| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Wang, Lei Chen, Miao Yu, Li-Hui Xu, Bao Cheng, Yong-Sheng Lin, Qiong Gu, Xian-Hui He, Jun X. Discovering new mTOR inhibitors for cancer treatment through virtual screening methods and in vitro assays. Scientific reports. vol 6. 2016-12-13. PMID:26732172. |
furthermore, cellular studies and western blot analyses revealed that 17 induces cell death via apoptosis by targeting both mtorc1 and mtorc2 within cells and arrests the cell cycle of hela at the g1/g0-phase. |
2016-12-13 |
2023-08-13 |
Not clear |
| Kaiping Wang, Zhizhen Song, Hongjing Wang, Qiang Li, Zheng Cui, Yu Zhan. Angelica sinensis polysaccharide attenuates concanavalin A-induced liver injury in mice. International immunopharmacology. vol 31. 2016-12-13. PMID:26741264. |
results of western blot analysis indicated that asp attenuated caspase-3-dependent apoptosis by caspase-8 and jnk-mediated pathway and inhibited the activation of il-6/stat3 and nf-κb signaling pathways in cona-induced liver damage in mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Badher Naveen, Anwita Mudiraj, Geeviman Khamushavalli, Phanithi Prakash Babu, Rajagopal Nagaraja. Concise total synthesis of water soluble metatacarboline A, C, D, E and F and its anticancer activity. European journal of medicinal chemistry. vol 113. 2016-12-13. PMID:26927685. |
further, western blot analysis and immunohistochemistry of mc d treated cells revealed activation of caspase dependent downstream signaling which led to apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Qianqian Sun, Shuangshuang Nie, Lingxiao Wang, Fan Yang, Zhangming Meng, Hengyi Xiao, Bing Xiang, Xiujun Li, Xianghui Fu, Shuang Wan. Factors that Affect Pancreatic Islet Cell Autophagy in Adult Rats: Evaluation of a Calorie-Restricted Diet and a High-Fat Diet. PloS one. vol 11. issue 3. 2016-12-13. PMID:26963814. |
pancreatic islet autophagy (lc3b and lamp2), ap (acid phosphatase) and apoptosis (apoptosis index, ai (tunel assay) and cleaved caspase-3) were detected using immunohistochemistry, elisa and western blot. |
2016-12-13 |
2023-08-13 |
rat |
| Ji-Sue Baik, Seo-Won Mun, Kyoung-Sook Kim, Shin-Ji Park, Hyun-Kyoung Yoon, Dong-Hyun Kim, Min-Kyu Park, Cheorl-Ho Kim, Young-Choon Le. Apoptotic Effects of Cordycepin Through the Extrinsic Pathway and p38 MAPK Activation in Human Glioblastoma U87MG Cells. Journal of microbiology and biotechnology. vol 26. issue 2. 2016-11-11. PMID:26597532. |
western blot data revealed that the levels of procaspase-8, -3, and bcl-2 were downregulated in cordycepintreated u87mg cells, whereas the levels of fas, fasl, bak, cleaved caspase-3, -8, and cleaved parp were upregulated, indicating that cordycepin induces apoptosis by activating the death receptor-mediated pathway in u87mg cells. |
2016-11-11 |
2023-08-13 |
human |
| Xiaofen Pan, Rui Meng, Zhonghua Yu, Jingjing Mou, Sha Liu, Ziyi Sun, Zhenwei Zou, Gang Wu, Gang Pen. Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression. International journal of oncology. vol 48. issue 3. 2016-11-10. PMID:26781335. |
cell viability, survival, dna double-strand breaks (dsb), apoptosis, cell cycle distribution, expression of shp-1 and other related proteins were detected with mtt assay, colony formation assay, immunofluorescent assay, flow cytometry and western blot analysis, respectively. |
2016-11-10 |
2023-08-13 |
human |
| Mirjana Popsavin, Vesna Kojić, Ljilja Torović, Miloš Svirčev, Saša Spaić, Dimitar Jakimov, Lidija Aleksić, Gordana Bogdanović, Velimir Popsavi. Synthesis and in vitro antitumour activity of tiazofurin analogues with nitrogen functionalities at the C-2' position. European journal of medicinal chemistry. vol 111. 2016-11-07. PMID:26859071. |
