| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Ali, M Olivo, G Y Yuen, S K Che. Induction of apoptosis by Hypericin through activation of caspase-3 in human carcinoma cells. International journal of molecular medicine. vol 8. issue 5. 2002-01-15. PMID:11605021. |
under apoptotic conditions, western blot analysis of poly (adp-ribose) polymerase, a caspase substrate, showed the classical cleavage pattern (116-85 kda) associated with apoptosis in pdt-treated cell lysates. |
2002-01-15 |
2023-08-12 |
human |
| K Piwocka, E Jaruga, J Skierski, I Gradzka, E Sikor. Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells. Free radical biology & medicine. vol 31. issue 5. 2001-12-14. PMID:11522452. |
we have demonstrated that glutathione depletion does not itself induce apoptosis in jurkat cells; though, it can release cytochrome c from mitochondria and caspase-3 from inhibition by curcumin, as shown by western blot. |
2001-12-14 |
2023-08-12 |
Not clear |
| A Galvez, M P Morales, J M Eltit, P Ocaranza, L Carrasco, X Campos, M Sapag-Hagar, G Díaz-Araya, S Lavander. A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes. Cell and tissue research. vol 304. issue 2. 2001-12-07. PMID:11396721. |
apoptosis was assessed by the observation of: (1) cell viability, (2) dna fragmentation detected by the tunel method and by agarose gel electrophoresis, and (3) poly(adp-ribose)polymerase (parp) degradation, and bcl-xs and bcl-xl levels by western blot analysis. |
2001-12-07 |
2023-08-12 |
rat |
| H J Chae, S C Kim, K S Han, S W Chae, N H An, H M Kim, H H Kim, Z H Lee, H R Ki. Hypoxia induces apoptosis by caspase activation accompanying cytochrome C release from mitochondria in MC3T3E1 osteoblasts. p38 MAPK is related in hypoxia-induced apoptosis. Immunopharmacology and immunotoxicology. vol 23. issue 2. 2001-12-07. PMID:11417843. |
to confirm what caspases are involved in apoptosis, western blot analysis was performed using anti-caspase-3 or -6 antibody. |
2001-12-07 |
2023-08-12 |
Not clear |
| C H Wu, M Rastegar, J Gordon, A R Saf. beta(2)-microglobulin induces apoptosis in HL-60 human leukemia cell line and its multidrug resistant variants overexpressing MRP1 but lacking Bax or overexpressing P-glycoprotein. Oncogene. vol 20. issue 48. 2001-12-07. PMID:11704825. |
however, western blot analysis revealed that caspases-1, -3, -6, -8, and -9 are not activated during beta(2)m-induced apoptosis in these cells. |
2001-12-07 |
2023-08-12 |
human |
| X Zhang, F L Kiechl. Disruption of replication protein A/single-stranded DNA complexes during apoptosis in HL-60 cells. Biochemical and biophysical research communications. vol 287. issue 4. 2001-12-04. PMID:11573944. |
we used gel mobility shift, super gel mobility shift, and western blot to determine the fate of rpa during hoechst 33342-induced apoptosis in hl-60 cells. |
2001-12-04 |
2023-08-12 |
Not clear |
| E Chatzaki, A Makrigiannakis, A N Margioris, E Kouimtzoglou, A Gravani. The Fas/FasL apoptotic pathway is involved in kappa-opioid-induced apoptosis of human endometrial stromal cells. Molecular human reproduction. vol 7. issue 9. 2001-11-01. PMID:11517294. |
in parallel, semi-quantitative western blot and flow cytometry analysis showed that u69593 caused a rapid but transient up-regulation of fas protein, suggesting that its effect on apoptosis is mediated by activation of the fas/fasl apoptotic pathway. |
2001-11-01 |
2023-08-12 |
human |
| Y Zhao, Z Lu, M Wu, Q Han, W Tao, Z Zha. Effects of phosphocreatine on apoptosis in a cell-free system. The Journal of biological chemistry. vol 276. issue 37. 2001-10-11. PMID:11432861. |
western blot showed that the degradation of lamins a and c is accelerated, which is possibly responsible for the nuclear changes during cell apoptosis. |
2001-10-11 |
2023-08-12 |
mouse |
| R G Wickremasinghe, K Ganeshaguru, D T Jones, C Lindsay, V J Spanswick, J A Hartley, M Wadhwa, R Thorpe, A V Hoffbrand, H G Prentice, A B Meht. Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cells. British journal of haematology. vol 114. issue 3. 2001-10-11. PMID:11552986. |
apoptosis was quantified using morphological criteria and western blot analysis for the apoptosis-specific p85 fragment of poly(adp ribose) polymerase. |
2001-10-11 |
2023-08-12 |
Not clear |
| S M Ali, M Olivo, G Y Yuen, S K Che. Photodynamic-induced apoptosis of human nasopharyngeal carcinoma cells using Hypocrellins. International journal of oncology. vol 19. issue 3. 2001-10-04. PMID:11494047. |
western blot analysis of poly (adp-ribose) polymerase, a caspase substrate, showed the classical cleavage pattern (116 to 85 kda) associated with apoptosis in hypocrellin a and b-treated cell lysates. |
2001-10-04 |
2023-08-12 |
human |
| O Kucuk, F H Sarkar, W Sakr, Z Djuric, M N Pollak, F Khachik, Y W Li, M Banerjee, D Grignon, J S Bertram, J D Crissman, E J Pontes, D P Woo. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 10. issue 8. 2001-09-20. PMID:11489752. |
biomarkers of differentiation and apoptosis were assessed by western blot analysis on benign and malignant parts of the prostate gland. |
