| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing Zhu, Xu Song, Jing Zhou, Yixin Wang, Jianxun Xia, Wenyi Qian, Jingying Zhu, Rong Gao, Jun Wang, Hang Xia. Target of HIV-1 Envelope Glycoprotein gp120-Induced Hippocampal Neuron Damage: Role of Voltage-Gated K(+) Channel Kv2.1. Viral immunology. vol 28. issue 9. 2016-08-11. PMID:26393286. |
with western blot and terminal deoxynucleotidyl transferase dutp nick end labeling assays, it was discovered that gp120-induced neuronal injury was largely due to activation of kv2.1 channels and resultant apoptosis mediated by caspase-3 activation, as the pharmacological blockade of kv2.1 channels largely attenuated gp120-induced cell damage and caspase-3 expression. |
2016-08-11 |
2023-08-13 |
human |
| Mashitoh Abd Rahman, Faiqah Ramli, Hamed Karimian, Firouzeh Dehghan, Noraziah Nordin, Hapipah Mohd Ali, Syam Mohan, Najihah Mohd Hashi. Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells. PloS one. vol 11. issue 3. 2016-08-11. PMID:27019365. |
dna laddering, activation of caspases-3, -8, and -9, multi-parametric cytotoxicity-3 analysis by high-content screening, measurement of reactive oxygen species generation, and western blot were employed to study the pathways involved in the apoptosis. |
2016-08-11 |
2023-08-13 |
human |
| Jun Huang, Ke Liu, Deye Song, Muliang Ding, Junjie Wang, Qingping Jin, Jiangdong N. Krüppel-like factor 4 promotes high-mobility group box 1-induced chemotherapy resistance in osteosarcoma cells. Cancer science. vol 107. issue 3. 2016-08-10. PMID:26676883. |
in this study, quantitative real-time pcr and western blot analysis revealed that klf4 expression was significantly increased in response to cisplatin, methotrexate and doxorubicin treatment in osteosarcoma cells, and knockdown of klf4 increased sensitivity to these anticancer drugs by decreasing cellular clonogenic ability and increasing apoptosis. |
2016-08-10 |
2023-08-13 |
Not clear |
| SweeKeong Yeap, Muhammad Nadeem Akhtar, Kian Lam Lim, Nadiah Abu, Wan Yong Ho, Seema Zareen, Kiarash Roohani, Huynh Ky, Sheau Wei Tan, Nordin Lajis, Noorjahan Banu Alithee. Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line. Drug design, development and therapy. vol 9. 2016-08-09. PMID:25733816. |
western blot analysis also indicated that the dhaqc (2) increased bax, p53, and cytochrome c levels in mcf-7 cells, which subsequently activated apoptosis as observed in annexin v/propidium iodide and cell cycle analyses. |
2016-08-09 |
2023-08-13 |
human |
| Feiya Sheng, Mengting Chen, Yuan Tan, Cheng Xiang, Mi Zhang, Baocai Li, Huanxing Su, Chengwei He, Jianbo Wan, Peng L. Protective Effects of Otophylloside N on Pentylenetetrazol-Induced Neuronal Injury In vitro and In vivo. Frontiers in pharmacology. vol 7. 2016-08-09. PMID:27504096. |
additionally, our western blot and rt-pcr results demonstrated that oton may attenuate ptz-induced apoptosis and neuronal activation in neuronal cells, mice, and zebrafish. |
2016-08-09 |
2023-08-13 |
mouse |
| Hisashi Takeuchi, Chinedu O Mmeje, Goodwin G Jinesh, Rikiya Taoka, Ashish M Kama. Sequential gemcitabine and tamoxifen treatment enhances apoptosis and blocks transformation in bladder cancer cells. Oncology reports. vol 34. issue 5. 2016-08-08. PMID:26323344. |
apoptosis was then evaluated by western blot analysis. |
2016-08-08 |
2023-08-13 |
Not clear |