results of western blot analysis indicate that the synthesized tiazofurin analogues induce apoptosis in a caspase-dependent way. |
2016-11-07 |
2023-08-13 |
human |
| Seung-Hee Kim, Kyung-A Hwang, Kyung-Chul Cho. Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models. The Journal of nutritional biochemistry. vol 28. 2016-11-07. PMID:26878784. |
to elucidate the molecular mechanisms of tcs and kaem, alterations in the expressions of cell cycle, apoptosis and metastasis-related genes were identified using western blot assay. |
2016-11-07 |
2023-08-13 |
mouse |
| b' Gordana Jevti\\xc4\\x87, Tatjana Nikoli\\xc4\\x87, Aleksandar Mir\\xc4\\x8di\\xc4\\x87, Tihomir Stojkovi\\xc4\\x87, Milica Velimirovi\\xc4\\x87, Vladimir Trajkovi\\xc4\\x87, Ivanka Markovi\\xc4\\x87, Alexander M Trbovich, Nevena V Radonji\\xc4\\x87, Nata\\xc5\\xa1a D Petronijevi\\xc4\\x8. Mitochondrial impairment, apoptosis and autophagy in a rat brain as immediate and long-term effects of perinatal phencyclidine treatment - influence of restraint stress. Progress in neuro-psychopharmacology & biological psychiatry. vol 66. 2016-11-04. PMID:26655035.' |
expression of caspase 3 and aif as markers of apoptosis and beclin 1, p62 and lc3, as autophagy markers, was assessed by western blot. |
2016-11-04 |
2023-08-13 |
rat |
| Glòria Garrabou, Ana-Sandra Hernàndez, Marc Catalán García, Constanza Morén, Ester Tobías, Sarai Córdoba, Marta López, Francesc Figueras, Josep M Grau, Francesc Cardellac. Molecular basis of reduced birth weight in smoking pregnant women: mitochondrial dysfunction and apoptosis. Addiction biology. vol 21. issue 1. 2016-11-01. PMID:25186090. |
the following parameters were measured in all tissues: mitochondrial chain complex iv [cytochrome c oxidase (cox)] activity by spectrophotometry, mitochondrial dna levels by reverse transcription polymerase chain reaction, oxidative stress by spectrophotometric lipid peroxide quantification, mitochondrial mass through citrate synthase spectrophotometric activity and apoptosis by western blot parallelly confirmed by tunel (terminal deoxynucleotidyl transferase dutp nick end labelling) assay in placenta. |
2016-11-01 |
2023-08-13 |
Not clear |
| Gang Chen, Yimin Liang, Xiao Liang, Qingfeng Li, Dalie Li. Tanshinone IIA Inhibits Proliferation and Induces Apoptosis Through the Downregulation of Survivin in Keloid Fibroblasts. Annals of plastic surgery. vol 76. issue 2. 2016-10-31. PMID:26101974. |
furthermore, the apoptosis antibody array kit and western blot analysis revealed that tanshinone iia decreased survivin expression in kfs (p < 0.001). |
2016-10-31 |
2023-08-13 |
Not clear |
| Yan-hong Wang, Wen-jie Zhao, Wei-juan Zheng, Li Mao, Hong-zhen Lian, Xin Hu, Zi-chun Hu. Effects of Different Zinc Species on Cellar Zinc Distribution, Cell Cycle, Apoptosis and Viability in MDAMB231 Cells. Biological trace element research. vol 170. issue 1. 2016-10-28. PMID:26198133. |
western blot analysis of the expression of several key proteins in regulating zinc-related transcription, cell cycle, apoptosis, including mtf-1, cyclin b1, cyclin d1, caspase-8 and caspase-9 in treated cells further confirmed the observed results on cell level. |
2016-10-28 |
2023-08-13 |
Not clear |
| Qingliang Shao, Wei Jiang, Yan Ji. MiR-124 effect in neurons apoptosis in newborn rat with thyroid hypofunction. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-28. PMID:26823764. |
