| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Chen, S Zheng, M C Willingham, W Fa. [Cloning of genes associated with taxol-induced apoptosis of human breast cancer cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 19. issue 3. 1999-10-05. PMID:10453491. |
results demonstrated that the expressive alteration of twelve clones isolated was associated with taxol-induced apoptosis identified by northern blot. |
1999-10-05 |
2023-08-12 |
human |
| P C Konturek, T Brzozowski, S J Konturek, R Pajdo, J E Konturek, S Kwiecień, A Taut, E G Hah. Apoptosis in gastric mucosa with stress-induced gastric ulcers. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 50. issue 2. 1999-09-22. PMID:10424718. |
the apoptosis rate in the gastric mucosa was determined by the terminal deoxynucleotidyl transferase (tdt) mediated 2-deoxyuridine 5-triphosphate (dutp)-biotin nick end-labeling (tunel) staining method and the expression of bax and bcl-2 mrna was analyzed by rt-pcr and southern blot hybridization. |
1999-09-22 |
2023-08-12 |
rat |
| S Nandi, P P Banerjee, B R Zirki. Germ cell apoptosis in the testes of Sprague Dawley rats following testosterone withdrawal by ethane 1,2-dimethanesulfonate administration: relationship to Fas? Biology of reproduction. vol 61. issue 1. 1999-09-03. PMID:10377033. |
apoptosis was examined in situ and biochemically, and fas protein content in the testis was monitored by western blot analysis. |
1999-09-03 |
2023-08-12 |
rat |
| Y Akao, Y Nakagawa, K Akiyam. Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro. FEBS letters. vol 455. issue 1-2. 1999-08-16. PMID:10428472. |
as2o3-induced apoptosis in neuroblastoma cells was shown to occur through the activation of caspase 3, as judged from western blot analysis and apoptosis inhibition assay. |
1999-08-16 |
2023-08-12 |
Not clear |
| Y Akao, Y Nakagawa, W Maruyama, T Takahashi, M Nao. Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3. Neuroscience letters. vol 267. issue 3. 1999-08-03. PMID:10380999. |
in this study, we tried to elucidate the intracellular mechanism of apoptosis induced by n-methyl(r)salsolinol, and proved activation of caspase 3 after incubation with this toxin by western blot analysis. |
1999-08-03 |
2023-08-12 |
human |
| P C Konturek, P Pierzchalski, S J Konturek, H Meixner, G Faller, T Kirchner, E G Hah. Helicobacter pylori induces apoptosis in gastric mucosa through an upregulation of Bax expression in humans. Scandinavian journal of gastroenterology. vol 34. issue 4. 1999-07-22. PMID:10365897. |
the apoptosis was analyzed by means of terminal deoxyribonucleotide transferase-mediated digoxigenin-11-deoxyuridine triphosphate biotin nick-end labeling (tunel) staining, and the expression of mrna for bax and bcl-2 by reverse transcription polymerase chain reaction (rt-pcr) and southern blot. |
1999-07-22 |
2023-08-12 |
human |
| T T Turner, T A Rile. p53 independent, region-specific epithelial apoptosis is induced in the rat epididymis by deprivation of luminal factors. Molecular reproduction and development. vol 53. issue 2. 1999-07-19. PMID:10331457. |
p53, a key apoptotic-pathway molecule in many tissues and conditions was tested by immunohistochemical and western blot techniques and was not upregulated in the initial segment epithelium within the time cells were undergoing apoptosis and well before the wave of apoptosis was complete. |
1999-07-19 |
2023-08-12 |
rat |
| J Zheng, Y P Deng, C Lin, M Fu, P G Xiao, M W. Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression. International journal of cancer. vol 82. issue 2. 1999-07-19. PMID:10389765. |
this effect was evidenced by a reduction of cell viability in the mtt assay, g1 arrest and significant apoptosis upon flow-cytometric analysis, presence of apoptotic bodies, formation of dna ladders upon gel electrophoresis and inhibition of viral early gene expression by rt-pcr and western blot. |
1999-07-19 |
2023-08-12 |
human |
| R Robles, X J Tao, A M Trbovich, D V Maravel, R Nahum, G I Perez, K I Tilly, J L Till. Localization, regulation and possible consequences of apoptotic protease-activating factor-1 (Apaf-1) expression in granulosa cells of the mouse ovary. Endocrinology. vol 140. issue 6. 1999-06-03. PMID:10342853. |
western blot analysis of fractionated protein extracts prepared from granulosa cells before and after in vitro culture without hormonal support to induce apoptosis indicated that mitochondrial cytochrome c release, a biochemical step required for the activation of apaf-1, occurs in granulosa cells cultured in vitro. |
1999-06-03 |
2023-08-12 |
mouse |
| A Rickers, N Peters, V Badock, R Beyaert, P Vandenabeele, B Dörken, K Bommer. Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis. European journal of biochemistry. vol 261. issue 1. 1999-05-19. PMID:10103059. |