| Qiuzhen Zhu, Yuefan Zhang, Yulan Liu, Hao Cheng, Jing Wang, Yue Zhang, Yaocheng Rui, Tiejun L. MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2. PloS one. vol 11. issue 2. 2016-08-08. PMID:26918757. |
levels of the apoptosis associated proteins were measured by western blot analysis. |
2016-08-08 |
2023-08-13 |
human |
| Xuenong Zhang, Yanyan Wang, Shishi Han, Huiyao Xiang, Yan Peng, Yinghua Wu, Songwei Pan, Ye Zhang, Jinlan Rua. RY10-4 Inhibits the Proliferation of Human Hepatocellular Cancer HepG2 Cells by Inducing Apoptosis In Vitro and In Vivo. PloS one. vol 11. issue 3. 2016-08-08. PMID:26974964. |
herein, employing flow cytometry, and western blot analysis, we demonstrate that ry10-4 can induce cell cycle arrest, intracellular reactive oxygen species (ros) production and apoptosis in hepg2 cells. |
2016-08-08 |
2023-08-13 |
human |
| Ge Wang, Cheng-Cheng Feng, Shao-Jun Chu, Rui Zhang, Yun-Min Lu, Jin-Shui Zhu, Jing Zhan. Toosendanin inhibits growth and induces apoptosis in colorectal cancer cells through suppression of AKT/GSK-3β/β-catenin pathway. International journal of oncology. vol 47. issue 5. 2016-08-05. PMID:26398368. |
quantitative real-time pcr and western blot analysis found that tsn effectively modulated molecules related to apoptosis and akt/gsk-3β/β-catenin signaling. |
2016-08-05 |
2023-08-13 |
mouse |
| Xia Sheng, Wen-Bin Li, De-Lin Wang, Ke-Hong Chen, Jian-Jia Cao, Zhao Luo, Jiang He, Mei-Cai Li, Wu-Jiang Liu, Chao Y. YAP is closely correlated with castration-resistant prostate cancer, and downregulation of YAP reduces proliferation and induces apoptosis of PC-3 cells. Molecular medicine reports. vol 12. issue 4. 2016-08-02. PMID:26126522. |
mtt, flow cytometry, reverse transcription‑quantitative polymerase chain reaction and western blot assays were used to analyse the effects of yap inhibition on the proliferation and apoptosis of pc‑3 cells. |
2016-08-02 |
2023-08-13 |
human |
| Yu Chen, Yongfei Guo, Haisong Yang, Guodong Shi, Guohua Xu, Jiangang Shi, Na Yin, Deyu Che. TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome. Oncotarget. vol 6. issue 27. 2016-08-02. PMID:26247633. |
gene set enrichment analysis in gene expression omnibus dataset revealed that apoptosis, epithelial-mesenchymal transition (emt) and transforming growth factor-β (tgf-β) signaling pathway-related genes were enriched in trim66 higher expression patients, which was confirmed by western blot analysis in osteosarcoma cells with trim66 silenced. |
2016-08-02 |
2023-08-13 |
mouse |
| Nan Hu, Lifang Yang, Maolong Dong, Jun Ren, Yingmei Zhan. Deficiency in adiponectin exaggerates cigarette smoking exposure-induced cardiac contractile dysfunction: Role of autophagy. Pharmacological research. vol 100. 2016-08-01. PMID:26276084. |
autophagy and apoptosis were examined using western blot. |
2016-08-01 |
2023-08-13 |
mouse |
| Hector Lafuente, Maria R Pazos, Antonia Alvarez, Nagat Mohammed, Martín Santos, Maialen Arizti, Francisco J Alvarez, Jose A Martinez-Orgad. Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia. Frontiers in neuroscience. vol 10. 2016-07-27. PMID:27462203. |
western blot studies were performed to quantify protein nitrosylation (oxidative stress), content of caspase-3 (apoptosis) and tnfα (inflammation). |
2016-07-27 |
2023-08-13 |
Not clear |
| Marcella Nebbioso, Gianfranco Scarsella, Aloisa Librando, Nicola Pescosolid. Biomolecular Modulation of Neurodegenerative Events during Ageing. Oxidative medicine and cellular longevity. vol 2015. 2016-07-25. PMID:26583065. |
