| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guanghong Liu, Peijie Du, Zhanxin Zhan. Myeloid differentiation factor 88 promotes cisplatin chemoresistance in ovarian cancer. Cell biochemistry and biophysics. vol 71. issue 2. 2015-10-07. PMID:25308861. |
the expression of p-akt protein, x-linked inhibitor of apoptosis protein (xiap), and multidrug resistance protein 1 (mrp1) was detected by western blot analysis. |
2015-10-07 |
2023-08-13 |
human |
| Heon-Sub Shin, Sang-Yong Park, Hyun-Geun Song, Eunson Hwang, Don-Gil Lee, Tae-Hoo Y. The Androgenic Alopecia Protective Effects of Forsythiaside-A and the Molecular Regulation in a Mouse Model. Phytotherapy research : PTR. vol 29. issue 6. 2015-10-06. PMID:25808759. |
western blot examination of tgf-β2 expression related to apoptosis signaling in mouse skin verified that forsythiaside-a reduced the expression of tgf-β2 by 75% and suppressed apoptosis by reducing the expression of caspase-9 by 40%, and caspase-3 by 53%, which play an roles up-regulator in the apoptosis signal. |
2015-10-06 |
2023-08-13 |
mouse |
| Li Wang, Lei Zhou, Han Zhang, Yan Li, Xinna Ge, Xin Guo, Kangzhen Yu, Hanchun Yan. Interactome profile of the host cellular proteins and the nonstructural protein 2 of porcine reproductive and respiratory syndrome virus. PloS one. vol 9. issue 6. 2015-10-05. PMID:24901321. |
two interested cellular proteins-bcl2-associated athanogene 6 (bag6) and apoptosis-inducing factor 1 (aif1) which may involve in transporting of nsp2 to endoplasmic reticulum (er) or prrsv-driven apoptosis were validated by western blot. |
2015-10-05 |
2023-08-13 |
Not clear |
| Benjamin Teong, Chia-Yun Lin, Shwu-Jen Chang, Gregory Cheng-Chie Niu, Chun-Hsu Yao, I-Fen Chen, Shyh-Ming Ku. Enhanced anti-cancer activity by curcumin-loaded hydrogel nanoparticle derived aggregates on A549 lung adenocarcinoma cells. Journal of materials science. Materials in medicine. vol 26. issue 1. 2015-09-29. PMID:25595721. |
treatment effect on a549 cells were assessed with cell viability assay, apoptosis assay, cell cycle analysis, reactive oxygen species detection, and western blot. |
2015-09-29 |
2023-08-13 |
Not clear |
| Yanan Wang, Yilan Zhen, Xian Wu, Qin Jiang, Xiaoliang Li, Zhiwu Chen, Gongliang Zhang, Liuyi Don. Vitexin protects brain against ischemia/reperfusion injury via modulating mitogen-activated protein kinase and apoptosis signaling in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 22. issue 3. 2015-09-29. PMID:25837275. |
extracellular signal-regulated kinases 1/2 (erk1/2), c-jun n-terminal kinases (jnk) and p38 phosphorylation, and apoptosis were measured via western blot at 24 h after reperfusion. |
2015-09-29 |
2023-08-13 |
mouse |
| Lei Wang, Wanhai Qin, Zhai Ruidong, Shiting Liu, Hu Zhang, Changjiang Sun, Xin Feng, Jingmin Gu, Chongtao Du, Wenyu Han, P R Langford, Liancheng Le. Differential gene expression profiling of Actinobacillus pleuropneumoniae during induction of primary alveolar macrophage apoptosis in piglets. Microbial pathogenesis. vol 78. 2015-09-24. PMID:25435362. |
the highest percentage of apoptosis in cells was confirmed using flow cytometry when the cells were infected at a multiplicity of infection (moi) of 10 and incubated for 5 h, with higher expression of activated caspase-3 as measured by western blot. |
2015-09-24 |
2023-08-13 |
Not clear |
| Sabrina Giacoppo, Maria Galuppo, Giovanni Enrico Lombardo, Maria Malgorzata Ulaszewska, Fulvio Mattivi, Placido Bramanti, Emanuela Mazzon, Michele Navarr. Neuroprotective effects of a polyphenolic white grape juice extract in a mouse model of experimental autoimmune encephalomyelitis. Fitoterapia. vol 103. 2015-09-18. PMID:25863350. |
