| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Zhong, Huiying Xu, Ge Chen, Gang Zhao, Yan Gao, Xiaodong Liu, Shumei Ma, Lihua Don. The role of hypoxia-inducible factor-1α in radiation-induced autophagic cell death in breast cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 9. 2016-02-25. PMID:25874499. |
cell counting kit-8 (cck-8) assay and colony formation assay were used to detect cell viability, western blot was used to detect protein expression, monodansylcadaverine (mdc) staining was used to analyze autophagy, and hoechts/pi staining was used to assess apoptosis. |
2016-02-25 |
2023-08-13 |
human |
| Nomundelger Gankhuyag, Bijay Singh, Sushila Maharjan, Yun-Jaie Choi, Chong-Su Cho, Myung-Haing Ch. Galactosylated poly(ethyleneglycol)-lithocholic Acid selectively kills hepatoma cells, while sparing normal liver cells. Macromolecular bioscience. vol 15. issue 6. 2016-02-22. PMID:25657071. |
western blot results confirm that the cell death is occurred through apoptosis induced by lpl nanoparticles. |
2016-02-22 |
2023-08-13 |
mouse |
| Darsan B Menon, V K Gopalakrishna. Terpenoids Isolated From the Shoot of Plectranthus hadiensis Induces Apoptosis in Human Colon Cancer Cells Via the Mitochondria-Dependent Pathway. Nutrition and cancer. vol 67. issue 4. 2016-02-22. PMID:25837437. |
the mechanism of apoptosis induction was studied by expression analysis of antiapoptotic bcl-2 and proapoptotic bax using rt-pcr and also by western blot analysis of proteins involved in the apoptotic pathway. |
2016-02-22 |
2023-08-13 |
human |
| Jianzhang Wu, Zhijian Cai, Xiaoyan Wei, Minxiao Chen, Shilong Ying, Lingyi Shi, Ren-Ai Xu, Fan He, Guang Liang, Xiuhua Zhan. Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro. BioMed research international. vol 2015. 2016-02-21. PMID:25977922. |
cell cycle and apoptosis were determined by flow cytometry, and the preliminary mechanism was studied by western blot. |
2016-02-21 |
2023-08-13 |
Not clear |
| Yan Chen, Fan Feng, Xudong Gao, Chunping Wang, Huiwei Sun, Cuihong Zhang, Zhen Zeng, Yinying Lu, Linjing An, Jianhui Qu, Fusheng Wang, Yongping Yan. MiRNA153 Reduces Effects of Chemotherapeutic Agents or Small Molecular Kinase Inhibitor in HCC Cells. Current cancer drug targets. vol 15. issue 3. 2016-02-17. PMID:25714700. |
western blot and luciferase assays were performed to assess whether mir-153 modulates the expression of important genes related to cell proliferation, apoptosis or survival. |
2016-02-17 |
2023-08-13 |
Not clear |
| Javier A García-Vilas, Ana R Quesada, Miguel A Medin. Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells. Scientific reports. vol 5. 2016-02-16. PMID:25620570. |
their mechanisms were studied by western blot, and cell cycle, apoptosis and zymographic assays. |
2016-02-16 |
2023-08-13 |
human |
| Jiao Cao, Qing Miao, Shan Miao, Linlin Bi, Song Zhang, Qian Yang, Xuanxuan Zhou, Meng Zhang, Yanhua Xie, Jin Zhang, Siwang Wan. Tetramethylpyrazine (TMP) exerts antitumor effects by inducing apoptosis and autophagy in hepatocellular carcinoma. International immunopharmacology. vol 26. issue 1. 2016-02-16. PMID:25841319. |
next, flow cytometric analysis and transmission electron microscope images showed that tmp enhanced cell apoptosis in hepg2 cells, and western blot results showed that tmp promoted cleavage of caspase-3 and parp in vitro and in vivo. |
2016-02-16 |
2023-08-13 |
Not clear |