western blot was applied to detect apoptosis related protein caspase-3, bcl-2 and bax expression. |
2016-10-28 |
2023-08-13 |
mouse |
| Qingliang Shao, Wei Jiang, Yan Ji. MiR-124 effect in neurons apoptosis in newborn rat with thyroid hypofunction. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-28. PMID:26823764. |
further western blot results revealed that apoptosis inhibition might be related to down-regulating activated caspase-3 and bax levels, and up-regulating tumor-suppressor gene bcl-2 expression. |
2016-10-28 |
2023-08-13 |
mouse |
| Zhongjian Chen, Tianpeng Zhang, Baojian Wu, Xingwang Zhan. Insights into the therapeutic potential of hypoxia-inducible factor-1α small interfering RNA in malignant melanoma delivered via folate-decorated cationic liposomes. International journal of nanomedicine. vol 11. 2016-10-28. PMID:27042054. |
western blot analysis and apoptosis test demonstrated that sirna-fc-lps substantially reduced the production of hif-1α-associated protein and induced the apoptosis of hypoxia-tolerant melanoma cells. |
2016-10-28 |
2023-08-13 |
Not clear |
| Ruinian Zheng, Zhijian You, Jun Jia, Shunhuan Lin, Shuai Han, Aixue Liu, Huidong Long, Senming Wan. Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells. Molecular medicine reports. vol 13. issue 2. 2016-10-27. PMID:26707143. |
it was found that curcumin markedly enhanced the antitumor effects of abt-737 on hepg2 cells, which was partially dependent on the induction of apoptosis, according to western blot analysis and flow cytometric apoptosis analysis. |
2016-10-27 |
2023-08-13 |
Not clear |
| Y Wang, L-L Jiang, J-F Wu, Z Li. Protective effect of Honokiol against endometriosis in Rats via attenuating Survivin and Bcl-2: A mechanistic study. Cellular and molecular biology (Noisy-le-Grand, France). vol 62. issue 1. 2016-10-26. PMID:26828978. |
moreover, it also inhibits the mrna levels of survivin gene and bcl-2 (b-cell lymphoma 2) in qpcr and western blot analysis together with increases the mrna level of apoptosis promoting factor bax. |
2016-10-26 |
2023-08-13 |
rat |
| Shuang Wang, Weiwei Cao, Hao Xing, Ying Li Chen, Qian Li, Tingting Shen, Chun Jiang, Daling Zh. Activation of ERK pathway is required for 15-HETE-induced angiogenesis in human umbilical vascular endothelial cells. Journal of receptor and signal transduction research. vol 36. issue 3. 2016-10-24. PMID:26460784. |
to test this hypothesis, we study the effect of 15-hete on cell proliferation, angiogenesis, and apoptosis using cell viability measurement, cell cycle analysis, western blot, scratch-wound, tube formation assay, and nuclear morphology determination. |
2016-10-24 |
2023-08-13 |
human |
| Zhi-jian Meng, Ke Ta. Enhancement of Chemosensitivity by Stathmin-1 Silencing in Gastric Cancer Cells In Situ and In Vivo. Oncology research. vol 23. issue 1-2. 2016-10-24. PMID:26802649. |
the cell growth inhibition, expression of associated proteins, cell cycle, and apoptosis were evaluated by mtt, western blot, and flow cytometric assays, respectively. |
2016-10-24 |
2023-08-13 |
Not clear |
| Xiaomin Zhang, Xi Chen, Juan Liu, Xiushuai Dong, Yinglan Jin, Yaoyao Tian, Yanming Xue, Liyan Chen, Yuying Chang, Yao Liu, Jinghua Wan. Knockdown of WISP1 inhibit proliferation and induce apoptosis in ALL Jurkat cells. International journal of clinical and experimental pathology. vol 8. issue 11. 2016-10-24. PMID:26823919. |
western blot was used to detect the expression of cell proliferation and apoptosis related genes. |
2016-10-24 |
2023-08-13 |
Not clear |