| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shihong Ma, Wenhua Tan, Botao Du, Wei Liu, Weijia Li, Dehong Che, Guangmei Zhan. Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26935490. |
downregulated expression levels of bcl‑2 and upregulated the expression of bax protein were demonstrated by western blot analysis, further indicating increased apoptosis. |
2016-12-28 |
2023-08-13 |
human |
| Xiaoli Cheng, Wenli Shi, Canguo Zhao, Dan Zhang, Piao Liang, Guohui Wang, Li L. Triptolide sensitizes human breast cancer cells to tumor necrosis factor‑α‑induced apoptosis by inhibiting activation of the nuclear factor‑κB pathway. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26935527. |
human breast cancer mda‑mb‑231 cells and mcf‑7 cells were treated with different concentrations of triptolide, with or without 10 ng/ml tnf‑α, for different durations, followed by measurement of cell proliferation using a 3‑[4,5‑dimethyltiazol‑2‑yl]‑2.5‑diphenyl‑tetrazolium bromide assay, apoptosis induction, through determination of caspase‑3 activity and poly (adp‑ribose) polymerase (parp) cleavage, and nf‑κb pathway activation, through determination of inhibitor of nf‑κb (iκb) and the nf‑κb downstream genes, x‑linked inhibitor of apoptosis protein (xiap) and cellular inhibitor of apoptosis protein1/2 (ciap1/2)] using western blot and reverse transcription‑quantitative polymerase chain reaction analyses. |
2016-12-28 |
2023-08-13 |
human |
| Xuxia Tang, Chen Zhang, Jiongzhou Wei, Yuting Fang, Rongxiang Zhao, Jianxin Y. Apoptosis is induced by shikonin through the mitochondrial signaling pathway. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26935754. |
mtt, annexin v‑phycoerythrin/7‑aminoactinomycin d staining, electron microscopy and jc‑1 probe staining were performed to analyze mitochondrial membrane potential, and western blot analysis was used to examine the activation of the mitochondrial signaling pathway, and the changes in mitochondrial apoptosis pathway‑associated protein expression. |
2016-12-28 |
2023-08-13 |
human |
| Rozina Noristani, Sandra Kuehn, Gesa Stute, Sabrina Reinehr, Mathias Stellbogen, H Burkhard Dick, Stephanie C Joachi. Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model. Journal of molecular neuroscience : MN. vol 58. issue 4. 2016-12-26. PMID:26746422. |
at 14 and 28 days, immune-histological and western blot analyses were performed to investigate the optic nerve structure (smi-32), retinal ganglion cells (brn-3a), apoptosis (cleaved caspase 3, fasl), and glial profile (iba1, ed1, gfap, vimentin). |
2016-12-26 |
2023-08-13 |
rat |
| Liming Cui, Bo Gao, Zhigang Cao, Xiaoying Chen, Shide Zhang, Weizhe Zhan. Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide. Molecular medicine reports. vol 13. issue 3. 2016-12-26. PMID:26781180. |
following treatment of the cells with 2, 4 and 8 µm ato for 48 h, cell counting kit‑8 (cck‑8), transwell and western blot assays were used to determine the extent of human mhcc97‑h hcc cell proliferation, apoptosis, invasion and b7‑h4 expression, respectively. |
2016-12-26 |
2023-08-13 |
human |
| Xiaohui Lin, Xiyuan Zhou, Danning Liu, Lixia Yun, Lina Zhang, Xiaohai Chen, Qinghe Chai, Langen L. MicroRNA-29 regulates high-glucose-induced apoptosis in human retinal pigment epithelial cells through PTEN. In vitro cellular & developmental biology. Animal. vol 52. issue 4. 2016-12-26. PMID:26822433. |
mir-29 was then downregulated in rpe cells, and its effect on hg-induced apoptosis was examined by tunel assay and western blot assay on caspase-7 protein. |
2016-12-26 |
2023-08-13 |
human |