| Jinxu Qi, Shichu Liang, Yi Gou, Zhenlei Zhang, Zuping Zhou, Feng Yang, Hong Lian. Synthesis of four binuclear copper(II) complexes: Structure, anticancer properties and anticancer mechanism. European journal of medicinal chemistry. vol 96. 2016-02-16. PMID:25899339. |
the formation of reactive oxygen species (ros), change in mitochondrial membrane potential and western blot analysis revealed that cu compounds could induce cancer cell apoptosis through the intrinsic ros-mediated mitochondrial pathway accompanied by the regulation of bcl-2 family proteins. |
2016-02-16 |
2023-08-13 |
Not clear |
| Yinan Hua, Timothy J Robinson, Yongtao Cao, Guo-Ping Shi, Jun Ren, Sreejayan Nai. Cathepsin K knockout alleviates aging-induced cardiac dysfunction. Aging cell. vol 14. issue 3. 2016-02-10. PMID:25692548. |
cardiac geometry, contractile function, intracellular ca(2+) properties, and cardiomyocyte apoptosis were evaluated using echocardiography, fura-2 technique, immunohistochemistry, western blot and tunel staining, respectively. |
2016-02-10 |
2023-08-13 |
mouse |
| Wanyuan Bao, Feng Zhu, Yunfei Duan, Yue Yang, Huihua Ca. HtrA1 resensitizes multidrug-resistant hepatocellular carcinoma cells by targeting XIAP. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 70. 2016-02-10. PMID:25776486. |
after an htra1 inhibitor, nvp-leb748 was adopted in the htra1 overexpressing cells, expression of proteins p-gp, mrp and xiap (x-linked inhibitor of apoptosis protein) in hepg2/adm cells were analyzed by western blot, and the activities of caspases 3, 7 and 9 were respectively measured using activity assay kits. |
2016-02-10 |
2023-08-13 |
Not clear |
| Song-Yuan Fan, Jian-Dong Jiang, Jun Qian, Yi-Cheng Lu, Guo-Han Hu, Chun Luo, Wei-Dong Hou, Qi Wan. Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence. PloS one. vol 10. issue 5. 2016-02-09. PMID:25993541. |
western blot analysis revealed that cells underexpressing rlip76 exhibited decreased b-cell lymphoma-2(bcl-2) expression but increased apoptosis effector caspase-3 expression. |
2016-02-09 |
2023-08-13 |
human |
| Constanze Buhrmann, Parviz Shayan, Patricia Kraehe, Bastian Popper, Ajay Goel, Mehdi Shakibae. Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. Biochemical pharmacology. vol 98. issue 1. 2016-02-09. PMID:26310874. |
the effect of resveratrol in parental crc cell lines (hct116, sw480) and their corresponding isogenic 5-fu-chemoresistant derived clones (hct116r, sw480r) was examined by mtt assays, intercellular junction formation and apoptosis by electron- and immunoelectron microscopy, nuclear factor-kappab (nf-κb) and nf-κb regulated gene products by western blot analysis in a 3d-alginate microenvironment. |
2016-02-09 |
2023-08-13 |
Not clear |
| Satoshi Harada, Takatoshi Nakagawa, Shunichi Yokoe, Shoko Edogawa, Toshihisa Takeuchi, Takuya Inoue, Kazuhide Higuchi, Michio Asah. Autophagy Deficiency Diminishes Indomethacin-Induced Intestinal Epithelial Cell Damage through Activation of the ERK/Nrf2/HO-1 Pathway. The Journal of pharmacology and experimental therapeutics. vol 355. issue 3. 2016-02-09. PMID:26404472. |
western blot analyses indicated that im-induced apoptosis decreased, and the potent, oxidative stress-related extracellular signal-regulated kinase (erk)/nuclear factor-erythroid2-like2 (nrf2)/heme oxygenase-1 (ho-1) signaling pathway was upregulated in iec6shatg5 cells. |
2016-02-09 |
2023-08-13 |
mouse |
| Xiaoli Zhang, Haiyu Zhang, Qing Gao, Shufang Ji, Lujun Bing, Jing Ha. Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway. Reproductive biomedicine online. vol 30. issue 5. 2016-02-08. PMID:25773528. |