western blot analysis revealed two cleavage products of approximately 68 kda and 45 kda after induction of apoptosis. |
1999-05-19 |
2023-08-12 |
human |
| K M McGinnis, M E Gnegy, K K Wan. Endogenous bax translocation in SH-SY5Y human neuroblastoma cells and cerebellar granule neurons undergoing apoptosis. Journal of neurochemistry. vol 72. issue 5. 1999-05-06. PMID:10217266. |
we used western blot analysis to demonstrate that the proapoptotic protein bax translocated from the cytosolic to the mitochondrial fraction in sh-sy5y human neuroblastoma cells undergoing staurosporine- or egta-mediated apoptosis. |
1999-05-06 |
2023-08-12 |
human |
| C Gao, N Tsuchid. Activation of caspases in p53-induced transactivation-independent apoptosis. Japanese journal of cancer research : Gann. vol 90. issue 2. 1999-04-14. PMID:10189888. |
western blot analysis showed that parp, cpp32 and ich-1 precursors were cleaved during apoptosis. |
1999-04-14 |
2023-08-12 |
human |
| Y Guo, N Kypriano. Restoration of transforming growth factor beta signaling pathway in human prostate cancer cells suppresses tumorigenicity via induction of caspase-1-mediated apoptosis. Cancer research. vol 59. issue 6. 1999-04-13. PMID:10096572. |
the significance of caspase 1 in tgf-beta1-mediated apoptosis was also determined by examining the expression and activation of caspase 1 by reverse transcription-pcr and western blot analyses, respectively. |
1999-04-13 |
2023-08-12 |
mouse |
| J P Roperch, V Alvaro, S Prieur, M Tuynder, M Nemani, F Lethrosne, L Piouffre, M C Gendron, D Israeli, J Dausset, M Oren, R Amson, A Telerma. Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nature medicine. vol 4. issue 7. 1999-04-07. PMID:9662377. |
previously, we cloned a cdna fragment, tsip 2 (tumor suppressor inhibited pathway clone 2), that detects by northern blot analysis of m1-ltr6 cells a 3-kb mrna downregulated during p53-induced apoptosis. |
1999-04-07 |
2023-08-12 |
mouse |
| M Podhorska-Okolow, M Sandri, S Zampieri, B Brun, K Rossini, U Carrar. Apoptosis of myofibres and satellite cells: exercise-induced damage in skeletal muscle of the mouse. Neuropathology and applied neurobiology. vol 24. issue 6. 1999-03-31. PMID:9888162. |
groups of five mice were sacrificed immediately after the end of the exercise, and after a rest period of 6 or 96 h. the amount of apoptosis in leg muscles was assessed by electron microscopy, by the terminal deoxynucleotidyl transferase assay and by electrophoretic detection of fragmented dna; the expression of bcl-2, bax, fas, ice, p53 and ubiquitin was examined by immunohistochemistry and western blot. |
1999-03-31 |
2023-08-12 |
mouse |
| F Sirzén, B Zhivotovsky, A Nilsson, J Bergh, R Lewensoh. Higher spontaneous apoptotic index in small cell compared with non-small cell lung carcinoma cell lines; lack of correlation with Bcl-2/Bax. Lung cancer (Amsterdam, Netherlands). vol 22. issue 1. 1999-03-15. PMID:9869102. |
important molecular determinants of apoptosis were studied by western blot. |
1999-03-15 |
2023-08-12 |
Not clear |
| R Araya, T Uehara, Y Nomur. Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria. FEBS letters. vol 439. issue 1-2. 1998-12-23. PMID:9849900. |
to confirm the involvement of caspase-3 during apoptosis, western blot analysis was performed using anti-caspase-3 antibody. |
1998-12-23 |
2023-08-12 |
human |
| S B Goodman, K Kugu, S H Chen, S Preutthipan, K I Tilly, J L Tilly, A M Dharmaraja. Estradiol-mediated suppression of apoptosis in the rabbit corpus luteum is associated with a shift in expression of bcl-2 family members favoring cellular survival. Biology of reproduction. vol 59. issue 4. 1998-12-07. PMID:9746731. |
northern blot analysis revealed an increase in bax mrna levels and a decrease in bcl-x mrna levels coincident with luteal cell apoptosis induced by estradiol withdrawal. |
1998-12-07 |
2023-08-12 |
rabbit |
| H C Toh, L Sun, C H Koh, S E A. Vinorelbine induces apoptosis and caspase-3 (CPP32) expression in leukemia and lymphoma cells: a comparison with vincristine. Leukemia & lymphoma. vol 31. issue 1-2. 1998-11-17. PMID:9720729. |
by western blot analysis, we demonstrated that cpp32 or caspase-3, a critical apoptosis inducer, and its active subunits p20 and p11 were upregulated in chemo- and apoptosis-sensitive lymphoma and leukemia cells treated with nvb. |
1998-11-17 |
2023-08-12 |
Not clear |
| Y Akao, H Mizoguchi, S Kojima, T Naoe, N Ohishi, K Yag. Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: activation of caspases and down-regulation of Bcl-2 protein. British journal of haematology. vol 102. issue 4. 1998-10-16. PMID:9734658. |
the arsenic-induced apoptosis in kocl44 and lyh7 cells was found to be linked to caspases by western blot and enzymological analyses. |
1998-10-16 |
2023-08-12 |
drosophila_melanogaster |