| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiling Du, Haipeng Wang, Fuhui Xu, Yongyi Huang, Zhixue Liu, Te Li. Enterovirus 71 induces apoptosis of SH‑SY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression. Molecular medicine reports. vol 12. issue 1. 2015-12-31. PMID:25779425. |
furthermore, quantitative polymerase chain reaction and western blot analyses demonstrated that expression level of the apoptosis inhibitor bcl-2 was markedly reduced, but the expression levels of the apoptosis-promoting factors bax, caspase-7, caspase‑3 and active caspase-3 were markedly higher in the sh-sy5y cells 12-48 h after ev71 infection, compared with the non-infected cells. |
2015-12-31 |
2023-08-13 |
human |
| Guo-Wei Wang, Chao Lv, Zhi-Ran Shi, Ren-Tao Zeng, Xue-Yun Dong, Wei-Dong Zhang, Run-Hui Liu, Lei Shan, Yun-Heng She. Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial pathway and the generation of reactive oxygen species. PloS one. vol 9. issue 12. 2015-12-21. PMID:25502685. |
flow cytometry and western blot analysis showed that the apoptosis was associated with cell cycle arrest during the g1 phase, up-regulation of p53 and p21, and down-regulation of cdk2 and cyclin d1. |
2015-12-21 |
2023-08-13 |
human |
| Bhavna Kumar, Arti Yadav, Kalman Hideg, Periannan Kuppusamy, Theodoros N Teknos, Pawan Kuma. A novel curcumin analog (H-4073) enhances the therapeutic efficacy of cisplatin treatment in head and neck cancer. PloS one. vol 9. issue 3. 2015-12-17. PMID:24675768. |
in addition, pretreatment of cisplatin-resistant hnscc cell lines with h-4073 significantly reversed the chemo-resistance as observed by cell viability assay (mtt), apoptosis assay (annexin v binding) and cleaved caspase-3 (western blot). |
2015-12-17 |
2023-08-12 |
mouse |
| Yu-qing Ge, Ru-bin Cheng, Bo Yang, Zhen Huang, Zhe Che. [Effect of cryptotanshinone on imatinib sensitivity and P-glycoprotein expression of chronic myeloid leukemia cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 12. 2015-12-17. PMID:26591531. |
the active changes in apoptosis regulatory proteins caspase-3, caspase-9 and parp were determined by western blot. |
2015-12-17 |
2023-08-13 |
Not clear |
| Raktim Biswas, Phil-Sang Chung, Jeong Hwan Moon, Seung-Ha Lee, Jin-Chul Ah. Carboplatin synergistically triggers the efficacy of photodynamic therapy via caspase 3-, 8-, and 12-dependent pathways in human anaplastic thyroid cancer cells. Lasers in medical science. vol 29. issue 3. 2015-12-15. PMID:24114422. |
several parameters like cytotoxicity assay by mtt, apoptosis study by annexin v and propidium iodide, cell cycle analysis by flow cytometry, confocal microscopic study, and western blot analysis for different apoptosis-related proteins like bax, cytochrome c, caspases 3, 9, 8, and 12, etc. |
2015-12-15 |
2023-08-12 |
human |
| Zhenbiao Wu, Emily Y He, Glenda I Scott, Jun Re. α,β-Unsaturated aldehyde pollutant acrolein suppresses cardiomyocyte contractile function: Role of TRPV1 and oxidative stress. Environmental toxicology. vol 30. issue 6. 2015-12-15. PMID:24376112. |
changes in apoptosis and trpv1 were evaluated using western blot analysis. |
2015-12-15 |
2023-08-12 |
Not clear |
| Shahla Karim Baloch, Lin Ma, Guo-Hua Xu, Li-Fei Bai, Hua Zhao, Cheng-Yi Tang, Yan-Jun Pang, Rong-Wu Yang, Xiao-Ming Wang, Gui-Hua Lu, Yong-Hua Yan. A potent anticancer agent of shikonin derivative targeting tubulin. Chirality. vol 27. issue 3. 2015-12-15. PMID:25663187. |
compound was simulated to have good binding site with tubulin and arrested the cell cycle at g2/m phase, which also induces apoptosis in hepg2 cells, in which p53 and members of bcl-2 protein family were both involved in the progress of apoptosis revealed by western blot. |
