| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bin-bin Wang, Xiao-hu Wang, Kai Liu, Shao-bo Sun, Peng Song, Ying-dong L. [Enhanced radiosensitivity of H22 ascitic tumor to 12C6+ ions radiation in ultra-filtration extract mixture from Astragalus mongholicus-treated mice]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 50. issue 12. 2016-05-26. PMID:27169282. |
the body weights, abdomen circumference of the mice were measured and the mouse behavior was monitored every day; survival time was recorded to evaluate life extension effect; flow cytometry technique was used to detect h22 cell apoptosis and cell cycle; protein levels of p53, bax, bcl-2 and cleaved caspase-3 were analyzed by western blot; the single cell gel electrophoresis was used to detect the level of deoxyribonucleic acid damage (dna damage). |
2016-05-26 |
2023-08-13 |
mouse |
| Xu-Feng Bu, Mu-Bing Wang, Zhi-Jian Zhang, Ying-Hai Zhao, Mi Li, Yu-Lan Ya. Autophagy is involved in recombinant Newcastle disease virus (rL-RVG)-induced cell death of stomach adenocarcinoma cells in vitro. International journal of oncology. vol 47. issue 2. 2016-05-24. PMID:26058483. |
western blot analysis indicated that rl-rvg and ndv induced increases in apoptosis, endoplasmic reticulum stress, and autophagy in the sgc-7901 and ags cells. |
2016-05-24 |
2023-08-13 |
Not clear |
| Claire Crafter, John P Vincent, Eric Tang, Phillippa Dudley, Neil H James, Teresa Klinowska, Barry R Davie. Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models. International journal of oncology. vol 47. issue 2. 2016-05-24. PMID:26095475. |
investigation of the mechanism by western blot analysis revealed that the addition of azd8931 prevented the induction of her2/her3 phosphorylation induced by azd5363 and resulted in concomitant inhibition of both the pi3k/akt/mtor and erk signalling pathways and induction of apoptosis. |
2016-05-24 |
2023-08-13 |
Not clear |
| D Yugandhar, V Lakshma Nayak, Sivakumar Archana, Kunta Chandra Shekar, Ajay Kumar Srivastav. Design, synthesis and anticancer properties of novel oxa/azaspiro[4,5]trienones as potent apoptosis inducers through mitochondrial disruption. European journal of medicinal chemistry. vol 101. 2016-05-24. PMID:26163220. |
furthermore, western blot analysis suggested that these compounds up-regulate the levels of p53, p21, p27 and bax, and down-regulate the level of bcl-2 confirming the apoptosis inducing properties. |
2016-05-24 |
2023-08-13 |
human |
| An Chen, Gonghui Li, Linlin Chen, Jingbin Guo, Yingfeng Li. Downregulation of microRNA-100 protects H2O2-induced apoptosis in neonatal cardiomyocytes. International journal of clinical and experimental pathology. vol 8. issue 5. 2016-05-24. PMID:26191255. |
through biochemical analysis of western blot, we found that mir-100 suppressed the expression of insulin-like growth factor 1 receptor (igf1r) during the process of hypoxia-induced apoptosis in cardiomyocytes. |
2016-05-24 |
2023-08-13 |
mouse |
| Jianping Bi, Ai Huang, Tao Liu, Tao Zhang, Hong M. Expression of DNA damage checkpoint 53BP1 is correlated with prognosis, cell proliferation and apoptosis in colorectal cancer. International journal of clinical and experimental pathology. vol 8. issue 6. 2016-05-24. PMID:26261485. |
after establishment of shrna-mediated knockdown stable hct-116 cell lines, cell proliferation, apoptosis and cell cycle distribution were detected by mtt and flow cytometry, and expression of up-and down-steam related proteins as γ-h2ax, chk2 and p53 were tested by western blot. |
2016-05-24 |
2023-08-13 |
Not clear |
| Jianguo Li, Xiue Feng, Rui Ge, Jiankuan Li, Qingshan L. Protective Effect of 2,4',5'-Trihydroxyl-5,2'-dibromo diphenylmethanone, a New Halophenol, against Hydrogen Peroxide-Induced EA.hy926 Cells Injury. Molecules (Basel, Switzerland). vol 20. issue 8. 2016-05-23. PMID:26251890. |
