliferation and invasion of colon cancer. Oncology reports. vol 37. issue 1. 2017-04-07. PMID:27840981. |
the cell proliferation was assessed by cck-8 test; the cell apoptosis was tested by facs analysis; the cell invasion was examined by transwell assay; the expression of hsp-70, caspase-3, hif-1α and mmp-9 proteins and genes were detected by western blot analysis and rt-pcr. |
2017-04-07 |
2023-08-13 |
mouse |