2015-12-15 |
2023-08-13 |
human |
| Sida Qin, Chongwen Xu, Shuo Li, Chengcheng Yang, Xin Sun, Xifang Wang, Shou-Ching Tang, Hong Re. Indomethacin induces apoptosis in the EC109 esophageal cancer cell line by releasing second mitochondria-derived activator of caspase and activating caspase-3. Molecular medicine reports. vol 11. issue 6. 2015-12-15. PMID:25673090. |
subsequently, flow cytometry was performed to investigate indomethacin‑induced apoptosis following the overexpression or knockdown of smac, and western blot analysis was performed to determine the expression of smac and the activation of caspase‑3. |
2015-12-15 |
2023-08-13 |
Not clear |
| Sida Qin, Chongwen Xu, Shuo Li, Chengcheng Yang, Xin Sun, Xifang Wang, Shou-Ching Tang, Hong Re. Indomethacin induces apoptosis in the EC109 esophageal cancer cell line by releasing second mitochondria-derived activator of caspase and activating caspase-3. Molecular medicine reports. vol 11. issue 6. 2015-12-15. PMID:25673090. |
western blot analysis demonstrated that indomethacin induced apoptosis through releasing smac into the cytosol and activating caspase‑3. |
2015-12-15 |
2023-08-13 |
Not clear |
| Sara Zanini, Francesco Giovinazzo, Daniele Alaimo, Ben Lawrence, Roswitha Pfragner, Claudio Bassi, Irvin Modlin, Mark Kid. GNA15 expression in small intestinal neuroendocrine neoplasia: functional and signalling pathway analyses. Cellular signalling. vol 27. issue 5. 2015-12-15. PMID:25701539. |
functional assays were undertaken to define the role of gna15 in the small intestinal nen cell line krj-i and in clinical samples from small intestinal nens using quantitative polymerase chain reaction, western blot, proliferation and apoptosis assays, immunoprecipitation, immunohistochemistry (ihc) and automated quantitative analysis (aqua). |
2015-12-15 |
2023-08-13 |
Not clear |
| Jiangyan Wang, Yu'an Xie, Yan Feng, Litu Zhang, Xinping Huang, Xiaoyun Shen, Xiaoling Lu. (-)-Epigallocatechingallate induces apoptosis in B lymphoma cells via caspase-dependent pathway and Bcl-2 family protein modulation. International journal of oncology. vol 46. issue 4. 2015-12-07. PMID:25647297. |
cell proliferation and cytotoxicity were determined by the cell counting kit (cck-8) assay; apoptosis was assessed by flow cytometry using the annexin v-pe/7aad double staining; fas, bcl-2 and bax mrna expression levels were determined by real-time pcr; caspase activity was measured by the caspase activity assay kit; the expression levels of apoptosis-associated proteins were determined by western blot analysis. |
2015-12-07 |
2023-08-13 |
Not clear |
| Yan Liu, Tingting Bi, Gang Wang, Wei Dai, Guoliang Wu, Liqiang Qian, Quangen Gao, Genhai She. Lupeol inhibits proliferation and induces apoptosis of human pancreatic cancer PCNA-1 cells through AKT/ERK pathways. Naunyn-Schmiedeberg's archives of pharmacology. vol 388. issue 3. 2015-12-04. PMID:25418891. |
the expression of apoptosis-related proteins in cells was evaluated by western blot analysis, and we found that lupeol induced cell apoptosis by decreasing the levels of p-akt and p-erk. |
2015-12-04 |
2023-08-13 |
human |
| Chunxiao Wu, Jiao Wang, Chun Li, Guoping Zhou, Xiuhong Xu, Xin Zhang, Xiao La. Effect of Electroacupuncture on Cell Apoptosis and ERK Signal Pathway in the Hippocampus of Adult Rats with Cerebral Ischemia-Reperfusion. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-12-04. PMID:26633985. |