the molecules involved in apoptosis mediated by oxidative stress, such as caspase-3 and inducible nitric oxide synthase, were also assayed by immunolocalization and western blot. |
2016-07-25 |
2023-08-13 |
rat |
| Guixin He, Wei Tan, Bingjian Wang, Jianzhou Chen, Guannan Li, Suhui Zhu, Jun Xie, Biao X. Increased M1 Macrophages Infiltration Is Associated with Thrombogenesis in Rheumatic Mitral Stenosis Patients with Atrial Fibrillation. PloS one. vol 11. issue 3. 2016-07-22. PMID:26930272. |
immunohistochemistry, western blot, and tunel assay were used to detect m1/m2 macrophage infiltration, the expression pattern of il-1β and inflammasome components, and apoptosis of cardiomyocytes in 71 specimens obtained from the left atrial appendage of patients with rheumatic mitral stenosis (ms) with or without thrombosis. |
2016-07-22 |
2023-08-13 |
Not clear |
| Chuhai Xie, Boyi Wu, Binwei Chen, Qunwei Shi, Jianhong Guo, Ziwen Fan, Yan Huan. Histone deacetylase inhibitor sodium butyrate suppresses proliferation and promotes apoptosis in osteosarcoma cells by regulation of the MDM2-p53 signaling. OncoTargets and therapy. vol 9. 2016-07-22. PMID:27445491. |
then, cell proliferation and apoptosis were determined by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide and flow cytometry assays, respectively; the expression of ki67, bax, bcl-2, mdm2, and p53 proteins was determined by using western blot assay. |
2016-07-22 |
2023-08-13 |
mouse |
| Rui Chen, Bin Wang, Ling Chen, Dunpeng Cai, Bing Li, Chuanxiang Chen, Enping Huang, Chao Liu, Zhoumeng Lin, Wei-Bing Xie, Huijun Wan. DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. Toxicology and applied pharmacology. vol 295. 2016-07-19. PMID:26825372. |
we also determined the effects on meth-induced autophagy and apoptosis after silencing ddit4 expression with synthetic sirna with or without pretreatment of a mtor inhibitor rapamycin in cardiomyocytes using western blot analysis, fluorescence microscopy and tunel staining. |
2016-07-19 |
2023-08-13 |
rat |
| Xiaoxia Hu, Fei Zhang, Dongwei Luo, Na Li, Qian Wang, Zhonghai Xu, Huiqin Bian, Yuting Liang, Yaojuan Lu, Qiping Zheng, Junxia G. URI promotes gastric cancer cell motility, survival, and resistance to adriamycin in vitro. American journal of cancer research. vol 6. issue 6. 2016-07-19. PMID:27429854. |
the protein levels of apoptosis and emt related genes were detected by western blot. |
2016-07-19 |
2023-08-13 |
Not clear |
| Lilach Moyal, Nataly Feldbaum, Neta Goldfeiz, Ada Rephaeli, Abraham Nudelman, Michal Weitman, Nataly Tarasenko, Batia Gorovitz, Leah Maron, Shiran Yehezkel, Iris Amitay-Laish, Ido Lubin, Emmilia Hoda. The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin. PloS one. vol 11. issue 1. 2016-07-15. PMID:26752418. |
myla cells, hut78 cells, spbl, and pbl from healthy normal individuals (npbl) were exposed to the test drugs, and the findings were analyzed by a viability assay, an apoptosis assay, and western blot. |
2016-07-15 |
2023-08-13 |
Not clear |
| Baiyan Wang, Qianqian Han, Yanqin Zh. Oxymatrine inhibited cell proliferation by inducing apoptosis in human lung cancer A549 cells. Bio-medical materials and engineering. vol 26 Suppl 1. 2016-07-14. PMID:26405930. |
the a549 cells inhibition rate, apoptosis, and the expression of bcl-2 and bax were examined by mtt method, annexin v/pi double staining method, real-time quantitative pcr and western blot, respectively. |
2016-07-14 |
2023-08-13 |
human |