meanwhile the expression of cleaved caspase-3, an executioner of apoptosis, was also detected by western blot. |
2016-05-23 |
2023-08-13 |
Not clear |
| Jian Yang, Lihua Chen, Jiawang Ding, Jing Zhang, Zhixing Fan, Chaojun Yang, Qinqin Yu, Jun Yan. Cardioprotective effect of miRNA-22 on hypoxia/reoxygenation induced cardiomyocyte injury in neonatal rats. Gene. vol 579. issue 1. 2016-05-23. PMID:26707060. |
overexpression of mir-22 attenuated cardiomyocyte apoptosis and mir-22 target gene creb binding protein (cbp) protein level, as determined by flow cytometry analysis and western blot respectively. |
2016-05-23 |
2023-08-13 |
rat |
| Gaiping Wang, Shasha Chen, Congcong Zhao, Xiaofang Li, Ling Zhang, Weiming Zhao, Cuifang Chang, Cunshuan X. Gene expression profiles predict the possible regulatory role of OPN-mediated signaling pathways in rat liver regeneration. Gene. vol 576. issue 2 Pt 2. 2016-05-21. PMID:26581507. |
thereafter, ipa software and western blot were used to analyze potential effects of every branch of opn signaling pathways during lr, and the results suggested that the genes expression changes of opn signaling pathways may account for enhanced cell proliferation, survival, adhesion and migration, augmented inflammation response and attenuated apoptosis during lr. |
2016-05-21 |
2023-08-13 |
rat |
| Xue Li, Zuoxu Xie, Cao Xie, Weiyue Lu, Chunli Gao, Henglei Ren, Man Ying, Xiaoli Wei, Jie Gao, Bingxia Su, Yachao Ren, Min Li. D-SP5 Peptide-Modified Highly Branched Polyethylenimine for Gene Therapy of Gastric Adenocarcinoma. Bioconjugate chemistry. vol 26. issue 8. 2016-05-19. PMID:26052814. |
western blot assays indicated that the expression of tumor necrosis factor-related apoptosis inducing ligand (trail) protein in sgc7901 cells treated with d-sp5-peg-pei/ptrail was higher compared with that in cells treated with mpeg-pei/ptrail. |
2016-05-19 |
2023-08-13 |
mouse |
| Kang Li, Zeng Dan, Yuqiang Nie, Xuejun Hu, Luobu Gesang, Zhaxi Bianba, Yongge Ze, Cuomu Cire. CD14 knockdown reduces lipopolysaccharide-induced cell viability and expression of inflammation-associated genes in gastric cancer cells in vitro and in nude mouse xenografts. Molecular medicine reports. vol 12. issue 3. 2016-05-18. PMID:26081375. |
mgc‑803 cells were stably transfected with cd14 short hairpin (sh)rna and treated with lps, followed by assessment of cell proliferation, apoptosis and gene expression using a cell counting kit‑8 assay, flow cytometry, reverse transcription‑polymerase chain reaction and western blot analysis, respectively. |
2016-05-18 |
2023-08-13 |
mouse |
| Dae-Hwan Nam, Jung-Hwa Han, Tae-Jin Lee, Tetsuro Shishido, Jae Hyang Lim, Geun-Young Kim, Chang-Hoon Wo. CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction. Journal of molecular and cellular cardiology. vol 85. 2016-05-17. PMID:26027784. |
in addition, western blot analysis revealed that mgo-induced myocyte apoptosis was inhibited by depletion of chop with sirna against ddit3, the gene name for rat chop. |
2016-05-17 |
2023-08-13 |
mouse |
| Sheau-Yun Yuan, Chen-Li Cheng, Hao-Chung Ho, Shian-Shiang Wang, Kun-Yuan Chiu, Chung-Kuang Su, Yen-Chuan Ou, Chi-Chen Li. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. European journal of pharmacology. vol 761. 2016-05-17. PMID:26086857. |
we also performed cell cycle analysis, annexin v and mitochondrial membrane potential assays, and western blot analysis to show that ntp inhibits cell growth in these cells by inducing both mitochondria-mediated and death receptor-mediated apoptosis. |
2016-05-17 |
2023-08-13 |
mouse |
| Lianhai Jin, Xingyu Zhao, Yingxin Qin, Wenhe Zhu, Wei Zhang, Anheng Liu, Zhengli Lu. Soy isoflavones protect against H₂O₂-induced injury in human umbilical vein endothelial cells. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26095641. |