in particular, by western blot, histological evaluations and immunolocalization of the main markers of inflammation, oxidative stress and apoptosis (tnf-α, inos, nitrotyrosine, parp, foxp3, bcl-2, caspase 3 and dna fragmentation), we documented that wgje counteracts the alteration of all these inflammatory and oxidative pathway, without any apparent sign of toxicity. |
2015-09-18 |
2023-08-13 |
mouse |
| Shou-Sheng Liu, Xiao-Pai Wang, Xiu-Bo Li, Jia-Yi Liang, Ling-Ling Liu, Ying Lu, Xue-Yun Zhong, Yun-Xian Che. Zoledronic acid exerts antitumor effects in NB4 acute promyelocytic leukemia cells by inducing apoptosis and S phase arrest. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 68. issue 8. 2015-09-16. PMID:25312823. |
the western blot analysis confirmed the induction of apoptosis and s phase arrest, revealing that the pro-apoptosis proteins bax, puma and activated caspase-9 were upregulated and the anti-apoptosis proteins bcl-2 and bcl-xl were downregulated. |
2015-09-16 |
2023-08-13 |
human |
| Xu-Feng Guo, Zi-Rong Yang, Jun Wang, Xiao-Fei Lei, Xiao-Guang Lv, Wei-Guo Don. Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25434307. |
apoptotic morphological features and proteins expression levels were detected by hoechst 33258 staining, an annexin v/propidium iodide apoptosis kit and western blot analysis, respectively. |
2015-09-16 |
2023-08-13 |
mouse |
| Jong Seok Lee, Young Rae Kim, Jun Myoung Park, Young Eon Kim, Nam In Baek, Eock Kee Hon. Cyanidin-3-glucoside isolated from mulberry fruits protects pancreatic β-cells against glucotoxicity-induced apoptosis. Molecular medicine reports. vol 11. issue 4. 2015-09-16. PMID:25501967. |
in addition, the effects of c3g on the glucotoxicity‑induced apoptosis of pancreatic β‑cells was evaluated using mtt assay, immunofluorescent staining, flow cytometric and western blot analyses. |
2015-09-16 |
2023-08-13 |
Not clear |
| Da-wei Zhang, Hai-yan Li, Wan-yee Lau, Liang-qi Cao, Yue Li, Xiao-feng Jiang, Xue-wei Yang, Ping Xu. Gli2 silencing enhances TRAIL-induced apoptosis and reduces tumor growth in human hepatoma cells in vivo. Cancer biology & therapy. vol 15. issue 12. 2015-09-16. PMID:25535898. |
apoptosis and the level of caspases proteins in smmc-7721 and hepg2 cells were detected by flow cytometry and western blot. |
2015-09-16 |
2023-08-13 |
mouse |
| Rujun Li, Junyang Li, Dongping Sang, Qing La. Phosphorylation of AKT induced by phosphorylated Hsp27 confers the apoptosis-resistance in t-AUCB-treated glioblastoma cells in vitro. Journal of neuro-oncology. vol 121. issue 1. 2015-09-14. PMID:25200832. |
cell growth was detected using cck-8 assay; caspase-3 activity assay kits and flow cytometry were used in apoptosis analysis; western blot analysis was used to detect p-hsp27 and p-akt levels; rna interference using the sirna oligos of hsp27 was performed to knockdown gene expression of hsp27. |
2015-09-14 |
2023-08-13 |
Not clear |
| Vasili Stegajev, Vesa-Petteri Kouri, Abdelhakim Salem, Stanislav Rozov, Holger Stark, Dan C E Nordström, Yrjö T Konttine. Activation of histamine H4 receptor inhibits TNFα/IMD-0354-induced apoptosis in human salivary NS-SV-AC cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25239604. |
apoptosis induced using tumor necrosis factor-α with nuclear factor-κb inhibitor imd-0354 was studied using phase contrast microscopy, western blot, flow cytometry and polymerase chain reaction (qrt-pcr). |
2015-09-14 |
2023-08-13 |
human |
| Jisun Paeng, Jae Hyun Chang, Sun Ha Lee, Bo Young Nam, Hye-Young Kang, Seonghun Kim, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kan. Enhanced glycogen synthase kinase-3β activity mediates podocyte apoptosis under diabetic conditions. Apoptosis : an international journal on programmed cell death. vol 19. issue 12. 2015-09-14. PMID:25284613. |
western blot analysis and tunel or hoechst 33342 staining were performed to identify apoptosis. |
2015-09-14 |