2001-09-20 |
2023-08-12 |
human |
| Y Xiong, H Lin, B D Chen, P L Peterson, C P Le. Appearance of shortened Bcl-2 and Bax proteins and lack of evidence for apoptosis in rat forebrain after severe experimental traumatic brain injury. Biochemical and biophysical research communications. vol 286. issue 2. 2001-09-20. PMID:11500052. |
to investigate whether apoptosis plays a role in traumatic brain injury (tbi), we examined the expression of bcl-2 and bax proteins and the release of mitochondrial cytochrome c in rat brains using western blot analysis. |
2001-09-20 |
2023-08-12 |
rat |
| A Lansiaux, M Facompré, N Wattez, M P Hildebrand, C Bal, D Demarquay, O Lavergne, D C Bigg, C Baill. Apoptosis induced by the homocamptothecin anticancer drug BN80915 in HL-60 cells. Molecular pharmacology. vol 60. issue 3. 2001-09-06. PMID:11502875. |
the use of cytometry, western blot analysis, confocal microscopy, and different colorimetric assays enabled us to demonstrate that bn80915 is a potent inducer of apoptosis in hl-60 cells. |
2001-09-06 |
2023-08-12 |
human |
| Y M Mu, T Yanase, Y Nishi, A Tanaka, M Saito, C H Jin, C Mukasa, T Okabe, M Nomura, K Goto, H Nawat. Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells. Endocrinology. vol 142. issue 8. 2001-08-16. PMID:11459807. |
a western blot analysis showed the apoptosis of the granulosa cells induced by palmitic acid to be accompanied by the down-regulation of an apoptosis inhibitor, bcl-2, and the up-regulation of an apoptosis effector, bax. |
2001-08-16 |
2023-08-12 |
human |
| J Usuda, T Okunaka, K Furukawa, T Tsuchida, Y Kuroiwa, Y Ohe, N Saijo, K Nishio, C Konaka, H Kat. Increased cytotoxic effects of photodynamic therapy in IL-6 gene transfected cells via enhanced apoptosis. International journal of cancer. vol 93. issue 4. 2001-08-09. PMID:11477550. |
because il-6 has been reported to induce apoptosis by downregulating expression of bcl-2, we analyzed the expression of apoptosis-related bcl-2, bax, and cytochrome c by western blot analysis. |
2001-08-09 |
2023-08-12 |
Not clear |
| L Groc, L Bezin, H Jiang, T S Jackson, R A Levin. Bax, Bcl-2, and cyclin expression and apoptosis in rat substantia nigra during development. Neuroscience letters. vol 306. issue 3. 2001-08-02. PMID:11406329. |
we also investigated by western blot analysis of nigral tissue isolated during the first postnatal week the expression of the anti- and pro-apoptotic proteins, bcl-2 and bax, respectively, since altered bcl-2 expression during developmental apoptosis has been described. |
2001-08-02 |
2023-08-12 |
rat |
| G Calvaruso, M Carabillò, M Giuliano, M Lauricella, A D'Anneo, R Vento, G Tesorier. Sodium phenylbutyrate induces apoptosis in human retinoblastoma Y79 cells: the effect of combined treatment with the topoisomerase I-inhibitor topotecan. International journal of oncology. vol 18. issue 6. 2001-07-26. PMID:11351256. |
western blot analysis demonstrated that exposure of y79 cells to phenylbutyrate decreased the level of the antiapoptotic factor bcl-2 and induced the activation of caspase-3, a key enzyme in the execution phase of apoptosis. |
2001-07-26 |
2023-08-12 |
human |
| S Urayama, A Kawakami, T Nakashima, S Yamasaki, A Hida, H Ida, M Kamachi, H Nakamura, T Origuchi, K Migita, Y Kawabe, K Eguch. New disease-modifying antirheumatic drug 2 acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (KE-298) selectively augments activation-induced T cell death. The Journal of laboratory and clinical medicine. vol 138. issue 1. 2001-07-26. PMID:11433223. |
fas expression and caspase-3 activity in activated t cells were also examined by flow cytometry, and expression of fas ligand (fasl), bcl-2-related proteins, and x chromosome-linked inhibitor of apoptosis protein (xiap) was determined by western blot analysis. |
2001-07-26 |
2023-08-12 |
Not clear |
| J Dai, R Shen, M Sumitomo, J S Goldberg, Y Geng, D Navarro, S Xu, J A Koutcher, M Garzotto, C T Powell, D M Nanu. Tumor-suppressive effects of neutral endopeptidase in androgen-independent prostate cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 7. issue 5. 2001-07-19. PMID:11350908. |
analysis of the mechanisms of nep-induced growth suppression revealed that nep expression in wt-5 cells induced a 4-fold increase in the number of pc cells undergoing apoptosis, and increased the expression of p21 tumor suppressor gene protein and the level of unphosphorylated retinoblastoma protein as determined by western blot. |
2001-07-19 |
2023-08-12 |
mouse |
| E Engidawork, T Gulesserian, R Seidl, N Cairns, G Lube. Expression of apoptosis related proteins in brains of patients with Alzheimer's disease. Neuroscience letters. vol 303. issue 2. 2001-06-28. PMID:11311497. |
to further substantiate this hypothesis we investigated the expression of a recently identified apoptosis related proteins and other apoptosis regulators in frontal cortex and cerebellum of ad by western blot and enzyme-linked immunsorbent assay technique. |
2001-06-28 |
2023-08-12 |
caenorhabditis_elegans |