| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D-W Luo, Z Zheng, H Wang, Y Fan, F Chen, Y Sun, W-J Wang, T Sun, X X. UPP mediated Diabetic Retinopathy via ROS/PARP and NF-κB inflammatory factor pathways. Current molecular medicine. vol 15. issue 8. 2016-07-11. PMID:26391545. |
to investigate whether upp activated ros/parp and nf-κb inflammatory factor pathways in diabetic retinopathy, human retinal endothelial cells (hrecs) and rats with streptozotocin-induced diabetes were used to determine the effect of upp on ros generation, cell apoptosis, mitochondrial membrane potential (ΔΨm) and inflammatory factor protein expression, through flow cytometry assay, immunohistochemistry, real-time pcr, western blot analysis and elisa. |
2016-07-11 |
2023-08-13 |
human |
| L Y Zhou, L Y Shi, Y Xia. Changes of HMGB1 expression on angiogenesis of ovarian cancer and its mechanism. Journal of biological regulators and homeostatic agents. vol 30. issue 1. 2016-07-07. PMID:27049097. |
western blot was adopted to investigate the changes of hmgb1, cxcl12 and vascular endothelial growth factor (vegf) before and after the transfection and flow cytometry (fcm) was applied to detect skov3 apoptosis. |
2016-07-07 |
2023-08-13 |
Not clear |
| Jianhui Zhuang, Yu Li, Yufen Ch. Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells. Anti-cancer drugs. vol 27. issue 4. 2016-07-06. PMID:26771864. |
western blot analysis shows that treatment with allicin-induced apoptosis through activation of caspases-3 and 9. |
2016-07-06 |
2023-08-13 |
human |
| Milad Iranshahy, Zahra Tayarani-Najaran, Jamal Kasaian, Morteza Ghandadi, Seyed Ahmad Emami, Javad Asili, Jima N Chandran, Bernd Schneider, Mehrdad Iranshah. Highly Oxygenated Sesquiterpene Lactones from Cousinia aitchisonii and their Cytotoxic Properties: Rhaserolide Induces Apoptosis in Human T Lymphocyte (Jurkat) Cells via the Activation of c-Jun n-terminal Kinase Phosphorylation. Phytotherapy research : PTR. vol 30. issue 2. 2016-07-01. PMID:26581585. |
western blot analysis revealed that rhaserolide could induce apoptosis in jurkat cells via the activation of c-jun n-terminal kinase phosphorylation. |
2016-07-01 |
2023-08-13 |
human |
| Shahanavaj Khan, Anees A Ansari, Abdul Arif Khan, Rehan Ahmad, Omar Al-Obaid, Wael Al-Katta. In vitro evaluation of anticancer and antibacterial activities of cobalt oxide nanoparticles. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 20. issue 8. 2016-06-28. PMID:26563952. |
western blot analysis results suggested significant role of co3o4-nps exposure in cell death due to apoptosis. |
2016-06-28 |
2023-08-13 |
human |
| Xilin Baoleri, Chao Dong, Yang Zhou, Zhaojun Zhang, Xueliang Lu, Pengming Xie, Yongqi L. Combination of L-gossypol and low-concentration doxorubicin induces apoptosis in human synovial sarcoma cells. Molecular medicine reports. vol 12. issue 4. 2016-06-27. PMID:26238307. |
in addition, an mtt assay was performed to measure the inhibitory rate of the drug, flow cytometry was used to detect alterations in apoptosis and the cell cycle, and western blot analysis was used to detect bcl‑2 and bax protein expression levels. |
2016-06-27 |
2023-08-13 |
human |
| Zhen Huang, Ye Xu, Wei Pen. Colchicine induces apoptosis in HT‑29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways. Molecular medicine reports. vol 12. issue 4. 2016-06-27. PMID:26299305. |
