| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiqiang You, Gewen Tan, Nengquan Sheng, Jianfeng Gong, Jun Yan, Di Chen, Huizhen Zhang, Zhigang Wan. Downregulation of myosin VI reduced cell growth and increased apoptosis in human colorectal cancer. Acta biochimica et biophysica Sinica. vol 48. issue 5. 2017-02-27. PMID:27044563. |
cell cycle distribution was assayed by flow cytometry and apoptosis was evaluated by annexin v. myo6 expression was detected by quantitative real-time polymerase chain reaction and western blot analysis. |
2017-02-27 |
2023-08-13 |
human |
| Song Hu, Xiaolin Li, Rongrong Xu, Lingyun Ye, Hui Kong, Xiaoning Zeng, Hong Wang, Weiping Xi. The synergistic effect of resveratrol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells. Acta biochimica et biophysica Sinica. vol 48. issue 6. 2017-02-27. PMID:27084520. |
results from hoechst staining, flow cytometry and western blot analysis suggested that resveratrol enhanced cisplatin-mediated apoptosis. |
2017-02-27 |
2023-08-13 |
Not clear |
| Chao Li, Yufen Tao, Chao Li, Bo Liu, Jiansheng Liu, Guanlin Wang, Hongqi Li. PU.1-Bim axis is involved in Trichostatin A-induced apoptosis in murine pro-B lymphoma FL5.12 cells. Acta biochimica et biophysica Sinica. vol 48. issue 9. 2017-02-27. PMID:27451443. |
to explore the underlying mechanism of tsa-induced apoptosis of fl5.12 cells, we further analyzed the hematopoietic transcription factor purine rich box-1 (pu.1) by western blot analysis. |
2017-02-27 |
2023-08-13 |
Not clear |
| L Wan, S H Dai, S Q Lai, L Q Liu, Q Wang, H Xu, W J Wang, J C Li. Apoptosis, proliferation, and morphology during vein graft remodeling in rabbits. Genetics and molecular research : GMR. vol 15. issue 4. 2017-02-27. PMID:27808365. |
using rabbits, rather than rodents, for a more representative model of human vein grafts, we aimed to establish a time course of changes in cell proliferation and apoptosis using morphometric and immunohistochemical analyses, western blot, terminal deoxynucleotidyl transferase dutp nick end labeling, and transmission electron microscopy (tem). |
2017-02-27 |
2023-08-13 |
human |
| X J Lai, X Y Cheng, L D H. microRNA 421 induces apoptosis of c-33a cervical cancer cells via down-regulation of Bcl-xL. Genetics and molecular research : GMR. vol 15. issue 4. 2017-02-27. PMID:27886335. |
bcl-xl expression and cell apoptosis were then measured by western blot and flow cytometry, respectively. |
2017-02-27 |
2023-08-13 |
Not clear |
| Wen-Jun Liu, Teng Zhang, Qu-Lian Guo, Chun-Yan Liu, Yong-Qi Ba. Effect of ATRA on the expression of HOXA5 gene in K562 cells and its relationship with cell cycle and apoptosis. Molecular medicine reports. vol 13. issue 5. 2017-02-21. PMID:27052693. |
hoxa5 mrna and protein expression in k562 cells was assessed by rt‑pcr and western blot analysis, and the relationship between hoxa5 expression and cell cycle and apoptosis was analyzed. |
2017-02-21 |
2023-08-13 |
human |
| Dejun Yang, Jian Shi, Hongbing Fu, Ziran Wei, Jiapeng Xu, Zunqi Hu, Yu Zhang, Ronglin Yan, Qingping Ca. Integrinβ1 modulates tumour resistance to gemcitabine and serves as an independent prognostic factor in pancreatic adenocarcinomas. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-21. PMID:27289231. |
changes in drug response after knockdown of integrinβ1 via rna interference (rnai) were evaluated using the viability of cancer cells as colon formation, proliferation using western blot of ki-67 and apoptosis using cleaved caspase-3 immunofluorescence. |
