| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Forloni, O Bugiani, F Tagliavini, M Salmon. Apoptosis-mediated neurotoxicity induced by beta-amyloid and PrP fragments. Molecular and chemical neuropathology. vol 28. issue 1-3. 1997-01-23. PMID:8871955. |
the intracellular cascade of events activated by peptides was investigated by northern blot and pcr analysis of expression of early genes (c-fos, c-jun, c-myc) and other proteins (p53, sgp-2 bcl-2, hsp70, ich-1) potentially involved in apoptosis. |
1997-01-23 |
2023-08-12 |
Not clear |
| X Ge, S Yannai, G Rennert, N Gruener, F A Fare. 3,3'-Diindolylmethane induces apoptosis in human cancer cells. Biochemical and biophysical research communications. vol 228. issue 1. 1996-12-13. PMID:8912651. |
western blot showed that wild-type p53 protein was unchanged after mcf-7 cells had been exposed to 50 microm 3,3'-diindolylmethane for 8 h. this study provides evidences that 3,3'-diindolylmethane induces apoptosis in human cancer cells and that the induction of apoptosis is independent of p53 pathway. |
1996-12-13 |
2023-08-12 |
human |
| H Yamada, M Nakagawa, I Higuchi, R Ohkubo, M Osam. Type II muscle fibers are stained by anti-Fas antibody. Journal of the neurological sciences. vol 134. issue 1-2. 1996-09-27. PMID:8747853. |
to examine whether apoptosis related proteins are present in skeletal muscles we studied biopsied muscles immunohistochemically and by western blot analysis. |
1996-09-27 |
2023-08-12 |
Not clear |
| Z Han, D Chatterjee, J Early, P Pantazis, E A Hendrickson, J H Wych. Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL. Cancer research. vol 56. issue 7. 1996-05-13. PMID:8603411. |
western blot analysis demonstrated that the parental hl-60 cells expressed both bcl-2 and bax, two factors known to be intimately involved in the control of apoptosis. |
1996-05-13 |
2023-08-12 |
human |
| L Scaglia, F E Smith, S Bonner-Wei. Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas. Endocrinology. vol 136. issue 12. 1995-12-28. PMID:7588296. |
the expression of trpm 2 and tgf beta 1, often enhanced in models of apoptosis, were studied during the post partum period by northern blot analysis and immunohistochemistry. |
1995-12-28 |
2023-08-12 |
rat |
| G Häcker, D L Vau. Expression of candidate cell death genes in cell lines during apoptosis. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 72. issue 11-12. 1995-10-05. PMID:7654317. |
we have cloned mouse candidate cell death genes rp-2 and nedd2 and used northern blot analysis to study their expression in a growth-factor-dependent cell line (fdc-p1) that can be induced to undergo apoptosis by growth factor withdrawal and in a thymoma line (st4) that undergoes apoptosis when irradiated. |
1995-10-05 |
2023-08-12 |
mouse |
| J J Yen, Y C Hsieh, C L Yen, C C Chang, S Lin, H F Yang-Ye. Restoring the apoptosis suppression response to IL-5 confers on erythroleukemic cells a phenotype of IL-5-dependent growth. Journal of immunology (Baltimore, Md. : 1950). vol 154. issue 5. 1995-03-29. PMID:7868889. |
the following findings suggest that overexpression of the hil-5 receptor alpha-chain may be responsible for restoring the apoptosis suppression ability of il-5: 1) the growth of jytf-1 cells remained cytokine-dependent; 2) the proliferation of jytf-1 cells in il-5 was not mediated by autocrine secretion; 3) jytf-1 and tf-1 cells responded similarly to other cytokines such as human erythropoietin; 4) northern blot analysis revealed that jytf-1 cells expressed approximately eightfold more il-5 receptor alpha-chain mrna than did tf-1. |
1995-03-29 |
2023-08-12 |
human |
| A O Hueber, M Pierres, H T H. Quantitating apoptosis by a nonradioactive DNA dot blot assay. Analytical biochemistry. vol 221. issue 2. 1995-01-30. PMID:7810894. |
quantitating apoptosis by a nonradioactive dna dot blot assay. |
1995-01-30 |
2023-08-12 |
Not clear |
| W H Kim, H W Schnaper, M Nomizu, Y Yamada, H K Kleinma. Apoptosis in human fibrosarcoma cells is induced by a multimeric synthetic Tyr-Ile-Gly-Ser-Arg (YIGSR)-containing polypeptide from laminin. Cancer research. vol 54. issue 18. 1994-09-27. PMID:8069868. |
tumor cells treated with this peptide showed the expected morphological changes associated with apoptosis, acridine orange staining of nuclei, increased numbers of 3'-oh ends of dna in nuclei, a dna ladder pattern on agarose gels, and increased transforming growth factor beta 1 mrna by northern blot. |
1994-09-27 |
2023-08-12 |
human |
| W D Jarvis, A J Turner, L F Povirk, R S Traylor, S Gran. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer research. vol 54. issue 7. 1994-04-28. PMID:7511048. |
finally, northern blot analysis revealed that exposure to calphostin c at a concentration that induced apoptosis (100 nm) failed to alter expression of bcl-2, an oncogene known to block apoptosis in both lymphoid and myeloid leukemia cells. |
1994-04-28 |
2023-08-12 |
human |
| A O Hueber, G Raposo, M Pierres, H T H. Thy-1 triggers mouse thymocyte apoptosis through a bcl-2-resistant mechanism. The Journal of experimental medicine. vol 179. issue 3. 1994-03-30. PMID:7906706. |
use of a quantitative dna dot blot assay indicated that thy-1-mediated thymocyte apoptosis was not blocked by rna or protein synthesis inhibitors, egta, or by cyclosporin a, and differed, therefore, from "activation-driven cell death". |
1994-03-30 |
2023-08-12 |
mouse |
| J Delic, M Morange, H Magdelena. Ubiquitin pathway involvement in human lymphocyte gamma-irradiation-induced apoptosis. Molecular and cellular biology. vol 13. issue 8. 1993-08-24. PMID:8393139. |
using in vitro nuclear transcription assays (run-on), northern (rna) blot analysis, immunolocalization studies, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis after immunoprecipitation, we demonstrate that (i) the ubiquitin mrna level is increased as a consequence of the activation of ubiquitin gene transcription 15 to 90 min after initiation of apoptosis; (ii) specifically in apoptotic cells, and not in all irradiated cells, nuclear proteins are highly ubiquitinated; and (iii) ubiquitin sequence-specific antisense oligonucleotide inhibition results in a decreased level of ubiquitinated nuclear proteins and considerably diminishes the proportion of cells exhibiting the apoptotic death pattern. |
1993-08-24 |
2023-08-12 |
human |
| A Facchinetti, L Tessarollo, M Mazzocchi, R Kingston, D Collavo, G Bias. An improved method for the detection of DNA fragmentation. Journal of immunological methods. vol 136. issue 1. 1991-03-22. PMID:1704901. |
an application of the southern blot technique is described which permits the detection of dna fragmentation due to cell death by apoptosis. |
1991-03-22 |
2023-08-11 |
Not clear |