western blot analysis results show that soy isoflavones can modulate the activation of nuclear factor‑κb and the mitochondria‑mediated apoptosis signaling pathway. |
2016-05-17 |
2023-08-13 |
human |
| Fu-quan Zhang, Wen-tao Yang, Shan-zhou Duan, Ying-chen Xia, Rong-ying Zhu, Yong-bing Che. JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small cell lung carcinoma cells with mutated EGF receptor. Oncotarget. vol 6. issue 16. 2016-05-12. PMID:25869210. |
cell proliferation, apoptosis, gene expression and tumor growth were evaluated by diphenyltetrazolium bromide (mtt) assay, flow cytometry, terminal deoxynucleotidyl transferase biotin-dutp nick end labeling (tunel) staining, western blot and a xenograft mouse model, respectively. |
2016-05-12 |
2023-08-13 |
mouse |
| Anushree Mondal, Urmi Chatterj. Artemisinin Represses Telomerase Subunits and Induces Apoptosis in HPV-39 Infected Human Cervical Cancer Cells. Journal of cellular biochemistry. vol 116. issue 9. 2016-05-10. PMID:25755006. |
expression of genes and proteins related to cell proliferation and apoptosis was quantified both at the transcriptional and translational levels by semi-quantitative rt-pcr and western blot analysis, respectively. |
2016-05-10 |
2023-08-13 |
human |
| Kevin Brasseur, Pascal Auger, Eric Asselin, Sophie Parent, Jean-Charles Côté, Marc Siroi. Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells. PloS one. vol 10. issue 8. 2016-05-10. PMID:26263002. |
upon treatment with proteinase k-activated parasporin-2aa1, morphological changes were observed and western blot analysis revealed the cleavage of poly (adp-ribose) polymerase, caspase-3 and caspase-9 in cancer cell lines exclusively, indicative of programmed cell death, apoptosis. |
2016-05-10 |
2023-08-13 |
human |
| Fangfang Cheng, Yanjing Yang, Li Zhang, Yudan Cao, Weifeng Yao, Yuping Tang, Anwei Din. A Natural Triterpene Derivative from Euphorbia kansui Inhibits Cell Proliferation and Induces Apoptosis against Rat Intestinal Epithelioid Cell Line in Vitro. International journal of molecular sciences. vol 16. issue 8. 2016-05-10. PMID:26274958. |
moreover, apoptosis induction was further confirmed by transmission electron microscope (tem) and jc-1 mitochondrial membrane potential, western blot and rt-pcr analysis. |
2016-05-10 |
2023-08-13 |
rat |
| Somin Lee, Ji-Eun Kim, Seong-Ho Hong, Ah-Young Lee, Eun-Jung Park, Hwi Won Seo, Chanhee Chae, Philip Doble, David Bishop, Myung-Haing Ch. High Inorganic Phosphate Intake Promotes Tumorigenesis at Early Stages in a Mouse Model of Lung Cancer. PloS one. vol 10. issue 8. 2016-05-10. PMID:26285136. |
mice were then sacrificed and subjected to inductively coupled plasma mass/optical emission spectrometry and laser ablation inductively coupled plasma mass-spectrometry analyses, western blot analysis, histopathological, immunohistochemical, and immunocytochemical analyses to evaluate tumor formation and progression (including cell proliferation, angiogenesis, and apoptosis), changes in ion levels and metabolism, autophagy, epithelial-to-mesenchymal transition, and protein translation in the lungs. |
2016-05-10 |
2023-08-13 |
mouse |
| Nissim Arish, Pazit Y Cohen, Regina Golan-Gerstl, Zvi Fridlender, Mark Richter Dayan, Philip Zisman, Raphael Breuer, Shulamit B Wallach-Daya. Overexpression of Telomerase Protects Human and Murine Lung Epithelial Cells from Fas- and Bleomycin-Induced Apoptosis via FLIP Upregulation. PloS one. vol 10. issue 5. 2016-05-03. PMID:25951185. |
bleomycin, and bleomycin-induced fas-mediated apoptosis following treatment with anti-fas activating mab or control igg, were assessed by annexin v staining, facs analysis, and confocal microscopy; caspase cleavage by western blot; flip or fas molecule detection by western blot and flow cytometry. |
2016-05-03 |
2023-08-13 |
mouse |