2017-02-21 |
2023-08-13 |
human |
| Lauren E Himmel, Maryam B Lustberg, A Courtney DeVries, Ming Poi, Ching-Shih Chen, Samuel K Kul. Minocycline, a putative neuroprotectant, co-administered with doxorubicin-cyclophosphamide chemotherapy in a xenograft model of triple-negative breast cancer. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 68. issue 9. 2017-02-21. PMID:27555377. |
biomarkers of apoptosis, cell stress, and dna damage were evaluated by western blot. |
2017-02-21 |
2023-08-13 |
mouse |
| Alecsandra O Souza, Maria J Tasso, Alana M C Oliveira, Lilian C Pereira, Filipe V Duarte, Danielle P Oliveira, Carlos M Palmeira, Daniel J Dort. Evaluation of Polybrominated Diphenyl Ether Toxicity on HepG2 Cells - Hexabrominated Congener (BDE-154) Is Less Toxic than Tetrabrominated Congener (BDE-47). Basic & clinical pharmacology & toxicology. vol 119. issue 5. 2017-02-17. PMID:27060917. |
the hepg2 cell line was exposed to bdes for 24 and 48 hr and submitted to assays to examine proliferation, viability, mitochondrial membrane potential, reactive oxygen species accumulation, phosphatidylserine exposure, nuclear fragmentation and evaluation of pro-caspase 3, pro-caspase 9, cytochrome c release, and apoptosis inductor factor release by western blot analysis. |
2017-02-17 |
2023-08-13 |
human |
| Hongli Hou, Weipeng Xing, Wuyin L. Brahma-related gene 1 induces apoptosis in a p53-dependent manner in human rheumatoid fibroblast-like synoviocyte MH7A. Medicine. vol 95. issue 51. 2017-02-17. PMID:28002318. |
factors involved in inflammation and apoptosis were quantified by qpcr and western blot. |
2017-02-17 |
2023-08-13 |
human |
| Jianguang Jia, Yiyu Qin, Ligong Zhang, Chenxu Guo, Yaguo Wang, Xicheng Yue, Jun Qia. Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis. Molecular medicine reports. vol 13. issue 5. 2017-02-16. PMID:27035431. |
furthermore, flow cytometry and western blot analysis showed that artemisinin caused g1-phase arrest of the cell cycle, promoted the generation of reactive oxygen species (ros), led to a collapse of the mitochondrial membrane potential and to triggered cytochrome c release from the mitochondria into the cytoplasm, which finally activated caspase‑3‑mediated apoptosis. |
2017-02-16 |
2023-08-13 |
human |
| Palaniappan Sakthivel, Andivelu Ilangovan, Mahabir Prasad Kaushi. Natural product-inspired rational design, synthesis and biological evaluation of 2,3-dihydropyrano[2,3-f]chromen-4(8H)-one based hybrids as potential mitochondrial apoptosis inducers. European journal of medicinal chemistry. vol 122. 2017-02-16. PMID:27376493. |
western blot analysis also revealed that these compounds persuade apoptosis through intrinsic pathway by up-regulating the pro-apoptotic protein bax and down-regulating the anti-apoptotic protein bcl-2. |
2017-02-16 |
2023-08-13 |
human |
| Wei Chen, Liuxuan Huang, Chenjun Hao, Wenshu Zeng, Xu Luo, Xiaodi Li, Longshu Zhou, Songshan Jiang, Zheng Chen, Yuanli H. MicroRNA-155 promotes apoptosis in SKOV3, A2780, and primary cultured ovarian cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 7. 2017-02-14. PMID:26779627. |
bioinformatic predictions, the dual-luciferase reporter assay, and western blot analysis were used to detect how mir-155 regulates x-linked inhibitor of apoptosis protein (xiap). |
2017-02-14 |
2023-08-13 |
Not clear |