the effect of colchicine on apoptosis in ht‑29 cells and the apoptosis‑associated signaling pathways were determined using various methods, including cell viability assay, annexin v/propidium idodide (pi) binding, pi staining, hoechst 33342 staining, mitochondrial membrane potential (Δψm) assay, reactive oxygen species (ros) assay and western blot analysis. |
2016-06-27 |
2023-08-13 |
human |
| Tony L H Chu, Qiunong Guan, Christopher Y C Nguan, Caigan D. Halofuginone Synergistically Enhances Anti-Proliferation of Rapamycin in T Cells and Reduces Cytotoxicity of Cyclosporine in Cultured Renal Tubular Epithelial Cells. PloS one. vol 10. issue 12. 2016-06-26. PMID:26671563. |
cell proliferation in cultures was determined using methylthiazol tetrazolium assay, and cell apoptosis assessed by flow cytometric analysis and western blot. |
2016-06-26 |
2023-08-13 |
Not clear |
| Wendian Zhang, Hechao Zhou, Ying Yu, Jingjing Li, Haiwen Li, Danxian Jiang, Zihong Chen, Donghong Yang, Zumin Xu, Zhonghua Y. Combination of gambogic acid with cisplatin enhances the antitumor effects on cisplatin-resistant lung cancer cells by downregulating MRP2 and LRP expression. OncoTargets and therapy. vol 9. 2016-06-22. PMID:27330316. |
cell counting kit-8 assay was used to observe the impacts of ga and/or cisplatin on the proliferation of lung cancer cells; flow cytometry was used to detect the effects of ga on cell cycle and apoptosis; western blot was used to examine the effects of ga on the expression of lung resistance protein (lrp) and multidrug resistance-associated protein 2 (mrp2) protein in a549/ddp cells. |
2016-06-22 |
2023-08-13 |
human |
| Zhangyuan Xiong, Rong Jiang, Xiangzhu Li, Yanna Liu, Fengjin Gu. Different Roles of GRP78 on Cell Proliferation and Apoptosis in Cartilage Development. International journal of molecular sciences. vol 16. issue 9. 2016-06-17. PMID:26370957. |
furthermore, overexpression of grp78 inhibited er stress-mediated apoptosis and then reduced apoptosis in chondrogenesis induced by bmp2, as assayed by cleaved caspase3, caspase12, c/ebp homologous protein (chop/ddit3/gadd153), p-jnk (phosphorylated c-jun n-terminal kinase) expression during the course of chondrocyte differentiation by western blot. |
2016-06-17 |
2023-08-13 |
Not clear |
| Shujun Li, Feng Li, Ren Niu, Helin Zhang, Airong Cui, Wenting An, Xiaolu Wan. Mir-192 suppresses apoptosis and promotes proliferation in esophageal aquamous cell caicinoma by targeting Bim. International journal of clinical and experimental pathology. vol 8. issue 7. 2016-06-14. PMID:26339371. |
in the present study, we assayed expression level of mir-192 in escc tissues and cell lines by real-time pcr, and defined the target gene and biological function by luciferase reporter assay, western blot and apoptosis assay. |
2016-06-14 |
2023-08-13 |
Not clear |
| Pengjuan Xu, Zhigui Li, Hui Wang, Xiaochen Zhang, Zhuo Yan. Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta₂₅₋₃₅ via the Autophagy Pathway. PloS one. vol 10. issue 11. 2016-06-13. PMID:26554937. |
in our study investigating the effect and potential mechanism of triptolide on cytotoxicity of differentiated rat pheochromocytoma cell line (the pc12 cell line is often used as a neuronal developmental model) induced by amyloid-beta25-35 (aβ25-35), we used 3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide (mtt) assay, flow cytometry, western blot, and acridine orange staining to detect whether triptolide could inhibit aβ25-35-induced cell apoptosis. |
2016-06-13 |
2023-08-13 |
rat |