2023-08-13 |
mouse |
| Yunyun Wang, Yong Liu, Guo Li, Zhongwu Su, Shuling Ren, Pingqing Tan, Xin Zhang, Yuanzheng Qiu, Yongquan Tia. Ephrin type‑A receptor 2 regulates sensitivity to paclitaxel in nasopharyngeal carcinoma via the phosphoinositide 3‑kinase/Akt signalling pathway. Molecular medicine reports. vol 11. issue 2. 2015-09-14. PMID:25351620. |
flow cytometry and western blot analysis demonstrated that over‑expression of epha2 decreased npc cancer cell sensitivity to paclitaxel by regulating paclitaxel‑mediated cell cycle progression but not apoptosis in vitro. |
2015-09-14 |
2023-08-13 |
Not clear |
| J Yang, H Sun, R Guan, W Liu, Y Xia, J Zhao, J Li. Hepatocellular protein profiles after hepatic ischemia/reperfusion injury with or without octreotide preconditioning in a rabbit model. Transplantation proceedings. vol 46. issue 10. 2015-09-14. PMID:25498038. |
these findings suggest that octreotide might exert an effect against hiri through up-regulating the expression of the anti-injury substances, such as heat-shock proteins 70 and 27 (confirmed by using western blot analysis); significantly raising the phosphatidylethanolamine-binding protein that alleviates ir-related apoptosis; and down-regulating mitochondrial metabolic enzymes such as nadh2 dehydrogenase and triosephosphate isomerase. |
2015-09-14 |
2023-08-13 |
rabbit |
| Qian Xu, Chunjuan Jiang, Yutao Rong, Chun Yang, Ying Liu, Kai X. The effects of fludarabine on rat cerebral ischemia. Journal of molecular neuroscience : MN. vol 55. issue 2. 2015-09-11. PMID:24825839. |
then rat brains were sectioned for triphenyltetrazolium chloride (ttc) stains, analyzed by western blot and tunel staining of apoptosis. |
2015-09-11 |
2023-08-13 |
rat |
| Ying Li, Jiani Yuan, Qian Yang, Wei Cao, Xuanxuan Zhou, Yanhua Xie, Honghai Tu, Ya Zhang, Siwang Wan. Immunoliposome co-delivery of bufalin and anti-CD40 antibody adjuvant induces synergetic therapeutic efficacy against melanoma. International journal of nanomedicine. vol 9. 2015-09-09. PMID:25506218. |
in a mouse b16 melanoma model, intravenous injection of anti-cd40-bfl achieved smaller tumor volume than did treatment with bfl (average: 117 mm(3) versus 270 mm(3), respectively); the enhanced therapeutic efficacy through a caspase-dependent pathway induced apoptosis, which was confirmed using terminal deoxynucleotidyl transferase-mediated dutp-fluorescein nick end labeling and western blot assay. |
2015-09-09 |
2023-08-13 |
mouse |
| Yongbiao Zheng, Haiyue Pang, Jifeng Wang, Guowei Shi, Jianzhong Huan. New apoptosis-inducing sesquiterpenoids from the mycelial culture of Chinese edible fungus Pleurotus cystidiosus. Journal of agricultural and food chemistry. vol 63. issue 2. 2015-09-09. PMID:25537793. |
furthermore, pleuroton b (2) could trigger the apoptosis of du-145 cells through the detection of apoptosis cells using annexin v-fitc staining by flow cytometry, the observation of condensed nuclei in the apoptosis cells, and the western blot analysis for the expression of apoptosis-related proteins bcl-2, bak, and bax. |
2015-09-09 |
2023-08-13 |
human |
| Ying Jiang, Longling Li, Xiaodan Tan, Bin Liu, Yanhong Zhang, Changqing L. miR-210 mediates vagus nerve stimulation-induced antioxidant stress and anti-apoptosis reactions following cerebral ischemia/reperfusion injury in rats. Journal of neurochemistry. vol 134. issue 1. 2015-09-09. PMID:25783636. |
rats treated with vns showed increased mir-210 expression as well as decreased apoptosis and antioxidant stress responses compared with the i/r group; these rats also showed increased p-akt protein expression and significantly decreased levels of cleaved caspase 3 in the ischemic penumbra, as measured by western blot and immunofluorescence analyses, respectively. |
2015-09-09 |
2023-08-13 |
rat |