| Ruxing Wang, Qian Xu, Lei Liu, Xiujun Liang, Luyang Cheng, Manli Zhang, Qingwen Sh. Antitumour activity of 2-dihydroailanthone from the bark of Ailanthus altissima against U251. Pharmaceutical biology. vol 54. issue 9. 2017-02-13. PMID:26956770. |
the western blot and rt-pcr assay showed that up-regulation of pro-apoptotic bax protein and down-regulation of anti-apoptotic bcl-2 protein as well as their mrna on u251 cells might be related to the apoptosis induction and proliferation inhibition. |
2017-02-13 |
2023-08-13 |
Not clear |
| Bing Liang, Wei Wei, Jianta Wang, Mingming Zhang, Ran Xu, Fei Wu, Haitao Xiao, Lei Tan. Protective effects of Semiaquilegia adoxoides n-butanol extract against hydrogen peroxide-induced oxidative stress in human lens epithelial cells. Pharmaceutical biology. vol 54. issue 9. 2017-02-13. PMID:26974044. |
the antioxidant effects of nsa were determined in terms of cell viability (mtt assay), apoptosis (annexinv/pi staining), radical scavenging capability (various enzymatic assays), loss of mitochondrial membrane potential (rhodamine 123 staining), expression of apoptotic markers including caspase-3 and caspase-9 and the change of bcl-2/bax ratio (western blot) in the hle cells. |
2017-02-13 |
2023-08-13 |
human |
| Yan-Ran Wu, Hai-Jun Qi, Dan-Fang Deng, Ying-Ying Luo, Sheng-Lan Yan. MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-13. PMID:27188433. |
western blot was used for detection of pten, p13k, and akt protein expressions, mtt method for cell proliferation, transwell assay for cell migration and invasion, and flow cytometry for cell cycle and apoptosis. |
2017-02-13 |
2023-08-13 |
human |
| Hong Chang, Chun Li, Kuiyuan Huo, Qiyan Wang, Linghui Lu, Qian Zhang, Yong Wang, Wei Wan. Luteolin Prevents H2O2-Induced Apoptosis in H9C2 Cells through Modulating Akt-P53/Mdm2 Signaling Pathway. BioMed research international. vol 2016. 2017-02-13. PMID:27525270. |
the expressions of signaling proteins related to apoptosis were analyzed by western blot and mrna levels were detected by real-time polymerase chain reaction (pcr). |
2017-02-13 |
2023-08-13 |
Not clear |
| Ying Lu, Xiang-Fu Liu, Ting-Rong Liu, Rui-Fang Fan, Yi-Chuan Xu, Xiang-Zhong Zhang, Ling-Ling Li. Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-13. PMID:27884749. |
the western blot test confirmed the induction of apoptosis by the upregulation of apoptosis-related proteins cleaved caspase-3 and cleaved parp. |
2017-02-13 |
2023-08-13 |
human |
| David Montoir, Sophie Barillé-Nion, Alain Tonnerre, Philippe Juin, Muriel Duflos, Marc-Antoine Bazi. Novel 1,6-naphthyridin-2(1H)-ones as potential anticancer agents targeting Hsp90. European journal of medicinal chemistry. vol 119. 2017-02-10. PMID:27153346. |
subsequently, cell cycle progression and apoptosis were conducted on best candidates, finally western blot analysis was performed to measure their ability to induce degradation of hsp90 client proteins. |
2017-02-10 |
2023-08-13 |
Not clear |
| Wenhe Zhu, Yan Cui, Xianmin Feng, Yan Li, Wei Zhang, Junjie Xu, Huiyan Wang, Shijie L. The apoptotic effect and the plausible mechanism of microwave radiation on rat myocardial cells. Canadian journal of physiology and pharmacology. vol 94. issue 8. 2017-02-10. PMID:27203380. |
furthermore, western blot analysis revealed significant changes in expression levels of proteins involved in oxidative stress regulation and apoptotic signaling pathways, indicating that microwave irradiation could induce myocardial cell apoptosis by interfering with oxidative stress and cardiac energy metabolism. |
2017-02-10 |
2023-08-13 |
rat |