| Xiaohui Lin, Xiyuan Zhou, Danning Liu, Lixia Yun, Lina Zhang, Xiaohai Chen, Qinghe Chai, Langen L. MicroRNA-29 regulates high-glucose-induced apoptosis in human retinal pigment epithelial cells through PTEN. In vitro cellular & developmental biology. Animal. vol 52. issue 4. 2016-12-26. PMID:26822433. |
the effects of pten downregulation on mir-29-mediated hg-induced rpe cell apoptosis were also examined by tunel and western blot assays. |
2016-12-26 |
2023-08-13 |
human |
| Jun-Hui Chen, Li-Kun Yang, Lei Chen, Yu-Hai Wang, Yun Wu, Bing-Jie Jiang, Jie Zhu, Pei-Pei L. Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of AQP4 expression in rabbits. International journal of molecular medicine. vol 37. issue 4. 2016-12-26. PMID:26935263. |
brain edema was detected using the dry-wet method after experimental sah was induced; aqp4 and caspase-3 expression was measured by western blot analysis, and neuronal apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dutp nick end labelling (tunel) staining at 72 h after sah. |
2016-12-26 |
2023-08-13 |
rabbit |
| Xiao-Xia Liu, Li Tang, Rui Ge, Jian-Kuan Li, Ya Kang, Mei-Xia Zhu, Qing-Shan Li, Xu-Liang Ha. iTRAQ-based quantitative proteomic analysis of the anti-apoptotic effect of hyperin, which is mediated by Mcl-1 and Bid, in H2O2-injured EA.hy926 cells. International journal of molecular medicine. vol 37. issue 4. 2016-12-26. PMID:26935776. |
in addition, flow cytometric analysis and western blot analysis of the apoptosis-related proteins, truncated bid (tbid), cleaved caspase-3, cleaved caspase-9, fas, fasl and caspase-8, demonstrated that the rate of apoptosis and the pro-apoptotic protein levels were decreased by hyperin pre‑treatment. |
2016-12-26 |
2023-08-13 |
human |
| Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Xiao Wang, Heng Song, Zhi-Kun Liu, Shu-Chai Zh. Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression. International journal of oncology. vol 48. issue 5. 2016-12-26. PMID:26936624. |
co-immunoprecipitation (co-ip) assay and western blot analysis were employed to detect the interaction between rnf2 and r-h2ax, h2ak119ub, and the expression of proteins associated with cell cycle and apoptosis, respectively. |
2016-12-26 |
2023-08-13 |
Not clear |
| Junpu Wang, Wanming Hu, Xiaoying Wu, Kuansong Wang, Jun Yu, Baihua Luo, Gengqiu Luo, Weiyuan Wang, Huiling Wang, Jinghe Li, Jifang We. CXCR1 promotes malignant behavior of gastric cancer cells in vitro and in vivo in AKT and ERK1/2 phosphorylation. International journal of oncology. vol 48. issue 5. 2016-12-26. PMID:26983663. |
proliferation, cell cycle, apoptosis, migration and invasion-related signaling molecule expression were measured by real-time rt-pcr and western blot analysis. |
2016-12-26 |
2023-08-13 |
mouse |
| Xiao Jiao Cheng, Jia Cheng Lin, Yan Fei Ding, Liming Zhu, Jing Ye, Shui Ping T. Survivin inhibitor YM155 suppresses gastric cancer xenograft growth in mice without affecting normal tissues. Oncotarget. vol 7. issue 6. 2016-12-23. PMID:26771139. |
immunohistochemistry staining and western blot showed that ym155 treatment inhibited expression of survivin and cd44, induced apoptosis and reduced cd44+ cscs in xenograft tumor tissues in vivo. |
2016-12-23 |
2023-08-13 |
mouse |
| Zhaoxia Wang, Yang Wang, Yunfei Chen, Jiyuan L. The IL-24 gene protects human umbilical vein endothelial cells against H₂O₂-induced injury and may be useful as a treatment for cardiovascular disease. International journal of molecular medicine. vol 37. issue 3. 2016-12-19. PMID:26820392. |
apoptosis and the measurement of the intracellular reactive oxygen species (ros) levels were determined by flow cytometry, and the levels of caspase-3, which is associated with apoptosis, were determined by western blot analysis. |