tdt (terminal deoxynucleotidyl transferase)-mediated dudp nick-end labelling assay was carried out to detect the oocyte apoptosis; immunocytochemical staining and quantitative real time-polymerase chain reaction detected the expression of c-kit and forkhead box o3a (foxo3a); western blot was performed to detect the expression of sohlh2, c-kit, saerine/threonine kinases (akt1) and foxo3a. |
2016-02-08 |
2023-08-13 |
mouse |
| Khadidiatou Guiro, Shyam A Patel, Steven J Greco, Pranela Rameshwar, Treena L Arinze. Investigating breast cancer cell behavior using tissue engineering scaffolds. PloS one. vol 10. issue 3. 2016-02-08. PMID:25837691. |
western blot analysis of carboplatin resistant (treated) mda-mb-231 (highly invasive, basal-like) and t47d (low-invasive, luminal) bccs showed an increase in bcl-2, oct-4 and sox-2, suggesting protection from apoptosis and increase in stem-like markers. |
2016-02-08 |
2023-08-13 |
Not clear |
| Haiwen Zhang, Xi Xia, Feifei Han, Qin Jiang, Yili Rong, Deguang Song, Yizhen Wan. Cathelicidin-BF, a Novel Antimicrobial Peptide from Bungarus fasciatus, Attenuates Disease in a Dextran Sulfate Sodium Model of Colitis. Molecular pharmaceutics. vol 12. issue 5. 2016-02-04. PMID:25807257. |
the morphology of the colon epithelium was observed by h&e staining; apoptosis index and infiltration of inflammatory cells in colonic epithelium were measured by tunel and immunohistochemistry; the expression level of endogenous mcramp was analyzed by immunofluorescence; and phosphorylation of the transcription factors c-jun and nf-κb in colon were analyzed by western blot. |
2016-02-04 |
2023-08-13 |
Not clear |
| Jinmin Hao, Zhiming Wang, Yaowu Wang, Zhaohui Liang, Xin Zhang, Zongmao Zhao, Baohua Jia. Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma. Oncology reports. vol 33. issue 6. 2016-02-04. PMID:25823503. |
western blot analysis, brdu assay and flow cytometry were used to measure eif3c protein levels, cell proliferation, cell apoptosis and cell cycle, respectively. |
2016-02-04 |
2023-08-13 |
human |
| Yunhui Hu, Kun Xu, Ernesto Yagü. miR-218 targets survivin and regulates resistance to chemotherapeutics in breast cancer. Breast cancer research and treatment. vol 151. issue 2. 2016-02-04. PMID:25900794. |
apoptosis was determined by flow cytometry after annexin v staining, by caspase 3/7 and caspase 9 activity assays and the levels of apoptosis-related proteins bcl-2 and bax by real-time pcr and western blot. |
2016-02-04 |
2023-08-13 |
mouse |
| Xiaofen Pan, Jingjing Mou, Sha Liu, Ziyi Sun, Rui Meng, Zhenwei Zhou, Gang Wu, Gang Pen. SHP-1 overexpression increases the radioresistance of NPC cells by enhancing DSB repair, increasing S phase arrest and decreasing cell apoptosis. Oncology reports. vol 33. issue 6. 2016-02-04. PMID:25962492. |
cell survival, dna double-strand breaks (dsbs), apoptosis, cell cycle distribution, and the expression of related proteins were assessed using colony formation assay, immunofluorescent assays (ifas), flow cytometry (fcm) and western blot analyses, respectively. |
2016-02-04 |
2023-08-13 |
human |
| Qian Wu, Ning Wang, Yan Wang, Guang-Yun Wang, Xin-Xin Pia. [Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 50. issue 2. 2016-02-02. PMID:25975022. |
the results of western blot manifested that pretreatment lig could decrease the release of cyt c from mitochondria, down-regulate caspase-3 protein expression and up-regulate bcl-2/bax ratio, thereby protects pc12 cells from apoptosis. |
2016-02-02 |
2023-08-13 |
Not clear |