| Peng Wu, Yuandai Luo, Lifang Zhen, Xianda Hu, Ying Shang, Yinuo Liao, Huiyuan Xue, Fukai Huang, Wei Xia. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-06-13. PMID:27293454. |
moreover, western blot and quantitative pcr (q-pcr) results indicated that the rsnp could suppress the apoptosis in the hippocampus of the vd animals by increasing the expression ratio of b-cell lymphoma-2 (bcl-2) to bcl-2-associated x protein (bax). |
2016-06-13 |
2023-08-13 |
rat |
| Mae A Goldgraben, Roslin Russell, Oscar M Rueda, Carlos Caldas, Anna Gi. Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner. RNA (New York, N.Y.). vol 22. issue 2. 2016-06-09. PMID:26670622. |
microarray and western blot analyses revealed induction of apoptosis, associated with interferon-β after activation of the double-stranded rna sensor pathway. |
2016-06-09 |
2023-08-13 |
Not clear |
| Agnieszka Rak, Eliza Drwal, Anna Wróbel, Ewa Łucja Gregoraszczu. Resistin is a survival factor for porcine ovarian follicular cells. Reproduction (Cambridge, England). vol 150. issue 4. 2016-06-03. PMID:26159832. |
next, the mrna and protein expression of selected pro-apoptotic and pro-survival regulators of cell apoptosis, caspase-9, -8 and -3 activity and dna fragmentation using real time pcr, western blot, fluorescent assay and an elisa kit, respectively, were analysed after resistin treatment. |
2016-06-03 |
2023-08-13 |
Not clear |
| Rekha Pal, Stephanie Green. microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma. PloS one. vol 10. issue 9. 2016-06-03. PMID:26394044. |
two medulloblastoma cell lines (daoy and uw228) were transiently transfected with control mirna, mirna-10b inhibitor or mirna-10b mimic and subjected to rt-pcr, mtt, apoptosis, clonogenic assay and western blot analysis. |
2016-06-03 |
2023-08-13 |
Not clear |
| Peng Zhang, Xiaofeng Zhu, Ying Wu, Ronglin Hu, Dongming Li, Jun Du, Xingyuan Jiao, Xiaoshun H. Histone deacetylase inhibitors reduce WB-F344 oval cell viability and migration capability by suppressing AKT/mTOR signaling in vitro. Archives of biochemistry and biophysics. vol 590. 2016-06-02. PMID:26558695. |
the expression of proteins related to both apoptosis and the cell cycle, and proteins of the akt/mammalian target of rapamycin (mtor) signaling pathway were analyzed by western blot. |
2016-06-02 |
2023-08-13 |
Not clear |
| Liannv Qiu, Jinlin Liu, Zhenni Wang, Weixiao Hu, Qiang Huang, Yonglie Zho. ZGDHu-1 and fludarabine have a synergistic effect on apoptosis of chronic lymphocytic leukemia cells. Oncology reports. vol 34. issue 3. 2016-06-01. PMID:26165829. |
expression of active caspase-3 and the bcl-2/bax ratio for determination of apoptosis were also investigated by flow cytometry and western blot analysis. |
2016-06-01 |
2023-08-13 |
Not clear |
| Luran Liu, Chang Liu, Yuting Lu, Lina Liu, Yan Jian. ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-31. PMID:26261584. |
the apoptosis associated caspase-12 and chop protein were detected by western blot. |
2016-05-31 |
2023-08-13 |
Not clear |
| Bin Xu, Ze-Zhang Ta. Piceatannol Enhances the Antitumor Efficacy of Gemcitabine in Human A549 Non-Small Cell Lung Cancer Cells. Oncology research. vol 22. issue 4. 2016-05-31. PMID:26351210. |
western blot analysis showed that gemcitabine induced the expression of the proapoptotic proteins bad and bak, and pretreatment with piceatannol further increased bak expression, leading to an increased number of cells undergoing late apoptosis. |
2016-05-31 |
2023-08-13 |
human |