2016-12-19 |
2023-08-13 |
human |
| Yan Zhang, Chenshuang Zou, Shuwen Yang, Jing F. P120 catenin attenuates the angiotensin II-induced apoptosis of human umbilical vein endothelial cells by suppressing the mitochondrial pathway. International journal of molecular medicine. vol 37. issue 3. 2016-12-19. PMID:26848040. |
in the present study, using western blot analysis and rt-pcr, we found that angii-induced cell apoptosis was correlated with a significant decrease in p120ctn expression. |
2016-12-19 |
2023-08-13 |
human |
| Sheng-Qi Wang, Bo-Xin Zhao, Yuan Liu, Ya-Tian Wang, Qian-Ying Liang, Yun Cai, Yun-Qi Zhang, Jiang-Hong Yang, Zhi-Hua Song, Guo-Feng L. New application of an old drug: Antitumor activity and mechanisms of doxycycline in small cell lung cancer. International journal of oncology. vol 48. issue 4. 2016-12-16. PMID:26846275. |
rt-pcr and western blot assays proved that apoptosis induction effect of doxycycline was achieved via inducing the expression of caspase-3 and bax, as well as attenuating the expression of survivin and bcl-2. |
2016-12-16 |
2023-08-13 |
Not clear |
| Bingshuo Liu, Zhiwei L. Black Currant (Ribes nigrum L.) Extract Induces Apoptosis of MKN-45 and TE-1 Cells Through MAPK- and PI3K/Akt-Mediated Mitochondrial Pathways. Journal of medicinal food. vol 19. issue 4. 2016-12-16. PMID:27007806. |
western blot assays showed that the bcl-2/bax ratio decreased in both mkn-45 and te-1 cells, indicating that bce induced apoptosis through the mitochondrial pathway. |
2016-12-16 |
2023-08-13 |
Not clear |
| Pei-Fang Wu, Chien-Chih Chiu, Chung-Yi Chen, Hui-Min David Wan. 7-Hydroxydehydronuciferine induces human melanoma death via triggering autophagy and apoptosis. Experimental dermatology. vol 24. issue 12. 2016-12-15. PMID:26174122. |
through western blot examinations, protein expressions were discovered to verify autophagy and apoptosis response mechanisms sharing the associated pathways. |
2016-12-15 |
2023-08-13 |
mouse |
| Yon-Suk Kim, Eun-Kyung Kim, Jin-Woo Hwang, Il-Bok Seo, Jae-Hyuk Jang, Sangkeun Son, Jae-Hyun Jeong, Sang-Ho Moon, Byong-Tae Jeon, Pyo-Jam Par. Characterization of the antioxidant fraction of Trapa japonica pericarp and its hepatic protective effects in vitro and in vivo. Food & function. vol 7. issue 3. 2016-12-14. PMID:26956465. |
furthermore, western blot analysis showed that the ef effectively inhibited t-bhp-induced apoptosis by suppressing caspase-3, caspase-7, caspase-8, and caspase-9. |
2016-12-14 |
2023-08-13 |
Not clear |
| Xiao-Qiang Wang, Bang-Bao Tao, Bin Li, Xu-Hui Wang, Wen-Chuan Zhang, Liang Wan, Xu-Ming Hua, Shi-Ting L. Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma. Oncotarget. vol 7. issue 3. 2016-12-13. PMID:26506595. |
moreover, based on gene set enrichment analysis (gsea) with the cancer genome atlas (tcga) dataset, we found that trem2 was positive related to kyoto encyclopedia of genes and genomes (kegg) apoptosis, cromer metastasis and kegg chemokine pathways, which was further validated by western blot in trem2 knockdown glioma cells and indicated a possible mechanism underlying its effects on glioma. |
2016-12-13 |
2023-08-13 |
human |
| Umesh T Sankpal, Ganji Purnachandra Nagaraju, Sriharika R Gottipolu, Myrna Hurtado, Christopher G Jordan, Jerry W Simecka, Mamoru Shoji, Bassel El-Rayes, Riyaz Bash. Combination of tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species. Oncotarget. vol 7. issue 3. 2016-12-13. PMID:26672603. |
effects on apoptosis were determined using flow cytometry (jc-1 staining to measure mitochondrial membrane potential), western blot analysis (c-parp expression) and caspase 3/7 activity. |
2016-12-13 |
2023-08-13 |
human |