apoptosis index of neural cells in local infarcted area was measured by tunel and p-erk expression was detected using immunohistochemistry technique and western blot analysis. |
2015-12-04 |
2023-08-13 |
rat |
| Ying-Nuo Hou, Wen-Yuan Ding, Yong Shen, Da-Long Yang, Lin-Feng Wang, Peng Zhan. Effect of hyperbaric oxygen on MMP9/2 expression and motor function in rats with spinal cord injury. International journal of clinical and experimental medicine. vol 8. issue 9. 2015-12-02. PMID:26628974. |
at 3 days after modeling, apoptosis of neuronal cells in spinal cord injury region in experimental group was detected by tunel method; gene and protein expression of mmp9/2 in spinal cord injury and surrounding tissues was detected by rt-pcr and western blot assay. |
2015-12-02 |
2023-08-13 |
rat |
| Zhaojun Wan, Huazheng Pan, Shihai Liu, Jingjuan Zhu, Weiwei Qi, Kai Fu, Teng Zhao, Jun Lian. Downregulation of SNAIL sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis by regulating the NF-κB pathway. Oncology reports. vol 33. issue 3. 2015-12-01. PMID:25607597. |
to determine how to sensitize hcc cells to trail-induced apoptosis after silencing snail, p53 was assessed by western blot analysis. |
2015-12-01 |
2023-08-13 |
Not clear |
| Zhaojun Wan, Huazheng Pan, Shihai Liu, Jingjuan Zhu, Weiwei Qi, Kai Fu, Teng Zhao, Jun Lian. Downregulation of SNAIL sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis by regulating the NF-κB pathway. Oncology reports. vol 33. issue 3. 2015-12-01. PMID:25607597. |
we also investigated the expression of bcl-xl, ciap2, survivin and raf-1 protein using western blot analysis and the apoptotic degree of huh-7 cells was detected using the hoechst test following the suppression of each gene, which was a possible molecular mechanism to sensitive trail-induced apoptosis through the downregulation of snail in hcc cells. |
2015-12-01 |
2023-08-13 |
Not clear |
| Qun Lu, Wenjie Mei, Shaohong Luo, Weibin H. Apoptosis of Bel-7402 human hepatoma cells induced by a ruthenium(II) complex coordinated by cordycepin through the p53 pathway. Molecular medicine reports. vol 11. issue 6. 2015-12-01. PMID:25651236. |
subsequent experiments using fcm and western blot analysis indicated that cor‑ru(ii) induced cell apoptosis via suppression of bcl‑2 expression and stimulation of p53 expression. |
2015-12-01 |
2023-08-13 |
human |
| F Yang, M Hu, Q Lei, Y Xia, Y Zhu, X Song, Y Li, H Jie, C Liu, Y Xiong, Z Zuo, A Zeng, Y Li, L Yu, G Shen, D Wang, Y Xie, T Ye, Y We. Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model. Cell death & disease. vol 6. 2015-11-30. PMID:25811798. |
in addition, western blot analysis demonstrated that the occurrence of its apoptosis was associated with activation of cleaved caspases-3 and bax, downregulation of bcl-2. |
2015-11-30 |
2023-08-13 |
Not clear |
| Hongliang Zhang, Qin Luo, Zhihong Liu, Yong Wang, Zhihui Zha. Abnormal expression of vesicular transport proteins in pulmonary arterial hypertension in monocrotaline-treated rats. Acta biochimica et biophysica Sinica. vol 47. issue 3. 2015-11-27. PMID:25630652. |
in addition, caspase-3, also examined by western blot analysis, was used as an indicator of apoptosis. |
2015-11-27 |
2023-08-13 |
rat |
| b' Patricia Bogdanov, Cristina Hern\\xc3\\xa1ndez, Lidia Corraliza, Andrea R Carvalho, Rafael Sim\\xc3\\xb. Effect of fenofibrate on retinal neurodegeneration in an experimental model of type 2 diabetes. Acta diabetologica. vol 52. issue 1. 2015-11-25. PMID:25029994.' |
retinal neurodegeneration was evaluated by measuring glial activation (immunofluorescence and western blot) and apoptosis. |
2015-11-25 |
2023-08-13 |
mouse |